Loma Linda University

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Kin-Hing Lau, PhD
Research Professor, Medicine
School of Medicine
Member, Biochemistry, SM, Faculty of Graduate Studies
Presentations    Research Presentations -- International
  • Meng X, Neises A, Lau K-HW, Baylink DJ, Zhang X (2011) Transdifferentiation of hematopoietic stem cells into mesenchymal stem cells for use in bone regeneration. The 33rd Annual Meeting of the American Society of Bone and Mineral Research, September 16-20, 2011, San Diego, California, abstract #1078. ( 9/2011 ) Link...
  • Sheng MH-C, Zhou X-D, Lau K-HW, Bonewald L, Baylink DJ (2011) Conditional knockout of IGF-I in osteocytes surprisingly accelerates fracture repair. The 33rd Annual Meeting of the American Society for Bone and Mineral Research, September 16-20, 2011, San Diego, California, abstract #1038. ( 9/2011 ) Link...
  • Sheng MH-C, Lau K-HW, Zhou X-D, Bonewald L, Baylink DJ (2011) Osteocyte-derived IGF-I functions as a portion of the circuitry for normal loading activation response in osteoblasts: Data from the osteocyte IGF-I conditional knockout mouse. The 33rd Annual Meeting of the American Society for Bone and Mineral Research, September 16-20, 2011, San Diego, California, abstract #1071. ( 9/2011 ) Link...
  • Zhou XD, Lau K-HW, Bonewald L, Baylink DJ, Sheng MH-C (2011) Evidence that osteocytes elaborate endocrine regulation of internal organs size: Data from the osteocytes IGF-I conditional knockout mice. The 33rd Annual Meeting of the American Society for Bone and Mineral Research, September 16-20, 2011, San Diego, California, abstract #FR0319. ( 9/2011 ) Link...
  • Kothari V, Zhang X, Lau K-HW, Baylink DJ, Das A (2011) Cellular and molecular mechanisms of accelerated fracture healing by Cox-2 gene therapy. Studies in a multiple fracture mouse model. The 33rd Annual Meeting of the American Society for Bone and Mineral Research, September 16-20, 2011, San Diego, California, abstract #MO0470. ( 9/2011 ) Link...
  • Rundle CH, Popa NL, Mohan S, Lau K-HW (2011) Microarray analysis of fracture gene expression in response to Cox-2 gene therapy identifies novel angiogenic genes. The Annual Meeting of the American Society for Bone and Mineral Research, September 16-20, 2011, San Diego, California, abstract #MO0207. ( 9/2011 ) Link...
  • Chen S-T, Coen MJ, Rundle CH, Wergedal JE, Lau K-HW (2011) HIV-Cox2-based, but not HIV-BMP4-based, in vivo gene transfer strategy promotes osteointegration in a rat model of biceps tenodesis. The 33rd Annual Meeting of the American Society for Bone and Mineral Research, September 16-20, 2011, San Diego, California, abstract #SA0075. ( 9/2011 ) Link...
  • Hall SL, Chen S-T, Kapoor A, Wergedal JE, Gridley DS, Mohan S, and Lau K-HW (2010) Stem cell antigen 1 positive (Sca-1+) cell-based gene therapy with a modified fibroblast growth factor 2 (FGF2) produces contrasting skeletal effects on femur as opposed to tail vertebra in mice. The 32nd Annual Meeting of the American Society for Bone and Mineral Research, October 15-19, Toronto, Ontario, Canda, abstract #1258. ( 10/2010 ) Link...
  • Rundle CH, Popa NL, Wergedal JE, Mohan S, and Lau K-HW (2010) Delayed healing and efficient in vivo retroviral transgene transduction in a mouse segmental defect model of bone healing. The 32nd Annual Meeting of the Amercian Society for Bone and Mineral Research, October 15-19, Toronto, Ontario, Canada, abstract #SA0090. ( 10/2010 ) Link...
  • Sheng MH-C, Wergedal JE, Amoui M, Baylink DJ, Mohan S, and Lau K-HW (2010) Evidence that osteoclast-derived osteoactivin is a novel bone coupling factor: transgenic animal and in vitro studies. The 32nd Annual Meeting of the American Society for Bone and Mineral Research, October 15-19, Toronto, Ontario, Canada, abstract #FR0183. ( 10/2010 ) Link...
