Carlos Casiano, PhD Professor, Basic Sciences School of Medicine Associate Professor, Medicine School of Medicine Member, Microbiology&Molecular Gen, SM, Faculty of Graduate Studies

Presentations 

  General Academic Presentation

• Invited Speaker. "Autoantibodies against LEDGF/DFS70: natural autoantibodies  or sensors of an augmented state of cellular oxidative stress?" 9th Dresden Symposium on Autoantibodies.   Dresden, Germany.  ( 9/2009 )

  Research Presentations -- International

• Seminar Speaker, "The emerging role of LEDGF in malignant transformation and chemoresistance". Division of Molecular Medicine, Catholic University of Leuven,  Belgium.    ( 12/2008 )

• Invited Conference Speaker,  "Autoantibodies in cancer: function of the DFS70/LEDGF autoantigen."   10th International Workshop on Autoantibodies and Autoimmunity.   Guadalajara, Mexico    ( 3/2008 )

• Seminar Speaker, "Mapping potential interacting partners of LEDGF/p75 using transcription factor protein microarrays."  Laboratory of Molecular Virology, University of Leuven,  Belgium.     ( 9/2007 )

• Invited Conference Speaker, "Identification of candidate interacting partners of the stress-response autoantigen DFS70/LEDGF using transcription factor protein arrays."  8th Dresden Symposium on Autoantibodies.   Dresden, Germany.    ( 9/2007 )

• Keynote Speaker. "Autoimmunity and Cell Death." Inaugural event of the Institute for Rheumatology Research and Muscle-skeletal Diseases. University of Guadalajara Health Science Center, Guadalajara, Mexico ( 1/2006 )

  Research Presentations -- National

• Seminar Speaker- The role of the stress transcription co-activator LEDGF/p75 in malignancy and chemoresistance.  Department of Biology, University of Texas, EL Paso.    ( 2/2009 )

• Invited Conference Speaker,  "The contribution of the augmented state of cellular oxidative stress to prostate cancer disparities."  SACNAS Conference, Salt Lake, Utah.   ( 10/2008 )

• Roundtable Discussion Leader. “Navigating the Road to a Successful career in Cancer Research: Networking for Professional and Scientific Development”. AACR Meeting, San Diego, CA ( 4/2008 )

• Invited Conference Speaker, "Profiling stress genes regulated by the stress oncoprotein LEDGF/p75 in prostate cancer cells using PCR arrays."  AACR Conference “The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved”.   Atlanta, GA    ( 11/2007 )

• Seminar Speaker,  "Modulation of prostate cancer resistance to chemotherapy by stress proteins."  Department of Pharmacology and Toxicology, University of Puerto Rico School of Medicine.      ( 10/2007 )

• Invited Conference Speaker "Oxidative stress and racial disparities in prostate cancer mortality: is there a connection? ." Second Annual Texas Conference on Health Disparities. University of North Texas Health Science Center, Fort Worth, TX ( 6/2007 )

• Seminar Speaker, "LEDGF and resistance to stress-induced cell death in prostate tumors." MARC U-STAR Program Seminar. Queens College, NY ( 5/2007 )

• Invited Conference Speaker, "Molecular Aspects of therapy resistance in advanced prostate cancer ." AACR Annual Scientific Meeting. Los Angeles, CA ( 4/2007 )

• Roundtable Discussion Leader. “Careers in Clinical and Translational Cancer Research:  Building a Career in Cancer Research”. AACR Meeting, Los Angeles, CA.    ( 4/2007 )

• Invited Conference Speaker, "Tumor-associated antigen arrays for the serological diagnosis of cancer ." 2007 Cambridge Research Institute Pep Talk-Protein Arrays Conference. San Diego, CA ( 1/2007 )

• Seminar Speaker. "Research Training and Educational Opportunities at LLUSM Center for Health Disparities and Molecular Medicine." . Metropolitan University, San Juan PR ( 10/2006 )

• Keynote Speaker. "ASCOS and Health Disparities: Is There a Connection?." 2006 Health Care Disparities Research Symposium. Temple University, Philadelphia, PA ( 9/2006 )

• Roundtable Discussion Leader. "Career Transitioning: Junior Faculty to Tenure." Annual Meeting of the American Association for Cancer Research. Washington DC ( 4/2006 )

