Subburaman Mohan, PhD Research Professor, Medicine School of Medicine Research Professor, Basic Sciences School of Medicine

Presentations 

  Research Presentations -- National

• Rehage M, Mohan S, Wergedal J, Tran K, Bonafede B, Hou D, Phang D, Kumar A, Qin X. "Overexpression of Pregnancy-associated plasma protein (PAPP)-A in Skeletal Muscle Enhances Postnatal Growth and Skeletal Myogenesis in Mice." The Endocrine Society 89th Annual Meeting. Toronto, Canada ( 6/2007 )

• Subburaman Mohan. " The Role of Growth Hormone/Insulin-Like Growth Factor Axis in the Age-Related Acquisition, Maintenance and Loss of Bone." Institute for Genetic Medicine Invited Lecture USC Department of Orthopaedic Surgery Grand Rounds,. University of Southern California, Los Angeles California ( 6/2007 )

• Subburaman Mohan. "Studies on Spontaeous Fracture Mouse Model for Osteoporosis Reveal Evidence for a Novel Nrf1 Molecular Pathway for Vitamin C Action in Bone." Institute for Genetic Medicine Invited Lecture USC Department of Orthopaedic Surgery Grand Rounds,. University of Southern California, Los Angeles California ( 6/2007 )

• Govoni KE, Donahue LR, Marden C, Baylink DJ, Mohan S. "Complex genetic regulation of bone density (BMD) and bone size in chromosome substitution strains (CSS).." The Endocrine Society?s 89th Annual Meeting. . Toronto, Canada ( 6/2007 )

• Subburaman Mohan. "Molecular Genetic Studies of Bone Mechanical Strain, Invited Lecture Department of Orthopedics." University of California at Irvine. Irvine, CA ( 5/2007 )

• Subburaman Mohan. "Cre/loxP-mediated Inactivation of IGF-I Gene in Type I collagen Expressing Cells Produces Neonatal Lethality and a Dramatic Effect on Skeletal Phenotype." 3rd International Congress of the GRS and IGF Society Conference. Kobe Japan ( 11/2006 )

• Subburamam Mohan. "Osteoporosis animal model, Spontaneous fracture (sfx) mouse, implication of vitamin C deficiency and Nrf1 pathway.." Invited talk at Ajou University. Suwon Korea, ( 11/2006 )

• Subburaman Mohan. "The role of growth hormone/IGF axis in development and aging." Invited talk at the Plenary Lecture and Joint Meeting of the Korean Neuroendocrine Study Group and Korean Adult Growth Hormone Study Group. Seoul , Korea ( 11/2006 )

• Subburaman Mohan. "The role of growth hormone/IGF axis in the age-related acquisition, maintenance and loss of bone." Invited talk at the Plenary Lecture at Joint Meeting of the Korean Society of Osteoporosis and Korean Society of Bone Metabolism. Seoul, Korea ( 11/2006 )

• Subburaman Mohan. "Studies on Spontaneous Fracture Mouse Model for Osteoporosis Reveal Evidence for a Novel Nrf1 Molecular Pathway for Vitamin C action in Bone." Invited talk at Combined Endocrine/Pediatric Grand Rounds, UCLA . University of California Los Angeles ( 11/2006 )

• Linares GR, Govoni KE, Xing W, Baylink DJ and Mohan S. "Evidence That Grx5, a Growth Hormone(GH)-Inducible Gene, Acts as a Free Radical Scavenger in Osteoblasts.." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Kesavan C, Baylink DJ, Kapoor S, Wergedal JE, Hongrun Yu and Mohan S. "Quantitative Trait loci for Tibia Periosteal Circumference in the C57BL/6J-C3H/HeJ mice intercross.." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Govoni KE, Donahue LR, Marden C, Baylink DJ and Mohan S. "Gender-Specific Regulation of Total Body BMD in Chromosome Substitution Strains." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Yu H, Baylink DJ, Davidson HM, Masinde GL, Edderkaoui B, Wergedal JE, and Mohan S. "Chromosome 9 MRL-SJL Congenic Mice Reveal Sex-Specific Genetic Regulation of Bone Size." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA, ( 9/2006 )

