Loma Linda University

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Barbara Holshouser, PhD
Professor, Radiology
School of Medicine
Professor, Basic Sciences
School of Medicine
Professor, Radiation Technology
School of Allied Health Professions
Publications    Book Review - Scholarly Journals--Published   Scholarly Journals--Published
  • Kirsch WM, McAuley G, Holshouser B, Petersen F, Ayaz M, Vinters HV, Dickson C, Haacke EM, Britt III W, Larsen J, Kim I, Mueller C, Schrag, Kido D. Serial Susceptibility Weighted MRI measures brain iron and microbleeds in dementia.  Journal of Alzheimer’s Disease, May 11, 2009. ( 5/2009 )
  • Kittle D, Holshouser B, Slater JM, Guenther BD, Pitsianis NP, Pearlstein RD. Technical note: rapid prototyping of 3D grid arrays for image guided therapy quality assurance. Med Phys. 2008 Dec;35(12):5708-12. ( 12/2008 )
  • Ghostine S, Raghavan R, Michelson D, Holshouser B, Tong K. Gliomatosis Cerebri Mimicking Rasmussen Encephalitis. J Neurosurg. 2007 Aug;107:143-146. ( 8/2007 )
  • Angeles DM, Ashwal S, Wycliffe ND, Ebner C, Fayard E, Sowers L, Holshouser BA. "Relationship between opioid therapy, tissue-damaging procedures, and brain metabolites as measured by proton MRS in asphyxiated term neonates." Pediatr Res. 61.5 (2007): 614-621. ( 5/2007 )
  • Larsen JP, Britt III W, Kido D, Bartnik Olson B, Holshouser BA, Kirsch WM. "Susceptibility Weighted Magnetic Resonance Imaging in the Evaluation of Dementia." Radiology Case Reports 2.4 (2007): -. ( 1/2007 )
  • Larsen JP, Britt III W, Kido D, Bartnik Olson B, Holshouser BA, Kirsch WM"Susceptibility Weighted Magnetic Resonance Imaging in the Evaluation of Dementia." Radiology Case Reports : 2007;2:1-4.  radiology.casereports.net ( 0/2007 )
  • Ashwal S, Babikian T, Gardner-Nichols J, Freier MC, Tong KA, Holshouser BA. "Susceptibility-weighted imaging and proton magnetic resonance spectroscopy in assessment of outcome after pediatric traumatic brain injury." Arch Phys Med Rehabil. 87. (2006): 50-58. ( 12/2006 )
  • Babikian T, Freier MC, Ashwal S, Riggs ML, Burley T, Holshouser BA. ". MR spectroscopy: predicting long-term neuropsychological outcome following pediatric TBI. ." J Magn Reson Imaging 24.4 (2006): 801-811. ( 10/2006 )
  • Ashwal S, Tong KA, Holshouser BA. "Use of advanced neuroimaging techniques in the evaluation of pediatric traumatic brain injury." Dev. Neurosci . (2006): 309-326. ( 10/2006 )
  • Holshouser BA, Tong KA, Ashwal S, Oyoyo U, Ghamsary M, Saunders D, Shutter L. "Prospective longitudinal proton magnetic resonance spectroscopic imaging in adult traumatic brain injury." JMRI 24. (2006): 33-40. ( 7/2006 )
  • Shutter L, Tong KA, Lee A, Holshouser B. ". Prognostic role of proton magnetic resonance spectroscopy in acute traumatic brain injury. ." J Head Trauma Rehabil 21. (2006): 334-349. ( 7/2006 )
  • Slaughter AF, Roddy S, Holshouser B, Abd-Allah S. "Magnetic resonance spectroscopy findings in a 14 year old coma patient after baclofen ingestion." Pediatr Neurol 34. (2006): 151-155. ( 7/2006 )
  • Babikian T, Freier MC, Tong KA, Nickerson JP, Wall CJ, Holshouser BA, Burley T, Riggs ML, Ashwal S. "Susceptibility weighted imaging: neuropsychological outcome andpediatric head injury." Peds Neurology Sept;33(3). (2005): 184-194. ( 7/2005 )
  • Holshouser BA, Tong KA, Ashwal S. "Proton MR spectroscopic imaging depicts diffuse axonal injury in children with traumatic brain injury." American Journal of Neuroradiology 26. (2005): 1276-1285. ( 7/2005 )
