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September 20, 2001 TODAY

Loma Linda University news


Loma Linda University study of pecans shows they significantly lower cholesterol

Sujatha Rajaram, PhD, co-principal investigator of the recent pecan study, answers questions posed by the press during a news conference held on September 6. Looking on is Barry L. Taylor, PhD, vice president for research affairs at the University.

The addition of pecans to the step I diet of the American Heart Association (AHA) significantly lowered cholesterol levels in research subjects, according to a recent study conducted at Loma Linda University and published in the September issue of the Journal of Nutrition.

Researchers at the University found that a diet containing pecans not only lowered total and LDL--or "bad"--cholesterol significantly more than the AHA diet, but also helped to maintain desirable levels of HDL--or "good"--cholesterol.

These findings were presented during a news conference at 1:00 p.m. on September 6, held at Loma Linda University Children's Hospital.

More than 40 news organizations so far, ranging from newspapers to television, have run stories on the findings.
This is the first controlled crossover metabolic feeding study ever done with pecans. Conducted by principal investigators Sujatha Rajaram, PhD, assistant professor of public health and preventive medicine, School of Public Health, and Joan Sabaté, MD, DrPH, chair and professor of nutrition, School of Public Health, the study required all research subjects to eat the majority of their meals in a laboratory kitchen over a period of eight weeks. This type of study, known as "the gold standard" among the research community, enables the researchers to eliminate a number of variables which could potentially skew their results.

The tightly monitored crossover study of 23 men and women measured their cholesterol levels while on the step I diet (recommended by the AHA as a first line of therapy for individuals with elevated cholesterol levels) with their cholesterol levels when 20 percent of their calories were replaced with pecans.

In the pecan diet, for instance, pecans were added to cereals, salads, and entrees such as pasta, amounting to about a handful of pecans a day.

"We found that the pecan-containing diet lowered ‘bad' cholesterol more than twice as much as the AHA step I diet," says Dr. Rajaram.

Compared to the participants' baseline cholesterol values, the pecan-containing diet lowered LDL cholesterol levels by 16.5 percent--more than twice as much as the step I diet, which only lowered LDL levels by 6.7 percent. Compared to participants' cholesterol values while on the AHA step I diet, the pecan diet lowered total cholesterol levels by 11.3 percent--more than twice as much as the step I diet, which only lowered total cholesterol by 5.2 percent.

The U.S. government's National Cholesterol Education Program notes that for every one percent reduction in LDL cholesterol, there is a 1.5 percent reduction in the incidence of coronary heart disease (CHD).

Using this figure, the cholesterol-lowering effects of the pecan diet correspond with a 25 percent decrease in the risk of CHD.

Findings related to HDL levels were significant as well. According to the researchers, the step I diet actually lowered HDL levels--an undesirable result, while the pecan diet increased HDL by 5.6 percent--a desirable result.

"This cholesterol-lowering effect is similar to what is often seen with cholesterol-lowering medications," notes Dr. Sabaté. "We confirmed that the addition of pecans to a basic heart-healthy diet will yield very desirable blood lipid profiles."

Dr. Sabaté adds, "Many consumers find low-fat, heart-healthy diets unpalatable and difficult to adhere to."

Study participants found that the pecans added taste, palatability, and satiety, according to the research team--which should help them keep their resolve to stay with a heart-healthy diet for the long term.

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Loma Linda University hosts third annual MITHS program

The third annual MITHS (Minority Introduction to Health Sciences) program was held from July 1 to July 19, 2001. Fifteen high school juniors arrived from all over the country: seven from Pine Forge Academy, Pine Forge, Pennsylvania; two from Peterson-Warren Academy, Inkster, Michigan; and one each from Huntsville Academy, Huntsville, Alabama; Hawaiian Mission Academy, Honolulu, Hawaii; Takoma Academy, Takoma Park, Maryland; Andrews Adventist Academy, Berrien Springs, Michigan; Greater Atlanta Adventist, Atlanta, Georgia; and Greater Miami Academy, Miami, Florida. The MITHS program, which is sponsored by the BALL (Black Alumni of Loma Linda and La Sierra Universities), was created to expose students to all of the health-science career programs available at LLU. Deans from each of the six professional schools and Faculty of Religion met with the students at specially arranged meetings to tell them about the opportunities available to them.

