Loma Linda University

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Faculty Directory
  
H. Bryant Nguyen, MD
Vice Chair, Research, Medicine
School of Medicine
Head, Medicine, Pulmonary & Critical Care Div
School of Medicine
Professor, Emergency Medicine
School of Medicine
Professor, Basic Sciences
School of Medicine
Professor, Medicine
School of Medicine
Publications    Scholarly Journals--Published
  • Selected Articles

    1. Nguyen HB, Evans WJ. Olfactory evoked potentials in normal human subjects.  J Undergraduate Res Bio Sci 1993;23:737-48. [Original Research]
    2. Estacion M, Nguyen HB, Gargus JJ.  Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L-cells. Am J of Physio 1996; 270:C1145-52. [Original Research]
    3. Nguyen HB, Estacion M, Gargus JJ.  Mutations causing achondroplasia and thanatophoric dysplasia alter bFGF induced calcium signals in human diploid fibroblasts. Hum Mol Gen 1997;6:681-9. [Original Research]
    4. Nguyen HB, Rivers EP, Havstad S, Knoblich B, Hays G, Ressler J, Tomlanovich MC.  Critical care delivery in the emergency department:  A physiologic assessment and outcome evaluation. Acad Emerg Med 2000;7:1354-61. [Original Research]
    5. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M.  Early goal-directed therapy in the treatment of severe sepsis and septic shock.  N Engl J Med 2001;345:1368-77. [Original Research]
    6. Donnino MW, Karriem-Norwood V, Rivers EP, Gupta A, Nguyen HB, Jacobsen G, McCord J, Tomlanovich MC.  Prevalence of elevated troponin I in end stage renal disease patients receiving hemodialysis. Acad Emerg Med 2004;11: 979-981. [Original Research]
    7. Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin AM, Ressler J, Tomlanovich MC. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004;32:1637-42. [Original Research, Feature Article]
    8. Hargrove J, Nguyen HB.  Outcome predictions for the critically ill patients in the emergency department.  Crit Care 2005;9:376-383. [Invited Review]
    9. Osborn TM, Nguyen HB, Rivers EP.  Emergency medicine and the surviving sepsis campaign: An international approach to managing severe sepsis and septic shock.  Ann Emerg Med 2005;46:228-31. [Invited Review]
    10. Nguyen HB, Corbett SW, Menes K, Cho T, McDaugharthy J, Klein W, Wittlake WA. Early goal-directed therapy, corticosteroid and recombinant human activated protein C for the treatment of severe sepsis and septic shock in the emergency department.  Acad Emerg Med 2006;13:109-13. [Original Research]
    11. Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trezciak S, Huang D, Osborn T, Stevens D, Talan DA.  Severe sepsis and septic shock: Review of the literature and emergency department management guidelines.  Ann Emerg Med 2006;48:28-54. [Practice Guidelines]
    12. Nguyen HB, Losey T, Rasmussen J, Oliver R, Guptill M, Wittlake WA, Corbett SW. Inter-rater agreement of a transcutaneous Doppler ultrasound cardiac output monitoring device: Implications for non-invasive hemodynamic monitoring in emergency department patients. Am J Emerg Med 2006;24:828:35. [Original Research]
    13. Otero R, Nguyen HB, Huang DT, Gaieski DF, Goyal M, Gunnerson K, Trzeciak S, Sherwin R, Holthaus CV, Osborn T, Jacobson G, Rivers EP. Early goal directed therapy in severe sepsis and septic shock: Revisiting the concepts, controversies and contemporary findings. Chest 2006;130:1579-95. [Invited Review]
    14. Nguyen HB, Smith D. Sepsis in the 21st century: Recent definitions and therapeutic advances.  Am J Emerg Med 2006;25:564-71. [Review]
    15. Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes S, Edwards J, Cho T, Wittlake WA. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality.  Crit Care Med 2007;35:1105-12. [Original Research]
    16. Nguyen HB, Lynch EL, Mou JA, Lyon K, Wittlake WA, Corbett SW.  The utility of a quality improvement bundle in bridging the gap between research and standard care in the management of severe sepsis and septic shock in the emergency department. Acad Emerg Med 2007;14:1079-86. [Special Contribution]
    17. Nguyen HB, Banta J, Cho T, Van Ginkel C, Burroughs K, Wittlake WA, Corbett SW. Mortality predictions using current physiologic scoring systems in patients meeting criteria for early goal-directed therapy and the severe sepsis resuscitation bundle.  Shock 2008;30:23-8. [Original Research]
    18. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Ngo L, Rivers EP. A prospective, multi-center derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis.  Critical Care Med 2009;37:96-104. [Original Research]
