Subburaman Mohan, PhD Research Professor, Medicine School of Medicine Research Professor, Basic Sciences School of Medicine

Research & Grantsmanship 

  Funded Research Project (PI)

• Endosteal Bone Volume Regulation and Osteoporosis ( 12/1986 - 6/2015 )

• Transgenic approaches to evaluate IGF-I role in peak bone density (02/2001 - 07/2012) ( 7/2000 - 7/2012 )

• Nrf1 Molecular Pathway, Vitamin C deficiency and Spontaneous Fractures ( 4/2007 - 3/2011 )

• Molecular genetic and gene therapy studies of the musculoskeletal system ( 9/2003 - 8/2008 )

• Molecular Genetic Studies of bone mechanical strain and of pedigrees with very high bone density ( 5/2001 - 8/2008 )

• Molecular mechanisms of soft-tissue regeneration and bone formation in mice:Implications in fracture repair and wound healing in humans ( 9/1999 - 3/2008 )

• Detection of the spontaneous fracture mouse mutant gene ( 9/2001 - 8/2007 )

• Identification of Genetic Loci That Regulate Insulin-like Growth Factor (IGF-I) Expression During Pre-pubertal Growth in Mice ( 8/2004 - 7/2007 )

• Research Training in Biomedical Studies of Bone ( 9/1987 - 4/2005 )

  Funded Research Project (CI)

• PAPP-A and Bone Metabolism ( 7/2004 - 6/2009 )

• The effects of Silencing RASSF1c and IGFBP5IP Gene Expression on Tumor Growth ( 1/2005 - 12/2008 )

• Gene expression changes associated with development and with long term hypoxia in placenta ( 7/2000 - 12/2008 )

  Abstracts Reporting Research -- Peer Reviewed

• Rehage M, Mohan S, Wergedal J, Tran K, Bonafede B, Hou D, Phang D, Kumar A, Qin X. "Overexpression of Pregnancy-associated plasma protein (PAPP)-A in Skeletal Muscle Enhances Postnatal Growth and Skeletal Myogenesis in Mice." Endocrine Society Program and Abstract 2007 .P2-408 (2007): 432-432. ( 1/2007 )

• Govoni KE, Donahue LR, Marden C, Baylink DJ, Mohan S. "Complex genetic regulation of bone density (BMD) and bone size in chromosome substitution strains (CSS)." Endocrine Society Program and Abstracts 2007 .P4-106 (2007): 694-694. ( 1/2007 )

• Edderkaoui B, Baylink D, Beamer W, Schultz K, Wergedal J, Mohan S. "Congenic Mice Reveal Gender Specificity of Femoral BMD in Chromosome 1." Journal of Bone and Mineral Research 21.1 (2006): S75-S75. ( 9/2006 )

• Govoni KE, Wergedal JE , Florin L, Angel P , Baylink DJ and Mohan S. "Conditional Deletion of IGF-I in Collagen Type 1alpha2 (Col1alpha2) Expressing Cells Results in Neonatal Lethality and a Dramatic Reduction in Bone Accretion." Journal of Bone and Mineral Research 21.1 (2006): S14-S14. ( 9/2006 )

• Srivastava AK, Mohan S, and Baylink DJ. "A Sensitized ENU Screening System to Discover Modifier Genes by Utilizing Mouse Models Deficient in Genes Regulating Skeletal Tissues." Journal of Bone and Mineral Research 21.1 (2006): S237-S237. ( 9/2006 )

• Srivastava AK, Baylink DJ, Wergedal JE and Mohan S. "Identification of Mutant with a Large Decrease in Bone Size Identified in a Sensitized ENU Screen using Growth Hormone Deficient Little Mouse." Journal of Bone and Mineral Research 21.1 (2006): S238-S238. ( 9/2006 )

