Lubo Zhang, PhD Int. Director of Center, Center for Perinatal Biology, School of Medicine School of Medicine Professor, Basic Sciences School of Medicine Member, Pharmacology, SM, Faculty of Graduate Studies

Research & Grantsmanship 

  Funded Research Project (PI)

• P01 HD31226    Zhang (PI-Project V)   NIH/NICHHD   Fetal and Adult Adaptations to Long-Term Hypoxia  Project V: Uterine Vascular Adaptation to Long-Term Hypoxemia.  The objective of this project is to determine the mechanisms whereby chronic hypoxia alters uterine vascular contractility in response to stress hormones. ( 9/2008 - 9/2009 )

• P01 HD31226     Zhang (Co-PI-Administrative Core)    NIH/NICHHD  Fetal and Adult Adaptations to Long-Term Hypoxia ( 9/2008 - 9/2009 )

• R01 HL82779     Zhang (PI)    NIH/NHLBI     Prenatal Cocaine Exposure and Cardiac Programming.   To explore the epigenetic mechanisms whereby prenatal cocaine exposure programs gene expression pattern in the fetal heart and its lifelong pathophysiological consequences in adult offspring ( 9/2008 - 9/2009 )

• R01 HL82779-02S1   Zhang (PI)     NIH/NHLBI     Prenatal Cocaine Exposure and Cardiac Programming.     To explore the epigenetic mechanisms whereby prenatal cocaine exposure programs gene expression pattern in the fetal heart and its lifelong pathophysiological consequences in adult offspring. ( 9/2008 - 9/2009 )

• R01 HL83966     Zhang (PI)     NIH/NHLBI     Maternal Hypoxia and Programming of Fetal Heart.     The objective of this project is to determine the molecular mechanisms whereby prenatal hypoxia increases cardiac vulnerability to ischemia and reperfusion injury in adult life. ( 9/2008 - 9/2009 )

• R01 HL89012     Zhang (PI)     Steroid Hormones and Uterine Vascular Adaptation to Pregnancy.     To explore the mechanisms whereby steroid hormones regulate uterine artery contractility during pregnancy. ( 9/2008 - 9/2009 )

  Funded Research Project (CI)

• P01 HD31226     Longo (Project II PI)/Zhang (Ptoject II CI)     NIH/NICHD     Fetal and Adult Adaptations to Long-Term Hypoxia  Project II:  Cerebrovascular Adrenergic Receptor and Second Messenger Adaptation to Long-Term Hypoxia  ( 9/2008 - 9/2009 )

• R01 HL90920     Xu (PI)/Zhang (CI)     NIH/NHLBI     High Salt in Pregnancy and Vascular Development     ( 9/2008 - 9/2009 )

• 18KT-0024     Xiao (PI)/Zhang (CI)      UC Tobacco-Related Disease Research Program     Prenatal Nicotine Exposure and Vascular Programming ( 9/2008 - 9/2009 )

• National Science Foundation     Wilson (PI)      MRI: Acquisition of a Multiphoton Confocal Microscope for Research, Training and Teaching ( 9/2008 - 9/2009 )

• S06GM073842     Yang (PI, CSUSB)/Zhang (consultant)     NIH     Nicotine and Endothelial Dysfunction ( 9/2008 - 9/2009 )

• 1R24DA025319     Yang (PI, CSUSB)/Zhang (consultant)     NIH     CSUSB Minority Drug Abuse Research Program ( 9/2008 - 9/2009 )

• R01 NS060936     Tang (PI)/Zhang (consultant)     NIH     Mechanisms of G-CSF-Induced Neuroprotection ( 9/2008 - 9/2009 )

  Non-Funded Research Project

• Zhang (PI)    Prenatal Nicotine Exposure and Epigenetic Programming of Gene Expression Pattern in the Heart ( 9/2008 - 9/2009 )

