Loma Linda University

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Andrew Wroe, PhD
Associate Professor, Radiation Medicine
School of Medicine
Publications    Scholarly Journals--Submitted
  • A. Teran, G. McAuley, J. M. Slater, J. D. Slater, A Wroe, Evaluation of the dosimetric properties of a diode detector to proton radiosurgery, Medical Physics, Submitted March 2014 ( 3/2014 )
  • K. Williams, R. Schulte, K. Schubert, A. Wroe, Evaluation of Mathematical Algorithms for Automatic Patient Alignment in Radiosurgery, Submitted to Technology in Cancer Research and Treatment February 2014. ( 2/2014 )
  • Nie Y, Chen Y, Hurley R, Bu S, Rhee K, Knect M, Plesiu G, Schneider J, Semotiuk A, Shihadeh F, Zubkov I, Koss P, McAuley G, Wroe A, Schubert K, Schulte R. An experimental system for focal irradiation of small animals with narrow proton beams: design and performance studies, Submitted to Physics in Medicine and Biology, 2013 ( 8/2013 )
  Scholarly Journals--Published
  • A. Wroe, D. Bush, R. Schulte, J. Slater, Clinical Immobilization Techniques in Proton Therapy, Technology in Cancer Research and Treatment, December 2013, DOI:10.7785/tcrt.2012.500398. ( 12/2013 )
    http://www.tcrt.org/Clinical-Immobilization-Techniques-for-Proton-Therapy-p18138.html
  • D. Gridley, M. Pecaut, X. Mao, A. Wroe, X. Luo-Owen, Biological Effects of Passive Versus Active Scanning Proton Beams on Human Lung Epithelial Cells, Technology in Cancer Research and Treatment, December 2013, DOI:10.7785/tcrt.2012.500392. ( 12/2013 )
  • J. Sanzari, X. Wan, G. Krigsfeld, A. Wroe, D. Gridley, A. Kennedy, The Effects of Gamma and Proton Radiation Exposure on Hematopoietic Cell Counts in the Ferret Model, Gravitational and Space Biology, Volume 1, Number 1, pages 79-94, October 2013. ( 10/2013 )
  • A. Wroe, D. Bush, J. Slater, Immobilization Considerations in Proton Therapy, Technology in Cancer Research and Treatment, September 2013, DOI: 10.7785/tcrt.2012.500376. ( 9/2013 )
  • J. Sanzari, X. Wan, G. Krigsfeld, G. L. King, A. Miller, R. Mick, D. Gridley, A. Wroe, S. Rightnar, D. Dolney, A. Kennedy, Effects of Solar Particle Event Proton Radiation on Parameters Related to Ferret Emesis, Radiation Research, 180, 2, pages 166-176, 2013, DOI: 10.1667/RR3173.1. ( 7/2013 )
  • J. Sanzari, X. Wan, A. Wroe, S. Rightnar, K. Cengel, E. Diffenderfer, G. Krigsfeld, D. Gridley, A. Kennedy, Acute Hematological Effects of Solar Particle Event Proton Radiation in the Porcine Model, Radiation Research, 180, 1, pages 7-16, 2013, DOI: 10.1667/RR3027.1. ( 5/2013 )
  • A. Wroe, A. Ghebremedhin, I. Gordon, R. Schulte, J. Slater, Water Equivalent Thickness Analysis of Immobilization Devices for Clinical Implementation in Proton Therapy, Technology in Cancer Research and Treatment, May 2013, DOI: 10.7785/tcrtexpress.2013.600260. ( 5/2013 )
  • G. Krigsfeld, A. Savage, J. Sanzari, A. Wroe, D. Gridley, A. Kennedy, Mechanism of hypocoagulability in proton-irradiated ferrets, International Journal of Radiobiology, May 2013, DOI:10.3109/09553002.2013.802394 ( 5/2013 )
  • A. J. Wroe, R. W. Schulte, S. Barnes, G. McAuley, J. D. Slater, J. M. Slater, Proton Beam Scattering System Optimization for Clinical and Research Applications, Medical Physics, Volume 40, Issue 4, 2013. ( 4/2013 )
