Research Interest

The regulation of cerebral blood flow is of critical importance to the developing fetus in utero, as well as to the newborn infant and adult.  In addition, acclimatization to high altitude long-term hypoxia alters the vascular regulatory mechanisms.  My laboratory explores the fundamental cellular signal transduction mechanisms that regulate tone in the cerebral vasculature, their change with development, and in response to acclimatization to hypoxia.  We also are attempting to understand the basic molecular mechanisms that regulate these changes with development and in response to hypoxia.

 Selected Publications

1. Goyal R, N Chu, A Arthur, L Zhang, and LD Longo.  Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility.  Am J Physiol Regul Integr Comp Physiol [Epub August 2010] PMID 20702800

2. Goyal R, A Mittal, N Chu, L Zhang, and LD Longo.  α1-Adrenergic receptor subtype function in fetal and adult cerebral arteries.  Am J Physiol Heart Circ Physiol 298: H1797-H1806, 2010.  PMID 20348219

3. Goyal R, A Mittal, N Chu, L Shi, L Zhang, and LD Longo.  Maturation and the role of PKC-mediated contractility in ovine cerebral arteries.  Am J Physiol Heart Circ Physiol 297: H2242-H2252, 2009.  PMID: 19749163

4. Gheorghe CP, R Goyal, A Mittal, and LD Longo.  Gene expression in the placenta:  Maternal stress and epigenetic responses.  Int J Develop Biol 54: 507-523, 2010.  PMID: 19876832

Total Publications: 296