Professor
Departments of Neurosurgery, Anesthesiology, Physiology and Pharmacology, Pathology and Human Anatomy
School of Medicine
Loma Linda University
Loma Linda , CA 92350
Phone: (909) 558-4723
Fax: (909) 558-0119
E-mail: johnzhang3910@yahoo.com
Research Group web page:
http://www.llu.edu/llumc/neurosciences/zhang/
The clinically related basic science research in the Zhang Neuroscience Research Laboratories focuses on cerebral vascular diseases (stroke). There are about 700,000 people suffering from stroke each year in the United States. Stroke is the third leading cause of death (>160,000 patients per year) and the first leading cause of long-term neurological disability in adults. Cerebral vascular diseases are divided into two types: hemorrhagic (responsible for <20% of cerebral vascular diseases) and ischemic (responsible for >80% of cerebral vascular disease). Direct medical expenses, lost income, and decreased productivity after cerebral vascular diseases cost billions of dollars in the United States .
The main research direction is focused on the ischemic and hemorrhagic stroke, as well as global cerebral ischemia, neonatal hypoxia, and neurological complications of neurosurgery and anesthesia. Animal models of above mentioned neurological disorders are currently employed in the studies of cerebral physiology including blood-brain barrier, brain edema, cerebral blood flow and intracranial pressure, cerebral morphology especially immunohistochemistry, molecular biology, neuro-imaging, and neurological functions. The main focus of research interests are cerebral vascular biology, neuroprotective strategies, gene therapy, signaling pathways, apoptosis, and hyperbaric medicine.
One of the goals of the Zhang Neuroscience Research Laboratories involves training in neuroscience research. The Laboratories currently host researchers from Japan, China, Poland, Ireland, Germany, Turkey, and India. In addition, neurosurgery and anesthesiology residents are encouraged to participate in the basic science research. Graduate students in basic science departments are encouraged to investigate clinical neuroscience problems.
Dr. Zhang's research efforts are supported by grants from American Heart Association, National Institute of Health, and several other foundations.
Editor for Book
Hyperbaric Oxygen on Neurological Diseases. Editor: John H. Zhang. Best Publishing. 2007
Cerebral Vasospasm IX. Editors: Talat Kiris, John H. Zhang. Springer Wien New York. 2007
Advances of Clinical Neurological Research. Editor: John H. Zhang. Research Signpost, 2007
Animal Models of Acute Neurological Injury. Editors: Jun Chen, Xiaoming Xu, Zao C. Xu, John H. Zhang. Humana 2007
Editor for Special Journal Issue
J.H. Zhang: Hyperbaric Oxygen on Neurological Disorders. Neurological Research 29 (2) March 2007
J.H. Zhang: Chinese Neurosurgery Research. Neurological Research July 2007
J.H. Zhang: Frontiers of Neurosurgery Research. Frontiers in Bioscience September 2007
J.H. Zhang: Molecular Neurosurgery. Neurological Research December 2007
Original Article
J. Cahill, J. Calvert, S. Marcantonio & J. Zhang. P53 May Play an Orchestrating Role in Apoptotic Cell Death after Experimental SAH. Neurosurgery 60: 531-545, 2007
http://dx.doi.org/10.1227/01.NEU.0000249287.99878.9B
V. Jadhav, I. Solaroglu, A. Obenaus, J. H. Zhang. Neuroprotection against Surgically Induced Brain Injury. Surgical Neurology 67: 15-20, 2007 http://dx.doi.org/10.1016/j.surneu.2006.07.014
V. Jadhav, G. Matchett, F. P. Hsu & J.H. Zhang. Inhibition of Src tyrosine kinase and effect on outcomes in a new in vivo model of surgically induced brain injury. J Neurosurg. 2007 Apr;106(4):680-6.
