Position
Professor of Pharmaceutical Sciences
Biography
PhD, Clinical Pharmacology, Flinders University of South Australia • MS, Pharmacology, Mahidol University • BS, Organic Chemistry, Mahidol University, Bangkok • Joined LLU in August, 2004
Research Interests
Grapefruit juice drug interactions; herbal-drug interactions; pharmacogenetics and pharmacokinetics in Native American Indians, Hawaiians, and Mexicans; herbal supplements and anti-cancer activity; effects of tea, ginseng, and wine on P450 and Phase II enzymes in relation to cancer prevention; clinical pharmacokinetics and metabolism of antimalarial drugs; P450 and Phase II conjugation enzymes in Antarctic Penguin liver.
Selected Publications
Wanwimolruk S, Wanwimolruk P. Characterization of CYP1A enzyme in Adelie penguin liver. Compar. Biochem. Physiol. 144C: 148-154 (2006).
Wanwimolruk S, Marquez PV. Variations in content of active ingredients causing drug interactions, in grapefruit juice products sold in California. Drug Metab. Drug Interact. 21: 233-243 (2006).
Numata M, Fawcett JP, Rosengren RJ, Wanwimolruk S. Ontogeny of hepatic microsomal 3-hydroxylation of quinine mediated by CYP3A in Adelie penguins. Compar. Biochem. Physiol. 138C: 53-58 (2004).
Niwattisaiwong N, X-X Lou, Coville PF, Wanwimolruk S. Effects of Chinese, Japanese and western tea on hepatic P450 enzyme activities in rats. Drug Metab. Drug Interact. 20: 43-56 (2004).
Pukrittayakamee S, Wanwimolruk S, Stepniewska K, Jantra A, Huyakorn S, Looareesuwan S, White NJ. Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria. Antimicrob Agents Chemother 47: 3458-3463 (2003).
Wanwimolruk S, Paine M, Pusek S, Watkins PB. Is quinine a suitable probe to assess the hepatic drug metabolizing enzyme CYP3A4? Br. J. Clin. Pharmacol. 54: 643-651 (2002).
Maliakal PP, Coville PF, Wanwimolruk S. Decreased hepatic drug metabolizing enzyme activity in rats with nitrosamine-induced tumors. Drug Metab. Drug Interact. 19: 13-27 (2002).
Pukrittayakamee S, Pitisuttithum P, Zhang H, Jantra A, Wanwimolruk S, White NJ. Effects of cigarette smoking on quinine pharmacokinetics in malaria. Eur. J. Clin. Pharmacol. 58: 315-319 (2002).
Maliakal PP, Coville PF, Wanwimolruk S. Tea consumption modulates hepatic P450 and phase II enzymes in Wistar rats. J. Pharm. Pharmacol. 53: 569-577 (2001).
Maliakal PP, Wanwimolruk S. Effect of herbal tea on drug metabolizing enzymes in rats. J. Pharm. Pharmacol. 53: 1323-1329 (2001).
Ho P-C, Saville DJ, Wanwimolruk S. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. J. Pharm. Pharmaceut. Sci. 4: 217-227 (2001).
Ho P-C, Ghose K, Saville DJ, Wanwimolruk S. Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers. Eur. J. Clin. Pharmacol. 56: 693-698 (2000).
Ho P-C, Chalcroft SC, Coville PF, Wanwimolruk S. Grapefruit juice has no effect on quinine pharmacokinetics. Eur. J. Clin. Pharmacol. 55: 393-398 (1999).
Wanwimolruk S, Bhawan S, Coville PF and Chalcroft SC. Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations. Eur. J. Clin. Pharmacol. 54: 431-435 (1998).
Affiliations
American Association of Pharmaceutical Scientists (AAPS)
Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)
Courses
RXPS 610 – Pharmacokinetics
RXPC 710 – Dietary Supplements
RXPC 718 – Clinical Toxicology