  • Lau K-HW, Kapur S, Kesavan C, Amoui M, and Mohan S (2010) Contrasting osteogenic response to mechanical stimulation between C57BL/6J and C3H/HeJ inbred mice is in part due to genetic variations in the leptin receptor, which is a negative bone mechanosensitivity modulating gene. The 32nd Annual Meeting for the American Society for Bone and Mineral Research, October 15-19, Toronto, Ontario, Canada, abstract #FR0103. ( 10/2010 ) Link...
  • Linares GR, Brommage R, Powell D, Xing W, Alarcon C, Kapoor A, Chen S-T, Lau K-HW, Wergedal JE, and Mohan S (2010) Claudin 18 (Cldn-18), a novel bone resorption (BR) regulator, interacts with zona-occluden-2 (ZO-2) to modulate RANKL signaling in osteoclasts. The 32nd Annual Meeting of the American Society for Bone and Mineral Research, October 15-19, Toronto, Ontario, Canada, abstract #1046. ( 10/2010 ) Link...
  • Hall SL, Wang S, Chen ST, Wergedal JE, Mohan S, and Lau K-HW. "Stem cell antigen-1+ (Sca-1+) cell-based gene therapy with modified fibroblast growth factor 2 (FGF2*) dramatically increases vertebral endosteal bone formation in mice". The 2nd International Conference on Osteoimmunology: Interactions of the immune and skeletal Systems June 8-13, 2008, in Rhodes, Greece. ( 6/2008 )
  • Lau K-HW. "Role of 1,25-dihydroxyvitamin D deficiency/resistance in the pathogenesis of senile osteoporosis." Annual meeting of the National Congress of Italian Society of Mineral Metabolism. November 22-23, 2000, Siena, Italy. ( 11/2000 )
  • Edderkaoui B, Mohan S, Lau K-HW, Li XM, Strong D, Gu WK, and Baylink DJ. "Physical mapping of a QTL locus that controls bone density on mouse chromosome 1." The First North-American Scientific Meeting of Moroccan Association of Researchers and Scholars. September 15-18, 2000, Chicago, IL. ( 9/2000 )
  • Gu WK, Hellan M, Li XM, Sheng MH-C, Beamer WG, Wergedal J, Lau K-HW, Mohan S, and Baylink DJ. "Evaluation of the effect of a quantitative trait locus (QTL) on peak bone mineral density (BMD) using congenic mice." Annual meeting of the European Society for bone and mineral metabolism. September 22-26, 2000, Vienna, Austria. ( 9/2000 )
  • Lau K-HW. "Treatment of 1,25(OH)2D3 (D-hormone) deficiency/resistance with D-hormone or analogs." Germany Osteologie 2000. February 29 – March 4, 2000, Wûrzberg, Germany. ( 2/2000 - 3/2000 )
  Research Presentations -- National
  • Lau K-HW, Stiffel V, Chen S-T, Sheng MH-C, and Amoui M (2013) An osteoclast transmembrane protein-tyrosine phosphatase, PTP-oc, enhances osteoclast activity in part through dephosphorylation of the EphA4 receptor in osteoclasts. The 2013 Annual Meeting of the American Society for Bone and Mineral research, October 4-7, 2013, Baltimore, Maryland. Journal of Bone and Mineral Research 28 (Suppl 1), abstract #SU0268. ( 10/2013 )
  • Sheng MH-C, Lau K-HW, Zhou X-D, Rodriguez D, Finck A, and Baylink DJ (2013) Dichotomy in osteocyte regulation of anabolic action of mechanical loading challenge and that of bone repletion after a low dietary calcium challenge. The 2013 Annual Meeting for the American Society for Bone and Mineral Research, October 4-7, 2013, Baltimore, Maryland. Journal of Bone and Mineral Research 28 (Suppl 1), abstract #MO0279. ( 10/2013 )
  • Su R-J, Baylink DJ, Nieses A, Meng X, Kiroyan JB, Payne KJ, Duan Y, Tschudy-Seney B, Kearns-Jonker M, Lau K-HW, and Zhang X-B (2013) Efficient generation of integration-free iPS cells from human adult peripheral blood. The 2013 Annual meeting of American Society for Gene and Cell Therapy, May 15-18, 2013, Salt Lake City, Utah. Molecular Therapy 21 (Suppl 1s), abstract #468. ( 5/2013 )
  • Rundle CH, Lau K-HW, Zhou X-D, Baylink DJ, Sheng MH-C (2013) Accelerated bony union during fracture healing in osteocyte-specific IGF-1 knockout mice. The 2013 Annual Meeting of Orthopaedic Research Society, January 26-29, 2013, San Antonio, Texas, in press. Transactions to the 59th Annual Meeting of Orthopaedic Research Society 38, abstract # 1443. ( 1/2013 )
  • Sai A, Eshete B, Villarin M, Lau W, Baylink D, Nguyen HB (2013) Discovery of a novel outcome prognosticator for sepsis with therapeutic implications: decreased serum 1,25-dihydroxyvitamin D. The 42nd annual Critical Care Congress of the Society of Critical Care Medicine, January 19-23, 2013, San Juan, Puerto Rico. Critical Care Medicine 40 (12) (Suppl 1), 1-328, abstract #23. ( 1/2013 ) Link...
