Loma Linda University

Enrollment Information
Call us at: 909-558-1000

Faculty Directory
  
Daila Gridley, PhD
Professor, Basic Sciences
School of Medicine
Professor, Radiation Medicine
School of Medicine
Member, Microbiology&Molecular Gen, SM, Faculty of Graduate Studies
Publications    Book Review - Scholarly Journals--Published
  • Dicello, J.F., Gersey, B.B., Gridley, D.S., Coutrakon, G.B., Lesyna, D., Pisacane, V.L., Robertson, J.B., Schulte, R.W., Slater, J.D., Wroe, A.J., and Slater, J.M. Microdosimetric comparison of scanned and conventional proton beams used in radiation therapy. Radiat. Prot. Dosimetry. 143(2-4):513-518, 2011. ( 7/2010 - 6/2011 )
     
  • Gridley, D.S. and Pecaut, M.J. Genetic background and lymphocyte populations after total-body exposure to iron ion radiation. Int. J. Radiat. Biol. 87(1):8-23, 2011.  ( 7/2010 - 6/2011 )
     
  • Rizvi, A., Pecaut, M.J., Slater, J.M., Subramaniam, S., and Gridley, D.S. Low-dose gamma-rays modify CD4+ T cell signalling response to simulated solar particle event protons in a mouse model. Int. J. Radiat. Biol. 87(1):24-35, 2011.  ( 7/2010 - 6/2011 )
     
  Scholarly Journals--Published
  • Mao, X.W., Mekonnen, T., Kennedy, A.R., and Gridley, D.S. Differential expression of oxidative stress and extracellular matrix remodeling genes in low or high dose-rate photon-irradiated skin. Radiat. Res. 176(2):187-197. 2011. ( 7/2010 - 7/2011 )
     
  • Williams, J.W., Zhang, Y., Zhou, H., Gridley, D.S., Koch, C.J., Slater, J.M., Dicello, J.F., and Little, J.B. Sequentially-induced cellular responses define tumor cell radiosenstivity. Int. J. Radiat. Biol. 87(6):628-643, 2011. ( 7/2010 - 6/2011 )
     
  • Tariq, M.A., Soedipe, A., Ramesh, G.T., Wu, H., Zhang, Y., Shishodia, S., Gridley, D.S., Pourmand, N., Jejelowo, Y. The effect of acute dose charge particle radiation on expression of DNA repair genes in mice. Mol. Cell. Biochem. 349(1-2):213-218, 2011.  ( 7/2010 - 6/2011 )
     
  • Ni, H., Balint, K., Zhou Y., Gridley, D.S., Maks, C., Kennedy, A.R., and Weissman, D. Effect of solar particle event radiation on gastrointestinal tract bacterial translocation and immune activation. Radiat. Res. 175(4):485-492 2011. ( 7/2010 - 6/2011 )
     
  • Hall, S.L., Chen, S.-T., Wergedal, J.E., Gridley, D.S., Mohan, S., and Lau K.-H.W. Stem cell antigen-1 positive cell–based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice. J. Gene Med. 13:77-88, 2011. ( 7/2010 - 6/2011 )
     
  • Gridley, D.S., Luo-Owen, X., Rizvi, A., Makinde, A.Y., Pecaut, M.J., Mao, X.W., and Slater, J.M. Low-dose photon and simulated solar particle event proton effects on Foxp3+ T regulatory cells and other leukocytes. Technol. Cancer Res. Treat. 9(6):637-649, 2010. ( 7/2010 - 6/2011 )
     
  • Maks, C.J., Wan, X.S., Ware, J.H., Romero-Weaver, A.L., Sanzari, J.K., Wilson, J.M., Rightnar, S., Wroe, A.J., Koss, P., Gridley, D.S., Slater, J.M., and Kennedy, A.R. Analysis of white blood cell counts in mice following gamma or proton radiation exposure. Radiat. Res. 176(2):170-176, 2011. ( 7/2010 - 6/2011 )
     
