Research Interest

Dr. Perry’s research interests at Loma Linda University focus on nanoparticles for therapeutic applications, and surface modification of materials to impart more desirable physical properties. The projects that Dr. Perry is involved include using polymeric/metal composite nanoparticles in gene therapy and as a form of combinational/adjuvent treatment for pancreatic cancer.  Second, in collaboration with Dr. Jamie Milligan (University of California at San Diego) he is studying the condensation and compaction of DNA in aqueous environments. The motivation behind this research is to develop non-viral genetic therapy vehicles.

The collaboration with Dr. Hansel Fletcher (microbiology, Loma Linda University) involves pursuing the use of nanomaterials as novel treatments for chronic periodontal disease and Methicillin resistant S. aureus infections. In conjunction with the School of Dentistry (Dr. Steve Kurti) Dr. Perry is trying to develop a surface medication approaches to lengthen the life of polymeric composite dental fillings.

Selected Publications

1. Lee, M.; Urata, S. M.; Aguilera, J. A.; Perry, C. C.; Milligan, J. R., Modeling the Influence of Histone Proteins on the Sensitivity of DNA to Ionizing Radiation. Radiat. Res. 2012, 177 (2), 152-163.

2. Do, T.; Tang, V.; Konigsfeld, K.; Aguilera, J.; Perry, C.; Milligan, J., Damage clusters after gamma irradiation of a nanoparticulate plasmid DNA peptide condensate. Radiat. Environ. Biophys. 2012, 51 (1), 43-52.

3. Sabir, T. S.; Yan, D.; Milligan, J. R.; Aruni, A. W.; Nick, K. E.; Ramon, R. H.; Hughes, J. A.; Chen, Q.; Kurti, R. S.; Perry, C. C., Kinetics of Gold Nanoparticle Formation Facilitated by Triblock Copolymers. J. Phys. Chem. C 2012, 116 (7), 4431-4441.

4. Perry, C.; Urata, S.; Lee, M.; Aguilera, J.; Milligan, J., Radioprotective effects produced by the condensation of plasmid DNA with avidin and biotinylated gold nanoparticles. Radiat. Environ. Biophys., 2012 (online first) DOI: 10.1007/S00411-012-0429-6  pp. 1-12.

5. Osbourne, D.; Wilson Aruni, A.; Dou, Y.; Perry, C.; Boskovic, D. S.; Roy, F.; Fletcher, H. M., VimA–dependent modulation of the secretome in Porphyromonas gingivalis. Molecular Oral Microbiology 2012, (ONLINE FIRST) DOI: 10.1111/j.2041-1014.2012.00661.x

6. Perry, C. C.; Tang, V. J.; Konigsfeld, K. M.; Aguilera, J. A.; Milligan, J. R., Use of a Coumarin-Labeled Hexa-Arginine Peptide as a Fluorescent Hydroxyl Radical Probe in a Nanoparticulate Plasmid DNA Condensate. J. Phys. Chem. B 2011, 115 (32), 9889-9897.

7. Perry, C. C.; Sabir, T. S.; Livingston, W. J.; Milligan, J. R.; Chen, Q.; Maskiewicz, V.; Boskovic, D. S., Fluorescence of commercial Pluronic F127 samples: Temperature-dependent micellization. J. Colloid Interface Sci. 2011, 354 (2), 662-669.

8. Do, T. T.; Tang, V. J.; Aguilera, J. A.; Perry, C. C.; Milligan, J. R., Characterization of a Lipophilic Plasmid DNA Condensate Formed with a Cationic Peptide Fatty Acid Conjugate. Biomacromolecules 2011, 12 (5), 1731-1737.

9. Al-Abdullah, Z. T. Y.; Yuyoung, S.; Rantej, K.; Perry, C. C.; Wuzong, Z.; Qiao, C., The influence of hydroxide on the initial stages of anodic growth of TiO₂ nanotubular arrays. Nanotechnology 2010, 21 (50), 505601.

10. Tsoi, M.; Do, T. T.; Tang, V.; Aguilera, J. A.; Perry, C. C.; Milligan, J. R., Characterization of condensed plasmid DNA models for studying the direct effect of ionizing radiation. Biophys. Chem. 2010, 147 (3), 104-110.