• Chadwick RB, Bu LM, Hu Y, Zhu Y, Baylink DJ, and Mohan S. "Formin-2 Knockout Mice Exhibit Reduced Femur BMD and Cortical Thickness." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Srivastava AK, Mohan S, and Baylink DJ. "A Sensitized ENU Screening System to Discover Modifier Genes by Utilizing Mouse Models Deficient in Genes Regulating Skeletal Tissues." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Srivastava AK, Baylink DJ, Wergedal JE and Mohan S. "Identification of Mutant with a Large Decrease in Bone Size Identified in a Sensitized ENU Screen using Growth Hormone Deficient Little Mouse.." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Wergedal JE, Wood CA, Sheng MHC, Baylink DJ, Ackert-Bicknell CL, Beamer WG, and Mohan S.. "Determination of Quantitative Trait Loci (QTL) from Femoral Neck Parameters Identifies both Similar and Additional Genetic Loci to those from the Midshaft." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Hall SL, Lau K-HW, Chen ST, Sheng MH, Gyson R, Wergedal JE, Srivastava AK, Mohan S and Baylink DJ. "Sca-1 Cell-based gene therapy with fibroblast growth factor-2 gene (but not BMP-4) dramatically increased endosteal bone formation in mice." 28th Annual Meeting American Society for Bone and Mineral Research.. Philadelphia, PA ( 9/2006 )

• Edderkaoui B, Baylink DJ, Shultz K, Beamer WG, Wergedal JE, Porte R, Chaudhuri A and Mohan S. "Identification of Duffy Antigen/Receptor for Chemokine (DARC) as a Chromosome 1 BMD QTL Gene in Mice." 28th American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Edderkaoui B, Baylink D, Beamer W, Schultz K, Wergedal J, Mohan S. "Congenic Mice Reveal Gender Specificity of Femoral BMD in Chromosome 1." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Xing W, Singgih A, Kapoor A, Baylink DJ, and Mohan S. "A Novel Molecular Pathway Involving Antioxidant Response Element (ARE) and Nuclear factor-E2 related factor-1 (Nrf1) in Mediating Vitamin C Effects on Osterix Gene Expression and Osteoblast Differentiation." 28th Annual Meeting American Society for Bone and Mineral Research. Philadelphia, PA ( 9/2006 )

• Hall SL, Lau K-HW, Chen ST, Sheng MH, Gyson R, Wergedal JE, Srivastava AK, Mohan S and Baylink DJ. "Sca-1 Cell-based gene therapy with fibroblast growth factor-2 gene (but not BMP-4) dramatically increased endosteal bone formation in mice.." 28th Annual Meeting American Society for Bone and Mineral Research.. Philadelphia, PA ( 9/2006 )

• Govoni KE, Lee SK, Chadwick RB, Yu H, Kasukawa Y, Baylink DJ and Mohan S. "Whole Genome Microarray Analysis of the In Vivo Effects of a Single Effective GH Dose on Gene Expression in the Bone of GH-Deficient lit/lit mice: GH regulates T-box3 and 15, Novel Transcription Factors, Independent of IGF-1." 87th Annual Endocrine Society Meeting . Boston, MA ( 6/2006 )

• Hall SL, Lau K-HW, Chen S-T, Scheng MH-C, Srivastava AK, Klamut H, Wergedal JE, Gridley DS, and Mohan S. "Sca-1+ Cell-Based Gene Therapy with a Modified FGF-2 Increased Endosteal/Trabecular Bone Formation in Mice." 9th Annual Meeting of the American Society of Gene Therapy . Baltimore, MD ( 5/2006 - 6/2006 )

• Mohan S. "Molecular genetic approaches to identify genes relevant to the musculoskeletal system." Tottori University. Japan ( 10/2005 )

• Govoni K, Lee SK, Chung YS, Behringer R, LeRoith D, Wergedal JE, Baylink DJ, and Mohan S.. "Chondrocyte specific disruption of insulin-like growth factor (IGF)-I expression reduces bone density and bone size in mice.." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Mohan S, Kapoor A, Singgih A, Zhang Z, Taylor T, Yu H, Chadwick RB, Chung Y-S, Donahue LR, Rosen C, Crawford GC, Wergedal JE, and Baylink DJ. "Spontaneous Fractures In The Mouse Mutant Sfx Are Caused By Deletion Of Gulonolactone Oxidase (GULO) Gene, Causing Vitamin C Deficiency: Evidence That Vitamin C Is A Critical Determinant Of ATP Synthesis In Differentiating Osteoblasts." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Mohan S. "The role of insulin-like growth factor system in the age-related acquisition , maintenance and loss of bone." Visting professor. University of Akita, Japan ( 8/2005 )

• Mohan S. "The role of insulin-like growth factor system in the age-related acquisition , maintenance and loss of bone." Visiting professor. University of Okayama, Japan ( 8/2005 )

• Mohan S. "The role of insulin-like growth factor system in the age-related acquisition , maintenance and loss of bone." Visting professor. University of Osaka, Japan ( 8/2005 )