  • Slaughter AF, Roddy S, Holshouser BA, Abd-Allah S. "Magnetic resonance spectroscopy findings in a 14 year old coma patient after baclofen ingestion." Peds Neuro . (2005): -. ( 1/2005 )
  • Miller SP, Ramaswamy V, Michelson D, Barkovich AJ, Holshouser B, Wycliffe N, Glidden DV, Demming D, Partridge JC, Wu YW, Ashwal S, Ferriero DM. "Patterns of brain injury in term neonatal encephalopathy." Journal of Pediatrics 146. (2005): 453-460. ( 1/2005 )
  • Angeles D, Wycliffe N, Holshouser B, Deming D, Ashwal S. "Effects of opioid analgesics on MRI scores in asphyxiated term neonates." Pediatr Res 57.6 (2005): 873-878. ( 1/2005 )
  • Babikian T;Freier MC;Tong KA;Nickerson JP;Wall CJ;Holshouser BA;Burley T;Riggs ML;Ashwal S. "Susceptibility weighted imaging:neuropsychological outcome and pediatric head injury." Peds Neurology 33. (2005): 179-189. ( 1/2005 )
  • Ashwal S; Holshouser B;Tong K;Serna T;Osterdock R;Gross M;Kido D. "Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury." Journal of Neurotrauma 21. (2004): 1539-1552. ( 8/2004 )
  • Tong K;Ashwal S;Holshouser BA;Nickerson JP;Wall CJ;Shutter LA;Osterdock RJ;Haacke EM;Kido D. "Diffuse axonal injury in children: clinical correlation with hemorrhagic lesions." Ann Neurol 56. (2004): 36-50. ( 8/2004 )
  • Shutter L, Tong KA, Holshouser BA. "Proton MRS in acute traumatic brain injury: role of Glutamate/glutamine for outcome." Journal of Neurotrauma 21. (2004): 1693-1705. ( 8/2004 )
  • Ashwal S, Holshouser BA, Tong K, Serna T, Osterdock R, Gross M, Kido D. "Proton spectroscopy detected myoinositol in children with traumatic brain injury ." Pediatr Res 56. (2004): 630-638. ( 8/2004 )
  • Wycliffe ND,Choe J;Holshouser B;Oyoyo UE;Haacke EM;Kido DK. "Reliability in detection of hemorhage in acute stroke by a new 3-D GRE susceptibility weighted imaing technique compared to computed tomography: a retrospective study.." JMRI . (2004): 372-377. ( 8/2004 )
  • Tong KA, Ashwal S, Holshouser BA, Shutter LA, Herigault G, Haacke EM, Kido DK. Hemorrhagic shearing lesions in children and adolescents with post-traumatic diffuse axonal injury: improved detection and initial results. Radiology. 2003 May;227(2):332-9. ( 5/2003 )
  • Kadri M, Shu S, Holshouser B, Deming D, Hopper A, Peverini R, Ashwal S.  Proton magnetic resonance spectroscopy improves outcome prediction in perinatal CNS insults. J Perinatol. 2003 May;23(3):181-5. ( 5/2003 )
  • Brenner T, Freier C, Holshouser BA, Ashwal S. Prediction of Long-Term Intellectual and Neuropsychological Effects of Closed Head Injury in Infants and Children. Pediatric Neurology, 2003 Feb;29(2):104-114. ( 2/2003 )
  • Ashwal S, Holshouser BA, del Rio M, Tong KA, Applegate RL, Bailey LL. Serial Proton MRS of the Brain in Children Undergoing Cardiac Surgery. Pediatr Neurol, 2003;29:99-110. ( 0/2003 )
  • Ashwal S, Harder S, Holshouser B, Wycliffe N, Sheridan C, Oyoyo U, Kido D. Nonaccidental trauma: comparison of traditional magnetic resonance imaging with a new high-resolution blood-sensitive magnetic resonance technique and magnetic resonance spectroscopy. Ann Neurol, Sup.1:S136,2002. ( 0/2002 )
  • Ashwal S, Tong K, Holshouser B, Shutter L, Herigault G, Kido D, Haacke EM. Improved detection of hemorrhagic shearing lesions in children with postraumatic diffuse axonal injury: correlation with severity and outcome. Ann Neurol, Sup.1:S136,2002. ( 0/2002 )
  • Ashwal S, Brenner T, Freier C, Burley T, Holshouser B. Prediction of long-term neurological and neuropsychological effects of traumatic brain injury in infants and children using proton magnetic resonance spectroscopy. Ann of Neurol, Sup. 1:S136,2002. ( 0/2002 )