• Seminar Speaker, "LEDGF: a novel regulator of cell death and survival in the face of stress." UC Riverside Seminar in Biochemistry and Molecular Biology. Riverside, CA ( 3/2005 )

• Guest Lecturer, "Mechanisms of cell death in autoimmunity." Short course on Autoimmunity and Apoptosis. Department of Morphology, Escola Paulista de Medicina. Federal University of Sao Paulo, Brazil ( 12/2004 )

• Invited Conference Speaker, "Autoantibodies to the LEDGF (DFS70) autoantigen: what are they telling us? ." 7th Dresden Symposium on Autoantibodies. Dresden, Germany ( 9/2004 )

• Seminar Speaker, "Mechanisms of autoantigen cleavage during caspase-independent cell death ." University of Ghent Department of Molecular Biomedical Research Seminar. Ghent, Belgium ( 9/2004 )

• Seminar Speaker, "Role of LEDGF in cell death and survival." Laboratory of Molecular Virology and Gene Therapy Seminar. Catholic University of Leuven, Belgium ( 9/2004 )

  Poster Presentation

• Basu A, Banerjee H, Rojas H, Martinez SR, Roy S, Jia Z, Lilly MB, De Leon M, Casiano CA.  Differential expression of peroxiredoxins in prostate cancer: ethnic differences in the association of PRDX3 expression with clinical outcomes. Third AACR Conference on The Science of Cancer Health Disparities   Miami, FL. ( 10/2010 )

• Basu A, Mediavilla-Varela M, Martinez SR, Rojas H, Banerjee H, Roy S, Jia Z, Lilly MB, De Leon M, Casiano CA. Peroxiredoxin 3: a potential biological determinant of prostate cancer health disparities. Annual Meeting of the American Association for Cancer Research.  Washington, DC. ( 4/2010 )

• Leoh LS, Rios-Colon L, Martinez SR, Tungteakkhun S, Filippova M, Llano M, Gijsbers R, Debyser Z, Casiano CA. Methyl CPG binding protein MECP2 interacts with the transcription co-activator LEDGF/p75 and modulates its transcription function. Annual Meeting of the American Association for Cancer Research.  Washington, DC. ( 4/2010 )

• Basu A, Rojas H, Banerjee H, Cabrera I, Perez K, De Leon M, and Casiano CA.   Elevated expression of the stress oncoprotein LEDGF/p75 in major human cancers. Annual Meeting of the American Association for Cancer Research. Washington, DC. ( 4/2010 )

• Evans W,  Pacheco FJ,  Mediavilla-Varela M,  Almaguel F,  Leoh LS,  Ursales L, Lawrence T, De Leon M, and Casiano CA. Docosahexanoic acid attenuates ceramide production, ROS generation, autophagy, and lysosomal destabilization in TNF-treated L929 cells.  Annual Meeting of the American Association for Cancer Research.  Denver, CO. ( 4/2009 )

• Leoh LS, Rios-Colon L, Tungteakkhun S,  Filippova M, Casiano CA.  The methyl CPG binding protein MECP2 is a potential interacting partner of the stress response transcription co-activator LEDGF/p75. Annual Meeting of the American Association for Cancer Research.  Denver, CO.   ( 4/2009 )

• Mediavilla-Varela M, Pacheco FJ,  Daniels TR, Sahakian E, Martinez S, Ursales L, and Casiano CA.  Docetaxel-induced cytotoxicity is attenuated by the stress oncoprotein LEDGF/p75.  Annual Meeting of the American Association for Cancer Research.  Denver, CO.   ( 4/2009 )

• Basu M,  Mediavilla-Varela M,  Martinez S,  Poeschla EM, and Casiano CA.   Upregulation of peroxiredoxins in prostate cancer independent of LEDGF/p75. Annual Meeting of the American Association for Cancer Research. Denver, CO. ( 4/2009 )

• Mediavilla-Varela M,  Pacheco FJ, Almaguel F, Daniels TR, Padilla A, Perez J, Martinez S,  Ursales L, Leoh LS, Lilly MB, De Leon M, and Casiano CA.  Docetaxel-induced cytotoxicity in prostate cancer cells involves concomitant activation of caspase and lysosomal death pathways and is attenuated by the stress oncoprotein LEDGF/p75.  Keystone Symposium on Cell Death Pathways.  Whistler, BC. ( 3/2009 )

