Lubo Zhang, PhD Int. Director of Center, Center for Perinatal Biology, School of Medicine School of Medicine Professor, Basic Sciences School of Medicine Member, Pharmacology, SM, Faculty of Graduate Studies

Publications 

  Scholarly Journals--Submitted

• Xiao D, Huang X, Longo LD, Zhang L. PKC regulates a1-adrenoceptor-mediated contractions and baseline Ca2+ sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to high altitude hypoxia. Am J Physiol Regul Integr Comp Physiol in revision. ( 1/2009 - 9/2009 )

• Patterson A, Zhang L. Hypoxia and fetal heart development. Reprod Sci, invited review, in revision. ( 1/2009 - 9/2009 )

• Patterson AJ, Xiao D, Chen M, Zhang L. Chronic hypoxia induces epigenetic programming of PKCe gene repression in fetal rat heart. Circ Res in revision. ( 1/2009 - 9/2009 )

• Shi L, Mao C, Xu Z, Zhang L. Angiotensin converting enzymes and drug discovery in cardiovascular diseases. Drug Discovery Toda, invited review, in revision. ( 1/2009 - 9/2009 )

• Xiao D, Longo LD, Zhang L. High altitude long-term hypoxic effect on KATP and L-type Ca2+ channel activities in uterine arteries of nonpregnant and pregnant sheep. J Apply Physiol in revision. ( 1/2009 - 9/2009 )

  Scholarly Journals--Published

• Meyer K, Zhang L. Short and long-term adverse effects of cocaine abuse during pregnancy on the heart development. Ther Adv Cardiovasc Dis, invited review 3: 7-16, 2009. ( 1/2009 - 9/2009 )

• Zhang H, Meyer K, Zhang L. Fetal cocaine exposure causes programming of Prkce gene repression in the left ventricle of adult offspring. Biol Reprod 80: 440-448, 2009. ( 1/2009 - 9/2009 )

• Mao C, Shi L, Xu F, Zhang L, Xu Z. Development of fetal brain renin-angiotensin system and its influence on programmed hypertension in fetal origins. Prog Neurobiol 87: 252-263, 2009. ( 1/2009 - 9/2009 )

• Mao C, Xiao D, Zhu L, Ding Y, Xu Z,Zhang L. The effect of fetal and neonatal nicotine exposure on renal development of AT1 and AT2 receptors. Reprod Toxicol 27: 149-154, 2009. ( 1/2009 - 9/2009 )

• Meyer K, Zhang H, Zhang L. Prenatal cocaine exposure abolished ischemic preconditioning-induced protection in adult male rat hearts: Role of PKCe. Am J Physiol Heart Circ Physiol 296: H1566-H1576, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Huang X, Xu Z, Yang S, Zhang L. Prenatal cocaine exposure differentially causes vascular dysfunction in adult offspring. Hypertension 53: 937-943, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Huang X, Yang S, Zhang L. Direct chronic effect of steroid hormones in attenuating uterine arterial myogenic tone: role of PKC/ERK1/2. Hypertension 54: 352-358, 2009. ( 1/2009 - 9/2009 )

• Chang K, Xiao D, Huang X, Longo LD, Zhang L. Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway. Am J Physiol Heart Circ Physiol. 296: H1840-H1849, 2009. ( 1/2009 - 9/2009 )

• Xue Q, Zhang L. Fetal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: Role of PKCe. J Pharmacol Exp Ther 330: 624-632, 2009. ( 1/2009 - 9/2009 )

• Guan J, Mao C, Xu F, Zhu L, Liu Y, Geng C, Zhang L, Xu Z. Low doses of nicotine-induced fetal cardiovascular responses, hypoxia, and brain cellular activation in ovine fetuses. Neurotoxicology 30: 290-297, 2009. ( 1/2009 - 9/2009 )

• Meyer K, Zhang H, Zhang L. Direct effect of cocaine on epigenetic regulation of PKCε gene repression in the fetal rat heart. J Mol Cell Cardiol 47: 504-511, 2009. ( 1/2009 - 9/2009 )

• Xu F, Mao C, Liu Y, Wu L, Xu Z, Zhang L. Losartan chemistry and its effects via AT1 mechanisms in the kidney. Current Medicinal Chemistry 16: 3701-3715, 2009. ( 1/2009 - 9/2009 )

• Xu F, Mao C, Hu Y, Rui C, Xu Z, Zhang L. Cardiovascular effects of losartan and its relevant clinical application. Current Medicinal Chemistry 16: 3841-3857, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Yang S, Zhang L. Prenatal cocaine exposure causes sex-dependent impairment in the myogenic reactivity of coronary arteries in adult offspring. Hypertension 2009 Aug 24. [Epub ahead of print]. ( 1/2009 - 9/2009 )

• Mao C, Ding Y, Zhou, Zhang H, Xu Z, Zhang L. Changes of renal AT1/AT2 receptors and structures in ovine fetuses following exposure to long-term hypoxia. Am J Nephrol, Accepted for Publication, 2009. ( 1/2009 - 9/2009 )