  • Baluchamy, S., Ravichandran, P., Periyakaruppan, A., Ramesh, V., Hall, J.C., Zhang, Y., Jejelowo, O., Gridley, D.S., Wu, H., and Ramesh, G.T. Induction of cell death through alteration of oxidants and antioxidants in lung epithelial cells exposed to high energy protons. J. Biol. Chem. 285(32):24769-24774, 2010. ( 7/2009 - 6/2010 )
  • Baluchamy, S., Zhang, Y., Ravichandran, P., Ramesh, V., Sodipe, A., Hall, J.C., Jejelowo, O., Gridley, D.S., Wu, H., and Ramesh, G.T. Differential oxidative stress gene expression profile in mouse brain after proton exposure. In Vitro Cell. Dev. Biol. Anim. 46(8)718-725, 2010. ( 7/2009 - 6/2010 )
  • Baluchamy, S., Zhang, Y., Ravichandran, P., Ramesh, V., Sodipe, A., Hall, J.C., Jejelowo, O., Gridley, D.S., Wu, H., and Ramesh, G.T. Expression profile of DNA damage signaling genes in 2 Gy proton exposed mouse brain. Mol. Cell. Biochem. 341(1-2):207-215, 2010. ( 7/2009 - 6/2010 )
  • Gridley, D.S., Grover, R.S., Loredo, L.N., Wroe, A.J., and Slater, J.D. Proton beam therapy for tumors of the central nervous system. Expert Rev. Neurother. 10(2):319-330, 2010. (Invited review) ( 7/2009 - 6/2010 )
  • Hall SL, Chen S-T, Gysin R, Gridley DS, Mohan S, Lau L-H. Stem cell antigen-1+ cell-based bone morphogenetic protein-4 gene transfer strategy in mice failed to promote endosteal bone formation . J. Gene Med. 11(10):877-888, 2009. ( 7/2009 - 6/2010 )
  • Pearlstein RD, Higuchi Y, Moldovan M, Johnson K, Fukuda S, Gridley DS, Crapo JD, Warner DS, Slater JM. Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. Int. J. Radiat. Biol. 86(2):145-163, 2010. ( 7/2009 - 6/2010 )
  • Makinde AY, Rizvi A, Crapo JD, Pearlstein RD, Slater JM, Gridley DS. A metalloporphyrin antioxidant alters cytokine responses after radiation in a prostate tumor model. Radiat. Res. 173(4):441-452, 2010. ( 7/2009 - 6/2010 )
  • Zhang Y, Clement J, Gridley DS, Rodhe L, Wu H. Protein expression profile changes in human fibroblasts induced by low dose energetic protons. Adv. Space Res. 44:1450-1456, 2009. ( 7/2009 - 6/2010 )
  • Tian, J., Pecaut, M.J., Slater, J.M., and Gridley, D.S. Spaceflight modulates expression of extracellular matrix, adhesion and profibrotic molecules in mouse lung. J. Appl. Physiol. 108(1):162-171, 2010. ( 6/2009 - 6/2010 )
  • Lebsack, T.W., Fa, V., Woods, C.C., Gruener, R., Manziello, A.M., Pecaut, M.J., Gridley, D.S., Stodieck, L.S., Ferguson, V.L., and DeLuca, D. Microarray analysis of spaceflown murine thymus tissue reveals changes in gene expression regulating stress and glucocorticoid receptors. J Cell. Biochem. 110(2):372-381, 2010. ( 6/2009 - 6/2010 )
  • Pecaut, M.J. and Gridley, D.S. The impact of mouse strain on iron ion radio-immune response of leukocyte populations.  Int. J. Radiat. Biol. 86(5):409-419, 2010. ( 6/2009 - 6/2010 )
  • Williams, J.R.,  Zhang, Y., Zhou, H., Russell, J., Gridley, D.S., Koch, C.J., Slater, J.M.,  and Little, J.B.. Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo. Radiat. Oncol. 5:71-84, 2010. ( 5/2009 - 6/2010 )
  • Mao, X.W., Green, L.M., Mekonnen, T., Lindsey, N., and Gridley, D.S. Gene expression analysis of oxidative stress and apoptosis in proton irradiated rat retina. In Vivo. 24(4):425-430, 2010. ( 7/2009 - 5/2010 )
  • Gridley DS, Pecaut MJ, Rizvi A, Coutrakon GB, Luo-Owen X, Makinde AY, Slater JM. Low-dose, low-dose-rate proton radiation modulates CD4+ T cell gene expression. Int. J. Radiat. Biol. 85(3):250-261, 2009. ( 7/2008 - 6/2009 )
  • Ortega MT, Pecaut MJ, Gridley DS, Stodieck LS, Ferguson VL, Chapes SK. Shifts in bone marrow cell phenotypes caused by space flight. J. Appl. Physiol. 106(2):548-555, 200 ( 7/2008 - 6/2009 )
  • Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Pecaut MJ. Low dose, low dose rate photon radiation modifies leukocyte distribution and gene expression in CD4+ T cells. J. Radiat. Res. (Tokyo). 50(2):139-150, 2009. ( 7/2008 - 6/2009 )
  • Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson VL, Pecaut MJ. Spaceflight effects on T lymphocyte distribution, function and gene expression. J. Appl. Physiol. 106(1):194-202, 2009. ( 7/2008 - 6/2009 )
  • Mao XW, Crapo JD, Mekonnen T, Lindsay N, Martinez P, Gridley DS, Slater JM. Radioprotective effect of a metalloporphyrin compound in rat eye model. Curr. Eye Res. 34:62-72, 2009. ( 7/2008 - 6/2009 )
  • Makinde AY, Luo-Owen X, Rizvi A, Crapo JD, Pearlstein RD, Slater JM, Gridley DS. Effect of      a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation. Anticancer Res. 29:107-118, 2009. ( 7/2008 - 6/2009 )
  • Komorowa-Timek E, Oberg KC, Timek TA, Gridley DS, Miles DA. The effect of AlloDerm envelopes on periprosthetic capsule formation with and without radiation. Plast. Reconstr. Surg. 123(3):807-816, 2009. ( 7/2008 - 6/2009 )
  • Tian J, Pecaut MJ, Coutrakon GB, Slater JM, Gridley DS. Response of extracellular matrix regulators in mouse lung after exposure to photons, protons and simulated solar particle event protons. Radiat. Res. 172(1):30-41, 2009. ( 7/2008 - 6/2009 )
  • Baqai FP, Gridley DS, Slater JM, Luo-Owen X, Stodieck LS, Ferguson V, Chapes SK, Pecaut MJ. Effects of spaceflight on innate immune function and antioxidant gene expression. J. Appl. Physiol. 106(6):1935-1942, 2009. ( 7/2008 - 6/2009 )
  • Lloyd SAJ, Bandstra ER, Travis ND, Nelson GA, Bourland JD, Pecaut MJ, Gridley DS, Willey JS, Bateman TA. Spaceflight-relevant types of ionizing radiation and cortical bone:  Potential LET effect? Adv. Space Res. 42:1889-1897, 2008. ( 7/2007 - 6/2008 )
     