• Xing W, Singgih A, Kapoor A, Baylink DJ, and Mohan S. "A Novel Molecular Pathway Involving Antioxidant Response Element (ARE) and Nuclear factor-E2 related factor-1 (Nrf1) in Mediating Vitamin C Effects on Osterix Gene Expression and Osteoblast Differentiation." Journal of Bone and Mineral Research 21.1 (2006): S41-S41. ( 9/2006 )

• Linares GR, Govoni KE, Xing W, Baylink DJ and Mohan S. "Evidence That Grx5, a Growth Hormone(GH)-Inducible Gene, Acts as a Free Radical Scavenger in Osteoblasts." Journal of Bone and Mineral Research 21.1 (2006): S386-S386. ( 9/2006 )

• Chadwick RB, Bu LM, Hu Y, Zhu Y, Baylink DJ, and Mohan S. "Formin-2 Knockout Mice Exhibit Reduced Femur BMD and Cortical Thickness." Journal of Bone and Mineral Research 21.1 (2006): S203-S203. ( 9/2006 )

• Kesavan C, Baylink DJ, Kapoor S, Wergedal JE, Hongrun Yu and Mohan S.. "Quantitative Trait loci for Tibia Periosteal Circumference in the C57BL/6J-C3H/HeJ mice intercross." Journal of Bone and Mineral Research 21.1 (2006): S240-S240. ( 9/2006 )

• Govoni KE, Donahue LR, Marden C, Baylink DJ and Mohan S. "Gender-Specific Regulation of Total Body BMD in Chromosome Substitution Strains." Journal of Bone and Mineral Research 21.1 (2006): S237-S237. ( 9/2006 )

• Yu H, Baylink DJ, Davidson HM, Masinde GL, Edderkaoui B, Wergedal JE, and Mohan S. "Chromosome 9 MRL-SJL Congenic Mice Reveal Sex-Specific Genetic Regulation of Bone Size." Journal of Bone and Mineral Research 21.1 (2006): S238-S238. ( 9/2006 )

• Wergedal JE, Wood CA, Sheng MHC, Baylink DJ, Ackert-Bicknell CL, Beamer WG, and Mohan S. "Determination of Quantitative Trait Loci (QTL) from Femoral Neck Parameters Identifies both Similar and Additional Genetic Loci to those from the Midshaft." Journal of Bone and Mineral Research 21.1 (2006): S241-S241. ( 9/2006 )

• Hall SL, Lau K-HW, Chen ST, Sheng MH, Gyson R, Wergedal JE, Srivastava AK, Mohan S and Baylink DJ. "Sca-1 Cell-based gene therapy with fibroblast growth factor-2 gene (but not BMP-4) dramatically increased endosteal bone formation in mice." Journal of Bone and Mineral Research 21.1 (2006): S34-S34. ( 9/2006 )

• Strong D, Linkhart TA, Amaar Y, Baylink DJ, Mohan S. " Insulin-Like Growth Factor Binding Protein (IGFBP)-6 Inhibits Osteoblast Differentiation and Binds to Lim Mineralization Protein (LMP)-1, an Intracellular Protein That Stimulates Osteoblast Differentiation." Endocrine Society 87th Annual Meeting . (2005): P3-691-. ( 6/2005 )

• Chadwick RB, Bu LM, Yu H, Hu Y, Sachdev R, Tan Q, Wergedal JE, Mohan S, Baylink DJ. "Digit Tip Regeneration And Global Gene Expression Profiling In The MRL Super-Healer Mouse." Wound Healing And Regeneration Meeting . (2005): 38-. ( 5/2005 )

• Lau k.-H.W., Kapur S, Mohan S and Baylink DJ. "Fluid Shear Stress Synergizes with IGF-I on Osteoblast Proliferation Through Intergrin-dependent Upregulation of IGF-I Receptor Phosphorylation Levels." Orthopedic Research Society . (2005): 0845-. ( 3/2005 )

• Chadwick R, Bu LM, Yu H, Sachdev R, Tan QW, Wergedal JE, Mohan S, Baylink DJ. " Digit Tip Regeneration and Global Gene Expression Profiling in the MRL Super-Healer Mouse." J Bone Min Res 19.supp 1 (2004): M043-. ( 11/2004 ) Link...