J. Calvert & J. Zhang. Oxygen Treatment Restores Energy Status following Experimental Neonatal Hypoxia-Ischemia. Pediatric Critical Care Med 8: 165-173, January 2007 http://dx.doi.org/10.1097/01.PCC.0000257113.75488.84
T. Tsubokawa, V. Jadhav, I. Solaroglu, Y. Shiokawa, Y. Konishi & J. Zhang. Lecithinized Superoxide Dismutase Attenuates Focal Cerebral Ischemic Injury via Anti-Apoptotic Mechanisms in Rats. Stroke 38: 1057-1062, February 2007 http://dx.doi.org/10.1161/01.STR.0000257978.70312.1d
G. Matchett, J. Calinisan, G. Matchett, R. Martin & J. Zhang. The Effect of Granulocyte-Colony Stimulating Factor in Global Cerebral Ischemia in Rats. Brain Research 1136: 200-207, 2007 http://dx.doi.org/10.1016/j.brainres.2006.12.023
W. Lo, T. Brava, V. Jadhav, J. Zhang, J. Tang. NADPH Oxidase Inhibition Improves Neurological Outcomes in Surgically-induced Brain Injury. Neuroscience Lett 414: 228-232, 2007 http://dx.doi.org/10.1016/j.neulet.2006.12.055
H. Yatsushige, R. Ostrowski, T. Tsubokawa, A. Colohan, J. Zhang. Role of c-Jun N-terminal Kinase in Early Brain Injury after SAH. J Neurosci Res 85: 1436-1448, 2007 http://dx.doi.org/10.1002/jnr.21281
K. Yata, G. Matchett, T. Tsubokawa, J. Tang, K.Kanamaru & J.H. Zhang. Granulocyte-Colony Stimulating Factor Inhibits Apoptotic Neuron Loss after Neonatal Hypoxia-Ischemia in Rats. Brain Research 1145: 227-238, 2007 http://dx.doi.org/10.1016/j.brainres.2007.01.144
Z. Huang, Z. Kang, G. Gu, G. Peng, Y. Liu, H. Tao, W. Xu, J.H. Zhang, X. Sun. Therapeutic Effects of Hyperbaric Oxygen in a Rat Model of Endothelin-1 Induced Focal Cerebral Ischemia. Brain Research 1153: 204-213, 2007 http://dx.doi.org/10.1016/j.brainres.2007.03.061
E. Titova, R.P. Ostrowski, L.C. Sowers, J.H. Zhang, J. Tang. Effects of Apocynin and Ethanol on Intracerebral Hemorrhage-Induced Brain Injury in Rats. Clin Exp Pharmacol Physiol 34(9): 845-850, 2007
M. Zhou, G. Matchett, V. Jadhav, N. Dach & J. Zhang. The Effect of 2-Methoxyestradiol, a HIF-1α Inhibitor, in Global Cerebral Ischemia in Rats. Neurological Research
S. Liu, J. Tang, R. Ostrowski, E. Titova, C. Monroe, W. Chen, W. Lo, R. Martin, J. Zhang. Oxidative Stress after SAH in gp91phox Knockout Mice. Canadian J Neurological Sciences
M. Yamaguchi, V. Jadhav, A. Obenaus, A. Colohan & J. Zhang. MMP-9 Inhibition Attenuates Brain Edema in an in vivo Model of Surgically-Induced Brain Injury. Neurosurgery
R. Ostrowski, G. Graupner, E. Titova, J. Zhang, J. Chiu, N. Dach, D. Corleone, J. Tang, J. Zhang. The Hyperbaric Oxygen Preconditioning-Induced Brain Protection is mediated by A Reduction of Early Apoptosis after Transient Global Cerebral Ischemia. Neurobiology of Disease
T. Sugawara, R. Ayer, V. Jadhav, J. H. Zhang. A New Grading System Evaluating Bleeding Scale in Filament Perforation Subarachnoid Hemorrhage Rat Model. J Neurosci Methods 2007
S. Zhang, Q. Zhang, J. Zhang, X. Qin. Electro-stimulation of Cerebellar Fastigial Nucleus (FNS) Improves Axonal Regeneration. Frontiers in Bioscience. 2007
R. Ayer, T. Sugawara, W. Chen, W. Tong, J.H. Zhang. Melatonin Decreases Mortality Following Severe Subarachnoid Hemorrhage. Journal of Pineal Research
