Loma Linda University

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Andre Obenaus, PhD
Associate Professor, Pediatrics
School of Medicine
Assoc Res Prof, School of Behavioral Health
Associate Professor, Basic Sciences
School of Medicine
Publications    Scholarly Journals--Published
  • Yamaguchi, M., Jadhav, V., Obenaus, A., Colohan, A., Zhang, J.H. (2008)  Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury.  Neurosurgery.  61(5):1067-75   ( 1/2008 - 12/2008 )
  • Tong KA, Ashwal S, Obenaus A, Nickerson JP, Kido D, Haacke EM. (2008) Susceptibility-Weighted MR Imaging: A Review of Clinical Applications in Children. AJNR Am J Neuroradiol. 2008 Jan;29(1):9-17   ( 1/2008 - 12/2008 )
  • Rostek, C., Turner, E.L., Robbins, M., Rightnar, S., Xiao, W., Obenaus, A. and Harkness, T.A.A. (2008) Involvement of homologous recombination repair after proton-induced DNA damage. Mutagenesis Mar; 23:119-29   ( 1/2008 - 12/2008 )
  • Obenaus, A., Huang, L., Smith, A., Favre, C, Nelson, G. Kendall, E (2008) Magnetic resonance imaging and spectroscopy of the rat hippocampus 1 month after 56Fe Radiation. Rad Res. Feb; 169:149-61   ( 1/2008 - 12/2008 )
  • Sugawara, T., Wang, A., Jadhav, V., Tsubokawa, T., Obenaus, A., Zhang, J.H. (2008)  Magnetic resonance imaging in the canine double-haemorrhage subarachnoid haemorrhage model.  Acta Neurochir. Suppl 104:235-239. ( 1/2008 - 12/2008 )
  • Rola, R., Fishman, K., Baure, J., Rosi, S., Lamborn, K.R., Obenaus, A., Nelson, G., Fike, J.R. (2008) Hippocampal neurogenesis and neuroinflammation after cranial irradiation with 56Fe. Rad Research 169:626-32   ( 1/2008 - 12/2008 )
  • Vlkolinsky, R., Krucker,T., Smith, A., Lamp, T., Nelson, G., Obenaus, A. (2008) Early effects of 56Fe radation on normal and lipopolysaccaride-inhibited synaptic plasticity in mouse hippocampus. Rad Res. 169:523-30   ( 1/2008 - 12/2008 )
  • Gridley, D.S., Obenaus, A., Bateman, T.A., Pecaut, M.J. (2008) Chronic changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation. Intl J Radiat Biol 84:549-59   ( 1/2008 - 12/2008 )
  • Willey, JS, Grilly, LG, Howard, SH, SA, Pecaut, MJ, Obenaus A, Gridley, DA, Nelson, GA and Bateman, TA (2008) The effects of 56Fe radiation on the architecture and structural properties of trabecular and cortical bone. Radiation Res 170:201-7 ( 1/2008 - 12/2008 )
  • Jadhav, V., Sugawara, T., Zhang, J.H., Jacobson, P., Obenaus, A. (2008) Magnetic Resonance Imaging Detects and Predicts Early Brain Injury After Subarachnoid Hemorrhage In A Canine Experimental Model J. Neurotrauma 25:1099-106 ( 1/2008 - 12/2008 )
  • Jadhav, V., Solaroglu, I., Obenaus, A., Zhang, J.H.. (2007) Neuroprotection against Surgically Induced Brain Injury. Surgical Neurology 67:15-20 ( 1/2007 - 12/2007 )
  • Ashwal, S., Tone, B., Tian, H.R., Obenaus, A. (2007) Comparison of two neonatal ischemic injury models using magnetic resonance imaging. Peds Res. 61:9-14   ( 1/2007 - 12/2007 )
  • Prasuhn, D.E. Jr., Yeh, R.M., Obenaus, A., Manchester, M., Finn, M. G. (2007) Viral MRI Contrast Agents: Coordination of Gd by Native Virions and Attachment of Gd Complexes by Azide-Alkyne Cycloaddition, Chem. Commun, 2007, 1269 - 1271   ( 1/2007 - 12/2007 )
  • Leung, F.W., Go, V.L.W., Scremin, O.U., Obenaus, A., Tuck, M.L., Golub, M.S., Eggena, P., Leung, J.W. (2007) Pilot studies to demonstrate that intestinal mucosal afferent nerves are functionally linked to visceral adipose tissue. Dig Dis Sci 52:2695-702. ( 1/2007 - 12/2007 )
  • Obenaus, A., Robbins, M., Blanco, G, Galloway, N., Snissarenko, E., Gillard, E., Lee, S., Currás-Collazo, M. (2007) Magnetic resonance imaging alterations in two rat models of mild neurotrauma, J. Neurotrauma 24:1147-60. ( 1/2007 - 12/2007 )