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Steve Green to present concert at Loma Linda University

The sound of gospel music will return to Loma Linda on Saturday evening, October 20, when Steve Green returns for the fourth time to present a concert.

A Christian vocalist from Nashville, Tennessee, Mr. Green heads up a team who will present the concert in the University Church of Seventh-day Adventists in Loma Linda.

The concert will begin at 7:30 p.m., and it is expected that all 2,000 seats will be sold in the near future.

Ticket donations are $15 for front reserved seating; $12 for reserved seating in the back of the sanctuary and the balcony; and $6 for open seating in the two wings of the church.

Tickets may be obtained by sending your request and remittance and a stamped, self-addressed envelope to: Concert Series, Box 647, Calimesa, California 92320.

A special seating arrangement is being offered for the concert. A section will be devoted to the "founder's circle" for individuals wishing to support the international mission of Mr. Green. A $100 donation that is 75 percent tax deductible will include a preconcert reception and buffet with Mr. Green, a special gift, and front center seating in the church sanctuary.

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Faculty notes

* Retired professor of microbiology Raymond E. Ryckman, PhD, has been informed that his three-volume work on Chagas' disease and triatominae vectors will be published on the Internet. Dr. Ryckman was informed of the publication status by C. B. Beard, PhD, head of the division of parasitic diseases, National Centers for Disease Control, Atlanta. At an international conference in Cartagena, Colombia, in August, 2001, Dr. Beard, along with several other scientists met for the purpose of finding how to best place Dr. Ryckman's work for maximum availability.
Recently, Dr. Beard spent three days at LLU with Dr. Ryckman discussing this project. Dr. Ryckman's work has more than 24,000 references and is published in four languages. He is currently collaborating with the Centers for Disease Control relative to their ongoing research on parasitic disease.

* LLU was presented with a certificate of recognition by Southern California Edison for participating in its 2001 voluntary conversation program. Vice chancellor for financial affairs Verlon Strauss, CPA, was presented with the "beat the peak" award in August .

* LLUMC and BioErgonomics, Inc. (BioE), have entered into an agreement granting BioE an option to acquire an exclusive license to commercialise certain new technology covered under LLUMC's patent rights for "Iron Regulating Protein-2 (IRP-2) as a Diagnostic for Alzheimer's Disease and Other Neurodegenerative Diseases." "The ability to positively detect Alzheimer's disease in patients at a very early stage, prior to the onset of symptoms, will contibute greatly to the success of treatment and provide a very important tool to researchers toward possibly discovering the cure of this devastating disease," says Wolff Kirsch, MD, professor of biochemistry and neurosurgery, and director of the Neurosurgery Center for Research, Training, and Education at LLUMC. Over the past year, LLUMC, BioE, and the National Institutes of Health have participated in a collaborative research project investigating
proteins that may contribute directly to the development of Alzheimer's disease. This research is directed towards developing technology to identify and quantify these proteins in peripheral blood cells and provide a simple blood test to identify Alzheimer's disease prior to the onset of symptoms.

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Loma Linda University online faculty showcase displays online courses available

Faculty packed Wong Kerlee International Conference Center on Wednesday, July 18, and it wasn't just for the "veggie" enchiladas. They came to see what their colleagues were doing with online education across the University. The LLUonline faculty showcase provided an overview of online courses at LLU.

Vice chancellor for academic affairs Lisa M. Beardsley, PhD, MPH, raised questions for faculty to consider as they watched the showcase.

"Educational technology is exciting. It is estimated to evolve at a rate of one generation every 18 months, so it can also be expensive," says Dr. Beardsley. "This can be a technological ‘black hole' that sends both faculty and resources hurtling through it at an unsettling, uncontrollable speed.

