Thomas Linkhart, PhD

Research & Grantsmanship 

  Funded Research Project (PI)

• Development and application of bone specific promoters and transcription factors for gene therapy for skeletal repair ( 7/2006 - 6/2007 )

• Regulation of growth factor activities and osteoblast functions in bone. ( 7/2006 - 6/2007 )

  Funded Research Project (CI)

• Development of Skeletal Targeting Vectors for Gene Therapy. ( 7/2006 - 12/2007 )

• Development of A Mouse Model for Marrow Transplantation Using Growth Factor Gene Therapy ( 7/2006 - 6/2007 )

• Development Of Nonviral Vectors For Application To Hard And Soft Tissue Injury ( 7/2006 - 6/2007 )

  Abstracts Reporting Research -- Peer Reviewed

• 135. Strohbach CA, Rundle CH, Chen S-T, Wergedal JE, Linkhart TA, Baylink DJ, Lau K-HW, Strong. DD. "In vivo retroviral-based gene therapy with LIM Mineralization Protein (LMP)-1 enhances fracture healing.." J Orthopedic Research . (2007): -. ( 1/2007 )

• Pérez L, Wang X, Gutierrez G, Strong D, Linkhart T.. "Role of Transcription Factor NFI in Regulation of Human Osteoblast IGF-Binding Protein 5 Gene Expression. ." Proceedings of the American Society for Cell Biology Annual Meeting . (2006): -. ( 12/2006 )

• Pérez L, Wang X, Gutierrez G, Strong D, Linkhart T. . " Role of Transcription Factor NFI in Regulation of Human Osteoblast IGF-Binding Protein -5 gene Expression.." Journal of Bone and Mineral Research 21.Suppl (2006): SA145-. ( 9/2006 )

• Zhang H, Bae S, Linkhart TA, Sowers LC, and Zhang L. "Effect of cocaine on protein kinase C isozyme gene expression pattern in the developing heart.." Proceedings of the World Congress of Pharmacology (IUPHAR 2006) . (2006): -. ( 7/2006 )

• Perez L, Wang X, Gutierrez G, Strong D, Linkhart T. "Regulation of IGF Binding Protein-5 Transcription in Human Osteoblasts by AP-2 Transcription Factors." Endocrine Society Annual Meeting . (2005): P3 700-. ( 6/2005 )

• Strong D, Linkhart T, Amaar Y, Baylink DJ, Mohan S.. "Insulin-Like Growth Factor Binding Protein (IGFBP)-6 Inhibits Osteoblast Differentiation and Binds to Lim Mineralization Protein (LMP)-1, an Intracellular Protein That Stimulates Osteoblast Differentiation." Endocrine Society, Annual Meeting . (2005): P3 691-. ( 6/2005 )

• Strong DD, Amaar Y, Mohan S, Linkhart T. "Insulin-like Growth Factor Binding Protein (BP)-6 inhibits osteoblast differentiation and binds to LIM Mineralization Protein-1 (LMP-1), an intracellular protein that stimulates osteoblast differentiation.." American Society for Biochemistry and Molecular Biology annual meeting. FASEB Journal 19.4 (Part1) . (2005): A742-. ( 4/2005 )

• Moran C, Farley J, Linkhart T.. "Effects of Neurotrophic Factors on Osteoblast Growth and Mineralization." American Society for Bone and Mineral Research 26th Ann Mtg. . (2004): Abstr 517-. ( 10/2004 )