Donna Strong, PhD Research Professor, Medicine School of Medicine Research Professor, Basic Sciences School of Medicine

Research & Grantsmanship 

  Funded Research Project (PI)

• Effect of naturally occurring single nucleotide and length polymorphisms on human CbfaI promoter activity in osteoblasts ( 7/2000 - 6/2008 )

• Molecular Biology of the IGF-II System in Bone Cells ( 4/2002 - 3/2008 )

• Characterization of the transcriptional mechanism by which cox-2 inhibitis IGFBP-6 expression ( 3/2002 - 2/2008 )

• Development of Skeletal Targeting Vectors for Gene Therapy ( 12/2000 - 12/2007 )

• Development and application of bone specific promoters and transcription factors for gene therapy ( 10/1998 - 9/2007 )

• Polymorphisms in the 3'UTR of Arylhydrocarbon receptor nuclear transporter (ARNT) 2 in MRL/SJL F2 Mice Regulate the Stability of its mRNA and Associate with the Ability to heal wounds ( 6/2004 - 6/2007 )

• Effect of Naturally occurring single nucleotide and length polymorphisms on human Cbfa I promoter activity in osteoblasts ( 6/2004 - 6/2006 )

• Molecular Biology Studies of the IGF-II System in Bone Cells ( 7/2004 - 6/2005 )

  Funded Research Project (CI)

• A novel approach to increase endosteal bone formation. ( 10/2006 - 10/2007 )

• A pilot study to assess osteoblast and prostate cancer cell interactions ( 7/2006 - 6/2007 )

• Molecular genetic and gene therapy studies of the musculoskeletal system-Subproject #8-Nuclear targeting of transposon-based plasmid vectors for gene therapy ( 10/2003 - 9/2006 )

  Abstracts Reporting Research -- Peer Reviewed

• C.A. Strohbach, C.H Rundle, S-TChen, J.E. Wergedal, T.A. Linkhart, D.J. Baylink, K-H.W. Lau, D.D. Strong. "In vivo retroviral-based gene therapy with LIM Mineralization Protein (LMP)-1 enhances fracture healing.." Orthopaedic Research Society Transactions 32. (2007): 0226-. ( 2/2007 )

• L.A. Perez-Casellas, X .Wang, G. Gutierrez, D.D. Strong, T.A. Linkkhart . "Role of transcription factor NF1 in Regulation of human osteoblast IGF-binding protein-5 gene expression." J Bone and Mineral Res 21. (2007): SA145-. ( 1/2007 )

• L.A. Perez-Casellas, G. Gutierrez, D.D. Strong, T.A. Linkhart. "Role of transcription factor NF1 in regulation of human osteoblast IGF binding protein 5 gene expression.." Abstracts for American Society for Cell Biology . (2006): 1849-. ( 12/2006 )

• Rundle CH, Strong DD, Chen S-T, Sheng MH-C, Wergedal JE, Lau K-HW, Baylink DJ. "Retroviral-based gene therapy with cyclo-oxygenase-2 promotes bony union and accelerates fracture healing in the rat." Molecular Therapy 13. (2006): S308-. ( 1/2006 )

• Hall SL, Felt JC, Linkhart TA, Strong DD. "Effects of R-FB, a unique nonsteroidal anti-inflammatory drug, on Cox2 mediated inhibition of ." J Bone & Mineral Res 20.Suppl 1 (2005): S129-. ( 9/2005 )

• Strohbach CA, Linkhart TA, Mohan S, Shi Y, Glackin C, Strong DD. "Non-canonical Wnt11 transcriptionally suppresses expression of insulin-like growth factor binding protein-6, an inhibitor of osteoblast differentiation." J Bone & Min Res 20.Suppl1 (2005): S129-. ( 9/2005 )

• Strong DD, Dean DA, Linkhart TA. "Development of an osteoblast-specific DNA nuclear targeting sequence from the human type1a2 procollagen promoter for derelopment of efficient plasmid expression vectors." J Bone & Mineral Res 20.Suppl 1 (2005): S354-. ( 9/2005 )

• Hall SL, Felt JC, Linkhart TA, Strong DD. "Effects of R-FB, a unique nonsteroidal anti-inflammatory drug, on Cox2 mediated inhibition of insulin-oke growth factor binding protein-6(BP6) transcription.." J Bone & Mineral Res 20.Supp 1 (2005): S129-. ( 1/2005 )

• Strohbach CA, Linkhart TA, Mohan S, Shi Y, Glackin C, Strong DD.. "Non-canonical Wnt11 transcriptionally suppresses expression of insulin-like growth factor binding protein-6, an inhibitor of osteoblast differentiation.." J Bone Miner Res (Suppl 1) 20. (2005): SA148.-. ( 1/2005 )

• DD Strong, DA Dean, TA Linkhart. "Development of an osteoblast-specific DNA nuclear targeting sequence from the human type12 procollagen promoter for development of efficient plasmid expression vectors. ." J Bone Min Res (Suppl 1) 21.SA145 (2005): -. ( 1/2005 )

• DD Strong, DA Dean, TA Linkhart. . "." J Bone Min Res 21. (2005): -SA145. ( 1/2005 )

• LA Perez-Casellas, G. Gutierrez, DD Strong, TA Linkhart. "." . (1900): -. (*)

• LA Perez-Casellas, G. Gutierrez, DD Strong, TA Linkhart. "." J Bone Min Res 21. (1900): -. (*)

• Strong. "." 20.Supp 1 (1900): -. (*)

• Hall S, Felt JC, Linkhart RA, Strong DD. "Effects of R-FB, a unique nonsteroidal anti-inflammatory drug, on Cox2 mediated inhibition of insulin-like growth factor binding proetin-6 (BP6) transcription.." J Bone Miner Res (Suppl 1) 20. (): SA145-. (*)