  • S. Barnes, G. McAuley, J. M. Slater, A. J. Wroe, The effects of mapping CT images to Monte Carlo materials on GEANT4 proton simulation accuracy, Medical Physics, Volume 40, Issue 4, 2013. ( 4/2013 )
  • G. McAuley, S. Barnes, J. M. Slater, A. Wroe, Monte Carlo simulation of single-plane magnetically focused narrow proton beams, Physics in Medicine and Biology, Vol 58, pages 535-553, 2013. ( 1/2013 )
  • R. Schulte, A. Wroe, New Developments in Treatment Planning and Verification of Particle Beam Therapy, Translational Cancer Research, Vol. 1, No. 3, pages 184-195, 2012. ( 10/2012 )
  • R. F. Hurley, R.W. Schulte, V. A. Bashkirov, A. J. Wroe, A. Ghebremedhin, H. F.-W. Sadrozinski, V. Rykalin, G. Coutrakon, P. Koss, and B. Patyal, Water-equivalent path length calibration of a prototype proton CT scanner, Medical Physics, Volume 39, Issue 5, Pages 2438-2446, 2012. ( 5/2012 )
  • A.L. Ziebell, B. Clasie, A. Wroe, R.W. Schulte, M.I. Reinhard, S.J. Dowdell, M.L. Lerch, M. Petasecca, V.L. Perevertaylo, O.S. Zinets, I.E. Anokhin, and A.B. Rosenfeld, Solid state diode – Ionization chamber method for measuring out-of-field neutron dose in proton therapy, Radiation Measurements, Volume 46, Issue 12, pages 1638-1642, 2011 ( 12/2011 )
  • D. Gridley, T. Freeman, A. Makinde, A. Wroe, X. Luo-Owen, J. Tian, X. Mao, S. Rightnar, A. Kennedy, J. Slater, M. Pecaut, Comparison of proton and electron radiation effects on biological responses in liver, spleen and blood, International Journal of Radiation Biology, Vol 87, Issue 12, pp. 1173-1181, 2011. ( 11/2011 )
  • Dicello J. F., Gersey B. B., Gridley D. S., Coutrakon G. B., Lesyna D., Pisacane V. L., Robertson J. B., Schulte R. W., Slater J. D., Wroe A. J., and Slater J.M., Microdosimetric comparison of scanned and conventional proton beams used in radiation therapy, Radiat Prot Dosimetry. 143, 513-518, 2011 ( 6/2011 )
  • Casey J. Maks, X. Steven Wan, Jeffrey H. Ware, Ana L. Romero-Weaver, Jenine K. Sanzari, Jolaine M. Wilson, Steve Rightnar, Andrew J. Wroe, Peter Koss, Daila S. Gridley, James M. Slater and Ann R. Kennedy, Analysis of White Blood Cell Counts in Mice after Gamma- or Proton-Radiation Exposure, Radiation Research, Volume 176, Issue 2, 2011. ( 4/2011 )
  • D. Gridley, R. Grover, L. Loredo, A. Wroe, J. D. Slater, J. M. Slater, Proton-beam therapy for tumors of the CNS. Expert Review of Neurotherapeutics p319-330, 2010. ( 2/2010 )
  • Clasie B., Wroe A., Kooy H., Depauw N.,Flanz J., Paganetti, H., and Rosenfeld A., Experimental and theoretical assessment of out-of-field absorbed dose in proton fields. Medical Physics, Volume 37, Issue 1, pages 311-321, 2010 ( 1/2010 )
  • V. A. Bashkirov, R. W. Schulte, A. J. Wroe, H. Sadrozinski, E. Gargioni, B. Grosswendt, Experimental Validation of Track Structure Models, IEEE Transactions on Nuclear Science, Volume 56, Issue 5, pages 2859-2863, 2009 ( 10/2009 )
  • A. L. Ziebell, S. J. Dowdell, M. I. Reinhard, B. Clasie, A. Wroe, R. W. Schulte, M. L. Lerch, M. Petaseca, V. Perevertaylo, I. E. Anokhin, A. B. Rosenfeld, Dual detector system for measuring out-of-field neutron dose in proton therapy, IEEE Nuclear Science Symposium Conference Record, PP 2358-2361, 2009. ( 10/2009 )
