Marino De Leon, PhD Professor, Basic Sciences School of Medicine

Presentations 

  Research Presentations -- International

• A Padilla,A.L.K Almeyda, K. Payne, M. De León,Characterization of Palmitic acid induced lipotoxicity and lipoapoptosis in Schwann cells. Keystone Symposium: Cell Death Pathways. Vancouver, Canada (2010). ( 3/2010 )

• P.W. Baron, R. Ben-Youssef, O.Ojogho, J. Weissman, E. Franco, A. Kore, J. Limjoco, De León, M, Zaida Cordero-MacIntyre.Immunosuppressive drugs and new onset diabetes mellitus after kidney transplantation in recipients of Hispanic origin. XXII International Congress of The Transplantation Society 2008. Sidney, Australia. Transplantation ( Jourmal of the Transplantation Society) July 27. 2008. Vol. 86.Number 28. pg.319 (Supplement). ( 7/2008 )

• Ramzi Ben-Youssef, MD, Okechukwu Ojogho, MD, Edson Franco, MD, Jill Weissman, PharmD, Waheed Baqai, MPH, Arputharaj Kore, MD, Marino De Leon, PhD, Zaida Cordero-MacIntyre, PhD, and Pedro W. Baron, MD. Immunosuppressive drugs and new onset diabetes mellitus after kidney transplantation in recipients of Hispanic origin. Paper to be presented at the 22nd International Congress o the Transplantation Society, August 10-14, Sydney, Australia, 2008. ( 7/2008 )

• P.W. Baron, R. Ben-Youssef,, E. Franco, J. Weissman, W.Baqai, A. Kore, Marino DeLeon, Zaida Cordero-MacIntyre and O. Ojogho. New Onset Post-transplant Diabetes in Hispanic Kidney Transplant Recipients. XXII International Congress of The Transplantation Society 2008. Sidney, Australia. Transplantation (Jourmal of the Transplantation Society) July 27. 2008. Vol. 86.Number 28. pg.372 (Supplement). ( 7/2008 )

  Research Presentations -- National

• Lorena Salto, Lawrence Beeson, Marino De León, Zaida Cordero-MacIntyre. En Balance Program Successfully Lowers Fasting Blood Glucose, HbA1c and Other Blood Serum Parameters in a Hispanic Population. Experimental Biology 2010, Anaheim, CA. ( 7/2010 )

• Michael Batech, MPH1, W. Lawrence Beeson, , Eloy Schultz, Lorena Salto, Anthony Firek,, Marino De León, Hector Balcazar, Zaida Cordero-MacIntyre. Comparison of Body Composition by Bioelectrical Impedance Analysis and Dual-Energy X-Ray Absorptiometry in Hispanic Diabetics. Experimental Biology 2010, Anaheim, CA. ( 7/2010 )

• Emmanuel Ojo, Ihuoma Chukwueke, Lawrence Beeson1, Eloy Shulz, Anthony Firek, De León, Marino, Hector Balcazar, Zaida Cordero-MacIntyre. Association of bone mineral density (BMD), bone mineral content (BMC) and serum lipids in Hispanics with type 2 diabetes. Experimental Biology 2010, Anaheim, CA. ( 7/2010 )

• Lorena Salto, Lawrence Beeson, De León, M, Zaida Cordero-MacIntyre. Improved Type 2 Diabetes Control Outcomes as a Result of a Culturally-appropriate Diabetes Education Program. Experimental Biology 2009, New Orleans, LA. ( 11/2009 )

• Michael Batech, Gina Wheeler, Lawrence Beeson, ,Hector Balcazar, Marino De León, Zaida Cordero-MacIntyre. Effect of a Spanish Diabetes Education on Physical Activity Changes and Diabetes Control. Experimental Bioliogy 2009. New Orleans, LA. ( 7/2009 )

• Mendler, Michel H., Schulz Eloy, Beeson, Larry, Salto Lorena, Poynard, Thierry, Munteanu Mona, Firek, Anthony, Marino De León, Cordero-MacIntyre Zaida “En Balance” a 3-month comprehensive diabetes education program for Latinos with type 2 diabetes leads to significant improvements in SteatoTest® and NashTest® and is associated with clinical and biochemical indices of decreased insulin resistance. American Association for the Study of Liver Disease. AASLD. Boston, MA 2009. ( 7/2009 )

• A  Padilla, A.L.K. Almeyda, L.S.  Leoh, K. Payne, M. De León, Characterization of Palmitic Acid-induced Lipotoxicity in Immortalized Schwann Cells. Society for Neuroscience, Chicago, Ill (2009). ( 6/2009 )

• A Padilla, M. De León. Characterization of Palmitic acid-induced lipotoxicity on immortalized Schwann cells. American Society for Neurochemistry, San Antonio, Texas (2008). ( 10/2008 )

• Riggs ML, Carlos A. Casiano , Daisy D Deleon and Marino De Leon. Building research self- efficacy to facilitate Research Performance. Second Annual Conference On Understanding Interventions that encourage Minorities to Pursue Research Careers, May 2-4, Atlanta, Georgia, 2008. ( 7/2008 )

• Figueroa JD, Bu Liming, Miranda JD and Marino De Leon. Novel Roles of Fatty Acid binding Protein 5 in the Injured Spinal Cord. Neuroscience 2008, November 15-19, Washington DC. ( 7/2008 )