• Mohan S. "The Role of IGF System in The Age-Related Acquisition, Maintenance and Loss of Bone." An International Symposium on the Basic and Clinical Aspects of PTH and PTHrP. Yale University, New Haven, CT ( 7/2005 )

• Govoni K, Lee SK, Chadwick RB, Yu H, Kasukawa Y, Baylink DJ, Mohan S. "Whole Genome Microarray Analysis of the In Vivo Effects of a Single Effective GH Dose on Gene Expression in the Bones of GH-Deficient lit/lit Mice: GH Regulates T-box3 and 15, Novel Transcription Factors, Independent of IGF-I." Endocrine Society 87th Annual Meeting. San Diego, CA ( 6/2005 )

• Chadwick RB, Bu LM, Yu H, Hu Y, Sachdev R, Tan Q, Wergedal JE, Mohan S, Baylink DJ. "Digit Tip Regeneration And Global Gene Expression Profiling In The MRL Super-Healer Mouse." 15th Annual Meeting & Exhibition of the Wound Healing Society. Chicago, IL ( 5/2005 )

• Mohan S. "Insulin-like growth factors in physiology and disease." Physiology & Disease Gordon Research Conference. Ventura, CA ( 2/2005 - 3/2005 )

• Edderkaoui B, Mohan S, Wergedal J, Dunn N, Beamer W, Donahue LR, and Baylink DJ. "Three closely mapped genetic loci in chromosome 1 acting via different mechanisms contribute to BMD phenotype." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Govoni KE, Donahue LR, Marden C, Baylink DJ, Mohan S. "Complex genetic regulation of bone density (BMD) and bone size in chromosome substitution strains (CSS). "The Endocrine Society''''s 89th Annual Meeting" (*)

• Rehage M, Mohan S, Wergedal J, Tran K, Bonafede B, Hou D, Phang D, Kumar A, Qin X.. "Overexpression of Pregnancy-associated plasma protein (PAPP)-A in Skeletal Muscle Enhances Postnatal Growth and Skeletal Myogenesis in Mice.." The Endocrine Society''s 89th Annual Meeting. (*)

• Govoni KE, Donahue LR, Marden C, Baylink DJ, Mohan S.. "Complex genetic regulation of bone density (BMD) and bone size in chromosome substitution strains (CSS).." The Endocrine Society 89th Annual Meeting. (*)

  Poster Presentation

• Rundle CH, Wang X, Wergedal JE, Srivastava AK, Davis EI, Lau K-HW, Mohan S, and Baylink DJ. "Loss of sex-specific differences in bone size in leptin-deficient (ob/ob) mice.." 52nd Annual meeting of Orthopaed Res Soc. Chicago, Il, USA ( 3/2006 )

• Qin X, Wergedal JE, Rehage M, Tran K, Newton J, Baylink DJ, Mohan S. "Transgenic Mice Overexpressing Pregnancy-Associated Plasma Protein (PAPP)-A, an IGFBP Protease, in Osteoblasts Exhibit a Dramatic Increase in Bone Accretion.." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Srivastava AK, Mohan S, Chest V, Wergedal JE and Baylink DJ. "Mapping an ENU mutant with high bone density reveals a major locus on distal region of chromosome 4." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Srivastava AK, Mohan S and Baylink DJ. "An update on N-Ethyl-N-nitrosourea (ENU) induced mutation screen for musculoskeletal phenotypes in mouse.." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Edderkaoui B, Baylink DJ, Beamer WG, Shultz KL, Dunn N, Wergedal JE, and Mohan S. "CAST chromosome 1 QTL is complex and contains three BMD loci and one bone size locus: Evidence from subcongenic lines.." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Yu H, Mohan S, Edderkaoui B, Masinde GL, Wergedal JE, Beamer W and Baylink DJ. "Detecting BMD and Bone Size QTL Using a Cross of MRL and CAST Inbred Strains of Mice Both of Which Exhibit High BMD." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Strohbach C, Linkhart TA, Mohan S, Shi Y, Glackin C, Strong DD. "Non-canonical Wnt 11 Transcriptionally Suppresses Expression of Insulin-like Growth Factor Binding Protein-6, an Inhibitor of Osteoblast Differentiation.." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Kesavan C, Mohan S, Yu H, Oberholtzer S, Wergedal JE, Baylink DJ. "Novel Mechanoresponsive BMD and Bone Size QTL Identified in a Genome Wide Linkage Study Involving C57BL/6J-C3H/HeJ Intercross.." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Wang X, Rundel CH, Srivastava A, Tesfai J, Davis EI, Wergedal JE, Lau K-HW, Mohan S, and Baylink DJ. "Loss of sex-specific difference in bone size in leptin knockout mice.." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Govoni K, Rung-Aroon J, Baylink DJ, and Mohan S. "T-box 3, a transcription factor, is an important regulator of osteoblast proliferation. ." 27th Annual Meeting American Society of Bone and Mineral Research. Nashville, Tennessee, USA ( 9/2005 )