11. Osbourne, D. O.; Aruni, W.; Roy, F.; Perry, C.; Sandberg, L.; Muthiah, A.; Fletcher, H. M., Role of vimA in cell surface biogenesis in Porphyromonas gingivalis. Microbiology 2010, 156 (7), 2180-2193.

12. Mandi Tsoi, Trinh T. Do, Vicky Tang, Joseph A. Aguilera, Christopher C. Perry, Jamie R. Milligan, “Characterization of condensed plasmid DNA models for studying the direct effect of ionizing radiation”, Biophysical Chemistry 147 (2010) 104–110

13. Rogstad, D. K.; Herring, J. L.; Theruvathu, J. A.; Burdzy, A.; Perry, C. C.; Neidigh, J. W.; Sowers, L. C., Chemical Decomposition of 5-Aza-2′-deoxycytidine (Decitabine): Kinetic Analyses and Identification of Products by NMR, HPLC, and Mass Spectrometry. Chem. Res. Toxicol. 2009, 22 (6), 1194-1204.

14. Perry, C. C.; Weatherly, M.; Beale, T.; Randriamahefa, A., Atomic force microscopy study of the antimicrobial activity of aqueous garlic versus  ampicillin against Escherichia coli and Staphylococcus aureus. J. Sci. Food Agric. 2009, 89 (6), 958-964.

15. C.C. Perry, M. Weatherly, T. Beale, A. Randriamahefa, “Atomic force microscopy study of the antimicrobial activity of aqueous garlic versus  ampicillin against Escherichia coli and Staphylococcus aureus”, Journal of the Science of Food and Agriculture 89 (2009) 958-964.

15. Waddell, E.A; Shreeves, S;Carrell, H; Perry, C.C.; Reid, B.A.; McKee, J.  “Surface Modification of Sylgard 184 Polydimethylsiloxane by 254 nm Excimer Radiation and Characterization by Contact Angle Goniometry, Infrared Spectroscopy, Atomic Force and Scanning Electron Microscopy”, Applied Surface Science 254 (2008) 5314-5318.

17. C.C. Perry, T. Brower, C. Zhang, E. Waddell, C.W. Bates Jr,  J. Mitchell, “Chemical Etching of Nanocomposite Metal-Semiconductor Films Monitored by Raman Spectroscopy and Surface Probe Microscopy”, Proceedings of SPIE-The International Society for Optical Engineering  (2008)  6891-45. 

18. C. C. Perry, N. S. Faradzhev T. E. Madey, D. H. Fairbrother, “Electron stimulated reactions of methyl iodide co-adsorbed with amorphous solid water”, J. Chem. Phys. 126 (2007) 204701.

19. Christopher, Perry, Alexandrine Randriamahefa,, Carl Lokko, Whitney Evans, Julian Watkins, Holly Carrell,  Natalie King, Darayas Patel.   “Iron oxide nanoparticles as drug delivery agents in MIA PaCa-2 pancreatic cells”,    Proceedings of SPIE-The International Society for Optical Engineering  6441 (2007) 64411T.

20. Patel, Darayas; Perry, Christopher; Kennedy, Sarah.   “Spectroscopic studies and AFM analysis of Ho3+ and Tm3+ doped yttrium oxide nanoparticles”,    Proceedings of SPIE-The International Society for Optical Engineering  (2007),  6469 (Optical Components and Materials IV).

21. C.C. Perry, N.S. Faradzhev, D.H. Fairbrother, and T.E. Madey, “Electron-driven reactions of halogenated compounds in condensed matter: Effects of solvent matrices on reaction dynamics and kinetics”, Int. Rev. Phys. Chem., 23  (2004) 289-340.

22. N.S. Faradzhev, C.C. Perry, D.O. Kusmierek, D.H. Fairbrother, and T.E. Madey, “Kinetics of electron-induced decomposition of CF₂Cl₂ co-adsorbed with water (ice): A comparison with CCl₄”, J. Chem. Phys.121 (2004) 8547.