Research interest

1. Relationship between procedural pain and oxidative stress in premature neonates
2. Biochemical markers of neonatal pain
3. Strategies that will reduce hypoxia-ischemia in premature neonates
4. Biochemistry of neonatal brain injury
5. Opioid-mediated neuroprotection in neonates
6. Necrotizing enterocolities

 Selected Publications

 1. Mannoia K, Boskovic D, PhD, Slater L, Plank M, BS, Angeles D, Gollin G. Necrotizing Enterocolitis Is Associated With Neonatal Intestinal Injury.  Journal of Pediatric Surgery, 2011, In Press.

 2. Plank M, Boskovic D, Tagge E, Chrisler J, Slater L, Angeles K, Angeles D.  An animal model for measuring the effect of common NICU procedures on ATP metabolism. Biological Research in Nursing,  2010, In Press

 3. Plank M, Sowers L, Boskovic D, Angeles DM.  Biochemical markers of neonatal hypoxia. 2008.  Pediatric Health, 2:4, 485-501.

 4. Calderon T, Boskovic D, Sowers L, Angeles DM.  Use of purines and xanthine oxidase as markers of neonatal hypoxia-ischemia. 2008.  Advances in Neurological Research, 209-277.  Research Signposts, Editor:  John H. Zhang

 5. Calderon T, Wu W, Rawson R, Sakala E, Sowers L, Boskovic D, Angeles DM.  Effect of Mode of Birth on Purine and Malondialdehyde in Umbilical Arterial Plasma in Normal Term Newborns.  J Perinatology, 2008, 28, 475-481.

 6. Angeles DM, Ashwal S, Deming D, Yellon S, Hopper A, Peverini R. Are elevated peripheral leukocytes markers of septic etiology in asphyxiated infants with neurological disability? J Perinatol. 2008 Jan;28(1):85-6

 7. Morkos AA, Hopper AO, Deming DD, Yellon SM, Wycliffe N, Ashwal S, Sowers LC, Peverini RL, Angeles DM.  Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates.  J Perinatol. 2007 Jun;27(6):365-70.

8. Angeles DM, Ashwal S, Wycliffe N, Ebner C , Fayard E, Sowers L, Holshouser B.  2007.  Relationship Between Opioid Therapy, Tissue Damaging Procedures And Brain Metabolites As Measured By Proton MRS In Asphyxiated Term Neonates. Pediatr Res. 2007 May;61(5 Pt 1):614-21

 9. Angeles DM, Chang M, Leong V, Pearce WJ.  Dexamethasone alters vascular reactivity by enhancing COX-related vasodilation in fetal ovine carotids. 2006. Biology of the Neonate, 90(1):1-8. Epub 2005 Dec 14

10. Angeles DM, Wycliffe N, Michelson D, Holshouser B, Deming D, Pearce W, Sowers L, Ashwal S.  2005.  Use of opioids in asphyxiated term neonatesl  Effects on neuroimaging and clinical outcomes. Pediatric Research,  57(6), 873-878

11. Angeles, D.M., Williams, J., Purdy, R., Zhang, L., Pearce, W.J. (2001). Effects Of Maturation And Acute Hypoxia On Receptor-IP₃ Coupling In Ovine Common Carotid Arteries. Am J Physiol Regulatory Integrative Comp Physiol, 280: R410-R417218

12. Angeles, D.M., Williams ,J., Zhang, L., Pearce ,W.J. (2000) Acute hypoxia modulates 5-HT receptor density and agonist affinity in fetal and adult ovine carotid arteries. Am J Physiol Heart Circ Physiol  2000 Aug;279(2):H502-10