Enrollment Information
1-800-422-4LLU (1-800-422-4558)
Department of microbiology and molecular genetics
Faculty profile
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Alan P. Escher Center for Molecular Biology & Gene Therapy |
- PhD, Cornell University, 1992
- Postdoctoral fellowship, University of Alberta, Edmonton, Alberta, Canada
- Current research interests
- Recent publications
- Teaching
Current research interests
Type 1 diabetes
Type 1 diabetes is a disease with high morbidity and mortality with a prevalence ever increasing in young children. In almost all cases, patients fail to synthesize insulin due to the autoimmune destruction of pancreatic beta cells. Our goal is to find means of preventing and treating pathogenic autoimmunity by developing gene-based approaches for induction of tissue-specific tolerance.
Bioluminescence
Light-catalyzing and fluorescent proteins can be used as markers to study gene expression, protein translocation, and protein-protein interactions. We are engineering and using these marker proteins for applications to medicine.
A. F. Li, J. Hough, D Henderson, A. Escher. (2004). Co-delivery of pro-apoptotic BAX with a DNA vaccine recruits dendritic cells and promotes efficacy of autoimmune diabetes prevention in mice. Vaccine 22: 1751-1763.
A.F. Li, A. Escher. (2003). Intradermal or oral delivery of GAD-encoding genetic vaccines suppresses type 1 diabetes. DNA Cell Biol 22: 227-232.
F. Li, M. Filippova, O. Fagoaga, S. Nehlsen-Cannarella, A. Escher. (2002). Decreased insulitis and blood glucose levels after injection of GAD-transduced lymphocytes into NOD mice. Mol Ther6: 701-709.
M. Filippova, J. Liu, A. Escher. (2001). Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice. DNA Cell Biol 20:175-181
G. Nelson, A. Escher. (2001). Solubility of a luciferase-GFP fusion protein in bacterial and mammalian cells.In Bioluminescence and Chemiluminescence, (eds) Case JF, Herring PJ, Robison BH, Haddock SHD, Kricka LJ, Stanley PE (World Scientific Press, Singapore), pp297-300.
M. Filippova, J. Liu, A. Escher. (2001). Secreted Renilla luciferase as a marker of gene expression in mammalian systems. In Bioluminescence and Chemiluminescence, (eds) Case JF, Herring PJ, Robison BH, Haddock SHD, Kricka LJ, Stanley PE (World Scientific Press, Singapore), pp 441-444.
J. Liu, Y. Wang, A.A. Szalay, A. Escher. (2000). Visualizing and quantifying protein secretion using a Renilla luciferase-GFP fusion protein. Luminescence. 14:1-5.Coordinator of MICR 536, Laboratory in Gene Transfer and Gene Expression.
School of Medicine - Graduate School - Loma Linda University
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