Jiping Tang, MDChongqing Medical University, 1983
Associate Professor
Department of Physiology & Pharmacology
School of Medicine
Loma Linda University
Loma Linda, CA 92350
(909) 558-7693
(909) 558-0119 (FAX)
jtang@llu.edu
jipingtang@yahoo.com
Diabetes mellitus is a syndrome of impaired carbohydrate, fat, and protein metabolism caused by either lack of insulin secretion (type I diabetes) or decreased sensitivity of the tissues to insulin (type II diabetes). Diabetic complications, including cardiovascular-renal failure, are the leading cause of death in humans. My research has been focused on the pathophysiology of the pancreatic beta cell, alterations in insulin secretion and cardiovascular-renal dysfunction in diabetes using the animal models of diabetes e.g., streptozotocin-induced diabetic rat (type I diabetes) and Zucker diabetic fatty rat (type II diabetes). The role of hexosamine pathway in the regulation of insulin synthesis was examined using transgenic mice over expressing the rate-limiting enzyme for hexosamine synthesis, glutamine: F6P amidotransferase (GFA) that enhances hexosamine production.
In recent years, my studies have been focused on the mechanisms of brain injury caused by strokes that associated with diabetes mellitus. Stroke is the third-leading cause of death and a leading cause of adult disability in the United States. Ischemic stroke occurs when blood clots or other particles block arteries to the brain and cause severely reduced blood flow (ischemia). Hemorrhagic stroke occurs when a blood vessel in the brain leaks or ruptures (bleeding in the brain), causing cell damage and brain edema. Diabetes mellitus is a major risk factor for cerebrovascular diseases. Diabetic patients are more prone to stroke and have a higher mortality after stroke than patients without diabetes. To evaluate the mechanisms of stroke-induced brain injury and the effects of diabetes on stroke, animal models of hemorrhagic or ischemic stroke with or without diabetes are employed in our studies including brain edema, the changes in blood-brain barrier, cerebral blood flow and intracranial pressure, and cerebral biochemical and morphological changes. In addition, genetically engineered mice are used to evaluate the effect of matrix metalloproteinase-9 (MMP-9) deficiency and reduction of oxidative stress in cerebral disorders. Our goal is to explore the possibility of appropriately targeted therapeutic strategy to reduce brain injury in patients who are afflicted with stroke and diabetes.
My research interests also include the studies of brain injuries in neonates. Neonatal hypoxia ischemia brain injury leads to neurodevelopmental sequelae in affected infants. It affects not only the infants who experience the injury, but also their families. The care of affected children is dispersed over several medical specialties including pediatricians, child neurologists, physio-, speech-, and psycho-therapists; hence, the costs to society for treatment and care of such cases are extremely high. We are currently investigating the neuroprotective effects and mechanisms of various treatments in neonatal hypoxia rat model in hope to provide information to new clinical strategies for the prevention and treatment of hypoxia ischemia brain damage in human babies.
Laboratory Techniques
Animal models of human disease, including ischemic stroke, hemorrhagic stroke, and neonatal hypoxia ischemia. Techniques including immunohistochemistry, molecular biological and biochemical assays for evaluating oxidative stress, inflammation, and apopotosis.