  • Ashwal S, Holshouser BA, Shu SK, Simmons PL, Perkin RM, Tomasi LG, Knierim DS, Sheridan C, Craig K, Andrew GH, Hinshaw DB Jr. Predictive Value of Proton MR Spectroscopy in Pediatric Closed Head Injury. Pediatr Neurol  23:114-25, 2000. ( 0/2000 )
  • Holshouser BA, Ashwal,S, Shu, S, Hinshaw, DB Jr. Proton MR Spectroscopy in Children with Acute Brain Injury: Comparison of Short and Long Echo Time Acquisitions. J Magn Reson Imaging 11:9-19, 2000. ( 0/2000 )
  • Ashwal S, Tong K, Holshouser BA. Correlation of diffusion-weighted imaging, T2 relaxation times and MR spectroscopy in pediatric hypoxic-ischemic brain injury. Ann Neurol 48:539,2000. ( 0/2000 )
  • Ashwal S, Holshouser BA, Hinshaw DB. Magnetic resonance spectroscopy imaging for evaluation of acute pediatric brain injury. Ann Neurol 48:539,2000. ( 0/2000 )
  • Shu S, Ashwal S, Holshouser BA, Hinshaw DB. Prognostic value of proton MR spectroscopy in perinatal insults. Ann Neurol 48:518,2000. ( 0/2000 )
  • Graham GD, Barker PB, Brooks WM, Morris DC, Ahmed W, Bryniarski E, Hearshen DO, Sanders JA, Holshouser BA, Turkel CC. MR spectroscopy study of dichloroacetate treatment after ischemic stroke. Neurology. 2000 Nov 14;55(9):1376-8. ( 0/2000 )
  • Ashwal S, Holshouser  BA, Tomasi LG, Shu S, Perkin RM, Nystrom GA, Hinshaw DB Jr. 1H-Magnetic Resonance Spectroscopy-determined Cerebral Lactate and Poor Neurological Outcomes in Children with Central Nervous System Disease. Ann Neurol 1997; 41:470-481. ( 0/1997 )
  • Ashwal S, Holshouser BA. New Neuroimaging Techniques and Their Potential Role in Patients with Acute Brain Injury. J Head Trauma Rehabil, 1997; 12(4):13-35 ( 0/1997 )
  • Holshouser BA, Ashwal S, Luh GY, Shu S, Kahlon S, Auld KL, Tomasi LG, Perkin RM, Hinshaw DB Jr. 1H-MR Spectroscopy after Acute CNS Injury: Outcome Prediction in Neonates, Infants and Children. Radiology, 1997; 202:487-496. ( 0/1997 )
  • Shu S, Ashwal S, Holshouser BA, Nystrom G, Hinshaw DB Jr. Diagnostic and Prognostic Value of Proton Magnetic Resonance Spectroscopy in Perinatal Central Nervous System Insults. Pediatr Neurol, 1997; 17(4): 309-318. ( 0/1997 )
  • Ashwal S, Holshouser BA, Hinshaw DB Jr., Schell RM, Bailey L. Proton Magnetic Resonance Spectroscopy in the Evaluation of Children with Congenital Heart Desease and Acute Central Nervous System Injury. J Thorac Cardiovasc Surg, 1996; 112:403-414. ( 0/1996 )
  • Kennedy AS, Archambeau JO, Archambeau MH, Holshouser BA, Thompson J, Moyers M, Hinshaw D JR., Slater JM. Magnetic Resonance Imaging as a Monitor of Changes in the Irradiated Rat Brain. An Aid in Determining the time course of Events in a Histologic Study. Investigative Radiology, April 1995, 30(4):214-220. ( 4/1995 )
  • Auld KL, Ashwal S, Holshouser BA, Tomasi LG, Perkin RM, Ross BD, Hinshaw DB Jr. Proton Magnetic Resonance Spectroscopy in Children with Acute Central Nervous System Injury. Pediatric Neurology, June 1995, 12:323-334. ( 6/1995 - 0/1995 )
  • Holshouser BA, Komu M, Moller HE, Zijlmans J, Kolem H, Hinshaw DB Jr, Sonninen P, Vermathen P, Heerschap A, Masur H, Rinne U, de Koster A, Tosk JM. Localized Proton NMR Spectroscopy in the Striatum of Patients with Idiopathic Parkinson''''''''s Disease: A Multicenter Pilot Study. Magnetic Resonance in Medicine, 1995, 33:589-594. ( 0/1995 )
  • Holshouser BA, Hinshaw DB Jr, Shellock FG. Sedation, Anesthesia, and Physiologic Monitoring During MR Imaging:  Evaluation of Procedures and Equipment. Journal of Magnetic Resonance Imaging, 1993, 3:553-448. ( 0/1993 )
