Sub-Investigators: Prowse* M (Physical Therapy Graduate Student), Bains G, McNulty* NL (Clinical Neurophysiology Resident), Lekkala* M (Neurology Resident), Berk L, Swope DM, Tsao BE, Demattos N. This is a pilot study to quantify strain gauge measurements of dorsiflexion of the toes and to further study teh EDB model before and after injection of Botulinum toxin type A into the EDB muscle of healthy human volunteers.

Sub-Investigator: Tsao BE. This is study to serially evaluate the results of nerve conduction studies in a subject who had clinically successful carpal tunnel release. One of the objects is to follow the time-sequence of anticipated improvement of the nerve conduction study results.

Sub-Investigators: Tsao BE, Swope DM. This project is to evaluate the time course of the development and disappearance of fibrillation potentials in the extensor digitorum brevis (EDB) muscle following a single intramuscular injection of Botulinum toxin into the EDB muscle and if fibrillation potentials are seen in the EDB muscle at more than 3 weeks, to also evaluate other muscles via needle EMG testing.

Sub-Investigators: Tsao BE, Swope DM. This pilot project is to determine if fibrillation potentials are reliably present when tested via needle EMG examination performed daily or almost-daily of the extensor digitorum brevis (EDB) muscle after intrmuscular injection of Botulinum toxin into the EDB muscle in healty volunteers. This study is also to determine when the fibrillation potentials begin to appear, when they are most dense, and when they diminish in density.

Co-Investigators: Griffin* C (Resident Physician), Brandstater ME, Nist LD, Al-Sayed* F (Resident Physician). This is a study to evaluate the effect of prior activation of a muscle on the size of the compound muscle action potential which can be recorded following electrical stimulation of the nerve. This has specific implications for projects which try to quantify--especially with serial electrophysiologic studies--the effect which an agent may have on the muscle or neuromuscular junction.