  • A. Wroe, R. Schulte, A. Fazzi, A. Pola, S. Agosteo, A. Rosenfeld, RBE estimation of proton radiation fields using a DE-E telescope, Medical Physics, Volume 36, Issue 10, pages 4486-4494, 2009. ( 9/2009 )
  • S. Dowdell, B. Clasie, A. J. Wroe, S. Guatelli, P. Metcalfe, R. Schulte, A. Rosenfeld, The suitability of tissue substitutes for neutron dosimetry in proton therapy, Medical Physics, Volume 36, Issue 12, pages 5412-5419, 2009. ( 4/2009 )
  • Wroe A., Clasie B., Kooy H., Flanz J., Schulte R., and Rosenfeld A., Out-of-field dose equivalents delivered by passively scattered therapeutic proton beams for clinically relevant field configurations. Int J Radiat Oncol Biol Phys. 73, 306-313, 2009. ( 1/2009 )
  • V. Bashkirov, R. Schulte, A.Wroe, A. Breskin, R. Chechik, S. Schemelinin, G. Garty, H. Sadrozinski, E. Gargioni, B. Grosswendt, Experimental Verification of Track Structure Models, IEEE NSS/MIC/RTSD Conference Record, pages 2890-2894, 2008. ( 10/2008 )
  • R. W. Schulte, A. J. Wroe, V. A. Bashkirov, G. Y. Garty, A. Breskin, R. Chechik, S. Shchemelinin, E. Gargioni, B. Grosswendt, and A. B. Rosenfeld, Nanodosimetry-Based Quality Factors for Radiation Protection in Space, Zeitschrift für Medizinische Physik: Special Issue on Medical Physics Aspects of Space Radiation Research, Z. Med. Phys. 18, 286-296, 2008. ( 8/2008 )
  • A. Wroe, A. Rosenfeld, M. Reinhard, V. Pisacane, J. Ziegler, M. Nelson, F. Cucinotta, M. Zaider, J. Dicello, Solid State Microdosimetry with Heavy Ions for Space Applications, IEEE Transactions on Nuclear Science, 54, 6, pp. 2264-2271, 2007. ( 12/2007 )
  • A. J. Wroe, A. B. Rosenfeld, R. W. Schulte; Out-Of-Field Dose Equivalents Delivered by Proton Therapy of Prostate Cancer, Medical Physics, Vol. 34, Issue 9, pp. 3449-3456, 2007. ( 7/2007 )
  • R. Siegele, M. Reinhard, D. Prokopovich, M. Ionescu, D. D. Cohen, A. B. Rosenfeld, I. M. Cornelius, A. Wroe, M. L. F. Lerch, A. Fazzi, A. Pola, and S. Agosteo, Characterisation of a Delta E-E particle telescope using the ANSTO heavy ion microprobe, Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms, vol. 260, pp. 270-275, 2007 ( 4/2007 )
  • I. Cornelius, A. Rosenfeld, M. Reinhard, A. Fazzi, D. Prokopovich, A. Wroe, R. Siegele, A. Pola, S. Agosteo; Charge collection imaging of a monolithic DE-E telescope for radiation protection applications, Radiation Protection Dosimetry, Volume 122, pp. 387-389, 2007 ( 1/2007 )
  • V. Bashkirov, R. Schulte, A. Breskin, R. Chechik, S. Schemelinin, G. Garty, A.Wroe, H. Sadrozinski, B. Grosswendt, Ion-counting nanodosimeter with particle tracking capabilities, Radiation Protection Dosimetry, Volume 122, pp. 415-419, 2006 ( 12/2006 )
  • A. J. Wroe, A. B. Rosenfeld, I. M. Cornelius, D. Prokopovich, M. Reinhard, R. Schulte, V. Bashkirov, Silicon Microdosimetry in Heterogeneous Materials: Simulation & Experiment, IEEE Transactions on Nuclear Science, Volume 53, Issue 6, pp. 3738 – 3744, 2006 ( 12/2006 )
  • Anatoly Rosenfeld, Andrew Wroe, Martin Carolan, Iwan Cornelius, Method of Monte Carlo verification in Hadron Therapy with non-tissue equivalent detectors, SSD 2004 Special Issue Article, Radiation Protection Dosimetry, Volume 116, Issue 1-4, pp. 487-490, 2006. ( 4/2006 )