Review
R. L. Macdonald, R. Pluta, and J. H. Zhang. Cerebral Vasospasm after Subarachnoid Hemorrhage: The Emerging Revolution. Nature Clinical Practice Neurology 3(5): 256-263, 2007 http://dx.doi.org/10.1038/ncpneuro0490
J. Hansen-Schwartz, P. Vajkoczy, R. L. Macdonald, R. M. Pluta, J. H. Zhang. Cerebral Vasospasm: Looking beyond vasoconstriction. TiPS 28(6): 252-256, 2007 http://dx.doi.org/10.1016/j.tips.2007.04.002
I. Solaroglu, V. Jadhav, J.H. Zhang. Neuroprotective Effect of Granulocyte-Colony Stimulating Factor (Review). Frontiers in Biosciences 12: 712-724, 2007 http://dx.doi.org/10.2741/2095
J. W. Calvert, J.H. Zhang. HBO and Brain Physiology (Review). Neurological Research 2007 29: 132-141, 2007
E. Titova, R. Ostrowski, J.H. Zhang, J. Tang. Experimental Models of SAH for Studies of Cerebral Vasospasm. Neurological Research July 2007
J. Cahill, J. H. Zhang. Early Brain Injury (Review). Acta Neurochirurgica Supplement 2007
S. Armin, A. Colohan, J. H. Zhang. Vasospasm in Traumatic Brain Injury (Review). Acta Neurochirurgica Supplement 2007
R.E. Ayer, J.H. Zhang. Oxidative Stress in SAH: Significance in Acute Brain Injury and Vasospasm. Acta Neurochirurgica Supplement 2007
T. Sugawara, R. Ayer, J.H. Zhang. Role of Statins in Cerebral Vasospasm. Acta Neurochirurgica Supplement 2007
V. Jadhav, J. Zhang. Surgical Brain Injury: Prevention is better than Cure. Frontiers in Biosciences. 2007
S. Zhang, Q. Zhang, J. Zhang, X. Qin. A Key Role of NgR in Inhibition of Axonal Regeneration. Frontiers in Biosciences. 2007
T. Lekic, J. Zhang. Posterior Circulation Stroke and Animal Models. Frontiers in Biosciences. 2007
Editorial
R. Ayer, J.H. Zhang. Comment on: Neural Stem Cell Markers, Nestin and Musashi Proteins, in Progression of Human Glioma: Correlation of Nestin with Prognosis of Patient Survival. Surgical Neurology 68: 143-144, 2007
J.H. Zhang. Introduction to Special Issue: Hyperbaric Oxygen on Neurological Diseases. Neurological Research 29: 113-115, 2007
J. Hansen-Schwartz & J.H. Zhang. Cerebral Vasospasm Revisited - A Conference Where East Meets West. International Journal of Stroke 2: 2-3, 2007 http://dx.doi.org/10.1111/j.1747-4949.2007.00082.x
J. Zhang. Introduction to Special Issue: Chinese Neurosurgery Research. Neurological Research 2007
T. Kiris, J. Zhang. Preface: Cerebral Vasospasm after Subarachnoid Hemorrhage. Springer, 2007
J. Zhang. Editor's Remark: Hyperbaric Oxygen on Neurological Diseases. Ed: J.H. Zhang. Best Publishing 2007
J. Chen, X. Xu, J. Xu, J. Zhang. Preface. Animal Models of Acute Neurological Injury. Ed: J. Chen, X. Xu, J. Xu, J. Zhang. Humana 2007
J. Zhang. Preface: Advances of Neurological Research. Ed: J. Zhang. Research Signpost. 2007
J. Zhang. Introduction to Special Issue: Molecular Neurosurgery. Neurological Research 2007
Journal Supplement
J. Cahill, I. Solaroglu, J.H. Zhang. Apoptotic Markers in Vasospasm after Experimental SAH. Acta Neurochirurgica Supplement 2007
W. Shi, L. Huang, R. Wang, J. Sun, F. Wang, C. Liu, L. Zhou, J.H. Zhang. Oxyhemoglobin Induces Apoptosis in Mice Brain Cells In Vivo. Acta Neurochirurgica Supplement 2007