• Strong D, Linkhart TA, Amaar Y, Baylink DJ, Mohan S. "Insulin-Like Growth Factor Binding Protein (IGFBP)-6 Inhibits Osteoblast Differentiation and Binds to Lim Mineralization Protein (LMP)-1, an Intracellular Protein That Stimulates Osteoblast Differentiation." Endocrine Society 87th Annual Meeting. San Diego, CA ( 6/2005 )

• Lau k.-H.W., Kapur S, Mohan S and Baylink DJ. "Fluid Shear Stress Synergizes with IGF-I on Osteoblast Proliferation Through Intergrin-dependent Upregulation of IGF-I Receptor Phosphorylation Levels." Orthopedic Research Society. San Francisco, CA ( 3/2005 )

• Lee SK, Govoni K, Chung Y-S, Kesavan C, Baylink DJ, LeRoith D, Clemens T and Mohan S. "Targeted Disruption og IGF-I Gene in Mature Osteoblasts Using Human Osteocalcin Promoter Drive Cre in Mice." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Salih DA, Kasukawa Y, Tripathi G, Lovett FA, Anderson NF, Carter EJ, Wergedal JE, Baylink DJ, Pell J and Mohan S. "Transgenic Overexpression of IGFBP-5 in Mice Leads to Unexpected Decrease in Peak BMD in a Gender Specific Manner: Evidence for IGF-independent Mechanism of Action." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Xing W, Baylink DJ, Kesavan C, Yu H, Chadwick R, Hu Y, Rajkumar R and Mohan S. "Global Analysis of 22,000 Genes in the Bones Reveals Involvement of Several Novel Genes/ESTs and Pathways in Mediating the Anabolic Response of Mechanical Strain in Mice In Vivo." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Xing W, Baylink DJ, Kesavan C and Mohan S. "Transfer of 128-kb BMP-2 Genomic Locus by HSV-Based Infectious BAC Stimulates Osteoblast Differentiation: A Platform for Functional Genomic Studies." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Kesavan C, Baylink DJ, Wergedal JE and Mohan S. "Inbred Mouse Strains Dependent Variations in the Skeletal Adaptive Responses to 4-Point Bending: Evidence for Involvement of Different Genetic Mechanisms." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Chadwick R, Bu LM, Yu H, Sachdev R, Tan QW, Wergedal JE, Mohan S, Baylink DJ. "Digit Tip Regeneration and Global Gene Expression Profiling in the MRL Super-Healer Mouse." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Amaar Y, Baylink DJ, Tapia B, Mohan S. "Identification And Characterization Of A Novel IGFBP-5 Interacting Protein (IGFBP5-IP) By Yeast Two Hybrid Screen Of U2 Osteosarcoma cDNA Library: Evidence That IGFBP5-IP Is An Important Regulator Of Osteoblast Proliferation And Differentiation." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Masinde G, Mohan S, Klamut H, Covarubias M, Baylink DJ. "Impaired Cartilage Regeneration with Aging in the MRL Mouse Regeneration Model: Evidence for Blunted Growth Factor Expression." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Govoni KE, Lee SK, Chadwick RB, Yu H, Kasukawa Y, Linares G, Baylink DJ, and Mohan S. "Whole Genome Microarray Analysis of the In Vivo Effects of Single Effective Growth Hormone (GH) Dose on Gene Expression in Bones of GH-Deficient lit/lit Mice: Potential Involvement of Tbx3, a Novel Transcription Factor, in Mediating GH Effects in Bone." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Kesavan C, Mohan S, Oberholtzer S, and Baylink DJ. "Evidence That BMD Response To Mechanical Loading (ML) In Vivo Is Caused By Acute Up-Regulation Of Both Bone Formation (BF) Genes And Down Regulation Of Bone Resorption (BR) Genes." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )

• Kesavan C, Mohan S, Wergedal J, and Baylink DJ. "Bone anabolic response to a mechanical load is a complex trait and involves bone size, material bone density (mBMD) and volumetric bone density (vBMD) phenotypes." 26th Annual Meeting American Society of Bone and Mineral Research. Seattle, Washington ( 10/2004 )