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Thursday, March 20, 2003 TODAY

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Thyroid function essential to staying healthy Report

The following article appeared in the March/April 2003 issue of Wellbeing, the Just for Seniors 55+ Club newsletter.

Thyroid disorders affect up to 20 million Americans, the majority of them women. The most common form, hypothyroidism (low thyroid function) affects women in about 8 out of 10 cases. Hyperthyroidism (overactive thyroid function) is much less common and presents itself through many opposite symptoms of low thyroid function.

The thyroid, a small butterfly-shaped gland at the base of the throat, pumps out a cluster of hormones that govern multiple body functions including the metabolism of proteins and carbohydrates, oxygen consumption and bone formation. Thyroid hormones affect almost every organ of the body, and good health depends on a stable supply: too little and our bodies slow and become lethargic; too much and our bodies run too fast, causing weight loss, diarrhea, and an irregular heartbeat.

Low thyroid function (Hypothyroidism)

Low thyroid function can be difficult to recognize since it tends to develop slowly; many of the symptoms are vague and overlap with other conditions associated with aging and menopause.

Women between the ages of 40 and 60 are at highest risk of low thyroid function. It can also affect younger women who should be carefully monitored and treated during pregnancy.

What causes low thyroid function?

The thyroid gland needs iodine, found in soil and water, to function properly. Most people in the United States take in enough iodine by using iodized salt; eating fish and vegetables; and drinking water and milk.

Other causes of low thyroid function are environmental or medical exposure to radiation, inherited disorders, surgical removal of the gland, or radiation to reduce the size of the thyroid.

Many patients who develop thyroid problems don't have any of these risk factors, however.

Simple or nontoxic goiter is an enlargement of the thyroid that is not related to cancer or other diseases. The thyroid might enlarge in an effort to compensate for a lack of iodine in the diet or an excessive consumption of foods that interfere with thyroid synthesis.

A number of drugs can also interfere with thyroid function. Medications to watch for include lithium and phenylbutazone.

Symptoms

Symptoms may include: joint pain, muscle cramps, constipation, brittle hair and nails, headaches, menstrual flow that is heavier than normal, and signs of carpal tunnel syndrome.

Later symptoms include hoarseness, weight gain, depression, difficulty coping with the cold, and personality change.

Diagnosis and treatment

Diagnosis is simple. A blood test can identify low levels of thyroxine and elevated levels of thyroid stimulating hormone (TSH). Once identified, low thyroid levels can be corrected with daily doses of levothyroxine. Patients taking thyroid replacement should be monitored to ensure that the drug brings their levels to within normal range.

Overactive thyroid function (Hyperthyroidism)

Too much thyroid hormone circulating in the blood leads to hyperthyroidism, or overactive thyroid. This condition often has the opposite effects of low thyroid function. Rather than the slowed bodily functions caused by too little thyroxine, too much can cause weight loss, vision problems, diarrhea, heartbeat irregularities, light menstrual flow, sensitivity to heat, excessive sweating, and tremor.

What causes overactive thyroid?

Causes of excessive thyroid hormones include Graves' disease (a form of toxic goiter), pituitary tumors, hormone producing thyroid tumors, and temporary conditions such as illness or drug reactions.

Graves' disease represents a common type of toxic goiter that is much more likely to occur in women. Goiters are noncancerous enlargements of the thyroid gland. When they produce hormones, they are called toxic goiters. Signs of Graves' disease include goiter, protruding eyeballs, and general symptoms of hyperthyroidism, although not everyone will have all symptoms.

When tumors or nodules that affect thyroid function are identified, the primary concern is to distinguish benign or harmless growths from malignant or potentially dangerous growths and develop an appropriate treatment plan.

Among women with normal pregnancies about 1.4 percent show some signs of overactive thyroid, including a rapid heartbeat, an increase in body temperature, and tremor. The symptoms usually subside at the end of pregnancy.

A serious medical condition known as a thyroid storm can signal a sudden and dangerous change in health. Thyroid storm might be triggered by infection, trauma, and complications from diabetes, toxemia of pregnancy, or from stopping thyroid medication. Signs of thyroid storm include fever, restlessness, and irrational behavior.

Immediate medical attention is required and, even with treatment, fatality rates can be as high as 30 percent.

Diagnosis and treatment

Laboratory blood tests can diagnose hyperthyroidism. A radioactive iodine test showing the gland's ability to store and use iodine needed for hormone synthesis may also be performed.

Overactive thyroid is often treated with radioiodine ablation or surgery either to reduce the thyroid mass or completely remove the gland. After these procedures, many patients must take thyroid supplements to maintain normal blood levels.

For more information, talk to your family physician or an endocrinologist. Call (877) LLUMC55 for a referral.

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Thursday, March 20, 2003 TODAY


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