    19. Holthaus CV, Cannon C, Elkin R, Nguyen HB. Can my severe sepsis and septic shock patients wait any longer? Ann Emerg Med 2009; 54:135-6. [Editorial]
    20. Nguyen HB, Daniel-Underwood L, Van Ginkel C, Wong M, Lee D, San Lucas A, Palaganas J, Banta D, Denmark TK, Clem K.  An educational course including medical simulation for early goal-directed therapy and the severe sepsis resuscitation bundle: An evaluation for medical student training. Resuscitation 2009;80:674-79. [Original Research]
    21. Carpenter CR, Keim SM, Upadhye S, Nguyen HB. Risk stratification of the potentially septic patient in the emergency department: The Mortality in the Emergency Department Sepsis (MEDS) score. J Emerg Med 2009;37:319-27. [Invited Systematic Review]
    22. Nguyen HB, Oh J, Otero R, Burroughs K, Wittlake WA, Corbett SW. Standardization of severe sepsis management: A survey of methodologies in academic and community settings.  J Emerg Med 2010;38:122-30. [Original Research]
    23. Nguyen HB, Loomba M, Yang JJ, Jacobsen G, Shah K, Otero RM, Suarez A, Parekh H, Rivers EP. Early lactate clearance is associated with decreased biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. J Inflamm 2010;7:6-17. [Original Research]
    24. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson K, Milzman D, Gaieski DF, Goyal M, Cairns CB, Kupfer K, Lee SW, Rivers EP. The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin (NGAL) in the prediction of acute kidney injury in emergency department patients with suspected sepsis.  Ann Emerg Med 2010;56:52-9. [Original Research]
    25. Nguyen HB, Banta DP, Stewart G, Kim T, Bansal R, Anholm J, Wittlake WA, Corbett SW. Cardiac index measurements by transcutaneous Doppler ultrasound and transthoracic echocardiography in adult and pediatric emergency patients. Journal of Clinical Monitoring and Computing 2010;24:237-47. [Original Research]
    26. Walters EL, Morawski K, Dorotta I, Ramsingh D, Lumen K, Bland D, Clem K, Nguyen HB.  Implementation of a post-cardiac arrest bundle including therapeutic hypothermia and early goal-directed therapy in patients with return of spontaneous circulation after out-of-hospital cardiac arrest: A feasibility study. Shock 2011;35:360-6.  [Original Research]
    27. Perman SM, Chang AM, Hollander JE, Gaieski Df, Trzeciak S, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Goyal M, Cairns CB, Ngo L, Rivers EP, Shapiro NI. Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. Acad Emerg Med 2011;18:219-22. [Original Research]
    28. Nguyen HB, Kuan WS, Batech M, Shrikhande P, Mahadevan M, Li CH, Ray S, Dengel A, for the ATLAS Investigators.  Outcome effectiveness of the severe sepsis bundle with addition of lactate clearance as a bundle element: A multi-national evaluation. Crit Care 2011;15:R229. [Original Research]
    29. Nguyen HB, Van Ginkel C, Batech M, Chenoweth J, Banta J, Kim S, Corbett SW. Comparison of PIRO, APACHE II, and MEDS in patients meeting criteria for early goal-directed therapy and the severe sepsis resuscitation bundle. J Critical Care 2012; 27:362-9. [Original Research]
    30. Li CH, Kuan WS, Mahadevan M, Daniel-Underwood L, Chiu TF, Nguyen HB. A multinational randomized study comparing didactic lectures with case scenario in a severe sepsis medical simulation course. Emerg Med J 2012; 29:559-64. [Original Research]
    31. Dinh VA, Ko HS, Rao R, Bansal RC, Smith DD, Kim TE, Nguyen HB. Measuring cardiac index with a focused cardiac ultrasound examination in the emergency department. Am J Emerg Med 2012;30:1845-51. [Original Research]
    32. Na S, Kuan WS, Mahadevan M, Li CH, Shrikhande P, Ray S, Batech M, Nguyen HB, for the ATLAS Investigators.  Implementation of early goal-directed therapy and the Surviving Sepsis Campaign resuscitation bundle in Asia. Int J Qual Health Care 2012;24:452-462. [Original Research]
    33. Banta JE, Joshi KP, Beeson L, Nguyen HB. Patient and hospital characteristics associated with inpatient severe sepsis mortality in California, 2005-2010. Crit Care Med 2012;40:2960-6. [Original Research]
    34. Parekh HJ, Nguyen HB, Hall SL, Rehage M, Anholm J, Specth L, Linkhart TA. Direct pro-inflammatory effect of C-reactive protein on human pulmonary artery endothelial cells. Eur J Inflam 2012;10:357-64. [Original Research]
    35. Rivers EP, Jaehne AK, Nguyen HB, Papamatheakis DG, Singer D, Yang JJ, Brown S, Klausner H. Early biomarker activity in severe sepsis and septic shock and a contemporary review of immunotherapy trials: Not a time to give up, but to give it earlier. Shock 2013;39:127-37. [Original Research and Review]
