Loma Linda University

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Reiner Bonnet, MD
Adjunct Professor, Medicine
School of Medicine
Publications    Scholarly Journals--Published
  • Reck, M., J. von Pawel, H.-N. Macha, E. Kaukel, K.-M. Deppermann, R. Bonnet, K. Ulm, S. Hessler, U. Gatzemeier. "Efficient Palliation in Patients with Small-Cell Lung Cancer by a Combination of Paclitaxel, Etoposide and Carboplatin: Quality of Life and 6-Years-Follow-Up Results from a Randomized Phase III Trial." Lung Cancer 53. (2006): 67-75. ( 1/2006 )
    Purpose: Based on the promising
  • Schmücking, M., R. P. Baum, R. Bonnet, K. Junker, K.-M. Müller. "Korrelation histologischer und nuklearmedizinischer Befunde der Tumorregression in behandelten bösartigen Lungentumoren." Pathologe 26. (2005): 178-190. ( 1/2005 )
  • Mäder, I., ,R. Bonnet. "Dyskenisie der Atemwege." Atemweg.-Lungenkrkh. 30. (2004): 496-498. ( 12/2004 )
  • Gridley, D.S., R. Bonnet, D. A. Bush, C. Franke, G. A. Cheek, J. D. Slater, J. M. Slater. "Time course of Serum Cytokines in Patients Receiving Proton or Combined Photon/Proton Bwam Radiation for Resectable but Medically Inoperable Non-Small-Cell Lung Cancer." Intern. Journal Radiation Oncology Biol. Phys. 60. (2004): 759-766. ( 12/2004 )
    Purpose: We prospectively measured the levels of basic fibroblast growth factor (bFGF), tumor necrosis factor-Alpha (TNF-alpha), interleukin (IL)-1Beta, IL-6, IL-10, and procollagen III peptide (P III P) in serum from non-small-cell lung cancer patients treated with photons combined with protons or protons alone. These factors were quantified because they may be extremely important in the development of side effects, and the treated volume integral dose may be crucial in inducing them. Methods:Of the 12 participating patients, 6 with squamous cell carcinoma (SCC) and 3 with adenocarcinoma received combined photon/proton beam radiation, whereas 2 with SCC and 1 with large-cell carcinoma (LCC)received only proton radiation. Mean age was 73.6 years. There were 4 male and 8 female patients with a mean smoking history of 87.0 packyears. Nine patients had Stage 1, 2 had II, and 1 had stage IIIa lung cancer. Serum samples were obtained at baseline and on Days 15,30,45,60,90,120,150,180 and 210 after initiation of radiation therapy. Injury scores for pneumonitis and fibrosis based on computed tomography (CT) scans were assigned. Results: The percentage of lung volume irradiated was significantly less for patients treated with protons alone compared with those receiving photon plus proton therapy. Injury scores were also lower for proton only treatment (p = 0,039). When evaluated collectively, bFGF, TNF-Alpha, and IL-6 concentrations were significantly higher in the photon/proton group; radiation regimen, but not time after treatment initiation, was a significant factor in their levels. P III P level was also higher in the photon/proton patients and both radiation regimen and time after treatment had an impact. Conclusions: Although significant changes occurred in some of the measured cytokines and P III P, it was the difference in the volume integral dose that occurred when protons were used alone vs. mixed photon/proton therapy that correlated with the incidence of pneumonitis and/or fibrosis. However, it cannot be ruled out that differences in cytokine levels before radiotherapy initiation may have contributed to the outcome.
  • Karg, O., R. Bonnet, H. Magnussen, D. Köhler, J. Geissler, P. Haidl, I. Mäder, B. Schucher. "Atmungstherapeut - Einführung eines neuen Berufsbildes." Pneumologie 58. (2004): 850-853. ( 12/2004 )
  • " Effect of Polymeric Lung Volume Reduction (PLVR) Therapy on Composite COPD Outcome Measures" ( 0/2011 - Present ) Link...
  • "Polymeric Lung Volume Reduction (AeriSeal) in Patients with advanced heterogen Emphysema"  Pneumologie 65(2011),9 ( 0/2011 - Present )
  • " Treatment of Advanced Emphysema with Emphysematous Lung Sealent (AeriSeal)" Respiration 82 (2011),36 - 45 ( 0/2011 - Present )
  • "Dose- Finding Study of Polymeric Lung- Volume- Reduktion in Patients with advanced Emphysema" Pneumologie 64 (2010),165 ( 0/2010 - Present )
  • " Effective Endobronchial Volume Reduction Therapy for Emphysema using Synthetic Adhesive Hydrogel- Foam" Am j Respir Crit Care Med 181 (2010),A5173 ( 0/2010 - Present )
  • " CT Assessment of Regional Lung Volume Changes following Endobronchial Volume Reduction Therapy  in Emphysema Patients using a Synthetic Hydrogel Foam" Am j Respir Crit Care Med 181(2010), A5533 ( 0/2010 - Present )
  • "Repiratoric Insufficiency in Paraplegia" Pneumologie 63 (2009), 7 ( 0/2009 - Present )
  • The Will Rogers Phenomenon" Pneumologie 63 (2009), 36 ( 0/2009 - Present )