Research Interest

Regulation of Contractility - Relaxation Mechanisms of Cerebral Blood Vessels; Role of Endothelium, eNOS, cGMP, Inositol Phosphates, and Myosin Light Chain Ca2+ Sensitivity.

Selected Publications

1. Charles SM, Zhang L, Cipolla MJ, Buchholz JN, Pearce WJ. (2010) Roles of cytosolic Ca2+ concentration and myofilament Ca2+ sensitization in age-dependent cerebrovascular myogenic tone. Am J Physiol Heart Circ Physiol. 299(4):H1034-44.

2. Dolor RJ, Ruybalid RL, Uyeda L, Edson RG, Phibbs C, Vertrees JE, Shih MC, Jacobson AK, Matchar DB; THINRS Site Investigators. (2010) An evaluation of patient self-testing competency of prothrombin time for managing anticoagulation: pre-randomization results of VA Cooperative Study #481--The Home INR Study (THINRS).

J Thromb Thrombolysis. 30(3):263-75.

3. Khorram O, Han G, Bagherpour R, Magee TR, Desai M, Ross MG, Chaudhri AA, Toloubeydokhti T, Pearce WJ. (2010) Effect of maternal undernutrition on vascular expression of micro and messenger RNA in newborn and aging offspring. Am J Physiol Regul Integr Comp Physiol. 298(5):R1366-74. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2010299(3):R982.

4. Behringer EJ, Leite LD, Buchholz NE, Keeney MG, Pearce WJ, Vanterpool CK, Wilson SM, Buchholz JN. (2009) Maturation and long-term hypoxia alters Ca2+-induced Ca2+ release in sheep cerebrovascular sympathetic neurons. J Appl Physiol. 107(4):1223-34.

5. Pearce WJ. (2009) Multifunctional angiogenic factors: add GnRH to the list. Focus on "Gonadotropin-releasing hormone-regulated chemokine expression in human placentation". Am J Physiol Cell Physiol. 297(1):C4-5. No abstract available.

6. Pearce WJ, Williams JM, White CR, Lincoln TM. (2009) Effects of chronic hypoxia on soluble guanylate cyclase activity in fetal and adult ovine cerebral arteries.J Appl Physiol. 107(1):192-9.

7. Sakata N, Hayes P, Tan A, Chan NK, Mace J, Peverini R, Sowers L, Pearce WJ, Chinnock R, Obenaus A, Hathout E.(2009) MRI assessment of ischemic liver after intraportal islet transplantation. Transplantation. 87(6):825-30.

8. Behringer EJ, Vanterpool CK, Pearce WJ, Wilson SM, Buchholz JN. (2009) Advancing age alters the contribution of calcium release from smooth endoplasmic reticulum stores in superior cervical ganglion cells.J Gerontol A Biol Sci Med Sci. 64(1):34-44.

9. Injeti ER, Sandoval RJ, Williams JM, Smolensky AV, Ford LE, Pearce WJ. (2008)

Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared with adult ovine carotid arteries. Am J Physiol Heart Circ Physiol. 295(6):H2289-98.

10. Nauli SM, Kawanabe Y, Kaminski JJ, Pearce WJ, Ingber DE, Zhou J. (2008) Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation. 117(9):1161-71.