  • Hall SL, Chen S-T, Howard K, Gridley D, Mohan S, Lau K-HW (2012) Stem cell antigen-1 positive (Sca-1+) cell-based gene therapy with fibroblast growth factor-2 (FGF2) promotes robust recruitment of osteoprogenitors in the bone marrow of recipient mice. The 2012 Annual Meeting of the American Society for Bone and Mineral Research, October 12-15, 2012, Minneapolis, Minnesota. Journal of Bone and Mineral Research 27 (Suppl 1), S24, abstract #1075. ( 10/2012 ) Link...
  • Coen MJ, Chen S-T, Rundle CH, Wergedal JE, and Lau K-HW (2010) A rat model of biceps tenodesis – preliminary findings for tendon to bone healing. The 2010 Annual Meeting of the American Academy of Orthopaedic Surgeons, February 19-22, New Orleans, Lousiana, abstract #276. ( 2/2010 )
  • Amoui M, Sheng MH-C, Stiffel V, Chadwick R, Mohan S, and Lau K-HW (2009) The EphA4 receptor is a negative regulator of osteoclast functions. The 31st Annual Meeting of the American Society for Bone and Mineral Research. September 11-15, 2009, Denver, Colorado. ( 9/2009 )
  • Amoui M, Stiffel V, and Lau K-HW (2009) PTP-oc, a unique osteoclastic transmembrane protein-tyrosine phosphatase (PTP), is a potential upstream regulator of the interaction between the integrin signaling and ITAM/ITIM signaling in osteoclasts through direct dephosphorylation and upregulation of c-Src. The 31st Annual Meeting of the American Society for Bone and Mineral Research. September 11-15, 2009, Denver, Colorado. ( 9/2009 )
  • Chen S-T, Coen MJ, Rundle CH,Wergedal JE, and Lau K-HW (2009) Development of a rat model of biceps tenodesis – its applicability and preliminary findings of the HIV-BMP4 gene transfer-based strategy to promote tendon-to-bone healing. The 31st Annual Meeting of the American Society for Bone and Mineral Research. September 11-15, 2009, Denver, Colorado. ( 9/2009 )
  • Rundle CH, Popa N, Wergedal JE, Mohan S, and Lau K-HW (2009) Fracture healing in mice with targeted disruption of urokinase plasminogen activator (uPA) gene. The 31st Annual Meeting of the American Society for Bone and Mineral Research. September 11-15, 2009, Denver, Colorado. ( 9/2009 )
  • Hall SL, Chen ST, Mohan S, Wergedal JE, Strong DD, and Lau K-HW. "Stem cell antigen positive (Sca-1+) hematopoietic cell-based human growth hormone (hGH) gene therapy enhanced endosteal bone resorption in mice". The 30th Annual meeting of the American Society for Bone and Mineral Research. September 12-16, 2008, Montreal, Quebec, Canada. ( 9/2008 )
  • Lau K-HW, Kapur S, Amoui M, Wang X, Kesavan C, Mohan S, and Baylink DJ. Leptin-deficient (ob/ob) mice exhibit increased bone mechanosensitivity and corresponding osteoblasts show increased anabolic shear stress responses in vitro. The 29th Annual meeting of the American Society for Bone and Mineral Research. September 14-19, 2007, Honolulu, HI. ( 9/2007 )
  • Rundle CH, Wang X, Wergedal JE, Sheng MH-C, Porte RM, Lau K-HW, and Mohan S. "Bax-deficient mice exhibit marked increase in callus size and cartilage during endochondral repair of femur fractures."  The 29th Annual meeting of the American Society for Bone and Mineral Research. September 14-19, 2007, Honolulu, HI. ( 9/2007 )
  • Sheng MH-C, Amoui M, Srivastava AK, Wergedal JE, and Lau K-HW. "Transgenic overexpression of osteoclastic protein-tyrosine phosphatase, PTP-oc, in cells of osteoclastic lineage led to increased bone resorption and marked reduction in trabecular bone mass and density in adult mice." The 29th Annual meeting of the American Society for Bone and Mineral Research. September 14-19, 2007, Honolulu, HI. ( 9/2007 )
