Loma Linda University

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Faculty Directory
  
Kimberly Payne, PhD
Director, Translational Reserach, Basic Sciences
School of Medicine
Associate Professor, Pathology and Human Anatomy
School of Medicine
Associate Professor, Medicine
School of Medicine
Associate Professor, Pediatrics
School of Medicine
Member, Anatomy, SM, Faculty of Graduate Studies
Research & Grantsmanship    Funded Research Project (PI)
  • NIH/NCI R21CA162259-01A1.  Project Title: Xenograft Model to Study Impact of CRLF2-Ligand in Hispanic Childhood B-ALL. Role on Project: Principal Investigator. FUNDED. Total Costs $408,375. ( 7/2012 - 3/2015 )

    Goal: To develop an in vivo model of CRLF2 function in B-ALL by expressing human TSLP (hTSLP) in a xenograft model of B-ALL and to use this model to investigate CRLF-2-TSLP interactions as a therapeutic target in high risk CRLF2-d B-ALL.

  • NIH/NCI R43CA165739-01A1 (SBIR). Title: Development of novel small molecule drugs for the treatment of high risk BALL.  Role on Project: Co-Principal Investgator. Cathy Swindlehurst, PhD, Novomedix. FUNDED. Total Costs $150,000. Co-investigators Olivia Francis* Ineavely Delgado Baez.
    ( 8/2012 - 11/2014 )

    Goal: The goal of this program is to develop and ultimately commercialize small molecule drugs for the treatment of high risk pediatric B-cell acute lymphoblastic leukemia (B-ALL), with an initial focus on drug resistant B-ALL.

  • LLU-GCAT 2110246. Project Title: TSLP in Pediatric B-ALL. (Payne and Morris PIs) Role on Project: Co-Principal Investigator. FUNDED. Total Costs $75,000. ( 1/2012 - 12/2013 )
    Goal:To perform pilot studies for establishing the relationship between serum TSLP and IL-7 levels, and CRLF2 expression, ethnicity, and prognostic indicators in pediatric B-ALLpatients and to use a TSLP and IL-7 cytokine-specific human B-ALL xenograft model to determine the interplay between TSLP and IL-7 in the progression of CRLF2d B-ALL and the survival of subclones of minimal residual disease.
  • 245726 St. Baldrick’s Foundation Research Grant. Project Title: Role of TSLP in Pediatric Pre-B ALL with Deregulated CRLF2 Expression. Role on Project: Principal Investigator. FUNDED. Total costs $99,866.         ( 7/2012 - 6/2013 )
    Goal: Using a novel xenograft model transplanted with primary pediatric CRLF2 B-ALL cells we will study   the role of TSLP-CRLF2 interactions in leukemia cell survival/proliferation and gene expression in vivo.
  • LLU GRASP Award: Project Title: Natural Product Therapy to Inhibit B Cell Precursor Proliferation. Role on Project: Principal Investigator FUNDED. Total Costs $50,000. ( 2/2011 - 2/2012 )
  • NIH/NIDDK K01 DK066163. Title: IL-7 in Human B1 and B2 Lymphocyte Differentiation

     