  • A. J. Wroe, R. Schulte, V. Bashkirov, A.B. Rosenfeld, B. Keeney, P. Spraldin, H.F.W. Sadrozinski, B. Grosswendt, Nanodosimetric Cluster Size Distributions of Therapeutic Proton Beams, IEEE Transactions on Nuclear Science, Volume 53, Issue 2, pp. 532 – 538, 2006 ( 4/2006 )
  • Reinhard Schulte, Vladimir Bashkirov, Sergei Shchemelinin, Amos Breskin, Rachel Chechik, Guy Garty, Andrew Wroe, Bernd Grosswendt, Mapping the Sensitive Volume of an Ion-Counting Nanodosimeter, Journal of Instrumentation, Vol. 1, P04004, April 2006. ( 4/2006 )
  • V. L. Pisacane, Q. E. Dolecek, F. Maas, M. E. Nelson, P. J. Taddei, Z. Zhao, J. F. Ziegler, P. C. Acox, M. Bender, J. D. Brown, T. Garritsen, C. Gaughan, A. Hough, B. Kolb, J. Langlois, J. Ross, M. Sheggeby, D. Thomas, J. F. Dicello, F. A. Cucinotta, M. Zaider, A. B. Rosenfeld, and A. Wroe, MIcroDosimeter iNstrument (MIDN) on MidSTAR-I, SAE Transactions Journal of Aerospace, vol. 2006-01-2146, 2006. ( 1/2006 )
  • A. J. Wroe, I. M. Cornelius, A. B. Rosenfeld, V. L. Pisacane, J. F. Ziegler, M. E. Nelson, F. Cucinotta, M. Zaider, J. F. Dicello, Microdosimetry simulations of solar protons within a spacecraft, IEEE Transactions on Nuclear Science, Volume 52, Issue 6, Part 1, pp. 2591 – 2596, 2005 ( 12/2005 )
  • M. I. Reinhard, I. Cornelius, D. A. Prokopovich, A. Wroe, A. B. Rosenfeld, V.Pisacane, J. F. Ziegler, M. E. Nelson, F. Cucinotta, M. Zaider, and J. F. Dicello, Response of a SOI Microdosimeter to a 238PuBe Neutron Source, IEEE Nuclear Science Symposium Conference Record, 1 (23-29), pp. 68-72, 2005 ( 11/2005 )
  • Reinhard W. Schulte, Vladimir Bashkirov, Márgio C. Loss Klock, Tianfang Li, Andrew J. Wroe, Ivan Evseev, David C. Williams, Todd Satogata, Density resolution of proton computed tomography: Results of a Monte Carlo simulation study, Med Phys. 32, pp. 1035-46, 2005. ( 4/2005 )
  • A. J. Wroe, I. M. Cornelius, A. B. Rosenfeld, Role of inelastic reactions in absorbed dose distribution from proton therapeutic beam in different medium, Med Phys. 32, pp. 37-41, 2005 ( 1/2005 )
  • A. Rosenfeld, A. Wroe, I. Cornelius, D. Alexiev, M. Reinhard Analysis of inelastic interactions for therapeutic proton beam using Monte Carlo simulations, IEEE Trans. on Nucl. Sci , 51, 6, pp. 319-325, 2004 ( 12/2004 )
  • Wroe, A.J.; Schulte, R.; Bashkirov, V.; Rosenfeld, A.B.; Grosswendt, B.; Nanodosimetric cluster size distributions of therapeutic proton beams, Nuclear Science Symposium Conference Record, IEEE Volume 3, pp. 1857 – 1861, 2004 ( 10/2004 )
  Books and Chapters
  • Andrew Wroe, Steven Rightnar: Shielding and Radioprotection in Ion Beam Therapy Facilities, Ion Beam Therapy, Springer, 2011. ( 4/2011 )
  • James Slater, Jerry Slater, Andrew Wroe.; Proton radiation therapy in the hospital environment: conception, development, and operation of the initial hospital-based facility, Reviews of Accelerator Science and Technology Vol. 2, World Scientific, 2009. ( 12/2009 )
  Non-Scholarly Journals
  • A. J. Wroe, J. D. Slater, J. M. Slater, The Physics of Protons for Patient Treatment, NASA Health Risks of Extraterrestrial Environment Encyclopedia ( 9/2012 ) Link...