  • Rundle CH, Wang X, Porte RM, Wergedal JE, Mohan S, and Lau K-HW. "Plasminogen activator inhibitor (PAI-1) deficiency enhances fracture callus size but reduces cartilage remodeling during fracture repair." The 29th Annual meeting of the American Society for Bone and Mineral Research. September 14-19, 2007, Honolulu, HI. ( 9/2007 )
  • Strohbach CA, Rundle CH, Chen ST, Wergedal JE, Linkhart TA, Baylink DJ, Lau K-HW, and Strong DD. "In vivo retroviral-based gene therapy with Lim mineralization protein-1 enhances fracture healing." The 53rd Annual Meeting of Orthopeadic Research Society . San Diego, CA ( 3/2007 )
  • Hall SH, Lau K-HW, Chen ST, Sheng MH-C, Gysin R, Wergedal JE, Srivastava AK, Mohan S, and Baylink DJ. "Sca-1+ cell-based gene therapy with fibroblast growth factor-2 gene (but not BMP-4) dramatically increased endosteal bone formation in mice." The 28th annual Meeting of the American Society for Bone and Mineral Research. September 15-19, 2006, Philadelphia, PA. ( 9/2006 )
  • Yang J, Amoui M, and Lau K-HW . "Targeted deletion of the promoter of osteoclastic protein-tyrosine phosphatase (PTP-oc) in RAW264.7 cells abolished PTP-oc expression and blocked their differentiation into osteoclast-like cells." The 28th annual meeting of the American Society for Bone and Mineral Research. September 15-19, 2006, Philadelphia, PA. ( 9/2006 )
  • Hall SL, Lau K-HW, Chen S-T, Sheng MH-C, Srivastava A, Klamut H, Wergedal JE, Gridley DS, Mohan S, and Baylink DJ. "Sca-1+ cell-based gene therapy with a modified FGF-2 increased endosteal/trabecular bone formation in mice." Annual meeting of the American Society for Gene Therapy. May 31-June 4, 2006, Baltimore, Maryland. ( 5/2006 - 6/2006 )
  • Rundle CH, Strong DD, Chen S-T, Sheng MH-C, Wergedal JE, Lau K-HW, and Baylink DJ. "Retroviral-based gene therapy with cyclooxygenase-2 promotes the bony union and accelerates fracture healing in the rat." Annual meeting of the American Society for Gene Therapy. May 31-June 4, 2006, Baltimore, Maryland. ( 5/2006 - 6/2006 )
  • Rundle CH, Wang X, Wergedal JE, Srivastava AK, Davis EI, Lau K-HW, Mohan S, and Baylink DJ. "Loss of sex-specific differences in bone size in leptin-deficient (ob/ob) mice." Annual meeting of the Orthopedic Research Society. March 19-22, 2006, Chicago, Illinois. ( 3/2006 )
  • Yang J, Amoui M, and Lau K-HW. "Identification of two repressor elements responsible for cell-specific expression of an osteoclastic protein-tyrosine phosphatase (PTP-oc) within its intronic promoter." Annual meeting of the American Society for Cell Biology. December 10-14, 2005, San Francisco, California. ( 12/2005 )
  • Wang X, Rundel CH, Srivastava A, Tesfai J, Davis EI, Wergedal JE, Lau K-HW, Mohan S, and Baylink DJ. "Loss of sex-specific difference in bone size in leptin knockout mice." Annual Meeting of the American Society for Bone and Mineral Research. September 21-26, 2005, Nashville, Tennessee. ( 9/2005 )
  • Kapur S, Baylink DJ, and Lau K-HW. "The canonical Wnt pathway is downstream to the BMP signaling pathway in mediating fluid shear stress-induced osteoblast proliferation." Annual meeting of the American Society for Bone and Mineral Research. September 21-26, 2005, Nashville, Tennessee. ( 9/2005 )