    ( 10/2006 - 11/2008 )
    Goal: The goal of this project was to define the role of IL7 in human B1 and B2 lymphocyte lineage commitment and development.
  Funded Research Project (CI)
  • NIH/NIGMS R25 GM060507. Title: The NIH-LLU Initiative for Maximizing Student Development. Principal Investigator: Marino DeLeon ( 4/2013 - 7/2017 )
  Abstracts Reporting Research -- Peer Reviewed
  • Parrish YK , Baez I, Milford TA, Benitez  A, Galloway  N, Willeman-Rogerio  J, Sahakian E, Wall  NR, Dovat S and Payne KJ. "IL-7 in Human B Cell Development: Assembling the Puzzle Pieces," Program for the FASEB Summer Meeting: Molecular Mechanisms of Lymphocyte Differentiation: From Stem Cells to Effector Cells ( 6/2009 )
  • Payne KJ, Baez I, Milford TA, Benitez  A, Galloway  N, Willeman-Rogerio  J, Sahakian E, Wall NR, Dovat S and Parrish YK. Human cord blood, but not adult bone marrow, gives rise to IL-7-independent B cell production. The Journal of Immunology, Program for American Association of Immunologists 96th Annual Meeting, 2009, abstract #138.5 ( 5/2009 )
  • Dovat. S., Popescu M., Gurel, Z. and Payne K.J. Dephosphorylation of Ikaros by a specific phosphatase regulates its function in chromatin remodeling.The Journal of Immunology, Program for American Association of Immunologists 96th Annual Meeting, 2009, abstract #136.9. ( 5/2009 )
  • Benitez A,  Tatosyan L, Lee S,  Milford T-A, Colburn K, Baez I, and Payne KJ. Transitional Stages of Human Splenic B cell Development. Program of the Keystone Symposium: B Cells in Context. Abstract selected for Minority Travel Award  (Abigail Benitez) ( 2/2009 )
  • Gurel Z,  Ronni T, Ho S, Kuchar J, Payne KJ, Turk CW and Dovat S. "Phosphorylation of Ikaros by CK2 kinase regulates expression of the TdT gene during T cell differentiation." Program for the Aegean Conferences: 4th Annual International Conference on Gene Regulation in Lymphocyte Development. ( 10/2008 ) Link...
  • Milford TM, Parrish YK, Baez I, Rogerio JW, Sahakian E, Kagoda M, Benitez A, Huang G, and Payne KJ. "IL-7 is required for B cell development from adult human bone marrow due to decreased B lymphoid generative capacity." EB2008 Meeting Program pp. 112, 264. ( 4/2008 )
  • Gurel Z, Ronni T, Ho S, Kuchar J, Payne KJ, Turk CW, and Dovat S. "Phosphorylation regulates Ikaros function and its targeting to pericentromeric heterochromatin in T cell leukemia." AACR Annual Meeting 2008 Program, p. 156. ( 4/2008 )
  • Lee S, Milford T-A, Baez I, Sevilla Y, Colbrun KK, Payne KJ. Transitional B Cell Stages of Development in Human Fetal Spleen. Program of the  Annual Meeting of the Western Society for Clinical Investigation 2008. This abstract earned Dr. Steve Lee a travel award. ( 1/2008 )
  • Parrish YK, Baez I, Milford TM, Rogerio JW, Sahakian E, Kagoda M, Benitez A, Huang G, and Payne KJ. "Human B Cell Development from Adult Bone Marrow is Profoundly Dependent on IL-7 Due to Decreased B Lymphoid Generative Capacity."  Blood 110 (11): 959a, 2007. ( 12/2007 )
  • Imperio P, Kagoda M, Baez I, Benitez A, Milford T-A and Payne KJ. "Laying the Foundation for an Artificial Bone Marrow to Study Human B Cell Development." Program, Bios, and Abstract, LLUSOM and CHDMM 2007 Health Disparities Research Symposium . (2007): 35-36. ( 8/2007 )
  • Sevilla Y, Baez I, Milford T-A, Kagoda M, Morris C, and Payne KJ. "A Culture Model Supporting Growth and Survival of Primary Pre-B ALL Cells." Program, Bios, and Abstract, LLUSOM and CHDMM 2007 Health Disparities Research Symposium . (2007): 93-94. ( 8/2007 )
  • Tapanni Roni, Sam Ho, Zafer Gurel, Kimberly Payne and Sinisa Dovat. "Function of Ikaros in Human Cells is Regulated by Co-expression of its Largest Isoforms." AACR Annual Meeting 2007 Proceedings 48. (2007): 295-295. ( 4/2007 )
  • Parrish YK, Rogerio JW, Kagoda M, Sahakian E, Huang G, Baez I, and Payne KJ. "IL-7 Activity is Essential for In Vitro Human B Cell Production from Adult BM." Keystone Symposia on Molecular and Cellular Biology 2007 Abstract Book: Biology of B Cells in Health and Disease . (2007): 103-103. ( 2/2007 )
  Abstracts Reporting Research -- Non-Peer Reviewed
  • Benitez A, Kagoda M, Milford T-A, Baez I, and Payne KJ. "Evaluating Potential Differences in B Lymphocyte Subsets by Analysis of V Gene Usage," Program of the Eleventh Annual Research Symposium, Loma Linda University, p. 17. ( 9/2008 )
  • Milford TM, Parrish YK, Baez I, Rogerio JW, Sahakian E, Kagoda M, Benitez A, Huang G, and Payne KJ. "IL-7 is required for B cell development from adult human bone marrow due to decreased B lymphoid generative capacity." Program of the Eleventh Annual Research Symposium, Loma Linda University, p. 8. ( 9/2008 )
  • Benitez A, Kagoda M, Milford T-A, Baez I, and Payne KJ. "Evaluating Potential Differences in B Lymphocyte Subsets by Analysis of V Gene Usage," Program of the LLUSOM and CHDMM 2008 Health Disparities Research Symposium, p. 20. ( 8/2008 )
  • Ramirez GE, Francis OL, Baez I, Benitez A; Milford T-A, Nwosu M, Morris C , and  Payne KJ. "Can Human Stromal Cell Lines Replace Bone Marrow Stroma in Supporting Development of Human B Cells?" Program of the LLUSOM and CHDMM 2008 Health Disparities Research Symposium, p. 96. ( 8/2008 )
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