  Abstracts Reporting Research -- Non-Peer Reviewed

• Xiao D, Xu Z, Zhang L. Translational up-regulation of Bax and Bcl-2 following cocaine exposure induces apoptosis in fetal rat brain. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Zhang L, Xiao D, Hu X. cGMP inhibits pharmacomechanical coupling in the uterine artery of near-term pregnant sheep. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Zhang H, Meyer KD, Zhang L. Prenatal cocaine exposure and PKCe gene repression in the heart of adult offspring. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Meyer KD, Zhang H, Zhang L. PKCe plays a key role in cocaine-mediated programming of heart ischemic vulnerability in adult offspring. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Xue Q, Zhang L. Gender dichotomy of hypoxia-mediated programming of heart ischemic vulnerability in adult offspring. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Chen M, Zhang H, Xue Q, Zhang L. Fetal hypoxia programs DNA methylation and PKCε gene expression pattern in the heart of adult offspring. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Chang K, Xiao D, Zhang L. Chronic hypoxia increases PKC-mediated contractions of the uterine artery in pregnant sheep.56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Mao C, Wu J, Xiao D, Zhu L, Ding Y, Xu Z, Zhang L. Altered patterns of angiotensin receptor expression in the fetal and offspring brain. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Mao C, Xiao D, Ding Y, Xu Z, Zhang L. Renal AT1 and AT2 receptors affected by perinatal exposure to nicotine. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Feng X, Wu J, Lv J, Guan J, Xu Z, Zhang L. Expression of nicotine receptor subunits affected by prenatal nicotine in the fetal brain. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Mao C, Zhang Y, Liu Y, Zhu L, Wang A, Zhang L, Xu Z. Influence of maternal use of herb medicine danshen on ovine fetuses in utero. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Wu J, Yuan X, Li H, Chen L, Zhang L, Xu Z. Central cholinergic system in fetal rats affected by prenatal exposure to nicotine. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Huang X, Yang S, Zhang L. Sex hormones differentially regulate PKC-mediated uterine artery contractility. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Zhang L. Pregnancy up-regulates ERK signaling pathway in uterine artery: the role of estrogen and progesterone. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Huang X, Xiao D, Zhang L. Adaptation of uterine vascular ERK/PKC signaling pathway to high altitude hypoxia during pregnancy. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Huang X, Yang S, Zhang L. Prenatal cocaine exposure differentially causes vascular dysfunction in adult offspring. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Xue Q, Zhang L. Hypoxia exposure differentially down-regulates PKCε gene expression in developmental fetal heart. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Xiao D, Huang X, Xu Z, Zhang L. Prenatal nicotine exposure differentially regulates angiotensin II receptor protein and mRNA levels in aorta of adult male and female offspring. 56th Annual Meeting of the Society for Gynecological Investigation, Glasgow, Scotland, March 17-21, 2009. ( 1/2009 - 9/2009 )

• Monau TR, Vargas VE, Kaushal KM, Yellon SM, Zhang L, Ducsay CA. Nitric oxide inhibits ACTH induced cortisol production in the long term hypoxic sheep fetus. 55 Annual Meeting of the Society for Gynecological Investigation, San Diego, CA, March 26-29, 2008. Reproductive Sciences 15:75A, 2008. ( 9/2008 - 12/2008 )

• Meyer KD, Zhang L. Effect of cocaine and norepinephrine on protein kinase C-e expression in fetal cardiomyocytes. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Xue Q, Zhang L. Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the female adult rat. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Xue Q, Ducsay CA, Longo LD, Zhang L. Effect of long-term high altitude hypoxia on fetal pulmonary vascular contractility. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Xiao D, Yang S, Zhang L. Gender-dependent effect of prenatal cocaine exposure on coronary artery myogenic tone of adult offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Xiao D, Huang X, Yang S, Zhang L. Prenatal cocaine exposure differentially regulates vascular contractility in adult male and female offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Xiao D, Xu Z, Mao CP, Longo LD, Zhang L. Prenatal nicotine exposure causes a gender-related increase in angiotensin II-induced blood pressure elevation in adult offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Xiao D, Huang X, Xu Z, Yang S, Zhang L. Prenatal nicotine exposure caused a gender-related increase in vascular contractions to angiotensin II in adult male offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Xu Z, Xiao D, Mao C, Huang X, Zhang H, Zhang L. Prenatal nicotine alters AT1/AT2 receptor expression in heart and kidney of neonate offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Mao C, Xu Z, Xiao D, Zhang L. Effect of fetal nicotine exposure on central AT1/AT2 receptor mRNA and protein levels in neonate offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Zhang H, Zhang L. Fetal cocaine exposure causes a gender-related down-regulation of cardiac PKCe expression in offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Zhang H, Zhang L. Prenatal Cocaine treatment causes DNA methylation and down-regulation of PKCe gene expression in the heart of adult male offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Patterson A, Zhang L. Chronic hypoxia differentially regulates PKCe and PKCd protein expression in H9c2 cells. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Xiao, D., Chang, K., Zhang, L. Role of sex steroid hormones in the regulation of uterine artery myogenic tone during pregnancy in high-altitude ewes. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Chang K, Xiao D, Zhang L. Role of sex steroid hormones in the regulation of PKC-mediated uterine artery contractions during pregnancy in high-altitude ewes. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 9/2008 - 12/2008 )