  • Sheng MH-C, Lau K-HW, Baylink DJ, and Wergedal JE. "High osteoblastic activity in C3H/HeJ (C3H) mice compared to C57BL/6J (B6) mice may be related to a reduced population apoptosis in C3H osteoblasts." Annual meeting the American Society for Bone and Mineral Research. September 21-26, 2005, Nashville, Tennessee. ( 9/2005 )
  • Lau K-HW, Kapur S, Mohan S, and Baylink DJ (2005) Fluid shear stress synergizes with IGF-I on osteoblast proliferation through integrin-dependent upregulation of IGF-I receptor phosphorylation levels. Annual meeting of the Orthopedic Research Society. February 20-23, 2005, Washington, D.C ( 2/2005 )
  • Rundle CH, Wang H, Yu H, Chadwick RB, Tesfai J, Lau K-HW, Mohan S, Ryaby JT, and Baylink DJ. "Microarray analysis of fracture repair identifies the homeodomain transcription factor Prx-2 and other genes that imply similarities between bone repair and scarless fetal tissue healing." Annual meeting of the Orthopedic Research Society. February 20-23, 2005, Washington, D.C ( 2/2005 )
  • Lau K-HW, Kapur S, and Baylink DJ. "Fluid shear stress synergizes with IGF-I on osteoblast proliferation through integrin-dependent activation of IGF-I receptor." Annual meeting of the American Society for Bone and Mineral Research. October 1-5, 2004, Seattle, Washington ( 10/2004 )
  • Lau K-HW, Kapur S, and Baylink DJ.  "Global application of expression profiling reveals potential involvement of the Wnt, IGF-I, estrogen receptor (ER), and BMP/TGF-beta pathways in C57BL/6J (B6) but not C3H/HeJ (C3H) mouse osteoblasts in response to fluid shear stress." Annual meeting of the American Society for Bone and Mineral Research. October 1-5, 2004, Seattle, Washington ( 10/2004 )
  • Lau K-HW, Amoui M, and Baylink DJ. "An osteoclastic protein-tyrosine phosphatase (PTP-oc) regulates osteoclast activity in part by decreasing osteoclast apoptosis through c-src-dependent activation of NFkappaB." Annual meeting of the American Society for Bone and Mineral Research. October 1-5, 2004, Seattle, Washington ( 10/2004 )
  • Rundle CH, Wang H, Yu H, Chadwick RB, Tesfai J, Lau K-HW, Mohan S, Ryaby JT, and Baylink DJ. Rundle CH, Wang H, Yu H, Chadwick RB, Tesfai J, Lau K-HW, Mohan S, ryaby JT, and Baylink DJ. "Whole genome expression profiling of fracture healing under rigorous experimental design reveals novel pathways: pleiotrophin and Meox2 in fracture healing." Annual meeting of the American Society for Bone and Mineral Research. October 1-5, 2004, Seattle, Washington ( 10/2004 )
  • Lau K-HW, Kapur S, and Baylink DJ. "Fluid shear stress (a mechanical strain mimic) synergizes with IGF-I on human osteoblast proliferation through upregulation of the IGF-I signaling pathway." Annual meeting of American Society for Cell Biology, December 13-17, 2003, San Francisco, CA.  ( 12/2003 )
  • Chen S-T, Tai M-F, Chi K-M, Wen M-C, Rundle CH, Lau K-HW, and Baylink DJ. "Development of magnetic retroviral vectors for site-specific targeting in skeletal gene therapy". The 25th annual meeting of American Society for Bone and Mineral Research. September 18-23, 2003, Minneapolis, MN ( 9/2003 )
  • Sheng MH-C, Baylink DJ, Lau K-HW, and Wergedal JE. "Membranous bone shows identical phenotypes as endochondral bone where MAR and BFR were greater in the C3H (High Bone Density) than those in the B6 (Low Bone Density) Inbred Mice." The 25th annual meeting of the American Society for Bone and Mineral Research, September 18-23, 2003, Minneapolis, MN  ( 9/2003 )