"How do we educate our students for tomorrow's demands rather than for those of yesterday? How do we as faculty incorporate the very best of learning theory and educational assessment into this moving target?" Dr. Beardsley continues, "as Christian educators, how do we create a supportive learning community that nurtures spiritual, emotional, and professional maturity and values?"

Some of these questions were quickly answered by demonstrations from the faculty and staff who showcased what they are doing.

"Students love this," says Jan M. Nick, PhD, RN, assistant professor of nursing, School of Nursing, demonstrating grade posting in Blackboard 5.

"You'll love the group e-mail function…but be sure to organize your material in folders,"she says.

V. Leroy Leggitt, DDS, assistant professor of orthodontics, School of Dentistry; Ramon R. Gonzalez Jr., PhD, associate professor of physiology and pharmacology, School of Medicine; and William F. Colwell Jr., developer, academic computer resources, School of Medicine, demonstrated to the group QuickTime image rotations, shockwave animations, and PowerPoint to HTML conversions used in their courses.

Resa L. Chase, MD, associate professor of human anatomy and pathology, School of Medicine, uses LLUonline to facilitate communication within her course, "Cell Structure and Function," by utilizing built-in e-mail and discussion boards.

W. William Hughes III, PhD, professor of physical therapy, School of Allied Health Professions, spoke briefly on the merits of using LLUonline for asynchronous distance education, citing a student he taught in Korea during spring quarter 2001.

Janine Wagner, surgery education coordinator, demonstrated how LLUonline can aid in the coordination of students while reducing long-term financial overhead due to copying costs.

"I got a couple of good ideas, but it was more than that," says Jean B. Lowry, PhD, professor of speech-language pathology and audiology, School of Allied Health Professions.
She was one of the 125 who attended the showcase.

"I've been here since 1974. This has been a highly balkanized institution. Even with colloquium and the education fairs, I have never felt that there was much hope or desire for across-school pollination," Dr. Lowry states.

"I came out of this session with a new feeling that people in a different school may, in time, come to look beyond their specific school or discipline for collegial interaction…this [was an] opportunity to meet and learn from my colleagues in other schools," she says.

Last fall and winter quarters, Dr. Lowry taught "Introduction to Speech-Language Pathology" online to 14 students at four Adventist colleges/universities that do not offer the course. She will teach it again this fall.

There has been significant shuffle behind the scenes to make LLUonline viable, according to Dr. Beardsley.

Loma Linda University has been offering online courses through Blackboard for almost two years. It has enhanced a culture of collaboration and integration. Two delivery systems have merged into one at <http://lluonline.llu.edu>.

The old addresses will point to the new server, but all access is only through the "front door" of LLUonline <http://lluonline.llu.edu>.

Older Internet bookmarks such as <blackboard.llu.edu/mybb.html> or <../courses/COURSE101> or <../admin> no longer work.

There are 4,629 users and 1,903 users/students are enrolled in LLUonline. Two hundred and forty-four instructors are registered, with 269 courses in production or online. LLUonline receives around 2,000 hits per day.

"This is up from 1,400 just one month ago," Dr. Beardsley relates. "At 1.3 million page views since January, 2000, LLUonline gets more student hits than any other campus server."
The AOL merger with Time Warner was driven by AOL's need for content. Infrastructure and access is only valuable when it links to quality content.

"That's why faculty are essential partners in the success of LLUonline," says Dr. Beardsley in a challenge to the faculty to get their courses online. "I applaud your commitment to our students and to the mission of Loma Linda University."

Richard H. Hart, MD, DrPH, chancellor and chief executive officer for Loma Linda University, is personally chairing an "e-University executive committee" to position LLUonline to better serve a global constituency.

"We have a global network that is 10 years ahead of most other universities," he says. "We need to marry that asset with web technology to take LLU's mission of education, research, and health care to the next level."

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