Chien-Shing Chen, MD, PhD Head, Medicine, Hematology/Oncology Division School of Medicine Professor, Medicine School of Medicine Professor, Basic Sciences School of Medicine Professor, Pediatrics School of Medicine

Research & Grantsmanship 

  Funded Research Project (PI)

• An Open-Label, Randomized, Phase 2 Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Patients with Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma ( 2/2010 - 11/2011 )

• A Phase II Study of Pegylated Liposomal  Doxorubicin, Bortezomib and Dexamethasone (DVD) for Patients with Newly Diagnosed Multiple Myeloma (MM) ( 1/2009 - Present )

• Millennium Pharmaceuticals, Inc. Protocol C05012- A Two-Arm, Non-Randomized, Multicenter, Phase 2 Study of VELCADE® (bortezomib) in Combination with Rituximab, Cyclophosphamide, and Prednisone with or without Doxorubicin followed by Rituximab Maintenance in Subjects with Relapsed Follicular Lymphoma ( 11/2008 - Present )

• A Phase II Trial of Dasatinib (Sprycel®) in Subjects with Hormone-refractory Prostate Cancer, Previously Treated with Chemotherapy ( 10/2008 - Present )

• Loma Linda University Cancer Center Biospecimen Laboratory Specimen Collection Protocol ( 10/2008 - Present )

• A multi-center, open-label, exploratory study of Bcr-Abl kinetics in adult patients on nilotinib with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia in chronic phase (CML-CP) and a suboptimal molecular response to imatinib ( 9/2008 - Present )

• Examination of PNH, by level of CD59 on  red and White blood cells, in bone marrow failure syndromes (EXPLORE) ( 9/2008 - Present )

• Randomized, open label, phase II trial comparing rituximab plus sargramostim to rituximab monotherapy for the treatment of relapsed follicular B-cell lymphoma ( 5/2005 - Present )

• VELCADE® (bortezomib) for Injection therapy for early relapsed prostate cancer ( 3/2005 - Present )

  Funded Research Project (CI)

• Grants to promote Collaborative and Translational Research (GCAT), Loma Linda University (PI – Chen & Goyal)                $75000                                    2012-2014 Title: “Identification and Functional Analysis for Regenerative Potential of Very Small Embryonic-Like Stem Cells in Sheep.”  The major goal of this project is to develop sheep as a model of VSEL identification and analyze their differentiation ability in different organs and with developmental maturation.       Grants to promote Collaborative and Translational Research (GCAT), Loma Linda University (PI- Chen & Manaenko)          $75000    ( 4/2012 - 4/2013 )

  Grant Proposals--Funded

• Cancer Syndicate Grant Award, funding agency: A*STAR and the BMRC (Singapore), awarded for Animal model for pre-clinical testing in NUH/NUS.  Award:year 1, extended to a 3 year grant ( to March 09’). ( 1/2009 - 1/2010 )

• Singapore Cancer Syndicate 2004 Award, TN31: Non-myeloablative transplantation and targeted therapy in leukemia (3 years, 04’- March 09’) ( 1/2009 - 1/2010 )

• Singapore Cancer Syndicate 2004 Award, Development of an early phase clinical trials oncology program at The Cancer Institute (National Healthcare Group-NHG) (3 years, 04’-March 09’) ( 1/2009 - 1/2010 )