Loma Linda University

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Faculty Directory
  
John Buchholz, PhD
Vice Chair, Basic Sciences, Pharmacology Division
School of Medicine
Professor, Basic Sciences
School of Medicine
Member, Pharmacology, SM, Faculty of Graduate Studies
Research & Grantsmanship    Funded Research Project (PI)
  • Project #4: Modulation of Calcium-Induced Calcium Release (CICR) In Adrenergic Neurons Via nNOS Nerves. Funded 1/01/05 to 12/31/10. National Institutes of Health, HD#31226 ($810,000 total costs). ( 9/2010 - 12/2010 )
     
  • Principle Investigator ( 6/2005 - 12/2007 )
  • Principle Investigator ( 6/2006 - 7/2007 )
  • Principle Investigator ( 7/2004 - 7/2005 )
  • Principal Investigator Project 4 ( 7/2004 - 7/2005 )
  • Principal Investigator ( 7/2004 - 7/2005 )
  • Principal Investigator ( 7/2004 - 4/2005 )
  Grant Proposals--Approved
  •  Modulation of CICR in SCG Neurons: Development and Hypoxia. Submitted to NIH National Heart Lung Blood Institute. 20% tile ( 10/2010 )
     
  Grant Proposals--Submitted
  • Submitted Resarch grant entitled "Calcium Release in Cerebrovascular Adrenergic Neurons: Maturation and Hypoxia"  This proposal studies ovine fetal and adult adaptations to long-term hypoxia (LTH) at high altitude to investigate a mechanistic relationship between calcium signaling in sympathetic nerves arising from the superior cervical ganglion (SCG), modulation of transmitter release and their subsequent in vivo motor function.July 1, 2010 to June 30, 2014. $1, 875,000 total costs. ( 7/2009 - 10/2009 )
  Abstracts Reporting Research -- Peer Reviewed
  • Charles SM, Zhang L, Longo LD, Pearce WJ and Buchholz JN. . "Generation of myogenic tone requires release of calcium in rat cerebral arteries." FASEB Journal 1.1 (2008): A960.16-. ( 1/2008 )
  • Charles SM, Zhang L, Longo LD, Pearce WJ and Buchholz JN. "Generation of myogenic tone requires release of calcium in rat cerebral arteries." FASEB Journal 1.1 (2007): A960.16-. ( 1/2007 )
  • Buchholz JN, Vanterpool CK, Pearce WJ, Behringer EK. "Advancing age alters the contribution of release of calcium from internal stores to stimulation-evoked calcium transients." FASEB Journal 1.1 (2007): A945.9-. ( 1/2007 )
  • Charles SM, Zhang L, Longo LD, Pearce WJ, Buchholz JN:. "Maturation alters calcium dependent sensitivity of pressure dependent cerebrovascular myogenic tone." FASEB Journal 1.1 (2006): A208.15-. ( 12/2006 )
  • Behringer EJ, Vanterpool CK, Pearce WJ and Buchholz JN. "Late maturation and advancing age alter the contribution of release of calcium from internal stores to stimulation-evoked calcium transients." Society for Neuroscience Abstracts 1.1 (2006): A80.5-. ( 7/2006 )
  • Charles SM, Zhang L, Longo LD, Pearce WJ, Buchholz JN. "Maturation alters calcium dependent sensitivity of pressure dependent cerebrovascular myogenic tone." FASEB Journal . (2006): A208.15-. ( 6/2006 )
  • Charles SM, Zhang L, Longo LD, Pearce WJ, Buchholz JN. "Maturation alters calcium dependent sensitivity of pressure dependent cerebrovascular myogenic tone. ." FASEB Journal . (2006): A208.15 -. ( 1/2006 )
  • Charles, S.M., Pearce, W,J., Buchholz, J.N. "Generation of myogenic tone is dependent on at least two pools of calcium in rat cerebral arteries.." FASEB Journal . (2005): A383.3-. ( 11/2005 )
  • Vanterpool, C.K., Pearce, W.J., Buchholz, J.N. "Aging Alters Rapid and Spontaneous Intracellular Calcium Store Refilling In Rat Superior Cervical Ganglion Cells." . (2005): A632.8-. ( 11/2005 )
  • Vanterpool CK, Pearce, WJ and Buchholz, JN: . "Aging Selectively Alters The Genetic Expression of Ryanodine Channels in Rat Superior Cervical Ganglia." Society for Neuroscience Abstracts . (2005): A214.1-. ( 8/2005 )
  • Charles, S.M., Pearce, W,J., Buchholz, J.N. "Generation of myogenic tone is dependent on at least two pools of calcium in rat cerebral arteries. ." FASEB Journal, A383.3 . (2005): -. ( 1/2005 )
  • Vanterpool, C.K., Pearce, W.J., Buchholz, J.N.. "Aging Alters Rapid and Spontaneous Intracellular Calcium Store Refilling In Rat Superior Cervical Ganglion Cells. ." FASEB Journal, A632.8 . (2005): -. ( 1/2005 )
  • Vanterpool CK, Pearce, WJ and Buchholz, JN. "The Genetic Expression of Ryanodine Channels in Rat Superior Cervical Ganglia." Soc. Neurosci. Abstracts . (2005): -. ( 1/2005 )
  • Zhao, H.W., Ross, A.P., Buchholz, J.N., Drew, K.L. "Intracellular [Ca2+] in Cultured Hippocampal Slices of Arctic Ground Squirrels. Soc. ." Society for Neuroscience Abstracts, A963.18 . (2004): -. ( 11/2004 )
  • Vanterpool, C.K., Duckles, S.P., Buchholz, J.. "Advancing Age Alters Intracellular Calcium Store Refill In Rat Superior Cervical Ganglion Cells. ." Society for Neuroscienc Abstracts, A735.17 . (2004): -. ( 11/2004 )
  • Vanterpool, C.K., Duckles, S.P. and Buchholz, J.:. "Advancing Age Alters Intracellular Calcium Store Refill In Rat Superior Cervical Ganglion Cells. Soc.." Soc. Neurosci Abstacts A735.17 . (2004): -. ( 1/2004 )
  • Zhao, H.W., Ross, A.P., Buchholz, J.N., Drew, K.L. "Intracellular [Ca2+] in Cultured Hippocampal Slices of Arctic Ground Squirrels." Soc. Neurosci. Abstracts, A963.18 . (2004): -. ( 1/2004 )
  Abstracts Reporting Research -- Non-Peer Reviewed
  • Erik J. Behringer, Laura D. Leite, Nickolaus E. Buchholz, Michael G. Keeney, William J. Pearce, Conwin K. Vanterpool and John N. Buchholz. Development and Long-Term Hypoxia Alters Calcium-Induced Calcium Release in Sheep Cerebrovascular Sympathetic Neurons. Society for Neuroscience A482.4, 2008. ( 11/2008 )
  • Charles SM, Zhang L, Longo LD, Pearce WJ, Buchholz JN. Myogenic tone in juvenile rat MA is resistant to blockade of calcium influx and release of intracellular calcium. FASEB J. A913.3, 2008. ( 5/2008 )