  • Williams JR, Zhang Y, Zhou H, Russell J, Gridley DS, Slater JM, Koch CS, Dillehay LE, Little JB. Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation. Int. J. Radiat. Oncol. Biol. Phys. 72(3):909-917, 2008. ( 7/2007 - 6/2008 )
     
  • Pecaut MJ, Gridley, D.S. Radiation and secondary immune response to lipopolysaccharide. In Vivo.  22(4):423-434, 2008.  ( 7/2007 - 6/2008 )
     
  • Willey JS, Grilly LG, Howard SH, Pecaut MJ, Obenaus A, Gridley DS, Nelson GA, Bateman T.A. Bone architectural and structural properties after 56Fe26+ radiation-induced changes in body mass. Radiat. Res. 170(2):201-207, 2008. ( 7/2007 - 6/2008 )
     
  • Gridley DS, Obenaus A, Bateman TA, Pecaut MJ. Chronic changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation. Int. J. Radiat. Biol. 84(7):549-559, 2008. ( 7/2007 - 6/2008 )
     
  • Bandstra ER, Pecaut MJ, Anderson ER, Willey JS, De Carlo F, Stock SR, Gridley DS, Nelson GA, Levine HG, Bateman TA. Long-term dose response of trabecular bone in mice to proton radiation. Radiat. Res. 169:607-614, 2008. ( 7/2007 - 6/2008 )
     
  • Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Coutrakon GB, Koss P, Slater JM, Pecaut MJ. Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons. In Vivo. 22:159-170, 2008. ( 7/2007 - 6/2008 )
     
  • Williams JR, Zhang Y, Zhou H, Gridley DS, Russell J, Slater JM, Little JB. A Quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status. Int. J. Radiat. Biol. 84(4): 253-264. 2008.  ( 7/2007 - 6/2008 )
     