  • Wang, R., Ashwal, S., Tone, B., Tian, H.R., Badaut, J., Rasmussen, A., Obenaus, A. (2007) Albumin reduces blood-brain permeability but does not alter infarct size in a rat model of neonatal stroke. Peds Res. 62(3):261-6   ( 1/2007 - 12/2007 )
  • Obenaus, A., Jacobs, R.E. (2007) Magnetic resonance imaging of functional anatomy: Use for small epilepsy models. Epilepsia 48 (Suppl. 4): 11-17.   ( 1/2007 - 12/2007 )
  • Belayev, L., Obenaus, A., Zhao, W., Saul, I., Busto, R., Wu,C., Vigdorchik, A., Lin, B., Ginsberg, M.D. (2007) Experimental intracerebral hematoma in the rat: Characterization by sequential magnetic resonance imaging, behavior, and histopathology: Effect of albumin therapy. Brain Research 1157:146-55.   ( 1/2007 - 12/2007 )
  • Vlkolinsky, R., Krucker,T., Smith, A., Lamp, T., Nelson, G., Obenaus, A. (2007) Effects of lipopolysaccharide on (56)Fe-particle radiation-induced impairment of synaptic plasticity in the mouse hippocampus. Radiat Res.  Oct;168(4):462-70 ( 1/2007 - 12/2007 )
  • Hathout, E., Sowers, L., Wang, R., Tan, A., Mace, J., Peverini, R., Chinnock, R., Obenaus, A. (2007)  In vivo magnetic resonance imaging of vascularization in islet transplantation.  Transpl Int.  Sept 10; 20(12):1059-65   ( 1/2007 - 12/2007 )
  • Hou DJ, Tong KA, Ashwal S, Oyoyo U, Joo E, Shutter L, Obenaus A. (2007) Diffusion-weighted magnetic resonance imaging improves outcome prediction in adult traumatic brain injury. J Neurotrauma. 24(10):1558-69.   ( 1/2007 - 12/2007 )
  • Badaut, J., Ashwal, S., Tone, B., Regli, L., Tian, H.R., Obenaus, A. (2007) Temporal and Regional evolution of Aquaporin 4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke. Peds Res. 62(3):248-54 ( 1/2007 - 12/2007 )
  • Matrick,J., Hahn,J., Obenaus,A., Zhang, J.H. (2006) Surgically induced brain injury in rats: effect of erythropoietin. J Neurosci Methods 158: 234–241 ( 1/2006 - 12/2006 )
  • Ashwal, S., Tone, B., Tian, H.R., Chong, S. , Obenaus, A. (2006) Serial magnetic resonance imaging in a rat pup filament stroke model. Exp Neurol 202:294-301   ( 1/2006 - 11/2006 )
  • Haacke, E.M., Cheng, N.Y.C., House, M.J., Liu, Q., Neelavalli, J., Ogg, R., Khan, A., Ayaz, M., Kirsch, W., Obenaus, A. (2005) Imaging iron stores in the brain using magnetic resonance imaging (A Review). Magnetic Resonance Imaging 23(1):1-25   ( 1/2005 - 12/2005 )
  • Bartnik,B., Spigelman, I., Obenaus, A. (2005) Cell-permeant calcium buffer induced neuroprotection after cortical devascularization. Exp. Neurology 192(2):357-64   ( 1/2005 - 12/2005 )
  • Yong-Hing, C.J., Obenaus, A., Stryker,R., Tong, K., Sarty, G. (2005) Magnetic resonance imaging and mathematical modeling of progressive formalin fixation of the human brain. Magnetic Resonance in Medicine , 54:324-332 ( 1/2005 - 12/2005 )
  • Bhagat, YA, Obenaus, A., Hamilton, MG, Mikler, J., Kendall, EJ (2005) Neuroprotection from soman-induced seizures in the rodent: Evaluation with diffusion- and T2-weighted magnetic resonance imaging, Neurotoxicology 26(6):1001-1013. ( 1/2005 - 12/2005 )
  • Edit, S., Kendall, E.J., Obenaus, A. (2004) Neuronal and glial cell populations in the piriform cortex distinguished using an approximation of Q-space imaging following status epilepticus. AJNR Am J Neurorad 25:1225-1233.   ( 1/2004 - 12/2004 )
  • Ribak,C.E., Korn, M.J., Shan, A., Obenaus, A. (2004) Dendritic growth cones and recurrent basal dendrites are typical feature os newly-generated granule cells in the adult hippocampus. Brain Research 1000:195-199.   ( 1/2004 - 12/2004 )
  • Rola, R., Otsuka, S. Obenaus, A., Nelson, G., Limoli, C.L., Fike, J.R. (2004) Indicators of hippocampal neurogenesis are altered by 56Fe irradiation in a dose dependent manner. Rad Research 162:442-446   ( 1/2004 - 12/2004 )
