Loma Linda University

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Daisy De Leon, PhD
Professor, Basic Sciences
School of Medicine
Presentations    Research Presentations -- International
  • Vyas, S., and  De León, D.D., 2004. IGF-II regulation by resveratrol in human breast cancer cells. International Research Conference on Food, Nutrition and Cancer. Washington DC    ( 7/2004 )
     
  • Rosenfeld, R.G., Oh, Y., Neely E.K., De León, D.D., Cohen, P. Pham, H. 1990. New Perspectives in insulin-like growth factor receptors. Tokyo Growth Symposium.  ( 6/1990 )
     
  Research Presentations -- National
  • Vyas, S., and De León, D.D., 2002. Resveratrol as a chemopreventive and chemotherapeutic agent for breast cancer.  93rd Annual Meeting of American Association for Cancer Research, San Francisco, California     ( 10/2010 )
     
  • Kalla-Singh, S., Tan, Q.W., Brito,C., De León, M.A. and  De León, D.D.  2010. Insulin-like growth factor II (IGF-II) differential activation of the IGF-1 and insulin receptors in african-american and caucasian breast cancer tissues. AACR Annual Meeting, Washington, DC       ( 4/2010 )
     
  • Calderon, T., Kalla-Singh, S., De León, M.A., and De León, D.D. 2010. Differential expression of fatty-acid-binding proteins 3 and 5 among African American and Caucasian women with breast cancer. AACR Annual Meeting, Washington, DC.    ( 4/2010 )
     
  • Kalla-Singh, S., Tan, Q.W. and De León, D.D2009.  Insulin-like Growth Factor II (IGF-II) and its receptors: A comparison Study between African-American and Caucasian Women in Normal and Malignant Breast tissues Samples. AACR Annual Meeting, Denver, CO ( 4/2009 )
     
  • Ellerbee, A.P., Hamilton, N. and De León, D. D. 2009. IGF-II Regulates Phosphorylation of Estrogen Receptors In African American Breast Cancer Cells.  AACR Annual Meeting, Denver, CO. ** Awarded Susan G Komen Scholar-in-Training Award     ( 4/2009 )
     
  • Kalla-Singh, S., Tan, Q.W. and  De León, D.D. 2009. Insulin-like Growth Factor II (IGF-II) and its receptors: A comparison Study between African-American and Caucasian Women in Normal and Malignant Breast tissues Samples. AACR Health Disparities Meeting. Carefree- Arizona    ( 2/2009 )
     
  • Ellerbee, A.P., Hamilton, N. and De León, D.D. 2009. The Role of IGF-II in Estrogen Independent Tumors in African-American Breast Cancer Cells. AACR Health Disparities Meeting. Carefree- Arizona  ( 2/2009 )
     
  • Vyas, S., Moretta, D., Almaguel, F., De Leon, M. and De Leon, D.D. 2007 "Insulin-Like Growth Factor II (IGF-II) and Pro IGF-II Differentially Regulate Apoptosis, Bcl-2 Bcl-Xl In Mcf-7 Breast Cancer Cells." 89th Endocrine Society Annual Meeting. June 2007.  Toronto, Canada.   ( 6/2008 )
     
  • Vyas, S., Almaguel, F., De León, M. and De León, D.D. 2008. A Link to Breast Cancer Survival Disparity among African American Women: IGF-II Regulates Mitochondria to Prevent Apoptosis and Promote Chemoresistance. AACR Annual Meeting. April 2008. San Diego, CA.    ( 4/2008 )
     
  • Ellerbee, A.P.,  Hamilton, N. and De León, D.D. 2008. IGF-II regulates phosphorylation of estrogen receptors In breast cancer cells from African American patients. AACR Annual Meeting. April 2008. San Diego, CA  ( 4/2008 )
     