Chen W, Jadhav V, Tang J, Zhang JH. HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. Neurobiology of Disease, in press
Lekic T, Tang J, Zhang JH. A rat model of pontine hemorrhage. Acta Neurochir Suppl, in press
Elena T, Ostrowski R, Zhang JH, Tang J. Effect of amantadine sulphate on intracerebral hemorrhage-induced brain injury in rats. Acta Neurochir Suppl, in press
Lee S, Jadhav V, Ayer RE, Rojas H, Hyong A, Lekic T, Tang J, Zhang JH. Dual effects of melatonin on oxidative stress after surgical brain injury in rats. J Pineal Res. 2008 Jun 18 [Epub ahead of print]
Elena T, Ostrowski R, Kevil C, Tong W, Rojas H, Sowers L, Zhang JH, Tang J. Reduced brain injury in CD18 deficient mice after experimental intracerebral hemorrhage. Journal of Neuroscience Research, in press
Hyong A, Jadhav V, Lee, S, Tong W, Rowe J, Zhang JH, Tang J. Rosiglitazone, a PPAR Gamma Agonist, Attenuates Inflammation After Surgical Brain Injury in Rodents. Brain Res, 2008 Jun [Epub ahead of print]
Bravo TP, Matchett GA, Jadhav V, Martin RD, Jourdain A, Zhang JH, Tang J. Role of Histamine in Brain Protection in Surgical Brain Injury in Mice. Brain Res. 1205:100-107, 2008
Ostrowski R, Graupner G, Titova E, Zhang J, Chiu J, Dach N, Corleone D, Tang J, Zhang JH. The hyperbaric oxygen preconditioning-induced brain protection is mediated by a reduction of early apoptosis after transient global cerebral ischemia. Neurobiology of Disease. 29:1-13, 2008
Titova E, Ostrowski R, Sowers L, Zhang JH, and Tang J. Effects of Apocynin and Ethanol on Intracerebral Haemorrhage-Induced Brain Injury in Rats. CEPP, 34:845-850, 2007
Liu S, Tang J, Ostrowski R, Titova E, Monroe C, Chen W, Lo W, Martin R, and Zhang JH. Oxidative Stress after Subarachnoid Hemorrhage in gp91phox Knockout Mice. Can J Neurol Sci. 34:356-361, 2007
Lo W, Bravo B, Jadhav V, Zhang JH, Tang J. NADPH Oxidase Inhibition Improves Neurological Outcomes in Surgically-Induced Brain Injury. Neuroscience letters, 414/3:228-232, 2007
Yata K, Matchett G, Tsubokawa T, Tang J, Kanamaru K, Zhang JH. Granulocyte-coloney stimulating factor inhibits apoptotic neuron loss after neonatal hypoxia-ischemia in rats. Brain Res, 1145:227-238, 2007
Ostrowski R, Tang J, Zhang HJ. Hyperbaric oxygen suppresses NADPH oxidase in a rat subarachnoid hemorrhage model. Stroke, 37:1314-1318, 2006
Tang J, Kusaka I, Massey RA, Rollins S, Zhang HJ. Increased RhoA Translocation in Aorta of Diabetic Rats. Acta Pharmacologia Sinica, 27:543-548, 2006
Tang J, Fitzgerald SM, Boughtman BN, Cole SW, Brands MW, Zhang JH. Decreased RhoA Expression in Myocardium of Diabetic Rats. Canadian Journal of Physiology and Pharmacology, 83:775-783, 2005
Dai Y, Tang J, Zhang JH. Role of Cl- in Cerebral Vascular Tone and Expression of Na+-K+-2Cl- Co-transporter after Neonatal Hypoxia- Ischemia. Canadian Journal of Physiology and Pharmacology, 83:767-773, 2005
Tang J, Liu J, Zhou C, Ostanin D, Grisham M, Granger DN, Nanda A, Zhang JH. Role of NADPH Oxidase in the Brain Injury of Intracerebral Hemorrhage. J Neurochem. 94:1342-1350, 2005
Smelley C, Specian RD, Tang J, Zhang JH. Acute gastric changes after intracerebral hemorrhage in rats. Brain Res. 1038:198-207, 2005
Tang J, Liu J, Zhou C, Alexander S, Nanda A, Granger DN, Zhang JH. Deficiency of Metalloproteinase-9 Gene Enhances Brain Injury caused by Collagenase-Induced Intracerebral Hemorrhage. J Cereb Blood Flow Metab. 24:1133-1145, October 2004
Kusaka I, Kusaka G, Zhou C, Ishikawa M, Nanda A, Granger DN, Zhang JH & Tang J. Role of AT1 Receptors and NAD(P)H Oxidase in Diabetes-Aggravated Ischemic Brain Injury. Am J Physiol Heart Circ Physiol 286(6):H2442-51, 2004
Park S, Yamaguchi M, Zhou C, Calvert JW, Tang J, Zhang JH. Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke 35(10):2412-2417, 2004