  • Gridley DS, Coutrakon GB, Rizvi A, Bayeta EJM, Luo-Owen X, Makinde AY, Baqai F, Koss P, Slater JM, Pecaut MJ. Low dose photons modify liver response to simulated solar particle event protons. Radiat. Res. 169:280-287, 2008. ( 7/2007 - 6/2008 )
     
  • Williams JR, Zhang Y, Zhou H, Russell J, Gridley DS, Koch CJ, Little JB. Genotype-dependent radiosensitivity: Clonogenic survival, apoptosis and cell-cycle redistribution. Int. J. Radiat. Biol. 84(2):151-164, 2008. ( 7/2007 - 6/2008 )
     
  • Gridley, D.S., Makinde, A.Y., Luo, X., Rizvi, A., Crapo, J.D., Dewhirst, M.W., Moeller, B.J., Pearlstein, R.D., and Slater, J.M.  Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model.  Anticancer Res. 27(5A):3101-3109, 2007. ( 7/2007 - 6/2008 )
     
  • Hall, S.L., Lau, K.H.W., Chen, S.T., Wergedal, J.E., Srivastava, A., Klamut, H., Sheng, M.H., Gridley, D.S. Mohan, S., and Baylink, D.J. Sca-1+ hematopoietic cell-based gene therapy with a modified FGF-2 increased endosteal/trabecular bone formation in mice. Mol. Ther. 15(10):1881-1889, 2007. ( 7/2007 - 6/2007 )
     