  • Kalla-Singh, S, Tan, Q.W. and De León, D.D. 2008. Insulin-Like Growth Factor II (IGF-II): A Role In Breast Cancer Survival Disparity Between African-American And Caucasian Females. NIH Health Disparities Summit. Washington DC   ( 4/2008 )
     
  • Ellerbee, A.P., Hamilton, N. and De León, D.D. 2008. IGF-II Phosphorylates and Activates ER-a and ER-b In African-American Breast Cancer Cell Lines . NIH Health Disparities Summit. Washington DC     ( 4/2008 )
     
  • Vyas, S., Almaguel, F., De León, M. and De León, D.D. 2007. A Link to Breast Cancer Survival Disparity among African American Women: IGF-II Regulates Mitochondria to Prevent Apoptosis and Promote Chemoresistance. AACR Health Disparities Meeting. December 2007. Atlanta Georgia.   ( 12/2007 )
     
  • Ellerbee, A.P. Hamilton, N. and De León, D.D. 2007. IGF-II regulates phosphorylation of estrogen receptors In breast cancer cells from African American patients. AACR Health Disparities Meeting. December 2007. Atlanta Georgia      ( 12/2007 )
     
  • Ellerbee, A.P., Casiano, C.C., Brito, C. and De Leon, D.D. 2007 "Genistein and Curcumin Regulate proIGF-II to Promote Apoptosis of ER-/PR- Breast Cancer Cells from African American Patients ." 89th Endocrine Society Annual Meeting. June 2007. Toronto, Canada.    ( 6/2007 )
     
  • Tesfai, J. and De León, D.D. 2007. Knockdown of IGF-II gene by SiRNA induces apoptosis and growth inhibition in MCF-7 breast cancer cell line. 89th Endocrine Society Annual Meeting. June 2007. Toronto, Canada.    ( 6/2007 )
     
  • Vyas, S., Moretta, D., Almaguel, F., De Leon, M. and De Leon, D.D. "INSULIN-LIKE GROWTH FACTOR II (IGF-II) AND PROIGF-II DIFFERENTIALLY REGULATE APOPTOSIS, Bcl-2 and Bcl-XL IN MCF-7 BREAST CANCER CELLS." 89th Endocrine Society Annual Meeting. Toronto, Canada ( 6/2007 )
     
  • Vyas, S., Moretta, D., Almaguel, F., De Leon, F. and De Leon, D.D. 2007 "Differential expression of insulin-like growth factor II (IGF-II) and proIGF-II mediates resveratrol-induced apoptosis, mitochondrial polarization and proliferation in mcf-7 breast cancer cells." AACR Annual Meeting. Los Angeles, CA   ( 4/2007 )
     
  • Vyas, S., Moretta, D., Almaguel, F., De Leon, M. and De Leon, D.D. "DIFFERENTIAL EXPRESSION OF INSULIN-LIKE GROWTH FACTOR II (IGF-II) AND PROIGF-II MEDIATES RESVERATROL-INDUCED APOPTOSIS, MITOCHONDRIAL POLARIZATION AND PROLIFERATION IN MCF-7 BREAST CANCER CELLS." AACR Annual Meeting. Los Angeles, CA ( 4/2007 )
     
  • De Leon, D. D. 2006 "IGF-II and cathepsin D in Breast Cancer is Associated with Health Disparities in African American Patients." Endocrine Society 88th Annual Meeting. Boston Convention Center, MA (6/2006 )   ( 6/2006 )
     
  • De León, D.D. 1995. Differential Expression of IGFBP''''''''''''''''s in MCF-7 breast cancer cell transfected with IGF-II or proIGF-II: Effect on cell growth. Endocrine Society 77 Annual Meeting, Washington D.C.   ( 6/2005 )
     
  • Vyas, S., and  De León, D.D., 2005. Resveratrol-Induced apoptosis is associated with IGF-II Down-regulation in MCF-7 Breast Cancer Cells. Endocrine Society 87th Annual Meeting, San Diego    ( 6/2005 )
     
