Loma Linda University

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Denise Bellinger, PhD
Assoc Res Prof, Pathology and Human Anatomy
School of Medicine
Research & Grantsmanship    Funded Research Project (PI)
  • N.I.H. R21 CA116698 “Mechanisms of Psychosocial Influences on Prostate Cancer” 12/01/08 – 11/30/10. One-Year No Cost Extension through 11/30/11.  ( 12/2008 - 11/2011 )
    The goal of this grant is to investigate the effects of chronic psychological stress on prostate cancer growth murine RM-9 othrotopic prostate cancer model using both young and old.  Co-Investigators: Daila Gridley, Richard Hartman, Julia Kroh*, Melissa Dulcich*, Xian Luo*. We have completed the aims of the grant. We are preparing to submit our first manuscript ("Aging and stress effects on behavioral outcomes and tumor growth and behavior in a young and old mouse model of prostate cancer") from this research effort for a special issue of Brain Behav. Immunity (call for abstracts due Oct. 3, 2011).  We have presented 12 poster/oral presentations of data from this study has been presented at local and international conferences.
  • N.I.H. R01 NS44302, "Sympathetic Modulation of the Immune System in Aging", 8/01/02-7/31/08. ( 7/2002 - 8/2008 )
  • Longitudinal Age-Related Changes in Sympathetic Innervation of Spleens from Male Brown Norway and Fischer 344 Rats* ( 7/2005 - 6/2006 )
  • Characterization of Nerve-Bone Cell Interaction in the Remodelled Bones in Adjuvant-Induced Arthritis* ( 7/2005 - 6/2006 )
  • Immune-to-Brain Signaling in Experimental Arthritis* ( 7/2005 - 6/2006 )
  • Effect of Chronically Lowering SNS Activity on Immune Function in Aging* ( 7/2005 - 6/2006 )
  • Effects of Adrenergic Receptor Stimulation on In Vitro Viability and Proliferation of Two Prostate Cancer Cell Lines* ( 7/2005 - 6/2006 )
  • Effects of Subacute Rilmenidine Treatment on Splenic Norepinephrine Concentration and Blood Pressure in Aging Rats* ( 7/2005 - 6/2006 )
  • Neurotrophic Support of Sympathetic Innervation in Lymphoid Organs of Aging Rats* ( 7/2005 - 6/2006 )
  • Aging and Sympathetic Neurotransmission in Secondary Lymphoid Organs* ( 8/2004 - 7/2005 )
  • Longitudinal Age-Related Changes in Sympathetic Innervation of Spleens from Male Brown Norway Rats* ( 7/2004 - 6/2005 )
  • Characterization of Nerve-Bone Cell Interaction in the Remodelled Bones in Adjuvant-Induced Arthritis* ( 7/2004 - 6/2005 )
  • Effect of Age on Sympathetic Regulation of Primary Antibody Response to a T-Dependent Antigen, KLH* ( 8/2005 - Present )
  • Effects of Subacute Rilmenidine Treatment on Splenic Norepinephrine Concentration and Blood Pressure in Aging Rats* ( 8/2004 - Present )
  • Neurotrophic Support of Sympathetic Innervation in Lymphoid Organs of Aging Rats* ( 7/2004 - Present )
  • Effects of Adrenergic Receptor Stimulation on In Vitro Viability and Proliferation of Two Prostate Cancer Cell Lines* ( 7/2004 - Present )
  • Immune-to-Brain Signaling in Experimental Arthritis* ( 7/2004 - Present )
  • Effect of Chronically Lowering SNS Activity on Immune Function in Aging* ( 7/2004 - Present )
  Funded Research Project (CI)
  • Chronic Treatment of Middle-Aged Sprague-Dawley Rats with L-Deprenyl Inhibits Mammary Tumor Growth by Augmenting Neural-Immune Interactions* ( 5/2005 - Present )
  • A Neuroanatomical Link with Immunosenescence: I. Sympathetic Noradrenergic Innervationof Lymphoid Organs in Female F344 Rats ( 5/2005 - Present )
  • Fetal Programming: Testosterone Implants in Pregnant Ewes Modulates Neural-immune Functions in Lambs* ( 4/2005 - Present )
