Loma Linda University

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Faculty Directory
  
Xiaolei Tang
Research & Grantsmanship    Grant Proposals--Funded

  • W81XWH-12-1-0023 (Baylink)                                             04/30/12 ~ 10/29/18
    US Army MRAA                                                                             
    “Cell and molecular study of skeletal augmentation and repair”
    The major goals of this project are to determine mechanisms underlying the COX2-mediated enhancement of fracture healing as well as the optimal dose of the AAV(DJ)-COX2 for treating patients with bone fractures.
    Role: Co-investigator.

    W81XWH-15-0240 (Tang)                                                     08/01/15 ~ 01/31/18
    US Army MRAA                                                                             
    “A Novel Therapy for Inflammatory Bowel Disease-Dual Regulatory T-Cell Programming”
    The major goals of this project were to induce gut-homing regulatory T cells in the peripheral immune system for the treatment of experimental colitis.
    Role: PI.

    681205-2967 (Tang)                                                               02/16/15 ~ 02/15/18
    Loma Linda University, Department of Medicine                           
    “Direct Delivery of a Therapeutic Dose of the Active Vitamin D Metabolite to the Immune System for Specific Control of Experimental Autoimmune Encephalomyelitis”
    The major goes of this project were to evaluate a strategy that may deliver a therapeutic dose of 1,25(OH)2D exclusively into peripheral lymphoid tissues for the treatment of experimental allergic encephalomyelitis and thereby spare the concern of systemic side effects.
    Role: PI.

    681207-2967 (Tang & Goel)                                                   02/01/16 ~ 01/31/18
    Loma Linda University, Department of Medicine, GI Foundation.
    “Suppression of Experimental Colitis through Enhancing Mucosal Repair and Reinstating Immune Tolerance in the Inflamed Gut”
    The major goals of this project were to develop a novel combination therapy which accelerates the repair of disrupted mucosal barrier as well as specifically strengthens immune regulation in the intestines.
    Role: PI.

    PP1685 (Tang)                                                                        06/01/11 ~ 11/30/12
    National Multiple Sclerosis Society                                                   
    “Mapping Functional Qa-1 Epitopes in Myelin Proteins”
    The major goals of this project were to map new functional Qa-1 epitopes in the myelin proteins that are the main targets in multiple sclerosis patients. Functions of the CD8 T cells elicited by the new Qa-1 epitopes were also evaluated.
    Role: PI.  

    ( 10/2018 )
  Grant Proposals--Submitted
  • 1 R21 AI142170-01 (Tang)                                                   06/01/19 ~ 05/31/21
    NIAID                                                                                   
    “Targeting Intestinal Stem Cells to Augment the Repair of Epithelial Barrier”
    The major goals of this project are to evaluate whether the active vitamin D metabolite can be used as a therapy for inflammatory bowel disease via its role in the regenerative function of the Lgr5+ intestinal stem cells.
    Role: PI.

     
    W81XWH18PRMRPEA (Tang)                                            04/01/19 ~ 03/31/22
    US Army MRAA                                                                                         
    “A novel therapy for inflammatory bowel disease via stable and specific augmentation of gut immune regulation”
    The major goals of this project are to investigate whether a novel engineered dendritic cell, after in vivo administration, can undergo de novo conversion into a gut-homing tolerogenic DC in peripheral lymphoid tissues and provide a stable and safe control of chronic colitis.
    Role: PI.



    RG-1807-31986 (Tang)                                                          04/01/19 ~ 03/31/22
    National Multiple Sclerosis Society                                                                                   
    “Role of Active Vitamin D Metabolite in Remyelination”
    The major goals of this project are to determine the role of the active vitamin D metabolite in remyelination.
    Role: PI.

    ( 10/2018 )