• Casiano CA, Basu A, Mediavilla-Varela M, and Leoh LS. Contribution of the stress response protein LEDGF/p75 to prostate cancer chemoresistance.  AACR Conference on the Science of Cancer Health Disparities. Carefree, AZ. ( 2/2009 )

• Casiano CA, Basu A, Mediavilla-Varela M, and Leoh LS.  Contribution of the stress response protein LEDGF/p75 to prostate cancer chemoresistance.   NIH Summit:  The Science of Eliminating Health Disparities.   National Harbor, MD.  ( 12/2008 )

• Mediavilla-Varela M, Perez J, Leoh L, Padilla A, Almaguel F, Lilly MB, De Leon M, and Casiano CA.  Characterization of docetaxel-induced caspase-independent cell death in PCa cells. Annual AACR Meeting, San Diego, CA.   ( 4/2008 )

• Basu A, Mediavilla-Varela M, Leoh L, Munoz R.,  Poeschla EM, and Casiano CA.  Stress gene expression profiling in prostate cancer cells depleted of the stress-induced transcription coactivator LEDGF/p75. Annual AACR Meeting, San Diego, CA. ( 4/2008 )

• Chatterjee, P, Adkins E, and Casiano CA . "Profiling of potential interacting partners of the stress-response transcription co-activator LEDGF/p75 using transcription factor protein arrays." Annual Meeting of the American Association for Cancer Research. Los Angeles, CA ( 4/2007 )

• Basu A, Martinez S, Melendez L, Mediavilla-Varela M, and Casiano CA . "High expression of peroxiredoxins in prostate cancer cells." Annual Meeting of the American Association for Cancer Research. Los Angeles, CA ( 4/2007 )

• Mediavilla-Varela M, Daniels TR, and Casiano CA. "Regulation of the oxidoreductase ERp57/GRP58 by the stress transcription co-activator LEDGF/p75 in prostate cancer cells." Annual Meeting of the American Association for Cancer Research. Los Angeles, CA ( 4/2007 )

• Leoh LS, Brown-Bryan T, Mediavilla-Varela M, and Casiano CA . "Contribution of intron-derived C-terminal amino acid tail of LEDGF/p52 to its pro-apoptotic activity." Annual Meeting of the American Association for Cancer Research. Los Angeles, CA ( 4/2007 )

• Galloway NR, Greer L, Casiano CA, Oberg KC, Li F, Wall NR . "Survivin promoter is regulated by the stress response transcription factors HIF-1, LEDGF/p75, and YY1." Annual Meeting of the American Association for Cancer Research. Los Angeles, CA ( 4/2007 )

• Leoh LS, Brown-Bryan T, Mediavilla-Varela M, and Casiano CA . "Contribution of intron-derived C-terminal amino acid tail of LEDGF/p52 to its pro-apoptotic activity." AACR Special Conference on Innovations in Prostate Cancer Research. San Francisco, CA ( 12/2006 )

• Mediavilla-Varela M, Daniels TR, and Casiano CA. "Regulation of the oxidoreductase ERp57/GRP58 by the stress transcription co-activator LEDGF/p75 in prostate cancer cells." AACR Special Conference on Innovations in Prostate Cancer Research. San Francisco, CA ( 12/2006 )

• Basu A, Martinez S, Melendez L, Mediavilla-Varela M, and Casiano CA . "High expression of peroxiredoxins in prostate cancer cells." AACR Special Conference on Innovations in Prostate Cancer Research. San Francisco, CA ( 12/2006 )

• De Leon M, De Leon D, Montgomery S, Wall N, Woods VD, and Casiano CA . "Loma Linda University Center for Health Disparities Research Project EXPORT." NCI Cancer Health Disparities Summit. Bethesda, MD ( 7/2006 )

  Presentations given to non-academic audiences

• "The Growing Problem of Cancer Health Disparities. A discussion in Selma Schimmels cancer talk radio show The Group Room." AACR Annual Scientific Meeting. Los Angeles, CA ( 4/2007 )

• Moderator, AACR Press Conference on Perspectives on Cancer Health Disparities . AACR Annual Scientific Meeting. Los Angeles, CA ( 4/2007 )

• "Prostate Cancer Prevention for Latino Men." Missionary Alliance Spanish Church. San Bernardino, CA ( 3/2005 )

• "Cell Death in Health and Disease." Winter Wednesdays Seminars Series: "Glimpsing the Future: Advances in Medical Research". Loma Linda University Church ( 2/2005 )