Enrollment Information
1-800-422-4LLU (1-800-422-4558)
Center for Health Disparities and Molecular Medicine
Faculty profile
| Kimberly Payne, PhD | |
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Assistant Professor, Department of Pathology and Human Anatomy Member, Center for Health Disparities and Molecular Medicine |
Research interests
Dr. Payne's general research interest is in the development and function of human B cells, including the contribution of B cells and other components of the immune system to health disparities diseases.
Animal studies suggest that B cells can play a key role in inflammation-mediated cancer, a major area of health disparity. One component of Dr. Payne's research program is the development of assays that will allow her to study the function of B cells and other cells of the immune system in diseases, including inflammation-mediated cancers, for which there is health disparity. A second focus of research in Dr. Payne's laboratory is defining key events in human B1 and B2 lymphocyte differentiation and the differing roles that these two types of B cells play in the immune response. B1 cells are the predominant type of B cell early in life, while B2 cells make up the majority of B cells later in life. Pre-mature birth is an area of health disparity and has been linked with higher incidences of metabolic syndrome, heart disease, and stroke later in life. Inflammation is mediated by the immune system and plays a role in the development of these diseases of health disparity. Dr. Payne's work will provide important information about fetal/neonatal immunity and adult immunity and thus a basis for understanding the role of immunity in health disparities that exist at all stages of life. Dr. Payne's current work is funded by an NIH K01 Career Development Award.
Dr. Payne received her doctorate in microbiology and immunology from the University of Oklahoma Health Sciences Center where she defined some of the early events in mouse B cell development. As a postdoctoral fellow at Children's Hospital Los Angeles, Dr. Payne's research focused on the role of Ikaros DNA binding proteins and the SCL transcription factor in the production of cells of the blood and immune system. Dr. Payne's postdoctoral studies were funded by a Children's Hospital Los Angeles Research Institute Career Development Fellowship and an NIH National Research Service Award. As an Assistant Professor at the University of Southern California Keck School of Medicine, Dr. Payne studied the role of IL-7 in human B cell development. These studies were funded by a Faculty Research Career Development Award from the Saban Research Institute at Children's Hospital Los Angeles.
Dr. Payne's work has been presented at a number of national and international conferences. In 2004, she received a Travel Award to the Federation of Clinical Immunological Societies (FOCIS) Center of Excellence Trainee Satellite Symposium in Montreal, Canada. Dr. Payne was an invited speaker at the Leukemia and Lymphoma Society's Stohlman Symposium in Denver, Colorado in 2004 and was named as a recipient of an American Association of Immunology Junior Faculty Travel Award in 2006. Dr. Payne has served as an ad hoc reviewer for the journal, Experimental Hematology, and for the Journal of Immunology.
Selected publications
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Popescu M, Gurel Z, Ronni T, Song C, Hung K, Payne KJ, and Dovat S. Dephosphorylation of Ikaros by PP1 Regulates its Function and Protein Stability. J Biol Chem 2009, In press.
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Parrish YK, Baez I, Milford T-A, Benitez A, Galloway N, Willeman-Rogerio J, Sahakian E, Kagoda M, Huang G, Hao QL, Sevilla Y, Barsky LW, Zielinska E, Price MA, Wall NR, Dovat S, and Payne KJ. IL-7 Dependence of Human B Lymphopoiesis Increases During Progression of Ontogeny from Cord Blood to Bone Marrow. J Immunol. 182(7):4255-66, 2009.
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Gurel Z, Ronni T, Ho S, Kuchar J, Payne KJ, Turk C, and Dovat S Recruitment of Ikaros to Pericentromeric Heterochromatin is Regulated by Phosphorylation. J Biol Chem. 28;283(13):8291-300, 2008 Mar
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Ronni T, Payne KJ, Ho S, Bradley M, Dorsam G, and Dovat S. Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms. J Biol Chem. 282(4):2538-47, 2007.
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Payne KJ and Crooks GM. Immune-Cell Lineage Commitment: Translation from Mice to Humans Immunity26(6):674-7, 2007.
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Luo P, Wang A, Payne KJ, Peng H, Wang J-G, Parrish YK, Rogerio JW, Triche TJ, He Q, and Wu L. Intrinsic RARα-CAK Signaling Involves Coordination of the Restricted Proliferation and Granulocytic Differentiation of Human Hematopoietic Stem Cells Stem Cells 25(10):2628-37, 2007.
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Zhang Y, Payne KJ, Zhu J, Price M, Parrish YK, Zielinska E, Barsky LW, and Crooks GM. SCL expression at critical points in human hematopoietic lineage commitment. Stem Cells 23(6):852-860, 2005
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Payne KJ, Huang GY, Sahakian E, Zhu J, Barteneva NS, Barsky LW, Payne MA, and Crooks GM. Ikaros isoform X is selectively expressed in myeloid differentiation. Journal of Immunology 170:3091-3098, 2003.
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Payne KJ and Crooks GM. Human hematopoietic lineage commitment. Immunological Reviews 187:48-64, 2002
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Payne KJ, Nicolas J-H, Zhu J, Amis J, Barsky LW, and Crooks GM. Predominant expression of a novel Ikaros isoform in normal human hemapoiesis. Journal of Immunology 167:1867-1870, 2001.
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Medina KL, Garrett KP, Thompson LF, Rossi MID, Payne KJ, Kincade PW. Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. Nature Immunology 2:718-24, 2001.
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Tudor K-S, Payne KJ, Yamashita Y, Kincade PW. Functional assessment of precursors from murine bone marrow suggests a sequence of early B-lineage differentiation events. Immunity 12:335-345, 2000.
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Payne KJ, Medina KL, Kincade PW. Loss of c-kit accompanies B lineage commitment and acquisition of CD45R by most murine B lymphocyte precursors. Blood 94: 713-723, 1999.