  • Lau K-HW, Amoui M, Tillman JB, and Baylink DJ. "The structurally unique osteoclastic protein-tyrosine phosphatase is driven by an intronic promoter that is cell type-specific by virtue of repressor elements." The 25th annual meeting of the American Society for Bone and Mineral Research, September 18-23, 2003, Minneapolis, MN ( 9/2003 )
  • Lau K-HW, Amoui M, Suhr S-M, and Baylink DJ. "The enzymatic activity of a unique osteoclastic protein-tyrosine phosphatase (PTP-oc) is essential for activation of osteoclast-like cells: evidence for activation via the c-src/NFkB pathway." The 25th annual meeting of the American Society for Bone and Mineral Research, September 18-23, 2003, Minneapolis, MN  ( 9/2003 )
  • Rundle CH, Wang H, Mohan S, Wergedal JE, Lau K-HW, Ryaby JT, and Baylink DJ. "Microarray analysis of gene expression in the rat femur fracture reveals over 500 genes with significant changes in expression. The 49th Annual meeting of Orthopaedic Research Society, February 2-5, 2003, New Orleans, LA ( 2/2003 )
  • Rundle CH, Wang H, Mohan S, Wergedal JE, Lau K-HW, Ryaby JT, and Baylink DJ. "Microarray analysis of gene expression in the rat femur fracture reveals over 500 genes with significant changes in expression." Annual meeting of the Orthopedic Research Society. February 1-5, 2003, New Orleans, Louisiana. ( 2/2003 )
  • Amoui M, Suhr SM, Baylink DJ, and Lau K-HW. "The protein-tyrosine phosphatase (PTP) activity of PTP-oc is essential for both the differentiation of U937 cells into osteoclasts and their apoptosis." Annual meeting of the American Society for Bone and Mineral Research. September 20-24, 2002, San Antonio, Texas. ( 9/2002 )
  • Kapur S, Chen S-T, Baylink DJ, and Lau K-HW."Extracellular signal-regulated kinase (ERK)-1 and ERK2 are both essential in the mediation of the flow shear strain-induced human osteoblast proliferation." Annual meeting of the American Society for Bone and Mineral Research. September 20-24, 2002, San Antonio, Texas. ( 9/2002 )
  • Rundle CH, Miyakoshi N, Kasukawa Y, Chen S-T, Sheng MH-C, Wergedal JE, Lau K-HW, and Baylink DJ. "In vivo retroviral (MLV)-mediated BMP2/4 hybrid gene therapy enhances callus formation in the rat femoral fracture model." Annual meeting of the American Society for Bone and Mineral Research. September 20-24, 2002, San Antonio, Texas. ( 9/2002 )
  • Zhang XS, Linkhart TA, Wergedal JE, Chen ST, Peng H, Sheng MH-C, Lau K-HW, and Baylink DJ. "Development of a mouse model for endosteal bone gene therapy: intramedullary injection of bone marrow stromal cells producing human BMP4 from a retroviral vector." Annual meeting of the Orthopedic Research Soceity. February 10-13, 2002, Dallas, Texas. ( 2/2002 )
  • Rundle CH, Miyakoshi N, Kasukawa Y, Peng H, Chen S, Sheng MH-C, Wergedal JE, Lau K-HW, and Baylink DJ. "In vivo gene therapy: direct retroviral expression of a BMP2/4 hybrid gene induces bone formation during fracture repair." Annual meeting of the Orthopedic Research Soceity. February 10-13, 2002, Dallas, Texas. ( 2/2002 )
  • Lau K-HW. "Osteoblastic tartrate-resistant acid phosphatase." Tartrate-resistant acid phosphatase working group, associated with the annual meeting of the American Society for Bone and Mineral Research. October 11, 2001, Phoenix, Arizona. ( 10/2001 )
  • Lau K-HW, Suhr SM, Wu LW, and Baylink DJ. "The protein-tyrosine phosphatase (PTP) activity of PTP-oc is required for the dephosphorylation of PY-527 and activation of c-src in osteoclasts." Annual meeting of the American Society for Bone and Mineral Research. October 12-16, 2001, Phoenix, Arizona. ( 10/2001 )
