Joseph Fan, MD Associate Professor, Ophthalmology School of Medicine

Research & Grantsmanship 

  Funded Research Project (PI)

• A phase III, multicenter, randomized, double-masked, sham injection-controlled study of the efficacy and safety of ranibizumab in subfoveal choroidal neovascularization (CNV) with or without classic CNV secondary to age-related macular degeneration. ( 7/2006 - 12/2007 )

• A pilot study of peribulbar triamcinolone acetonide for diabetic macular edema. ( 7/2006 - 12/2007 )

• A randomized trial comparing intravitreal triamcinolone acetonide and laser photocoagulation for diabetic macular edema. ( 7/2006 - 12/2007 )

• A six-month, phase 3, multicenter, masked, randomized, sham-controlled trial (with six-month open-label extension) to assess the safety and efficacy of 700 ug Dexamethasone Posterior Segment Drug Delivery System (DEX PS DDS Applicator System) in the treatment of patients with macular edema following central retinal vein occlusion or branch retinal vein occlusion. ( 7/2006 - 12/2007 )

• Subclinical diabetic macular edema. ( 7/2006 - 12/2007 )

• Evaluation of vitrectomy for diabetic macular edema. ( 7/2006 - 12/2007 )

• An observational study of the development of diabetic macular edema following scatter laser photocoagulation. ( 7/2006 - 12/2007 )

• A randomized, controlled study of the safety, tolerability and biological effect of repeated intravitreal administration of VEGF trap in patients with neovascular age-related macular degeneration. ( 7/2006 - 12/2007 )

• A Phase 2 Evaluation of Anti-VEGF Therapy for Diabetic Macular Edema: Bevacizumab (Avastin). ( 7/2006 - 12/2007 )

• An exploratory study of the safety, tolerability and biological effect of intravitreal administration of VEGF trap in patients with neovascular age-related macular degeneration. ( 7/2006 - 12/2007 )

• A 3-year, phase 3, multicenter, masked, randomized, sham-controlled trial to assess to safety and efficacy of 700ug and 350ug dexamethasone posterior segment drug delivery system (DEX PS DDS Applicator System) in the treatment of patients with diabetic macular edema ( 7/2006 - 7/2007 )

• A phase III, multicenter, randomized, double-masked, sham injection-controlled study of the efficacy and safety of ranibizumab in subfoveal choroidal neovascularization (CNV) with or without classic CNV secondary to age-related macular degeneration. ( 1/2007 - Present )

  Funded Research Project (CI)

• The standard care versus corticosteroid for retinal vein occlusion (SCORE) study: Two randomized trials to compare the efficacy and safety of intravitreal injection(s) of triamcinolone acetonide with standard care to treat macular edema: One for central retinal vein occlusion and one for branch retinal vein occlusion. ( 7/2006 - 12/2007 )

• The Age-Related Eye Disease Study II (AREDS II): A Multi-center, Randomized Trial of Lutein, Zeaxanthin, and Long-Chain Omega-3 Fatty Acids (Docosahexaenoic acid [DHA] and Eicosapentaenoic acid [EPA]) in Age-Related Macular Degeneration. ( 1/2006 - 12/2007 )

  Abstracts Reporting Research -- Peer Reviewed

• Dovich, J., Lee, S., and Fan, J.T.. "19-year retrospective review of endogenous endophthalmitis at the Loma Linda Unviersity Medical Center." Association fro Research in Vision and Ophthalmology . (2006): -. ( 5/2006 )