  • Vyas, S., and De León, D.D., 2004. Resveratrol regulates IGF-II in MCF-7 human breast cancer cells. 95 th Annual Meeting of American Association for Cancer Research, Orlando, Florida  ( 3/2004 )
     
  • Vyas, S., and De León, D.D., 2003. Differential modulation of IGF-II by resveratrol in human breast cancer cell lines. 85th Annual Meeting of the Endocrine Society.  Philadelphia     ( 6/2003 )
     
  • Vyas, S., Asmerom, Y., and  De León, D.D., 2003. Differential modulation of cathepsin D and IGF-II by resveratrol in human breast cancer cell lines. 94th Annual Meeting of American Association for Cancer Research, Toronto, Canada    ( 4/2003 )
     
  • Faridi, J.S. and De León, D.D. 2000. Interactions of IGF-II in MCF-7 Breast Cancer Cells: Role of the IGF-II/M6P Receptor. 82nd Annual Meeting of the Endocrine Society.  Toronto, Canada  ( 6/2002 )
     
  • Ying, N., Jo-Wen, L., De Leon, M.,  De Leon, D.D., 2002. Human epidermal-type fatty acid-binding protein as a breast tumor suppressor. 93rd Annual Meeting of American Association for Cancer Research, San Francisco, California     ( 4/2002 )
     
  • De León, D. D. and Garberoglio, C., 2002.  Insulin like Growth Factor II (IGF-II) as a prognostic indicator for breast cancer. Breast Cancer  Research Symposium, Oakland, California.     ( 3/2002 )
     
  • Jian, T., and De León, D.D., 2000.  Expression of ProIGF-II and not IGF-II in the human breast cancer cell line MCF-7 induces loss of estrogen requirement for tumor growth in nude and SCID mice. 82nd Annual Meeting of the Endocrine Society.  Toronto, Canada     ( 6/2000 )
     
  • Nainani, S.R. and De León, D.D., 2000. "Resveratrol regulates IGF-II and cathepsin D routing in MCF-10 breast epithelial cells". 82nd Annual Meeting of the Endocrine Society.  Toronto, Canada.    ( 6/2000 )
     
  • Faridi, J.S. and De León, D.D. 1999. Interactions of IGF-II in MCF-7 Breast Cancer Cells: Role of the IGF-II/M6P Receptor. 81st Annual Meeting of the Endocrine Society.  San Diego, CA.   ( 6/1999 )
     
  • De León, D.D., Asmerom, Y., Kanacki, Z., and Garberoglio, C.,  1999. Cathepsin D in Breast Cancer.  California Breast Cancer Program. Second Symposium, Los Angeles, CA. ( 5/1999 )
     
  • Mehta, K. R. and De León, D.D. 1998. Effect of IGFBP-4 in Breast Cancer Cell Proliferation.  80th Annual Meeting of the Endocrine Society.  New Orleans, LA    ( 6/1988 - 6/1998 )
     
  • Chen, Q., Bowman, R., Ota, M., Heustis, D. and De León, D.D. 1997. Immunohistochemical Analysis of Breast Cathepsin D In Ten Breast Cancer Patients.  ASCP/CAP ( 9/1997 )
     
  • Issa, N.N, Boynton, B.P., Ulloth, L., Nainani, S.B., and De León, D.D. 1996.  IGF-II modulation of cathepsin D secretion in breast cancer cells: Effect of IGF-II antisense expression.  10th International Congress of Endocrinology.  San Francisco CA  ( 6/1996 )
     
  • Mehta, K. and De León, D.D. 1996.  Antiestrogen Modulation of Breast Cancer Cell Growth Through IGFBP-4 Regulation.  10th International Congress of Endocrinology.  San Francisco CA.  ( 6/1996 )
     