  • Gridley, D.S., Makinde, A.Y., Luo, X., Rizvi, A., Crapo, J.D., Dewhirst, M.W., Moeller, B.J., Pearlstein, R.D., and Slater, J.M. "Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model." Anticancer Res . (2007): -. ( 1/2007 )
    BACKGROUND: Antioxidants have potential to protect normal tissues against radiation-induced damage, but must not also protect tumor cells during radiotherapy. The major objectives were to determine whether a metalloporphyrin antioxidant affects prostate tumor response to radiation and identify possible mechanisms of interaction. MATERIALS AND METHODS: C57BL/6 mice with RM-9 tumor were treated with manganese (III) meso-tetrakis(1,3-diethylimidazolium-2-yl)porphyrin (MnTDE-2-ImP) and 10 gray (Gy) radiation. Tumor volume was quantified and a subset/group was evaluated for hypoxia-inducible factor-1? (HIF-1?), bone marrow-derived cell populations, and cytokines. RESULTS: The addition of MnTDE-2-ImP transiently increased tumor response compared to radiation alone. The group receiving drug plus radiation had reduced intratumoral HIF-1? and decreased capacity to secrete TNF-?, whereas production of IL-4 was increased. There were no toxicities associated with combination treatment. CONCLUSION: The results demonstrate that MnTDE-2-ImP did not protect the RM-9 prostate tumor against radiation; instead, radiation effectiveness was modestly increased. Possible mechanisms include reduction of radiation-induced HIF-1? and an altered cytokine profile.
  • Pecaut, M.J., Dutta-Roy, R.. Miller, G.M., and Gridley, D.S. "Radiation-induced modifications in primary immune response to lipopolysaccharide: lymphocyte distribution and function." In Vivo 21.3 (2007): 463-470. ( 1/2007 )
    Introduction: Lipopolysaccharide (LPS) is a major cause of septic shock and death due to infection with Gram-negative bacteria. The purpose of this study was to quantify the effects of whole-body irradiation on lymphocyte populations during response to challenge with LPS. Materials and methods: C57BL/6 mice (n = 10/group) were irradiated whole-body with 3 gray (Gy) ?-rays in a single fraction at 0.8 Gy/min. LPS (E. coli serotype 0111:B4) at 1 mg/kg was injected intraperitoneally 10 days later and mice were euthanized at 60 min and days 1, 7, and 14 post-inoculation for analyses. Results: Significant interactions between radiation and LPS were noted in circulating and splenic lymphocyte subpopulations, including T, B, and NK-cells, particularly at the early time points. There were significant interactions on circulating, but not splenic, CD62L+ T-cell populations. However, there were no interactions on CD62L+ B-cells. Finally, there were significant interactions in both early and late blastogenic responses. Conclusion: The data support the conclusion that response to infection with Gram-negative bacteria may be significantly compromised by exposure to ionizing radiation.
  • Hall, S.L., Lau, K.H.W., Chen, S.T., Wergedal, J.E., Srivastava, A., Klamut, H., Sheng, M.H.C., Gridley, D.S., Mohan, S., and Baylink, D.J. "An improved mouse Sca-1+ cell-based bone marrow transplantation model for use in gene- and cell-based therapeutic studies." Acta Haematologica 117.1-2 (2007): 24-33. ( 1/2007 )
    This study assessed the feasibility of an ex vivo Sca-1+ cell-based systemic FGF-2 gene therapy to promote endosteal bone formation. Sca-1 cells were used because of their ability to home and engraft into the bone marrow cavity. The human FGF gene was modified to increase protein secretion and stability by adding the BMP-2/4 hybrid signal sequence and by mutating two key cysteines. Retro-orbital injection of SCA-1+ cells transduced with an MLV-based vector expressing the modified FGF=2 gene into sub-lethally irradiated W41/W41 recipient mice resulted in long-term engraftment, marked elevation in serum FGF-2 level (>100-fold of normal value). Increase in serum bone formation markers, and massive endosteal bone formation. In recipient mice showing very high serum FGF-2 levels (>4,000 pg/ml), this enhanced endosteal bone formation was so robust that the marrow space was completely filled up with bony tissue and there was insufficient calcium available for the mineralization of all the newly formed bone, which led to hypocalcemia, secondary hyperparathyroidism, and osteomalacia. These side effects appeared to be dose-related. In conclusion, this study provided compelling test-of-principle evidence for the feasibility of a Sca-1+ cell-based ex vivo systemic FGF-2 gene therapy strategy to promote endosteal bone formation.
  • Luo, X., Slater, J.M., and Gridley, D.S. "Radiation and endostatin gene therapy in a lung carcinoma model: Pilot data on cells and cytokines that affect angiogenesis and immune status." Technology in Cancer Research and Treatment 5.2 (2006): 135-146. ( 4/2006 )
    The dose of radiation that can be safely delivered to cancers residing in sensitive areas such as the lungs is limited by concern for normal tissue damage. Therapies that target tumor vasculature have potential to enhance the efficacy of radiotherapy, with minimal risk for toxicity. We constructed a unique plasmid, pXLG-mEndo, containing the mouse endostatin gene. A significantly greater anti-tumor effect was obtained against Lewis lung carcinoma (LLC) in mice when pXLG-mEndo was combined with radiation compared to radiation alone. Here we report results of cellular and cytokine assessments performed 1 day after treatment. These analyses were done to obtain baseline data on leukocytes that affect angiogenesis, as well as anti-tumor immunity, and to detect possible treatment-related toxicities. White blood cell counts were dramatically elevated in blood and spleens of untreated tumor-bearing mice, primarily due to granulocytosis. Overall, the effect of radiation was more evident than that of the plasmids (pXLG-mEndo and parental pWS4); radiosensitivity of specific lymphocyte subsets was variable (B > T > NK; CD8+ Tc > CD4+ Th). Tumor presence resulted in dramatically elevated interleukin-2 (IL-2) and decreased tumor necrosis factor-? (TNF-?) in supernatants of activated splenocytes, but had no significant effect on interferon-? (IFN-?). Administration of pXLG-mEndo, radiation, or both modified the tumor-induced aberrations in IL-2 and TNF-?; IFN-? production was decreased by radiation. Red blood cell counts, hemoglobin, and hematocrit were low in tumor-bearing mice, but there were no treatment-related differences among groups. Platelet counts were reduced, whereas their volumes were increased in tumor-bearing mice; both parameters were only slightly affected by either pXLG-mEndo or control plasmid injection, however. The data demonstrate in the Lewis lung carcinoma model that tumor-localized endostatin gene therapy and radiation had significant effects on cells and cytokines that can influence angiogenesis, tumor growth and immune status.
