K.H. William Lau, PhD Research Professor, Medicine School of Medicine Member, Biochemistry, SM, Faculty of Graduate Studies

Research & Grantsmanship 

  Funded Research Project (PI)

• Investigation into the Functional Roles of Osteoclastic Protein-Tyrosine Phosphatase by Transgenic Approach - Funded by a Special Appropriation to the Musculoskeletal Disease Center ( 10/2003 - 9/2009 )

• Osteoclastic Phosphotyrosine Phosphatase and Resorption - Funded by VA BL R&D Merit Review program ( 7/2004 - 6/2009 )

• Signal transduction mechanism of mechanical strain on bone formation. ( 10/2002 - 3/2008 )

• Hematopoietic Stem Cell-Mediated Gene Therapy for Bone Disorders ( 10/2005 - 9/2007 )

• Gene Therapy of Fracture Repair ( 1/2005 - 8/2007 )

• Involvement of Mechano-Growth Factor in Mechanical Stress-Induced Bone Cell Proliferation and Differentiation ( 10/2004 - 9/2006 )

• Toward cell and gene therapy for soft tissue regeneration: molecular analysis of wound healing and tissue regeneration in the MRL mouse using in vitro cell culture models. ( 5/2004 - 9/2006 )

• Functional role of SHP-1 protein-tyrosine phosphatase in osteoclastogenesis. ( 7/2001 - 6/2005 )

• Osteoclastic Phosphotyrosine Phosphatase and Resorption - Funded by Veterans Affair Medical Research BLR&D Merit Review. Funding period: October 1, 2009 to September 30, 2013 ( 10/2009 - Present )

• Gene Transfer Approach for Biceps Tenodesis in a Rodent Model - Funded by the VA Rehab R&D Merit Review program. Funding period: October 1, 2008 - September 30, 2011. ( 10/2008 - Present )

  Funded Research Project (CI)

• Research Concept Award: “Test of Feasibility of a Novel Bax siRNA-Based Therapeutic Strategy for Post-Traumatic Osteoarthritis” funded by Department of Defense, USAMRAA Award number: W81XWH-11-1-0486 ( 9/2011 - 8/2012 )

• Molecular Genetic and Gene Therapy Studies of the Musculoskeletal System - Funded by the Army ( 9/2003 - 9/2009 )

• Molecular Genetics Studies of Bone Mechanical Strain and of Pedigrees with Very High Bone Density - Funded by the Army ( 4/2001 - 9/2009 )

• Molecular Medicine Research Studies of the Musculoskeletal System ( 11/2004 - 7/2009 )

• A Novel Approach to Increase Endosteal Bone Formation - Funded by the VA Merit Review Entry Program ( 8/2006 - 6/2009 )

• Regenerative Gene Function in Fracture Repair - Funded by the VA BL R&D Merit Review from Apr 1, 2008 to Mar 31, 2011. ( 4/2008 - Present )