  • Estrogen Administration and its Effect on Neural-Immune Interactions* ( 4/2005 - Present )
  • Adventist Health & Religion Study ( 7/2004 - Present )
  • Influence of the sympathetic nervous system on the development and progression of adjuvant-induced arthritis ( 7/2001 - Present )
  Grant Proposals--Funded
  • Templeton Foundation (Harold G. Koenig, M.D., PI, Michael B. King, M.D., Co-PI; Subcontract, Bellinger DL) “Online Conventional vs. Religious Psychotherapy for Major Depression in Primary Care” 03/01/11-02/28/13.  Subcontract, $82.000. Grant Consultant. ( 9/2009 - 9/2011 )
  • N.I.H. AG026348-01 (Jerry Lee and Kelly Morton Co-PI, Bellinger DL, Co-investigator) “Psychosocial and Biological Manifestations of Religion”, 9/30/05 – 8/31/10. One-Year No Cost Extension. 8/31/11. ( 9/2005 - 9/2011 )
  Grant Proposals--Submitted
  • Intramural Grants for Research and School Partnerships (GRASP) Grant: “Effects of Psychosocial Stress and Diet on Prostate Cancer”, Submitted Sept. 1, 2011, Funding period, 01/01/12-12/31/13. ( 8/2011 - 9/2011 )
  Abstracts Reporting Research -- Peer Reviewed
  • Garcia P, Millar B, Silva D, Molinaro C, ThyagaRajan S, and Bellinger DL. "Sympathetic Innervation of Spleens from Aging Male Brown Norway (BN) Rats: A Longitudinal Study." 6th LLU-NIH IMSD Annual Research Symposium, Meeting Abstract Book . (2006): 28-. ( 1/2006 )
  • Millar B, Perez SD, Flowers R, Evelsizer S, Albero S, Carter JL, ThyagaRajan S, Molinaro C, Wood C, Bellinger DL. "Aging alters sympathetic response at two time points following immunization with KLH in Fischer 344 and Brown Norway rats." 13th Annual Meeting of the Psychoneuroimmunology Research Society, Meeting Abstract Book . (2006): 10-. ( 1/2006 )
  • Carter JL, Amanda. Damjanovic AK, Molinaro CA, Vyas S, Gridley DS, ThyagaRajan S, and Bellinger DL. Society (PNIRS), Meeting Abstract Book . (2006): 8-9. 13th Annual Meeting of the Psychoneuroimmunology . Miami, FL. 06/01/2006. "Sympathetic modulation of mammalian cancer in vitro." 13th Annual Meeting of the Psychoneuroimmunology Research Society (PNIRS), Meeting Abstract Book . (2006): 8-9. ( 1/2006 )
  • Vyas S, Molinaro CA , Bellinger DL. "Effects of ageing and the antihypertensive drug rilmenidine on nerve growth factor (NGF) expression in the spleen of male F344 rats." 13th Annual Meeting of the Psychoneuroimmunology Research Society Meeting (PNIRS), Meeting Abstract Book . (2006): 12-. ( 1/2006 )
  • Lorton D, Lubahn CL, Carter J, Wood C, Estus C, Bellinger DL. "Increased noradrenergic innervation of the cervical dorsal horn in adjuvant-induced arthritis: further enhancement by treatment with adrenergic drugs." 36th Annual Meeting of the Society for Neuroscience, Abstract Meeting Book . (2006): 247.2-. ( 1/2006 )
  • Perez SD., Molinaro C, Vyas S, Millar B, Carter J, Wood C, ThyagaRajan S, and Bellinger DL.. "Chronically reducing sympathetic activity in the spleen during middle age does not reverse the age-related increase in beta-AR-stimulated cAMP production in splenocytes." 13th Annual Meeting of the Psychoneuroimmunology Research Society, Meeting Abstract Book . (2006): 10-. ( 1/2006 )
  • Bellinger DL, Millar B, Flowers S, Damjanovic AK, Nance DM, ThyagaRajan S.. "Estrogen and Immunity: Neuromodulation by Splenic Sympathetic Noradrenergic (NA) Nerve Fibers in Rats." 12th Annual Meeting of the Psychoneuroimmunology Research Society . (2005): -. ( 6/2005 )
  • Damjanovic AK, Carter J, Gridley DS, ThyagaRajan S, Molinaro C, Bellinger DL.. "Sympathetic Modulation of Mammalian Prostate Cancer." 12th Annual Meeting of the Psychoneuroimmunology Research Society . (2005): -. ( 6/2005 )
