William H. R. Langridge, PhDAddress:
Center for Health Disparities & Molecular Medicine
161 Mortensen Hall
Loma Linda University
Loma Linda, California 92350
Phone: (909) 558-4300, extension 81362
Fax: (909) 558-0177
Email: blangridge@llu.edu
Undergraduate: University of Illinois, Urbana, Illinois, 1962, BS.
Graduate: University of Massachusetts, Amherst, Massachusetts, 1973, PhD.
In 1973: Dr. Langridge received his doctoral degree in biological chemistry from the University of Massachusetts in Amherst, MA, where he identified and characterized a novel mitochondrial glutamate dehydrogenase enzyme that enables amoebae of the eukaryotic cellular “slime mold” Dictyostelium discoidium to convert amino acids into Krebs cycle intermediates essential for differentiation into a multicellular organism.
From 1974 to 1977: During his post doctoral research at the Boyce Thompson Institute for Plant Research at Cornell University in Ithaca, New York, Dr. Langridge studied the molecular basis underlying baculovirus and insect pox virus multiplication in cells and insects. His research focused on electron microscopic and restriction endonuclease mapping of baculovirus and insect pox virus genomes and characterization of early and late viral proteins synthesized during virus multiplication in cell culture and in vivo.
From 1977 to 1987: As Assistant Professor in the Boyce Thompson Institute, Dr. Langridge pioneered development of electroporation as a method for transfer and stable integration of foreign genes into the genome of higher plants. His research focused on the use of light-emitting reporter genes for identification of promoter function in tobacco, potato, and tomato plants.
From 1987 to 1993: Following acceptance of a position as Associate Professor in the University of Alberta, Centre for Plant Biotechnology, in Edmonton, Alberta, Canada Dr. Langridge combined plant cell transformation, light emitting reporter gene (luciferase) expression, and low light image analysis methods to detect and monitor endogenous plant hormone (auxin) transport during morphogenesis in transgenic food plants and in response to bacterial pathogenesis.
From 1993 to 2007: Following acceptance of a position as Professor at the Loma Linda University School of Medicine Center for Molecular Biology and Gene Therapy in Southern California, Dr. Langridge pioneered the development of edible plants expressing the human milk proteins beta casein and lactoferrin for improved infant nutrition and protection against infectious diseases. From 1996 to the present, Dr. Langridge has focused his research interests on the development of edible plants, bacteria, and vaccinia virus as production and delivery systems for immunomodulator-linked antigens and autoantigens as subunit mucosal vaccines for protection against human infectious and autoimmune diseases for the developing world.
The events surrounding 9/11/2001 have generated a prohibitive climate for obtaining bacterial and plant enterotoxin proteins from industrial sources for immunological and structural studies. Our research on the cholera toxin, ricin toxin, and shigatoxin B subunit immunomodulatory proteins over the past decade has placed us in an ideal position to supply these proteins to investigators needing them for their research.
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Last Revised: Fri, Mar 28, 2008