Research Interest

Viral oncogenes-induced cancerogenesis and ways to inhibit it, mechanisms of modulation of epithelial differentiation by human papillomavirus (HPV) oncogenes, modulation of host defense by HPV oncogens.

Selected Publications

1. Tungteakkhun, S. S., M. Filippova, N. Fodor and P. J. Duerksen-Hughes.  The Full Length Isoform of HPV 16 E6 and its Splice Variant E6* Bind to Different Sites on Procaspase 8 DED.  J. Virol. 84:1453-1463, 2010.  PMID:  19906919

2. Filippova, M., V. A. Filippov, M. Kagoda, T. Garnett, N. Fodor and P. J. Duerksen-Hughes.  Complexes of Human Papillomavirus 16 E6 Proteins Form Pseudo-DISC Structures During TNF-Medicated Apoptosis.  J. Virol.  83:210-227, 2009.  PMID:  18842714

3. Tungteakkhun, S., M. Filippova, J. W. Neidigh, N. Fodor and P. J. Duerksen-Hughes.  The Interaction Between HPV 16 E6 and FADD is Mediated by a Novel E6 Binding Domain.  J. Virol.  82:9600-9614, 2008.  PMID:  18632871

4. Filippov, V., E. L. Schmidt, M. Filippova and P. J. Duerksen-Hughes. Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes.  Gene.  420:34-41, 2008.  PMID:  18571879

5. Haynes, T.-A S., P. J. Duerksen-Hughes, M. Filippova, V. Filippov and K. Zhang.  C(18) Ceramide Analysis in Mammalian Cells Employing Reversed-Phase High Performance Liquid Chromatography Tandem Mass Spectrometry.  Analytical Biochemistry.  378:80-86, 2008.  PMID:  18423390

6. Filippov, V., M. Filippova and P. J. Duerksen-Hughes.  The Early Response to DNA Damage Can Lead to Activation of Alternative Splicing Activity Resulting in CD44 Splice Pattern Changes.   Cancer Research.  67:7621-7630, 2007.  PMID:  17699766

7. Garnett, T. O., M. Filippova and P. J. Duerksen-Hughes.  Bid is Cleaved Upstream of Caspase-8 Activation During TRAIL-Mediated Apoptosis in Human Osteosarcoma Cells.  Apoptosis.  12:1299-1315, 2007.   PMID:  17431792

8. Filippova, M., M. M. Johnson, M. Bautista, V. Filippov, N. Fodor, S. S. Tungteakkhun, K. Williams and P. J. Duerksen-Hughes.  The Large and Small Isoforms of HPV 16 E6 Bind to and Differentially Affect Procaspase 8 Stability and Activity.  J. Virology.  81:4116-4129, 2007.  PMID:  17267478

10. Garnett, T., M. Filippova, and P. J. Duerksen-Hughes.  Accelerated Degradation of FADD and Pro-Caspase 8 in Cells Expressing Human Papillomavirus 16 E6 Impairs TRAIL-Mediated Apoptosis.  Cell Death and Differentiation.  13:1915-1926, 2006.  PMID:  16528366

11. Filippova, M., T. A. Brown-Bryan, C. A. Casiano and P. J. Duerksen-Hughes.  The Human Papillomavirus 16 E6 Protein Can Render Cells Either Sensitive or Resistant to TNF:  Effect of Dose.  Cell Death and Differentiation. 12:1622-1635, 2005.  PMID:  15933739

12. Filippova, M., Parkhurst, L. and P. J. Duerksen-Hughes.  HPV 16 E6 Binds to FADD and Modulates Fas-Triggered Apoptosis.  J. Biol. Chem. 279:25729-25744, 2004.  PMID:  15073179

13. Filippova, M., H. Song, J. L. Connolly, T. S. Dermody and P. J. Duerksen‑Hughes. The Human Papillomavirus 16 E6 Protein Binds to TNF R1 and Protects Cells from TNF‑Triggered Apoptosis.  J. Biol. Chem. 277:21730-21739, 2002.  PMID:  11934887