• Goyal R, Mittal A, Chu N, Shi L, Zhang L, Longo LD. Maturation and the role of PKC-mediated contractility in ovine cerebral arteries. Am J Physiol Heart Circ Physiol. Accepted for Publication, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Xu Z, Huang X, Longo LD, Yang S, Zhang L. Prenatal gender-related nicotine exposure increases blood pressure response to angiotensin II in adult offspring. Hypertension 51: 1239-1247, 2008. ( 8/2008 - 9/2009 )

• Xue Q, Ducsay CA, Longo LD, Zhang L. Effect of long-term high altitude hypoxia on fetal pulmonary vascular contractility. J Appl Physiol 104:1786-1792, 2008. ( 8/2008 - 9/2009 )

• Mao C, Yuan X, Zhang H, Lv J, Guan J, Miao L, Chen L, Zhang Y, Zhang L, Xu Z. The effect of prenatal nicotine on mRNA of central cholinergic markers and hematological parameters in rat fetuses. Int J Dev Neurosci 26: 467-475, 2008. ( 8/2008 - 9/2009 )

• Chang K, Zhang L. Steroid hormones and uterine vascular adaptation to pregnancy. Reprod Sci  Invited Review, 15: 336-348, 2008. ( 8/2008 - 9/2009 )

• Lv J, Mao C, Zhu L, Zhang H, Pengpeng H, Xu F, Liu Y, Zhang L, Xu Z. Effects of prenatal nicotine on expression of nicotine receptor subunits in the fetal brain. Neurotoxicology, 29: 722-726, 2008. ( 8/2008 - 9/2009 )

• Zhang L, Xiao D, Hu X. Effect of cGMP on pharmacomechanical coupling in the uterine artery. J Pharmacol Exp Ther 327: 425-431, 2008. ( 8/2008 - 9/2009 )

• Mao C, Zhang H, Xiao D, Zhu L, Ding Y, Zhang Y,  Wu L, Xu Z, Zhang L. Perinatal nicotine exposure alters AT1 and AT2 receptor expression pattern  in the brain of fetal and offspring rats. Brain Res 1243: 47-52, 2008. ( 8/2008 - 9/2009 )

• Xiao D, Zhang L. Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain. Int J Med Sci 5: 295-302, 2008. ( 9/2008 - 12/2008 )

• Zhang H, Zhang L. Role of PKC isozymes in the regulation of α1-adrenoceptor-mediated contractions in the uterine arteries.Biol Reprod, 78: 35-42, 2008. ( 9/2008 - 12/2008 )

• Lawrence J, Xiao D, Xue Q, Rejali M, Yang S, Zhang L. Prenatal nicotine exposure increases heart susceptibility to ischemia/reperfusion injury in adult offspring. J Pharmacol Exp Ther 324: 331-341, 2008. ( 9/2008 - 12/2008 )

• Zhang H, Zhang L. Regulation of a1-adrenoceptor-mediated contractions of the uterine artery by PKC: role of the thick and thin filament regulatory pathways. J Pharmacol Exp Ther, 322: 1253-1260, 2007. ( 8/2008 - 12/2008 )

• Jonker SS, Zhang L, Louey S, Giraud GD, Thornburg KL, Faber JJ. Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart. J Appl Physiol 102: 1130-1142, 2007. ( 8/2008 - 12/2008 )

• Xiao D, Huang X, Lawrence J, Yang S, Zhang L. Fetal and neonatal nicotine exposure differentially regulates vascular contractility in adult male and female offspring. J Pharmacol Exp Ther 320: 654-661, 2007. ( 8/2008 - 12/2008 )

• Xiao DL, Zhang L. High altitude and pregnancy: adaptation of the uterine artery. In “Life on the Qinghai-Tibetan Plateau: Proceedings of the 6th World Congress on Mountain Medicine and High Altitude Physiology” Chapter 4, pp238-245, Peking University Medical Press, 2007. ( 8/2008 - 12/2008 )

• Zhang H, Darwanto A, Linkhart T, Sowers LC, Zhang L. Maternal cocaine administration causes an epigenetic modification of PKCe gene expression in fetal rat heart. Mol Pharmacol 71: 1319-1328, 2007. ( 8/2008 - 12/2008 )

• Xiao D, Huang XH, Yang S, Zhang L. Direct effects of nicotine on the contractility of the uterine artery in pregnancy. J Pharmacol Exp Ther 322: 180-185, 2007. ( 8/2008 - 12/2008 )

• Charles SM, Zhang L, Longo LD, Buchholz JN, Pearce WJ. Maturation alters calcium dependent sensitivity of pressure dependent cerebrovascular myogenic tone. Am J Physiol Regul Integr Comp Physiol 293: R737-R744, 2007. ( 8/2008 - 12/2008 )

• Meyer K, Zhang L. Fetal programming of cardiac function and disease. Reprod Sci, invited review, 14: 209-216, 2007. ( 8/2008 - 12/2008 )