  • Hamilton, S.A., Pecaut, M.J., Gridley, D.S., Travis, N.D., Graham, S., Newman, I.M., Bateman, T.A. "A murine model for space and therapeutic radiation-induced bone loss." J. Appl. Physiol. - Regul Integr Comp. Physiol 101.3 (2006): 789-793. ( 1/2006 )
    Cancer patients receiving radiation therapy are exposed to photon (gamma/X-ray), electron, and less commonly proton radiation. Similarly, astronauts on exploratory missions will be exposed to extended periods of lower-dose radiation from multiple sources and of multiple types, including heavy ions. Therapeutic doses of radiation have been shown to have deleterious consequences on bone health, occasionally causing osteoradionecrosis and spontaneous fractures. However, no animal model exists to study the cause of radiation-induced osteoporosis. Additionally, the effect of lower doses of ionizing radiation, including heavy ions, on general bone quality has not been investigated. This study presents data developing a murine model for radiation-induced bone loss. Female C57BL/6 mice were exposed to gamma, proton, carbon, or iron radiation at 2-Gray doses, representing both a clinical treatment fraction and spaceflight exposure for an exploratory mission. Mice were euthanized 110 days after irradiation. The proximal tibiae and femur diaphyses were analyzed using microcomputed tomography. Results demonstrate profound changes in trabecular architecture. Significant losses in trabecular bone volume fraction were observed for all radiation species: gamma, (-29%), proton (-35%), carbon (-39%), and iron (-34%). Trabecular connectivity density, thickness, spacing, and number were also affected. These data have clear implications for clinical radiotherapy in that bone loss in an animal model has been demonstrated at low doses. Additionally, these data suggest that space radiation has the potential to exacerbate the bone loss caused by microgravity, although lower doses and dose rates need to be studied.
  • Hamilton, S.A., Pecaut, M.J., Gridley, D.S., Travis, N.D., Graham, S., Newman, I.M., Bateman, T.A. "A murine model for space and therapeutic radiation-induced bone loss." J. Appl. Physiol. - Regul Integr Comp. Physiol 101.3 (2006): 789-793. ( 1/2006 )
    Cancer patients receiving radiation therapy are exposed to photon (gamma/X-ray), electron, and less commonly proton radiation. Similarly, astronauts on exploratory missions will be exposed to extended periods of lower-dose radiation from multiple sources and of multiple types, including heavy ions. Therapeutic doses of radiation have been shown to have deleterious consequences on bone health, occasionally causing osteoradionecrosis and spontaneous fractures. However, no animal model exists to study the cause of radiation-induced osteoporosis. Additionally, the effect of lower doses of ionizing radiation, including heavy ions, on general bone quality has not been investigated. This study presents data developing a murine model for radiation-induced bone loss. Female C57BL/6 mice were exposed to gamma, proton, carbon, or iron radiation at 2-Gray doses, representing both a clinical treatment fraction and spaceflight exposure for an exploratory mission. Mice were euthanized 110 days after irradiation. The proximal tibiae and femur diaphyses were analyzed using microcomputed tomography. Results demonstrate profound changes in trabecular architecture. Significant losses in trabecular bone volume fraction were observed for all radiation species: gamma, (-29%), proton (-35%), carbon (-39%), and iron (-34%). Trabecular connectivity density, thickness, spacing, and number were also affected. These data have clear implications for clinical radiotherapy in that bone loss in an animal model has been demonstrated at low doses. Additionally, these data suggest that space radiation has the potential to exacerbate the bone loss caused by microgravity, although lower doses and dose rates need to be studied.
  • Gridley, D.S., Dutta-Roy, R., Andres, M.A., Nelson, G.A., and Pecaut, M.J. "Acute effects of iron radiation on immunity, part II: leukocyte activation, cytokines, and adhesion." Radiation Research 165. (2006): 78-87. ( 1/2006 )
    The effects of high-linear energy transfer (LET) radiation on immune function have not yet been clearly established. The major goal of this portion of the study was to evaluate leukocyte responses after whole-body high-LET irradiation. C57BL/6 mice were exposed to 0, 0.5, 2, and 3 gray (Gy) 56^Fe^26+ (1055 MeV/nucleon, 148.2 keV/?m) and euthanized 4 days post-exposure. Spontaneous synthesis of DNA in blood and spleen cells was significantly increased in groups receiving either 2 or 3 Gy (P
  • Luo, X., Andres, M.L., Timiryasova, T.M., Fodor, I., Slater, J.M., and Gridley, D.S.. "Radiation-enhanced endostatin gene expression and effects of combination treatment." Technol. Cancer Res. Treat 4.2 (2005): 193-202. ( 1/2005 )
  • Gridley, D.S., Williams, J.R., and Slater, J.M.. "Low-dose/low-dose-rate radiation: a feasible strategy to improve cancer radiotherapy?." Cancer Ther. 3. (2005): 105-130. ( 1/2005 )
  • Pecaut, M.J., Dutta-Roy, R., Smith, A.L., Jones, T.A., Nelson, G.A., and Gridley, D.S.. "Acute effects of iron radiation on immunity, part I: population distributions." Radiat. Res. . (2005): -. ( 1/2005 )
  • Gridley, D.S. and Slater, J.M.. " Combining gene therapy and radiation against cancer.." Current Gene Therapy 4. (2004): 231-248. ( 7/2004 )
  • Pecaut, M.J., Miller, G.M., Nelson, G.A., and Gridley, D.S.. "Hypergravity-induced immunomodulation in a rodent model: Hematological and lymphocyte function analysis.." J. Appl. Physiol. 97. (2004): 29-38. ( 7/2004 )
  • Dicello, J.F., Christian, A., Cucinotta, F.A., Gridley, D.S., Markham, A.R., Moyers, M.F., Novak, G.R., Piantadosi, S., Ricart-Arbona, R., Simonson, D.M., Strandberg, J.D., Vazquez, M., Williams, J.R., Zhang, Y., Zhou, H., and Huso, D.. "In-vivo mammary tumorigenesis in the Sprague-Dawley rat and microdosimetric correlates." Phys. Med. Biol. 46.16 (2004): 3817-3830. ( 7/2004 )
  • Gridley, D.S. and Slater, J.M.. "Gene therapy: A possible aid to cancer radiotherapy.." Discovery Med. 4.24 (2004): 408-414. ( 1/2004 )
  • Gridley, D.S. and Slater, J.M.. "Combining gene therapy and radiation against cancer.." Current Gene Therapy 4. (2004): 231-248. ( 1/2004 )
  Scholarly Journals--Accepted
  • Gridley, D.S., Pecaut, M.J., Green, L.M., Sanchez, M.C., and Kadhim, M.A. Strain-related differences and radiation quality effects on mouse leukocytes: gamma-rays and protons (with and without aluminum shielding). In Vivo. In press, 2011.  ( 7/2010 - 6/2011 )
     
