Intracerebral Hemorrhage (ICH)

Involvement of immune system in secondary brain injury after ICH

Selected Publications

1. Manaenko A, Chen H, Zhang JH, Tang J (2011). Comparison of Different Preclinical Models of Intracerebral Hemorrhage. Acta Neurochir Suppl. 2011;111:9-142.

2. Manaenko A, Fathali N, Khatibi NH, Lekic T, Shum KJ, Martin R, Zhang JH, Tang J (2011). Post-treatment with SR49059 Improves Outcomes Following an Intracerebral Hemorrhagic Stroke in Mice. Acta Neurochir Suppl. 2011;111:191-196.

3. Manaenko A, Lekic T, John H. Zhang, Tang J (2011). NC1900, an Arginine Vasopressin Analogue, Fails to Reduce Brain Edema and Improve Neurobehavioral Deficits in an Intracerebral Hemorrhagic Stroke Mice Model. Acta Neurochir Suppl., 111:155-9.

4. Manaenko A, Lekic T, Ma Q, Zhang JH, Tang J (2011). Hydrogen Inhalation is Neuroprotective and Improves Functional Outcomes in Mice After Intracerebral Hemorrhage. Acta Neurochir Suppl.;111:179-83

5. Rolland W II, Manaenko A, Lekic T, Hasegawa Y, Ostrowski R,  Tang J, Zhang JH (2011). FTY720 is neuroprotective and improves  functional outcomes after ICH in mice. Acta Neurochir Suppl.;111:179-83

6. Lekic T, Manaenko A, Rolland W II, Tang J, Zhang JH (2011). A novel preclinical model of germinal matrix hemorrhage using neonatal rats. Acta Neurochir Suppl.;111:55-60

7. Lekic T, Manaenko A, Rolland W II, Virbel K, Tang J,  Zhang JH (2011). Neuroprotection by melatonin after germinal matrix hemorrhage in premature neonatal rats. Acta Neurochir Suppl.;111:201-206

8. Manaenko A*, Kueppers-Tiedt L*, Michalski D, Guenther A,  Hobohm C, Wagner A, Zhang JH, Schneider D [* Equally contributed] (in press). Combined systemic thrombolysis with alteplase and early hyperbaric oxugen therapy in experimental embolic stroke in rats-relationship to functionla outcome and reduction of structural damage. Acta Neurochir Suppl.;111:166-172

9. Lekic T, Manaenko A, William Rolland, Kelly Virbel, Jiping Tang, Zhang JH (2011). Beneficial effects of hyperbaric oxygen after neonatal germinal matrix hemorrhage. Acta Neurochir Suppl.;111:253-257

10. Lekic T, Manaenko A, William Rolland, Mathew Patterson, Jiping Tang, Zhang JH (2011). Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats. Acta Neurochir Suppl.;111:237-241

11. Lekic T, Ostrowski RP, Suzuki H, Manaenko A, Rolland W, Fathali N, Tang J, Zhang JH (2011). The postpartum period of pregnancy worsens brain injury and functional outcome after cerebellar hemorrhage in rats. Acta Neurochir Suppl.;111:37-41

12. Manaenko A, Fathal N, Lekic T, Hasegawa Y, Zhang JH , Tang J (2011). Arginine vasopressin V1A receptor inhibition imporves outcomes in intracerebral hemorrhage induced brain injred mice. Neurochemistry International 58 (4), 542-548

13. Manaenko A, Chen H, Kammer J, Zhang JH, Tang J (2011). Evans Blue Staining: Effect of routes of stain administration and circulation time on stain accumulation in brain tissue. Journal of Neuroscience Methods 195 (2), 206-210

14. Duris K, Manaenko A, Suzuki H, Rolland W, Tang J, Zhang JH (2011). Sampling of CSF via the Cisterna Magna and Blood Collection via Heart Affects Brain Water Content in rat SAH Model. Translational Stroke Research, 2(2), 232-237

15. Duris K, Manaenko A, Suzuki H, Rolland W, Kraft PR, Zhang JH (2011). Alpha 7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of SAH in rat. Stroke, in press

16. Manaenko A, Fathali N, Chen H, Suzuki H, Williams S, Zhang JH, Tang J (2010). Attenuation of Brain Injury by Geldanamycin in a Mouse Model of Intracerebral Hemorrhage. Neurochemistry International 57 (7), 844-850