    36. Nguyen HB. Central venous oxygen saturation: Not easily replaced. Crit Care Med 2013;41:1570-71. [Invited Editorial]
    37. Nguyen HB, Dinh VA. Solely targeting “Alactatemia” in septic shock resuscitation? Let’s be cautious, it’s not so simple. Chest 2013;143:1521-23. [Invited Editorial]
    38. Nguyen HB, Eshete B, Lau KHW, Sai A, Villarin M, Baylink D.  Serum 1,25-dihydroxyvitamin D: An outcome prognosticator in human sepsis. PLOS ONE 2013;8:e64348. [Original Research]
    39. Farshidpanah S, Klein WF, Matus MJ, Sai AJ, Nguyen HB. Validation of the vascular pedicle width as a diagnostic aid in critically ill patients with pulmonary edema by novice non-radiology physicians in-training. Anaesth Int Care 2014;42:321-29. [Original Resesarch]
    40. Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, DeMuth GE, Fitzgerald R, Gong MN, Graham DD, Gunnerson K, Heung M, Jortani S, Kleerup E, Koyner JL, Krell K, LeTourneau J, Lissauer M, Miner J, Nguyen HB, Ortega LM, Self WH, Sellman R, Shi J, Straseski J, Szalados JE, Wilber ST, Walker MG, Wilson J, Wunderink R, Zimmerman J, Kellum JA. Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. Am J Resp Crit Care Med 2014;189:832-39. [Original Research]
    41. Dinh VA, Farshidpanah S, Lu S, Stokes P, Chrissian A, Shah H, Giri P, Hecht D, Nguyen HB. Real-time ultrasound-guided percutaneous dilatational tracheostomy using a long-axis approach compared to landmark technique. J Ultra Med 2014;33:1407-15. [Original Research]
    42. Ginde AA, Blatchford PJ, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Rivers EP, Shapiro NI. Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. Shock 2014;42:99-107. [Original Research]
    43. Ani C, Farshidpanah S, Bellinghausen Stewart A, Nguyen HB. Variations in organism specific severe sepsis mortality in the United States: 1999-2008. Crit Care Med 2015;43:65-77. [Original Research]
    44. Brown TN, Ghelani-Allen A, Yeung D, Nguyen HB. Comparative effectiveness of physician diagnosis and guideline definitions in identifying sepsis patients in the emergency department. J Crit Care 2015;30:71-7. [Original Research]
    45. Tang Y, Choi J, Kim D, Tudtud-Hans L, Li J, Michel A, Baek H, Hurlow A, Wang C, Nguyen HB. Clinical predictors of adverse outcomes in severe sepsis patients with lactate 2 to 4 mM admitted from the emergency department. QJM 2015;108:279-87. [Original Research]
    46. Giri PC, Bellinghausen Stewart A, Dinh VA, Chrissian AA, Nguyen HB. Developing a percutaneous dilatational tracheostomy service by medical intensivists: Experience at one academic institution. J Crit Care 2015;30:321-6. [Original Research]
    47. Dinh VA, Giri PC, Rathinavel I, Nguyen E, Hecht D, Dorotta I, Nguyen HB, Chrissian AA. Impact of a 2-Day Critical Care Ultrasound Course During Fellowship Training: A Pilot Study. Crit Care Res and Prac 2015; 675041. [Original Research]
    ( 8/2015 )
  Books and Chapters
    1. Rivers EP, Otero RM, Nguyen HB.  Approach to the patient in shock. In: Emergency Medicine, A Comprehensive Study Guide, Tintinalli, 6th Edition, 2004:219-25.
    2. Rivers EP, Nguyen HB, Osborn T, Gaieski D, Goyal M, Gunnerson K, Trzeciak S, Sherwin R, Holthaus C, Otero R.  Early goal-directed therapy in severe sepsis and septic shock.  In: Kuhlen R, Moreno R, Ranieri M, Rhodes A.  ESICM, 25 Years of Progress and Innovation, 1st Edition, 2007:189-97.
      Greenwald PW, Weingart Sc, Nguyen HB. Severe sepsis and septic shock. In: Rowe B. Evidence-based Emergency Medicine, 1st Edition, 2008.
    3. Otero RM, Nguyen HB, Rivers EP. Approach to the patient in shock. In: Emergency Medicine, A Comprehensive Study Guide, Tintinalli, 7th Edition. 2010.
    4. Nguyen HB, Huang DT, Pinsky MR.  Hemodynamic monitoring. In: Emergency Medicine, A Comprehensive Study Guide, Tintinalli, 7th Edition. 2010.
    5. Walters EL, Nguyen HB. Hemodynamic monitoring and perfusion monitoring. In: Flaxman A. Critical Care Emergency Medicine, 1st Edition, 2011.
    6. Nguyen HB. Monitoring Technology: Invasive and Non-invasive. In: Yealy D, Callaway C. Emergency Department Critical Care, 1st Edition, 2011.
    7. Nguyen HB, Huang DT, Pinsky MR. Hemodynamic Monitoring. In: Emergency Medicine, A Comprehensive Study Guide, Tintinalli, 8th Edition. 2015.
    8. Walters EL, Dinh VA, Nguyen HB. Hemodynamic monitoring and perfusion monitoring. In: Farcy DA. Critical Care Emergency Medicine, 2nd Edition, 2015.
    ( 7/2003 - 8/2015 )