Park S, Zhou C, Tang J, Colohan A, J.H. Zhang JH. Apoptosis and Subarachnoid Hemorrhage. Pharmacology of Cerebral Ischemia. Ed. J. Krieglstein, S. Klumpp. p217-227, 2004
Sato M, Tang J, Nanda A & Zhang JH. Heat Shock Proteins Expression in Brain Stem after Subarachnoid Hemorrhage in Rats. Acta Neurochir Suppl 86: 477-482, 2003
Massey AR, Miao L, Smith BN, Liu J, Kusaka I, Zhang J, Tang J. Increased RhoA translocation in renal cortex of diabetic rats. Life Sciences 9350:1-10, 2003
Yin W, Tibbs R, Tang J, Badr A & Zhang J. Haemoglobin and ATP levels in CSF from a dog model of vasospasm. J Clin Neurosci 9:425-428, 2002
Miao L, Calvert J, Tang J & Zhang J. Rho-A and Rho-kinase in Cerebral Arteries in Diabetic Rats. Life Sci 71: 1175-1185, 2002
Satoh M, Perkins E, Kimura H, Tang J, Chun Y, Heistad DD, Zhang JH. Posttreatment with adenovirus-mediated gene transfer of calcitonin gene-related peptide to reverse cerebral vasospasm in dogs. J Neurosurg 97:136-42, 2002
Akin E, Clower B, Tibbs R, Tang J, Zhang J. Bilirubin produces apoptosis in cultured bovine brain endothelial cells. Brain Res 931:168-175, 2002
Miao L, Tang J, Esposito D & Zhang J. Age related Changes of P2 Receptor mRNA of Rat Cerebral Arteries. Exp Gerontol 37: 67-79, 2001
Miao L, Calvert J, Tang J, Parent A & Zhang J. Age related Rho A expression in Blood Vessels of Rats. Mechanism of Aging and Development 122: 1757-1770, 2001
Veerababu G, Tang J, Hoffman R, Daniels M, Hebert L, Crook E, Cooksey R & McClain D. Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance. Diabetes 49: 2070-2078, 2000.
Tang J & Zhang J. Mechanisms of [Ca2+] elevation by H2O2 in islets of rats. Life Sciences 68:475-481, 2000
Tang J, Neidigh J, Cooksey R & McClain D. Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance. Diabetes 49: 1492-6, 2000
Tibbs R, Tang J & Zhang J. Bilirubin Produces Apoptosis in Cultured Endothelial Cells. Ed. M. Garcia. On-line Proceedings of the 6th Internet World Congress on Biomedical Sciences '00 at Hospital of Ciudad Real, Diudad Real, Spain. 2000
She HY, Rockow S, Tang J, Nishimura R, Skolnik EY, Chen M, Margolis B & Li W. Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptors in living cells. Mol Biol Cell 8: 1709-1721, 1997
Tang J, Feng G & Li W. Induced direct binding of adapter protein NCK to the GTPase-activating protein (GAP)-associated protein p62 by epidermal growth factor. Oncogen 15: 1823-1832, 1997
Macdonald MJ, Tang J & Polonsky KS. Low mitochondrial glycerol phosphate dehydrogenase and pyruvate cardoxylase in pancreatic islets of Zucker diabetic fatty rats. Diabetes 45: 1626-1630, 1996
Rockow S, Tang J, Xiong W & Li W. Nck inhibits NGF and basic FGF induced PC12 cell differentiation via mitogen-activated protein kinase-independent pathway. Oncogen 12: 2351-2359, 1996
Tang J, Pugh W, Polonsky K & Zhang H. Preservation of Insulin Secretory responses to P2-purinoceptor agonists in Zucker diabetic fatty rats. Am J Physiol 270: 270: E504-E512, 1996
Roe MW, Worley JF, Tokuyama Y, Philipson LH, Sturis J, Tang J, Dukes ID, Bell GI & Polonsky KS. Non-insulin-dependent diabetes mellitus is associated with loss of pancreatic beta cell L-type Ca2+ channel activity. Am J Physiol 270: E133-140, 1996
Tokuyama Y, Sturis J, Depaoli A, Takeda J, Stoffel M, Tang J, Sun X, Polonsky K & Bell G. Evolution of -cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44: 1447-1457, 1995
Sturis J, Pugh WL, Tang J & Polonsky KS. Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat. Am J Physiol 269: E786-E792, 1995
Sturis J, Pugh WL, Tang J, Ostrega DM, Polonsky JS & Polonsky KS. Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat. Am J Physiol 267: E250-E259, 1994
Ryan EA, Tobin BW, Tang J & Finegood DT. A new model for the study of mild diabetes during pregnancy. Diabetes 42: 316-323, 1993
Last Revised: Thu, Jul 10, 2008