  • Obenaus, A., Smith, A. (2004) Radiation dose in rodent tissues during micro-CT imaging. J. X-Ray Sci Tech 12:241-249   ( 1/2004 - 12/2004 )
  • Jeffes, E.W.B., Zhang, J.G, Hoa, N., Petkar, A., Delgado, C., Chong, S., Obenaus, A., Sanchez, R., Khalaghizadeh, S., Khomenko, T., Knight, B.A., Alipanah, R., Nguyen, T.-V., Shah, C., Vohra, S., Zhuang, J.-L., Liu, J., Wepsic, H.T., Jadus, M.R. (2004) Anti-angiogenic drugs synergize with a membrane macrophage colony-stimulating factor (mM-CSF) based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma. J. Immunology 174(5):2533-43   ( 1/2004 - 12/2004 )
  • Dashtipour, K., Wong, A.M., Obenaus, A., Spigelman, I., Ribak, C.E. (2003) Temporal profile of hilar basal dendrite formation on dentate granule cells after status epilepticus, Epilepsy Research 54:141-151   ( 1/2003 - 12/2003 )
  • Gong, Z., Obenaus, A., Li, N., Sarty, G.E.,Kendall, E.J., (2003) Recurrent non-status generalized seizures alter the developing chicken brain. Epilepsia 44:1-8 ( 1/2003 - 12/2003 )
  • Bhagat, Y.A., Obenaus, A., Richardson, J.S., Kendall, E.J., (2002) Evolution of beta-amyloid induced neurotoxicity: Magnetic resonance imaging and anatomical correlation in the rodent hippocampus. Magnetic Resonance Material in Physics Biology and Medicine (MAGMA) 14: 223-232 ( 1/2002 - 12/2002 )
  • Kendall, E.J., Gong, Z., Obenaus,A., (2002) Biophysical alterations from recurrent generalized seizures in the avian brain. Image Analysis and Stereology 21: 77-86 ( 1/2002 - 12/2002 )
  • Haacke, E.M., Herigault, G., Kido, D., Tong, K., Obenaus, A. Yu,Y., Reichenbach, J.R., (2002) Observing tumor vascularity noninvasively using magnetic resonance imaging, Image Analysis and Stereology 21:107-113 ( 1/2002 - 12/2002 )
  • Obenaus, A., Yong-Hing, C.J., Sarty, G., Tong, K. (2001) A Reliable Method for Measurement and Normalization of Pediatric Hippocampal Volumes: Normative Data. Pediatric Research 49:1-9 ( 1/2001 - 12/2001 )
  • Bhagat, Y., Obenaus, A., Hamilton, M., Kendall, E.J. (2001) Magnetic Resonance Imaging Predicts Soman-Induced Pathology. Neuroreport. 12:1-7 ( 1/2001 - 12/2001 )
  • Bartnik, B.L., Kendall, E.J., Obenaus, A., (2001) Cortical devascularization:  quantitative diffusion weighted magnetic resonance imaging and histological findings. Brain Research 915:133-142. ( 1/2001 - 12/2001 )
  • Wall, C., Kendall, E.J., Obenaus, A. (2000) Rapid alterations in apparent diffusion coefficients with anatomical correlates in a model of status epilepticus. AJNR Am J Neurorad 21: 1841-1852. ( 1/2000 - 12/2000 )
  • Spigelman I., Yan X-X., Obenaus A., Lee E.Y-S., Wasterlain C.G., Ribak C.E. (1998) Sprouting of granule cell basal dendrites in a rat model of temporal lobe epilepsy. Neuroscience 86:109-120. ( 1/1998 - 12/1998 )
  • Spigelman, I., Obenaus. A., Mazarati, A.M., Wasterlain, C.G. (1998) Intravenously administered cell-permeant calcium buffer decreases evoked synatpic potentials in rat dentate gyrus in vivo. Brain Res. 810:269-273. ( 1/1998 - 12/1998 )
  • Dudek F.E., Obenaus A., Schweitzer J.S., Wuarin J.P. (1994)  Functional significance of hippocampal plasticity in epileptic brain: electrophysiological changes of the dentate granule cells associated with mossy fiber sprouting. Hippocampus, 4(3):259-65. ( 1/1994 - 12/1994 )
  • Roper, S.N., Obenaus, A., Dudek, F.E.  (1993) Increased propensity for non-synaptic epileptiform activity in immature rat hippocampus and dentate gyrus.  J. Neurophysiol. 70:857-62 ( 1/1993 - 12/1993 )
  • Obenaus, A., Esclapez, M., Houser, C.R. (1993) Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures. J. Neurosci. 13:4470-4485. ( 1/1993 - 12/1993 )