• Amaar Y, Baylink DJ, Tapia B, Mohan S. "Identification And Characterization Of A Novel IGFBP-5 Interacting Protein (IGFBP5-IP) By Yeast Two Hybrid Screen Of U2 Osteosarcoma cDNA Library: Evidence That IGFBP5-IP Is An Important Regulator Of Osteoblast Proliferation And Differentiation." J Bone Min Res 19.supp 1 (2004): SA158-. ( 11/2004 ) Link...

• Masinde G, Mohan S, Klamut H, Covarubias M, Baylink DJ. "Impaired Cartilage Regeneration with Aging in the MRL Mouse Regeneration Model: Evidence for Blunted Growth Factor Expression." J Bone Min Res 19.supp 1 (2004): M056-. ( 11/2004 ) Link...

• Kesavan C, Mohan S, Oberholtzer S, and Baylink DJ. "Evidence That BMD Response To Mechanical Loading (ML) In Vivo Is Caused By Acute Up-Regulation Of Both Bone Formation (BF) Genes And Down Regulation Of Bone Resorption (BR) Genes." J Bone Min Res 19.Supp 1 (2004): SU212-. ( 11/2004 ) Link...

• Kesavan C, Mohan S, Wergedal J, and Baylink DJ. "Bone anabolic response to a mechanical load is a complex trait and involves bone size, material bone density (mBMD) and volumetric bone density (vBMD) phenotypes." J Bone Min Res 19.supp 1 (2004): SU213-. ( 11/2004 ) Link...

• Lee SK, Govoni K, Chung Y-S, Kesavan C, Baylink DJ, LeRoith D, Clemens T and Mohan S. "Targeted Disruption og IGF-I Gene in Mature Osteoblasts Using Human Osteocalcin Promoter Drive Cre in Mice." J Bone Min Res 19.supp 1 (2004): SA166-. ( 11/2004 ) Link...

• Salih DA, Kasukawa Y, Tripathi G, Lovett FA, Anderson NF, Carter EJ, Wergedal JE, Baylink DJ, Pell J and Mohan S. "Transgenic Overexpression of IGFBP-5 in Mice Leads to Unexpected Decrease in Peak BMD in a Gender Specific Manner: Evidence for IGF-independent Mechanism of Action." J Bone Min Res 19.supp 1 (2004): 1181-. ( 11/2004 ) Link...

• Xing W, Baylink DJ, Kesavan C, Yu H, Chadwick R, Hu Y, Rajkumar R and Mohan S. "Global Analysis of 22,000 Genes in the Bones Reveals Involvement of Several Novel Genes/ESTs and Pathways in Mediating the Anabolic Response of Mechanical Strain in Mice In Vivo." J Bone Min Res 19.supp 1 (2004): SA180-. ( 11/2004 ) Link...

• Edderkaoui B, Mohan S, Wergedal J, Dunn N, Beamer W, Donahue LR, and Baylink DJ. "Three closely mapped genetic loci in chromosome 1 acting via different mechanisms contribute to BMD phenotype." J Bone Min Res 19.supp 1 (2004): 1206-. ( 11/2004 ) Link...

• Xing W, Baylink DJ, Kesavan C and Mohan S. "Transfer of 128-kb BMP-2 Genomic Locus by HSV-Based Infectious BAC Stimulates Osteoblast Differentiation: A Platform for Functional Genomic Studies." J Bone Min Res 19.supp 1 (2004): SA258-. ( 11/2004 ) Link...

• Kesavan C, Baylink DJ, Wergedal JE and Mohan S. "Inbred Mouse Strains Dependent Variations in the Skeletal Adaptive Responses to 4-Point Bending: Evidence for Involvement of Different Genetic Mechanisms." J Bone Min Res 19.supp 1 (2004): M215-. ( 11/2004 ) Link...