Loma Linda University

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Chandrasekhar Kesavan, PhD
Asst Res Prof, Medicine
School of Medicine
Publications    Scholarly Journals--Submitted
    • Mohan S, Wergedal JE, Das S, and Kesavan  C. Conditional Disruption of miR17-92 Cluster in Osteoblasts Result in Reduced Periosteal Bone Formation and Bone Anabolic Response to Mechanical Loading. Submitted Physiological genomics, 2014.
    • Muthusamy K, Mohan S, Nagamani S and Kesavan C. Identification of novel small molecules binding to the loop2 region of sclerostin-An in silico computational analysis. Submitted to Current computer-Aided Drug Design, 2014.
    ( 0/2014 )
  Scholarly Journals--Published
    • Mohan S, Chetan GB, Wergedal JE, Kesavan C. In vivo evidence of IGF-I–estrogen crosstalk in mediating the cortical bone response to mechanical strain. Bone Research 2 Article number 14007, 2014.
    • Nagamani S, Perumal SM, Perumal SLR, Kesavan C and Muthusamy K. ACE DD genotype associated with the female chronic kidny disease patients of tamil nadu population. Egyptian J. of Medical Human Genetics, In press, 2014.
    ( 0/2014 )
    • Lau KH, Baylink DJ, Zhou XD, Rodriguez D, Bonewald LF, Li Z, Ruffoni D, Müller R, Kesavan C, Sheng MH. Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E271-81.
    • Yu H, Watt H, Kesavan C, Mohan S. The negative impact of single prolonged stress (SPS) on bone development in mice. Stress. 2013 Sep;16(5):564-70.
    • Sengul A, Santisuk R, Xing W, Kesavan C. Systemic administration of an antagomir designed to inhibit miR-92, a regulator of angiogenesis, failed to modulate skeletal anabolic response to mechanical loading. Physiol Res. 2013 Apr 16;62(2):221-6.
    ( 0/2013 )
    • Edderkaoui B, Kesavan C, Baylink DJ, Wergedal JE, Srivastava AK, Mohan S. ENU  mutation mapped to a distal region of chromosome 11 is a major determinant of bone size. Physiol Genomics. 2013 Dec 15;45(24):1222-8.
    • Cheng S, Kesavan C, Mohan S, Qin X, Alarcon CM, Wergedal J, Xing W. Transgenic overexpression of ephrin b1 in bone cells promotes bone formation and an anabolic response to mechanical loading in mice. PLoS One. 2013 Jul 11;8(7):e69051.
    ( 0/2013 )
    • Cheng S, Zhao SL, Nelson B, Kesavan C, Qin X, Wergedal J, Mohan S, Xing W. Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice. PLoS One. 2012;7(3):e32887.
    • Xing W, Govoni KE, Donahue LR, Kesavan C, Wergedal J, Long C, Bassett JH, Gogakos A, Wojcicka A, Williams GR, Mohan S. Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I expression and bone acquisition in mice. J Bone Miner Res. 2012 May;27(5):1067-79.
    • Mohan S, Kesavan C. Role of insulin-like growth factor-1 in the regulation of skeletal growth. Curr Osteoporos Rep. 2012 Jun;10(2):178.
    • Yu H, Watt H, Kesavan C, Johnson PJ, Wergedal JE, Mohan S. Lasting consequences of traumatic events on behavioral and skeletal parameters in a mouse model for post-traumatic stress disorder (PTSD). PLoS One. 2012;7(8):e ( 0/2012 )
    • Nagamani S, Kesavan C, Muthusamy K. E-Pharmacophore mapping and docking studies on Vitamin D receptor (VDR). Bioinformation. 2012;8(15):705-10.
    • Sengul A, Mohan S, Kesavan C. Bone response to loading in mice with targeted disruption of the cartilage oligomeric matrix protein gene. Physiol Res. 2012;61(6):637-41.
    ( 0/2012 )
    • Kesavan C, Wergedal JE, Lau KH, Mohan S. Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading. Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1191-7.
    ( 0/2011 )
    • Kapur S, Amoui M, Kesavan C, Wang X, Mohan S, Baylink DJ, Lau KH. Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to
      mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains. J Biol Chem. 2010 Nov 26;285(48):37607-18.
    • Kesavan C, Mohan S. Bone mass gained in response to external loading is preserved for several weeks following cessation of loading in 10 week C57BL/6J mice. J Musculoskelet Neuronal Interact. 2010 Dec;10(4):274-80.
    ( 0/2010 )
    • Johnson IM, Kesavan C, Usha S, Malathi R. Analysis of group I intron splicing in the presence of naturally occurring methylxanthines. Clin Chim Acta. 2009 Feb;400(1-2):74-6.
    ( 0/2009 )
    • Kesavan C, Mohan S. Lack of anabolic response to skeletal loading in mice with targeted disruption of the pleiotrophin gene. BMC Res Notes. 2008 Dec 1;1:124.
    ( 0/2008 )
    • Kesavan C, Baylink DJ, Kapoor S, Mohan S. Novel loci regulating bone anabolic  response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross. Bone. 2007 Aug;41(2):223-30.
    ( 0/2007 )
    • Lau KH, Kapur S, Kesavan C, Baylink DJ. Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to
      the differential anabolic response to fluid shear. J Biol Chem. 2006 Apr 7;281(14):9576-88.
    • Kesavan C, Mohan S, Srivastava AK, Kapoor S, Wergedal JE, Yu H, Baylink DJ. Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross. Bone. 2006 Sep;39(3):634-43.
    ( 0/2006 )
    • Kesavan C, Joyee AG. 5-fluorouracil altered morphology and inhibited growth of Candida albicans. J Clin Microbiol. 2005 Dec;43(12):6215-6.
    • Xing W, Baylink D, Kesavan C, Hu Y, Kapoor S, Chadwick RB, Mohan S. Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice. J Cell Biochem. 2005 Dec 1;96(5):1049-60.
    • Kesavan C, Mohan S, Oberholtzer S, Wergedal JE, Baylink DJ. Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains. J Appl Physiol (1985). 2005 Nov;99(5):1951-7.
    • Kesavan C, Raghunathan M, Ganesan N. Morphological and growth altering effects of Cisplatin in C. albicans using fluorescence microscopy. Ann Clin Microbiol Antimicrob. 2005 Apr 25;4:7.
    ( 0/2005 )
    • Xing W, Baylink D, Kesavan C, Mohan S. HSV-1 amplicon-mediated transfer of 128-kb BMP-2 genomic locus stimulates osteoblast differentiation in vitro. Biochem Biophys Res Commun. 2004 Jul 2;319(3):781-6.
    ( 7/2004 )
    • Chandrasekar K, Shyla JH, Malathi R. Can antitumor platinum compounds be effective against Candida albicans?--A screening assay using disk diffusion method. J Clin Microbiol. 2000 Oct;38(10):3905
    ( 0/2000 )