  • Millar B, Silva D, ThyagaRajan S, Molinaro C, Karsten AH, Flowers SR, Perez SD, Bellinger DL.. "Immunization with KLH differentially affects splenic sympathetic activity in two strains of young and old rats." 12th Annual Meeting of the Psychoneuroimmunology Research Society . (2005): -. ( 6/2005 )
  • Lubahn CL, Schaller JA, Bellinger DL, Lorton D.. "Alpha1-, Adrenergic Drugs Targeting Alpha2-, and Beta2-Adrenergic Receptors, Alone and in Combination are Effective in Treating Adjuvant-Induced Arthritis in the Lewis Rat." 12th Annual Meeting of the Psychoneuroimmunology Research Society . (2005): -. ( 6/2005 )
  • Lorton D, Lubahn C, Schaller J, Carter J, Woods C, Bellinger DL.. "Inital Safety and Efficacy Study Demosntrates Promise for the Use of Beta2-Adrenergic Agonists and alpha-Adrenergic Antagonists as Joint Sparing Treatments for Adjuvant Arthritis (AA)." 12th Annual Meeting of the Psychoneuroimmunology Research Society . (2005): -. ( 6/2005 )
  • Carter J, Lubahn C, Lorton D, Flowers S, Ruff N, Bellinger DL.. "Anatomic Patterns of c-Fos Immunostaining in Lewis Rats with Adjuvant-Induced Arthritis." 12th Annual Meeting of the Psychoneuroimmunology Research Society . (2005): -. ( 6/2005 )
  • Perez S, Molinaro C, ThyagaRajan S, Millar B, Flowers S, Bellinger D.. "Strain Differences in Basal Sympathetic Activity: Effects of Aging and Stimulation of Central Imidazoline-1 Receptors in the Rostral Ventrolateral Medulla." 12th Annual Meeting of the Psychoneuroimmunology Research Society . (2005): -. ( 6/2005 )
  • Bassett K, Molinaro CA, Millar AB, Flowers S, Perez SD, Karsten AH, Bellinger DL.. "Age-Related Changes in Splenic Neurotrophin Content: A Possible Cause for Declining Sympathetic Innervation in Old Rats." The 33rd Annual Western Student Medical Research Forum . (2005): -. ( 2/2005 )
  • Clarke C, Karsten AH, Gridley DS, ThyagaRajan S, Molinaro C, Bellinger DL.. "Sympathetic Modulation of Mammalian Prostate Cancer." Annual Biomedical Research Conference for Minority Students (ABRCMS) . (2004): Poster No. A15-. ( 11/2004 )
  • Clarke C, Karsten AH, Gridley DS, ThyagaRajan S, Molinaro C, Bellinger DL.. "Sympathetic Modulatin of Mammalian Prostate Cancer." 4th LLU-NIH IMSD Annual Research Symposium . (2004): p. 28-. ( 8/2004 )
  • Garcia P, Millar B, Silva D, Molinaro C, ThyagaRajan S, Bellinger D. "Sympathetic Innervation of Spleens from Aging Male Brown Norway (BN) Rats: A Longitudinal Study." LLU-NIH IMSD Annual Research Symposium, Meeting Abstract Book . (): 28-. (*)
  • Garcia P, Millar B, Silva D, Molinaro C, ThyagaRajan S, and Bellinger DL . "Sympathetic Innervation of Spleens from Aging Male Brown Norway (BN) Rats: A Longitudinal Study." 6th LLU-NIH IMSD Annual Research Symposium, Meeting Abstract Book . (): 28-. (*)
  • Millar B, Perez SD, Flowers SR, Evelsizer S, Alberto S, Carter JL, ThyagaRajan S, Molinaro C, Wood C, Bellinger DL. "Aging alters sympathetic response at two time points following immunization with KLH in Fischer 344 and Brown Norway rats." 13th Annual Meeting of the Psychoneuroimmunology Research Society Book . (): -. (*)
  • Lorton D, Lubahn C, Carter J, Wood C, Estus C, Bellinger DL. "." . (): -. (*)
  • Lorton D, Lubahn C, Carter JL, Wood C, Estus C, Bellinger DL. "Adjuvant-induced arthritis induces an up-regulation of descending noradrenergic innervation to the cervical dorsal horn, an efect augmented by treatment with adrenergic drugs.." Soc for Neuroscience Meeting Abstract Book . (): -. (*)