• Yang S, Xiao D, Zhang L. Role of sex steroid hormones and ERK1/2 in pregnancy-suppressed uterine artery myogenic tone. SSR 2008, Kona, Hawaii, May 27-31, 2008. ( 9/2008 - 12/2008 )

• Tong W, Chen W, Zhang L, Ostrowski R, Zhang JH, Tang J. Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats. Neuroscience Meeting, 2008. ( 9/2008 - 12/2008 )

• Zhang L, Xiao D, Yang S. Prenatal cocaine exposure increases vascular contractility of resistance-sized mesenteric arteries in adult male offspring. The Beijing Joint Conference of Physiological Sciences 2008, October 19-22, 2008. ( 9/2008 - 12/2008 )

• Yang S, Gutierrez D, Zhang L. Nicotine inhibits nitric oxide synthase by competing for the BH4 binding site. The Beijing Joint Conference of Physiological Sciences 2008, October 19-22, 2008. ( 9/2008 - 12/2008 )

• Shelton C, Zhang L, Longo LD, Pearce WJ, Buchholz JN. Generation of myogenic tone requires release of Ca2+ in rat cerebral arteries. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Rejali M, Lawrence J, Xiao D, Zhang L, Yang S. Prenatal nicotine exposure differentially regulates coronary nitric oxide release in male and female adult offspring. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Rejali AR, Rejali M, Zhang L, Yang S. Effect of nicotine on intracellular Ca2+ concentrations and nitric oxide release in coronary artery endothelial cells. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Xiao D, Lawrence J, Yang S, Zhang L. Effect of prenatal nicotine exposure on coronary flow in adult offspring: a gender dichotomy. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Xiao D, Huang X, Lawrence J, Yang S, Zhang L. Fetal and neonatal nicotine exposure alters vascular contractility in adult offspring. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Xiao D, Lawrence J, Yang S, Zhang L. Effect of prenatal nicotine exposure on heart susceptibility to ischemia/reperfusion injury in adult male and female offspring. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Xiao D, Huang X, Zhang L. Effect of nicotine on uterine artery contractility. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Zhang H, Zhang L. Role of the AP-1 binding site in regulating PKCe promoter activity in the fetal heart. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Xue Q, Ducsay CA, Longo LD, Zhang L. Effect of chronic hypoxia on fetal pulmonary vascular contractility. EB2007, Washington DC, April 28- May 2, 2007. ( 7/2008 - 8/2008 )

• Yang S, Xue Q, Zhang L. Effect of prenatal nicotine exposure on caspase and PKC isozyme levels in adult heart. 32nd annual FEBS Congress, Vienna, Austria, July 7-12, 2007. ( 7/2008 - 8/2008 )

• Zhang L, Xiao D, Yang S. Prenatal cocaine exposure alters coronary artery reactivity in adult offspring. 32nd annual FEBS Congress, Vienna, Austria, July 7-12, 2007. ( 7/2008 - 8/2008 )

• Charles SM, Zhang L, Longo LD, Pearce WJ, Buchholz JN. Myogenic tone in juvenile rat MCA is resistant to blockade of calcium influx and release of intracellular calcium. EB2008, San Diego, CA, April 5-9, 2008. ( 7/2008 - 8/2008 )

• Lawrence J, Xiao D, Yang S, Zhang L. Maternal transient food restriction results in improved cardiac recovery from ischemia/reperfusion injury in male adult offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 7/2008 - 8/2008 )

• Lawrence J, Xiao D, Xue Q, Rejali M, Yang S, Zhang L. Prenatal nicotine exposure results in reduced cardiac recovery from ischemia/reperfusion injury in adult offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 7/2008 - 8/2008 )

• Meyer KD, Zhang L. Fetal cocaine exposure abolishes cardiac ischemic preconditioning-induced protection in adult offspring. 51th Annual Meeting of the Western Pharmacology Society, Kona, Hawaii, January 27-31, 2008. ( 7/2008 - 8/2008 )