17. Ma Q, Manaenko A, Rolland W II, Chen W, Zhang JH,  Tang J (2010).Vascular adhesion portein-1 inhibition porvides neuroprotectrion from intracerebral hemorrhage induced brain injury in mice. Journal of Cerebral Blood Flow, 1-13

18. Lekic T, Hartman R, Fathal N, Manaenko A, Tang J, Zhang JH (2010). Protective Effect of Melatonin upon Neuropathology, Striatal Function and Memory Ability after Intracerebral Hemorrhage in Rats. Journal of Neurotrauma 27, 627-637

19. Chen C,  Manaenko A, Liu W, Zhan Y, Ostrowski R, Zhang JH (2010). Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model. Neuroscience 11, 402-414

20. Manaenko A, Lekic T, Sozen T, Tang J, Zhang JH (2009). The Impact of Gap junction inhibitors Octanol and Carbenoxolone upon Brain Edema, Behavior and Mortality after ICH in mice. Journal of Neurol. Research 31, 173-178.

21. Tsuchiyama R, Sozen T, Manaenko A, Tang J, Zhang JH (2009).  The Effects of Nicotinamide Adenine Dinucleotide on Intracerebral Hemorrhage-Induced Brain Injury in mice. Journal of Neurol. Research 31(2):179-82.

22. Milosevic J, Adler I, Manaenko A, Stroch A, Schwarz J (2009). Non-hypoxic stabilization of hypoxia-inducible factors: relevance in neural progenitor/sten cells. Neurotox. Research 5(4), 367-380.

23. Günther A, Manaenko A, Franke H, Wagner A, Schneider D, Berrouschot J, Reinhardt R (2004). Hyperbaric and normobaric reoxygenation of hypoxic rat brain slices - impact on purine nucleotides and cell viability. Neurochem Int. 45, 1125-1132.

24. Reinhardt R, Manaenko A, Guenther A, Franke H, Dickel T, Garcia de Arriba S, Muench G, Schneider D, Wagner A, Illes P. (2003). Early biochemical and histological alterations in rat corticoencephalic cell cultures following metabolic damage and treatment with modulators of mitochondrial ATP-sensitive potassium channels. Neurochem Int. 43(6), 563-571.

25. Gunther A, Manaenko A, Franke H, Dickel T, Berrouschot J, Wagner A, Illes P, Reinhardt R. (2002). Early biochemical and histological changes during hyperbaric or normobaric reoxygenation after in vitro ischaemia in primary corticoencephalic cell cultures of rats. Brain Res. 946(1), 130-113.

26. Reinhardt R, Manaenko A, Pissarek M, Wagner A, Illes P (2002). Alterations of purine and pyrimidine nucleotide contents in rat corticoencephalic cell cultures following metabolic damage and treatment with openers and blockers of ATP-sensitive potassium channels. Neurochem Int. 427-433.

27. Pissarek M, Reinhardt R, Reichelt C, Manaenko A, Krauss G, Illes P (1999). Rapid assay for one-run determination of purine and pyrimidine nucleotide contents in neocortical slices and cell cultures. Brain Res Brain Res Protoc. 314-321.

28. Vtorushina I, Gorbunov I, Zarytova V, Komarova N, Lebedev A, Lochov S, Manaenko A, Siniakov A, Shishkina I (1992). Diastereomers of nonionic oligonucleotide analogs. VI. Isolation of diastereomers of ethyl phosphotriesters of the octanucleotide d(GCCAAACA) by high performance affinity chromatography. Bioorg. Khim. 18: 92-99

BOOK CHAPTERS:

1. Lekic T, Manaenko A, William Rolland, Jiping Tang, Zhang JH (2010). Corner turning test for evaluation of asymmetry after intracerebral hemorrhage in rodents. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments.

2. Lekic T, William Rolland, Manaenko A, Jiping Tang, Zhang JH (2010). Forelimb use asymmetry analysis of vertical exploratory activity after intracerebral hemorrhage in rats and mice. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments.

3. Lekic T, William Rolland, Manaenko A, Jiping Tang, Zhang JH (2010). The vibrissae-elicited forelimb placing test after intracerebral hemorrhage in rodents. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments.