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My research interests focus on the development of state-of-the-art methodologies in mass spectrometry for understanding histone modifications, DNA modifications or damage and their roles in epigenetic modulation and regulation of gene expression. Efforts have been given in qualitative and quantitative analysis of protein covalent modifications including phosphorylation, acetylation, methylation and ubiquitylation. Currently, I am active in development of a universal mass spectrometry-based methodology to define histone modification patterns and the behaviors of their responsible enzymes and their partners in cells of cancer. The method may be useful for cancer diagnosis and facilitation of chromatin based anti-cancer drug design. I am also interested in collaboration with scientists on campus and off campus to investigate biological significances by the means of mass spectrometry and proteomics. ( 1/1998 - 7/2010 )
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