  • Tosk JM, Holshouser BA, Aloia RC, Hinshaw DB Jr, Hasso AN, MacMurray JP, Will AD, Bozzetti LP. Effects of the Interaction between Ferric Iron and L-Dopa Melanin on T1 and T2 Relaxation Times Determined by Magnetic Resonance Imaging. Magnetic Resonance in Medicine, 26:40-45, 1992. ( 0/1992 )
  • Stark P, Agness M, Holshouser BA,Hinshaw DB Jr. Kernspintomograhie der Fallot-Tetralogie Radiologie, 31:375-377, 1991. ( 0/1991 )
  • Stark P, Wareham G, Holshouser BA, Hinshaw DB Jr. Kernspintomographische Untersuchung Der Aortenisthmusstenose. Radiologie, 30:481-483, 1990. ( 0/1990 )
  • Hinshaw DB Jr, Coates TL, Peckham N, Thompson JR, Hasso AN, Holshouser BA, Knierim DS. Pediatric Choroid Plexus Neoplasms:  MR, CT and Pathologic Correlation. Radiology, 173: 81-88, October 1989. ( 10/1988 )
  • Holshouser BA, Christiansen EL, Thompson, JR, Reynolds RA. Clinical Experience with a Portable Three-Dimensional Reconstruction Program. Proceedings SPIE Medical Imaging II Conference, Vol. 914 February 1988. ( 2/1988 )
  • Hinshaw DB Jr, Holshouser BA, Engstrom HIM, Tjan AHL, Christiansen EL, Catelli, WF. Dental Material Artifacts on MR Images. Radiology 1988; 166:777-779. ( 0/1988 )
  • Hinshaw DB Jr, Fahmy J, Peckham N, Thompson J, Hasso A, Holshouser BA, Paprocki T. The Bright Choroid Plexus on MR: CT and Pathologic Correlation. AJNR 9:483-486, May/June 1988. ( 0/1988 )
  • Hinshaw DB Jr, Holshouser BA, Hasso An, Thompson JR. Magnetic Resonance Imaging of the Normal Carotid Bifurcation.  Neuroradiology, 1987; 29:7-9. ( 0/1987 )
  • Holshouser BA, Bradley W. Microcomputer Patient Database Management System for an MRI Facility. AJNR 1986; 146: 871-874. ( 0/1986 )
  • Schulz E, Adams R. Aamodt L, Stone E, Johnson D, Holshouser B, Kirk G, Butterfield R. A Precision Pump for Simulated Cardiographic Studies.  J Nuc Med 1981; 22:643-644. ( 0/1981 )
  • Adams R, Holshouser B (Snell), Kirk G, Schulz E. Imaging I-125 with a Scintillation Camera. J Nuc Med 1978; 19:1259-1260. ( 0/1978 )
  Books and Chapters
  • Wycliffe ND, Thompson JR, Holshouser BA, Ashwal S. Pediatric Neuroimaging. Pediatric Neurology: Principles and Practice: Mosby Elsevier, 2006. 167 - 202 ( 1/2006 )
  • Tong KA, Oyoyo U, Holshouser BA, Ashwal S. Neuroimaging for Traumatic Brain Injury. Evidence-Based Imaging: Optimizing Imaging in Patient Care: Springer, 2006. 233 - 259 ( 1/2006 )
  • Tong KA;Oyoyo U;Holshouser BA;Ashwal S. Chapter 13:  Neuroimaging for Traumatic Brain Injury.  In:  "Evidence-based Imaging: Optimizing Imaging in Patient Care.  Medina LS, Blackmore CC (eds).  Springer, New York, NY, 2006:233-259 ( 0/2006 )
  • Tong KA, Oyoyo Udo, Holshouser BA, Ashwal S. “Neuroimaging for Traumatic Brain Injury”. In Evidence-Based Imaging: Optimizing Imaging in Patient Care. Eds. L. Santiago Medina and C. Craig Blackmore. Springer, New York, New York. Chap 13. pgs. 233-259, 2006. ( 0/2006 )
  •   Wycliffe ND, Thompson JR, Holshouser, BA, Ashwal S. “Pediatric Neuroimaging”. In Pediatric Neurology: Principles & Practice. Fourth Edition. Eds. Kenneth F. Swaiman, Stephen Ashwal and Donna M. Ferriero. Mosby Elsevier, Philadelphia, PA. Vol. I, Chap 11. pgs. 167-202. ( 0/2006 )
  • Wycliffe ND, Thompson JR, McLeary M, Holshouser, BA, Ashwal S. “Pediatric Neuroimaging”. In Pediatric Neurology: Principles & Practice. Third Edition. Eds. Kenneth F. Swaiman, Stephen Ashwal and Donna M. Ferriero. Mosby, Philadelphia, PA. Vol. I, Chap 11. pgs. 122-141 ( 0/1999 )
  • Hinshaw DB Jr, Holshouser BA, Engstrom H. Magnetic Resonance Imaging of Deep Facial Anatomy in Craniofacial Radiological Diagnosis and Management, Chapter 1.009, ed. Robert F. Sloan, 1986, Los Angeles, CA.   ( 0/1986 )