  • Lau K-HW, Koyama H, Nakade O, Takada Y, and Kaku T. "Melatonin increases bone mass by suppressing bone resorption through down-regulation of the RANKL-mediated osteocalstogenesis in mice." Annual meeting of the American Society for Bone and Mineral Research. October 12-16, 2001, Phoenix, Arizona. ( 10/2001 )
  • Kapur S, Baylink DJ, and Lau K-HW. "Fluid flow shear strain activates multiple pathways on human osteoblast proliferation and competing pathways on human osteoblast differentiation." Annual meeting of the American Society for Bone and Mineral Research. October 12-16, 2001, Phoenix, Arizona. ( 10/2001 )
  • Yoon HK, Lau K-HW, Hwang CS, Kang YS, Moon IK, Yim CH, Chung HY, Han KO, Jang HC, Ahn JY, Han IK, and Choi YK. "Primary cultures of human osteoblasts express a calcium-sensing receptor (CaSR)." Annual meeting of the American Society for Bone and Mineral Research. October 12-16, 2001, Phoenix, Arizona. ( 10/2001 )
  • Gu W, Li X, Lau K-HW, Edderkaoui B, Donahue LR, Rosen CJ, Beamer WG, Schultz KL, Srivastava AK, Mohan S, and Baylink DJ. "Differential gene expression between a congenic strain that contains a quantitative trait locus (QTL) of high bone density from CAST/EiJ and its wild type strain C57BL/6J." Annual meeting of the American Society for Bone and Mineral Research. October 12-16, 2001, Phoenix, Arizona. ( 10/2001 )
  • Gu W, Edderkaoui B, Beamer W, Li X, Sheng MH-C, Wergedal J, Shultz K, Lau K-HW, Donahue LR, Rosen C, Mohan S, and Baylink DJ. "Studies using congenic mice reveal that chromosome 1 QTL locus in Cast/EiJ mouse contributes to 30% variation in BMD difference between CAST and C57BL mice." Annual meeting of the American Society for Bone and Mineral Research. October 12-16, 2001, Phoenix, Arizona. ( 10/2001 )
  • Sheng MH-C, Baylink DJ, Lau K-HW, and Wergedal JE. "Increased osteoblast activity in the C3H/HeJ (C3H) mice compared to the C57BL/HeJ (B6) mice is associated with a higher serum IGF-1 level and a greater osteoblastic response in collagen production to IGF-1 and TGF-beta1." Annual meeting of the American Society for Bone and Mineral Research. October 12-16, 2001, Phoenix, Arizona. ( 10/2001 )
  • Gysin R, Wergedal JE, Sheng MH-C, Kasukawa Y, Miyakoshi N, Chen ST, Peng H, Lau K-HW, Mohan S, and Baylink DJ. "Complete healing of critical size rat calvarial defect by stromal cells transduced with BMP-4 retroviral vector." Annual meeting of the American Society for Bone and Mineral Research. October 12-16, 2001, Phoenix, Arizona. ( 10/2001 )
  • Gysin R, Wergedal JE, Sheng M, Kasukawa Y, Miyakoshi N, Chen ST, Peng H, Lau K-HW, Mohan S, and Baylink DJ. "Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP-4 gene completely heals critical size calvarial defect in rats." Annual meeting of the American Society of Gene Therapy. May 30-June 3, 2001, Seattle, WA. ( 5/2001 - 6/2001 )
  • Koyama H, Nakade O, Takada Y, and Lau K-HW. "Melatonin increases bone mass by suppressing bone resorption in mice." Annual meeting og the American Association of Dental Research. March 3-7, 2001, Chicago, IL. ( 3/2001 )
  • Gu WK, Li XM, Mohan S, Lau K-HW, Edderkaoui B, Donahue LR, Rosen C, Beamer WG, and Baylink DJ. "Identification of candidate genes that control peak bone density by combination of cDNA microarray analysis and physical mapping." Annual meeting of the American Society for Human Genetics. October 3-7, 2000, Philadelphia, PA. ( 10/2000 )