  • Tian, J. Zhao, WL, Tian, S., Slater, J.M., Deng, Z., and Gridley, D.S. Expression of genes involved in mouse lung cell differentiation/regulation after acute exposure to photons and protons with and without low dose pre-irradiation. Radiat. Res. In press, 2011. ( 7/2010 - 6/2011 )
     
  • Pecaut, M.J. and Gridley, D.S. Impact of head-only iron radiation on the peripheral LPS response. In Vivo. In press, 2011. ( 7/2010 - 6/2011 )
     
  • Rizvi, A., Pecaut, M.J., and Gridley, D.S. Low-dose gamma-rays and simulated solar particle event protons modify splenocyte gene and cytokine expression patterns. J. Radiat. Res. (Tokyo). In press, 2011. ( 7/2010 - 6/2011 )
     
  • Gridley, D.S., Luo-Owen, X., Rizvi, A., Makinde, A.Y., Pecaut, M.J., Mao, X.W., and Slater, J.M. Low-dose photon and simulated solar particle event proton effects on Foxp3+ T regulatory cells and other leukocytes. Technol. Cancer Res. Treat. In press, 2010. ( 6/2009 - 6/2010 )
  • Gridley, D.S. and Pecaut, M.J. Genetic background and lymphocyte populations after total-body exposure to iron ion radiation. Int. J. Radiat. Biol. In press, 2010. ( 6/2008 - 6/2010 )
  • Rizvi, A., Pecaut, M.J., Slater, J.M., Subramaniam, S., and Gridley, D.S. Low-dose g-rays modify CD4+ T cell signaling response to simulated solar particle event protons in a mouse model. Int. J. Radiat. Biol. In press, 2010. ( 6/2008 - 6/2010 )
  • Gridley DS, Pecaut MJ, Rizvi A, Coutrakon GB, Luo-Owen X, Makinde AY, Slater JM. Low-dose, low-dose-rate proton radiation modulates CD4+ T cell gene expression. Int. J. Radiat. Biol. In press, 2008. ( 7/2008 - 6/2009 )
     
  • Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Pecaut MJ. Low dose, low dose rate photon radiation modifies leukocyte distribution and gene expression in CD4+ T cells. J. Radiat. Res. (Tokyo). In press, 2008. ( 7/2008 - 6/2009 )
     
  • Ortega MT, Pecaut MJ, Gridley DS, Stodieck LS, Ferguson VL, Chapes SK. Shifts in bone marrow cell phenotypes caused by space flight. J. Appl. Physiol. In press, 2008. ( 7/2008 - 6/2009 )
     
  • Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson V, Pecaut MJ. Spaceflight effects on T lymphocyte distribution, function and gene expression. J. Appl. Physiol. In press, 2008.  ( 7/2008 - 6/2009 )
     
  • Mao XW, Crapo JD, Mekonnen T, Lindsay N, Martinez P, Gridley DS, Slater JM. Radioprotective effect of a metalloporphyrin compound in rat eye model. Curr. Eye Res. In press, 2008.  ( 7/2008 - 6/2009 )
     
  • Makinde AY, Luo-Owen X, Rizvi A, Crapo JD, Pearlstein RD, Slater JM, Gridley DS. Effect of          a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation. Anticancer Res. In press, 2008. ( 7/2008 - 6/2009 )
     
  • Makinde AY, Rizvi A, Crapo JD, Pearlstein RD, Slater JM, Gridley DS. A metalloporphyrin antioxidant alters cytokine responses after radiation in a prostate tumor model. Radiat. Res. In press, 2009. ( 7/2008 - 5/2009 )
  Books and Chapters
  • Gridley, D.S., Green, L.M., Nelson, G.A., Pecaut, M.J., and Slater, J.M.. Cancer, Radiotherapy and SOD mimetics. In: Therapeutic Applications of Superoxide Dismutase and Its Mimetics. Georgetown, TX: Landes Bioscience, . ( 7/2006 - 6/2007 )
  • Gridley, D.S., Green, L.M., Nelson, G.A., Pecaut, M.J., and Slater, J.M. Cancer, radiotherapyand SOD mimetics. In: Therapeutic Applications of Superoxide Dismutase and Its Mimetics. Georgetown: Landes, 2006. ( 6/2006 )
  Non-Scholarly Journals
  • Research highlighted in: Faculty from department of radiation medicine featured in conference proceedings. James M. Slater, MD, FACR, Editor-in-Chief; William Preston, EdD, Editor. Proton Treatment Center Newsletter. 16(2):5-7, Autumn, 2007.  ( 7/2007 - 6/2008 )
     
  • Research highlighted in: Radiation Medicine offers symposium on proton therapy. James M. Slater, MD, FACR, Editor-in-Chief; William Preston, EdD, Editor. Proton Treatment Center Newsletter. 16(1):5-13, Summer 2007.  ( 7/2007 - 6/2008 )
     
  • James M. Slater, M.D., F.A.C.R., Editor-in-Chief and Daila S. Gridley, Ph.D"Research highlighted in: Investigations in basic science highlighted at annual meeting." Proton Treatment Center Newsletter, Winter 2006. Volume 15(1) : 91 - 10 ( 7/2006 - 6/2007 )
  • James M. Slater, M.D., F.A.C.R., Editor-in-Chief"Research highlighted in: Investigations in basic science highlighted at annual meeting." Treatment Center Newsletter. Volume 15(1): 01 12 2006: 9 - 10 ( 12/2006 )
  • James M. Slater, M.D., F.A.C.R., Editor-in-Chief"Research highlighted in: LLU, NASA collaborate on basic research in proton radiation." Proton Treatment Center Newsletter, Winter 2006. Volume 15(1) 01 12 2006: 8 ( 12/2006 )
  • James M. Slater, M.D., F.A.C.R., Editor-in-Chief, Daila S. Gridley, Ph.D"Research highlighted in: LLU, NASA collaborate on basic research in proton radiation." Proton Treatment Center Newsletter, Winter 2006 01 01 2006: 8 ( 1/2006 )
  • Gridley, D.S. and Slater, JM (Editor-in-Chief)"Cytokines and proton treatment of non-small-cell lung cancer.." Proton Treatment Center Newsletter 01 01 2005: 7 - 10 ( 1/2005 )
  • "None." 01 01 1900: (*)