  • Issa, N.N, Boynton, B.P., Ulloth, L., Nainani, S.B., and De León, D.D. 1996.  Modulation of Cathepsin D by IGF-II in Breast Cancer Cells. American Federation of Clinical Research, Carmel, CA. ( 2/1996 )
     
  • De León, D.D. ,Terry C. and Nissley P., 1994.   Expression of Insulin-like growth factor II (IGF-II) in MCF-7 Breast Cancer cells increases the secretion of Cathepsin-D. ASCB 34th Annual Meeting, San Francisco, CA.    ( 12/1994 )
     
  • De León, D.D., Terry C. and Nissley P. 1993. Rapid and sensitive detection of insulin-like growth factor II by chemiluminescence: Dot-blot analysis. Endocrine Society 75th Annual Meeting, Las Vegas Nevada.  ( 6/1993 )
     
  • Lopaczynsky,W., Thomas, C.L., De León, D.D., Phang, L., Blakemore, K.J., Kelley, R.I. and  Nissley, P. 1992. Insulin-like growth factor-I receptor expression and function in fibroblasts from 2 patients with deletion of the distal arm of chromosome 15. Endocrine Society 74th Annual Meeting, San Antonio, TX.    ( 6/1992 )
     
  • De León, D.D. and Wilson D.M. 1990. Role of Insulin-like growth factors in human breast cancer cell proliferation: Effects of insulin-like growth factor receptor antibodies. Endocrine Society 72nd Annual Meeting, Atlanta, GA.     ( 7/1990 - 6/1990 )
     
  • De León, D.D., Wilson D.M., Powers, M., Lamson G. and Rosenfeld, R.G. 1990. Hormonal Regulation of Insulin-like growth factors in human breast cancer cells. Cellular and Molecular biology of breast cancer/ UCLA Symposia. Tamarron, Colorado. J. Cell Biochem. Suppl. 14B.    ( 6/1990 )
     
  • Bakker,B., Wilson, D.M., Lamson, G., De León, D.D., Powers, M., Rosenfeld, R.G. and Hintz, R.L. 1989. Insulin-Like Growth factor I and II in human breast cancer cell line: A Re-evaluation. Clinical Research 37(1):192 A. ( 6/1989 )
     
  • De León, D.D., Bakker B., and Wilson, D.M., 1988.  Insulin-like growth factors and binding proteins in human breast cancer cells. Endocrine Society  70thAnnual Meeting, New Orleans, Abs. # 865:p.237  ( 6/1988 )
     
  • De León, D.D. and Barkley, M.S. l987. LH receptors and progesterone secretion during the estrous cycle among inbred strains of mice. Biol Rep 36: Suppl. l:232. ( 6/1987 )
     
  • De León, D.D. and Barkley, M.S. l986. Male genotype influences estrous cyclicity in the mouse. Proc Fed Amer Soc Exp Biol 45(3):303.   ( 6/1986 )
     
  • De León, D.D. and Barkley, M.S. l984.  Male Genotype influences the regularity of the estrous cycle in selected strains of mice. Biol Rep 30: Suppl. 1:167     ( 6/1984 )
     
  Poster Presentation
  • Ellerbee, A.P., Casiano, C.C., Brito, C. and De Leon, D.D. "Genistein and Curcumin Regulate proIGF-II to Promote Apoptosis of ER-/PR- Breast Cancer Cells from African American Patients ." 89th Endocrine Society Annual Meeting. Toronto, Canada ( 4/2007 )
     
  • Daisy D De Leon. "IGF-II and cathepsin D in Breast Cancer is Associated with Health Disparities in African American Patients." Endocrine Society 88th Annual Meeting. Boston Convention Center, MA ( 6/2006 )
  • Vyas, Sharda, and D D. De León. " Differential Expression of IGF-II and Pro IGF-II Mediates Resveratrol-induced Apoptosis, Mitochondrial Polarization in MCF-7 cells. ." Endocrine Society 88th Annual Meeting. Boston Convention Center, MA ( 6/2006 )