H. Yatsushige, M. Yamaguchi-Okada, J. Cahill, A. Colohan, J.H. Zhang. Inhibition of c-Jun N-terminal Kinase Pathway Attenuates Cerebral Vasospasm through Suppression of Apoptosis. Acta Neurochirurgica Supplement 2007
W. Tang, G. Zhu, J. Zhang, Z. Chen, Z. Liu, X. Wang, H. Feng. Effect of Oxyhemoglobin on Proliferation and Migration of Cultured Vascular Advential Fibroblast. Acta Neurochirurgica Supplement 2007
Z. Liu, G. Zhu, J. Zhang, Z. Chen, W. Tang, X. Wang, H. Feng. Ecdysterone Attenuates Vasospasm following Experimental SAH in Rabbits. Acta Neurochirurgica Supplement 2007
W. Tang, G. Zhu, J. Zhang, Z. Chen, Z. Liu, X. Wang, H. Feng. Effect of Oxyhemoglobin on Proliferation and Migration of Cultured Vascular Smooth Muscle Cells. Acta Neurochirurgica Supplement 2007
Z. Chen, H. Feng, J.H. Zhang, W. Tang, Z. Liu, G. Zhu, X. Wang. Proliferation of Vascular Smooth Muscle Cells Following Experimental SAH and the Effect of Ecdysterone. Acta Neurochirurgica Supplement 2007
Z. Chen, G. Zhu, J.H. Zhang, Z. Liu, W. Tang, H. Feng. Ecdysterone-Sensitive Smooth Muscle Proliferation Stimulated by Conditioned Medium of Endothelial Cells Cultured with Bloody CSF. Acta Neurochirurgica Supplement 2007
T. Sukawara, A. Wang, V. Jadhav, A. Obenaus, & J.H. Zhang. MRI in the Canine Double-Hemorrhage SAH Model. Acta Neurochirurgica Supplement 2007
Book Chapter
R. Ostrowski, A. Colohan, J. Zhang. Molecular Signaling Pathways in Early Brain Injury after SAH. Ed P. Chan, Hand Book of Neurochemistry and Molecular Neurobiology - Acute Ischemic Injury and Repair in the Nervous System. Pp235-253, 2007
J. Cahill, J. Zhang. Early Brain Injury and the Role of Apoptosis after a Subarachnoid Hemorrhage. Advances of Clinical Neurological Research. Ed: J.H. Zhang. Research SignPost 2007
G. A. Matchett, C. Higuchi, M. Allard, R. Martin, J. Zhang. Volatile Anesthetics and Cerebral Ischemia: Neuroprotective Mechanisms, Clinical Implications. Ed: J.H. Zhang. Research SignPost 2007
G.A. Matchett, R. Martin, J. Zhang. Hyperbaric Oxygen Therapy and Cerebral Ischemia. Ed: J.H. Zhang. Research SignPost 2007
R. P. Ostrowski, J. Zhang. Mechanisms of Hyperbaric Oxygen in Neurological Disorders. Hyperbaric Oxygen Therapy for Neurological Diseases. Ed: J.H. Zhang. Best Publishing 2007
P. Ren, X.J. Sun, J. H. Zhang. Hyperbaric Oxygen for Carbon Monoxide Poisoning. Hyperbaric Oxygen Therapy for Neurological Diseases. Ed: J.H. Zhang. Best Publishing 2007
J. Cahill, J. Zhang. Invasive Cerebral Blood Flow and Blood Pressure Monitoring In the Rodent Model. Animal Models of Acute Neurological Injury. Ed: J. Chen, X. Xu, J. Xu, J. Zhang. Humana 2007
R. Ayer, J. Cahill, T. Sugawara, V. Jadhav, J. Zhang. Surgical Procedures and Care. Animal Models of Acute Neurological Injury. Ed: J. Chen, X. Xu, J. Xu, J. Zhang. Humana 2007
J. Cahill, J. Zhang. The Monofilament Puncture Model for the Induction of a Subarachnoid Hemorrhage in the Rodent. Animal Models of Acute Neurological Injury. Ed: J. Chen, X. Xu, J. Xu, J. Zhang. Humana 2007
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Last Revised: Mon, Oct 08, 2007