  • Roper, S.N., Obenaus, A., Dudek, F.E.  (1992) Osmolality and non-synaptic epileptiform bursts in rat CA1 and dentate gyrus. Ann. Neurol.  31:81-85. ( 1/1992 - 12/1992 )
  • Cronin, J., Obenaus, A., Houser, C.R., Dudek, F.E.  (1992) Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibers. Brain Res.  572:305-310. ( 1/1992 - 12/1992 )
  • Meier, C. L., Obenaus, A., Dudek, F.E. (1992) Persistent hyperexcitability in isolated hippocampal CA1 of kainate-lesioned rats.  J. Neurophysiol. 68:2120-2127. ( 1/1992 - 12/1992 )
  • Klancnik, J.M., Obenaus, A., Phillips, A.G., Baimbridge, K.G. (1991) The effects of serotonergic compounds on evoked responses in the dentate gyrus and CA1 region of the hippocampal formation of the rat. Neuropharmacology  30(11):1201-1209. ( 1/1991 - 12/1991 )
  • Dudek, F.E., Obenaus, A., Tasker, J.G. (1990) Osmolality-induced changes in extracellular volume alter epileptiform bursts independent of chemical synapses in the rat: Importance of non-synaptic mechanisms in hippocampal epileptogensis. Neurosci. Lett.  120:267-270. ( 1/1990 - 12/1990 )
  • Obenaus, A., Mody, I., Baimbridge, K.G. (1989) Dantrolene-Na (Dantrium) blocks induction of long-term potentiation in hippocampal slices.  Neurosci. Lett.  98:172-178. ( 1/1989 - 12/1989 )
  Scholarly Journals--Accepted
  • Obenaus, A., Ashwal, S. (2008) Magnetic Resonance Imaging in Cerebral Ischemia: Focus on Neonates. Neuropharmacology (Epub ahead of print, Jun 14) 55:271-80   ( 1/2008 - 12/2008 )
  • Chen; W., Ostrowski; R.P., Obenaus, A., Zhang, J.H. (2008) Prodeath or Prosurvival: Two Facets of Hypoxia Inducible Factor-1 in Perinatal Brain Injury. Expt. Neurol (in press)   ( 1/2008 - 12/2008 )
  • Huang, L., Smith, A., Cummings, P., Kendall, EJ., Obenaus, A. (2008) Neuroimaging Assessment of Memory-Related Brain Structures in Rat Model of Acute Space-like Radiation. J. Mag Res Image (in press)   ( 1/2008 - 12/2008 )
  • Dénes, B., Fodor, N., Obenaus, A., Fodor, I. (2008)  Engineering oncolytic vaccinia viruses for non-invasive optical imaging of tumors. The Open Biotechnology Journal (in press)   ( 1/2008 - 12/2008 )
  • Hathout, E., Chan, N.K., Tan, A., Sakata, N., Mace, J., Pearce, W., Peverini, R., Chinnock, R., Sowers, L., Obenaus, A. (2008)  In vivo Imaging Demonstrates a Time-Line for New Vessel Formation in Islet Transplantation. Pediatric Transplantation (in press) ( 1/2008 - 12/2008 )
  • Sakata, N., Tan, A., Chan, N.K., Obenaus, A., Mace, J., Peverini, R., Sowers, L., Chinnock, R., Hathout, E. (2008) Efficacy comparison between intraportal and subcapsular islet transplants in a murine diabetic model. Transplantation Proceedings (in press) ( 1/2008 - 12/2008 )
  • Galloway, N., Tong, K., Ashwal, S., Udochukwu, O.,Obenaus, A. (2008) Diffusion-Weighted Imaging Improves Outcome Prediction in Pediatric Traumatic Brain Injury. J. Neurotrauma (in press)   ( 1/2008 - 12/2008 )
  Books and Chapters
  • Ashwal, S., Tong, K.A., Obenaus, A., Holshouser, B.A. (2009) Advanced Neuroimaging Techniques in Children with Traumatic Brain Injury. New Frointiers in Pediatric Traumatic Brain Injury, Cambridge University Press, ed. Anderson, V., Yeates, K. ( 1/2009 - 12/2009 )
  • Nehlig, A., Obenaus, A. (2006) Imaging approaches in small animal models. In: Models of Seizures and Epilepsy, ed. Pitkanen, Moshe, Schwartzkroin. ( 1/2006 - 12/2006 )
  • Obenaus, A., Klancnick, J.M., Baimbridge, K.G.  (1991)  Serotonergic attenuation of low Ca2+ induced bursting in the CA1 region of the rat hippocampus. In: Physiology, Pharmacology and Development of Epiloptogenic Phenomena, ed. Klee/Lux/Speckmann, Experimental Brain Research Series, Volume 20: 111-114.   ( 1/1991 - 12/1991 )