As the human body continues to expand, so does the epidemic of type 2 diabetes, and novel approaches to the treatment of metabolic diseases will be needed. My research interest involves the development of imidazoline compounds as therapeutic agents to treat metabolic disease such as type 2 diabetes. Clinically useful imidazolines such as moxonidine have the potential to treat both hypertension and type 2 diabetes. We are interested in testing novel compounds to be used as single agent therapy for diabetics with hypertension. We are also studying the mechanism of cross-talk between imidazoline and insulin receptor signaling pathways.
1. Lincoln P. Edwards, Terry A. Brown-Bryan, Lancelot McLean and Paul Ernsberger. Pharmacological Properties of the Central Antihypertensive Agent, Moxonidine. Cardiovasc Ther. 2012, 30(4):199-208.
2. Tesfai J, Crane L, Baziard-Mouysset G, Edwards LP (2012) Novel I1-Imidazoline Agonist S43126 Augment Insulin Secretion in Min6 Cells. J Diabetes Metab 3:183.
3. Jerusalem Tesfai,Louis Crane, Genevieve Baziard-Mouysset and Lincoln P. Edwards. Novel I1-Imidazoline S43126 Enhance Insulin Action in PC12 Cells . Pharmacological Reports, 2011, 63, 1442-1449.
4. Lancelot S. McLean, Louis Crane, Genevieve Baziard-Mouysset and Lincoln P. Edwards. The novel imidazoline compound, S43126 induces apoptosis in PC12 cells. (submitted)
5. Lancelot S. McLean and Lincoln P. Edwards. The Association between Diabetes and Oral Cancer.. (In Preparation)
6. Terry A. Brown-Bryan and Lincoln P. Edwards. Moxonidine Stimulates Glucose Uptake through a IRAS-IRS dependent Signaling Pathway. (In Preparation)
7. Lincoln P. Edwards. Terry A. Brown-Bryan, Lancelot McLean and Paul Ernsberger. Moxonidine: An Imidazoline Agent Targeting Metabolic Syndrome. (In press).
8. Jerusalem Tesfai1,Louis Crane2, Genevieve Baziard-Mouysset2 and Lincoln P. Edwards3 Novel I1-Imidazoline S43126 Enhance Insulin Action in PC12 Cells .(in preparation).
9. Wentsworth B. Kennedy1, Louis Crane2, Ramon R. Gonzalez3, Genevieve Baziard-Mouysset4, and Lincoln. P. Edwards Characterization of S43126 an Imidazoline agonist and its involvement as an anti-hypertensive drug in rats.(in preparation).
10. Oommen K. George, , Ramon R. Gonzalez Jr.,, Lancelot McLean, Raymond G. Hall, J., and Lincoln. P. Edwards. Angiotensin II induced tension development in rat-tail artery involves PLD and PKC Advanced Studies in Biology, (In press)
8. Wentsworth B. Kennedy, Louis Crane, Ramon R. Gonzalez, Oommen K.George, and Lincoln. P. Edwards. Effects of a Catecholamine and some Imidazolines on Induced Tension in Rat-Tail Artery. Cellular and Molecular Neurobiology, 2006 Jul;26(4-6):643-55s (Special Issue in honor of Dr. Julius Axelrod, Nobel Laureate)
11.. Oommen K. George, Ramon R. Gonzalez, and Lincoln. P. Edwards (2003). Moxonidine, a selective α2-adrenergic and Imidazoline receptor Agonist, is permissive to α1-adrenergic receptor pathway in the rat-tail artery. J. of Cardiovascular Pharmacology vol.43, number 2, February 2004.
12. Edwards,L.P., and Ernsberger, P: The I1-imidazoline Receptor in PC12 Pheochromocytoma Cells Reverses NGF-Induced ERK Activation and Induces MKP-2 Phosphatase. Brain Research (2003) 980/1 pp. 71-79
13. Edwards, L., Whitter, E. and Hessinger, D. Apparent membrane pore-formation by Portuguese Man-of-war (Physalia physalis) venom in intact cultured cells.. Toxicon 40 (2002 ) 1299-1305.
14. Edwards L, Fishman D, Horowitz P, Bourbon N, Kester M, Ernsberger P. The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK). J. Neurochem 2001 Dec1; 79(5):931-940
15. Edwards, L., and Hessinger, D. Portuguese Man-of-war (Physalia physalis) venom induces calcium influx into cells by permeabilizing plasma membranes. Toxicon 2000 Aug; 38(8):1015-28
16. Edwards, L.P., and Ernsberger, P. (2000) Assay of Arachidonic Acid Release Coupled to α1- and α2-Adrenergic Receptors, in Methods in Molecular Biology, vol.126. (Adrenergic Receptor Protocols Curtis A. Machida editor), Humana Press, Totowa, New Jersey ,pg. 375 – 390
17. Edwards, L., Luo, E., Hall, R., Gonzalez Jr.,R.R. and Hessinger, D.A. The Effect of Portuguese Man-of-war (Physalia physalis) venom on calcium, sodium and potassium fluxes of cultured embryonic chick heart cells. Toxicon (2000)Mar; 38(3): 323-335