  • Dimai H-P, Wirnsberger G, and Lau K-HW. "Contrasting effects of oral magnesium supplementation on ionized magnesium concentrations in fresh whole blood as opposed to that in serum." Annual meeting of the American Society for Bone and Mineral Research. September 22-26, 2000, Toronto, Ontario, Canada. ( 9/2000 )
  • Dimai H-P, Domej W, Leb G, and Lau K-HW. "Bone loss in patients with untreated chronic obstructive pulmonary disease (COPD) is in part mediated by an increase in bone resorption (BR) that is associated with hypercapnia." Annual meeting of the American Society for Bone and Mineral Research. September 22-26, 2000, Toronto, Ontario, Canada. ( 9/2000 )
  • Suhr SM, Baylink DJ, and Lau K-HW. "Evidence that a unique osteoclast-specific protein-tyrosine phosphatase (PTP) is involved in osteoclast formation." Annual meeting of the American Society for Bone and Mineral Research. September 22-26, 2000, Toronto, Ontario, Canada. ( 9/2000 )
  • Suhr SM, Karri S, Baylink DJ, and Lau K-HW. "Antisense oligonucleotide evidence that a unique osteoclastic protein-tyrosine phosphatase (PTP-oc) is essential for osteoclastic resorption." Annual meeting of the American Society for Bone and Mineral Research. December 1-6, 1999, Washington, DC. ( 12/1999 )
  • Lau K-HW, Arias M, Goodwin C, Mohan S, and Baylink DJ. "Bone cell mitogenic action of fluoroaluminate (AlF4-), but not that of fluoride (F), is mediated through insulin-like growth factor (IGF)." Annual meeting of the American Society for Bone and Mineral Research. December 1-6, 1999, Washington, DC. ( 12/1999 )
  Research Presentations -- Regional
  •  Lau K-HW. "Gene Therapy of Bone Fractures." Department of Orthopeadic Surgery, Sapporo Medical University. November 21, 2002, Sapporo, Sapporo, Japan. ( 11/2002 )
  • Lau K-HW. "Osteoclastic Protein-Tyrosine Phosphatase and Bone Resorption." School of Dentistry, Health Sciences University of Hokkaido. November 22, 2002, Ishikari-Gun, Hokkaido, Japan. ( 11/2002 )
  • Lau K-HW. "Molecular mechanism of osteogenic action of fluoride: Inhibition of a protein-tyrosine phosphatase or an activation of protein-tyrosine kinase?" The Center of Mineral Metabolism and Clinical Research, the University of Texas Southwestern Medical School. July 26, 2002, Dallas, Texas. ( 7/2002 )
  Research Presentations -- Local/Campus
  • Lau K-HW. "Challenges For Skeletal Gene Therapy." The 13th Annual Orthopaedic Research Symposium, Department of Orthopaedic Surgery, Loma Linda University School of Medicine. June 2, 2005, San Bernardino, CA. ( 6/2005 )
  • Lau K-HW (2005) Progress Toward Skeletal Gene Therapy at the Musculoskeletal Disease Center of the Jerry L. Pettis Memorial VA Medical Center. The 13th Annual Orthopaedic Research Symposium, Department of Orthopaedic Surgery, Loma Linda University School of Medicine. June 2, 2005, San Bernardino, CA. ( 6/2005 )
  • Lau K-HW. "Gene Therapy of Fractures." ASG Traveling Fellowship Seminar. Sponsored by Dept. of Orthopaedic Surgery, Loma Linda University. February 21, 2003, Loma Linda, California. ( 2/2003 )
  • Kapur S, Baylink DJ, and Lau K-HW. "Fluid flow shear strain activates multiple pathways on human osteoblast proliferation and competing pathways on human osteoblast differentiation." Loma Linda University 4th Research Conference. September 10, 2001, Loma Linda, California. ( 9/2001 )