• Amelia Padilla, Audra L Almeyda, Kimberly Payne and Marino De Leon. Characterization of Palmitic Acid-induced Lipotoxicity in Immortalized Schwann Cells. 2008 Society For Neuroscience Meeting, November 15-19, Washington DC. ( 7/2008 )

• Liming Bu and Marino De Leon. Epithelial Fatty Acid Biniding Protein (E-FABP) is an Endogenous Antioxidant in PC12 Cells Under Oxidative Stress.2008. Society For Neuroscience Meeting, November 15-19, Washington DC. ( 7/2008 )

• Liming Bu, Kevin De Leon, Zaida Cordero-MacIntyere and Marino De Leon. E-FABP Polymorphisms are Associated with Non-Insulin Dependent Diabetes in African American and Caucasian Polulations, but Not in Latino Population. NIH Summit: The Science of Eliminating Health Disparities, National Center On Minority Health and Health Disparities, Washington DC, December 16-18, 2008. ( 7/2008 )

• Sharda Vyas, Frankis Almaguel, Marino De Leon, and Daisy D De León. 2008. A Link to Breast Cancer Survival Disparity among African American Women: IGF-II Regulates Mitochondria to Prevent Apoptosis and Promote Chemoresistance. AACR Annual Meeting. April 2008. San Diego, CA. ( 7/2008 )

• Lorena Salto1, Lawrence Beeson3, Marino DeLeon1, Zaida Cordero-MacIntyre. Effect of a Spanish Diabetes Education on Dietary Changes and Diabetes Control.  Experimental Biology 2008, San Diego, CA. FASEB Journal. ( 7/2008 )

• Emmanuel Ojo, Lawrence Beeson, Marino DeLeon, Zaida Cordero-MacIntyre. Effect of a culturally and language-sensitive diabetes education on dietary changes and plasma lipid profile in Hispanic diabetics. Experimental Biology 2008, San Diego, CA FASEB Journal. ( 7/2008 )

• Pedro W. Baron, Ramzi Ben-Youssef, Edson Franco, Jill Weissman, Waheed Baqai, Arputharaj Kore, Marino De Leon, PhD, Zaida Cordero-MacIntyre, and Okechukwu Ojogho. New onset posttransplant diabetes in Hispanic kidney transplant recipients. Paper to be presented at the 22nd International Congress of the  Transplantation Society, August 10-14, Sydney, Australia, 2008. ( 7/2008 )

• A Padilla, A.L.K. Almeyda, K. Payne and M. De León. Characterization of Palmitic Acid-induced Lipotoxicity in Immortalized Schwann Cells. Society for Neuroscience, Washington, DC (2008). ( 6/2008 )

• Almaguel FG, Liu J-W and De Leon M. Cellular pathways in Fatty acid Induction of Apoptotic Cell Death. Society For Neuroscience, Washington DC, Program No. 900.4, 2008. ( 7/2007 )

• Liming B, Montero, M and Marino De Leon. Epithelial Fatty Acid Binding Protein (E-FABP) is and endogenous antioxidant in PC12 Cells Under Oxidative Stress. Paper presented at the 40th Annual Meeting of the American Society for Neurochemistry, San Antonio, Texas. ( 7/2007 )

• Sharda Vyas, Frankis Almaguel, Marino De León and Daisy D De León. 2007. A Link to Breast Cancer Survival Disparity among African American Women: IGF-II Regulates Mitochondria to Prevent Apoptosis and Promote Chemoresistance. AACR Health Disparities Meeting. December 2007. Atlanta Georgia. ( 7/2007 )

• A Padilla, M. De León.Characterization of Palmitic acid-induced lipotoxicity on immortalized Schwann cells. Society for Neuroscience, San Diego, CA (2007). ( 6/2007 )

• A. Padilla, M. De León.Effects of Levels of Free Fatty Acid on Schwann cell Survival. American Diabetes Association 67th Annual Meeting, Chicago, ILL (2007). ( 6/2007 )

• Marino De Leon. "Augmented State of Cellular Oxidative Stress (ASCOS) and Health Disparities Diseases." LLUAHSC Strategic Directions for LLUAHSC Research. Temecula, CA ( 1/2007 )

• Almaguel, FG, Liu J-W and De Leon M. Saturated Fatty acid-induced apoptotic Cell death in Nerve Growth Factor Differentiated PC12 Cells. Journal of Neurochemistry 94(Suppl. 2):174, 2005. ( 7/2005 )

• Marino De Leon. "The biology of Fatty acids and Stroke." Oakwood College Science Club. Huntsville, Alabama ( 4/2005 )

• Marino De Leon. "Function of fatty acids and epidermal fatty acid binding protein during neuronal injury." Public seminar at the University of California, Riverside. Riverside, California ( 7/2004 )

• Almaguel, F., Liu J-W and Marino De Leon. Palmitic acid-induced cell death in nerve growth factor differentiated PC12 cells involves up-regulation of FAS-R, FAS-L and pro-apoptotic BNIP3 mRNA. Paper presented at the 5th International Cell Death Symposium on “The Mechanism of Cell Death”, Maynooth, Ireland, 2004. ( 7/2004 )

• Ulloth E J, Figuereo S, Colohan RT, De Leon M. Palmitic and Stearic Acids Induced Neuronal Fas receptor-ligand mediated Apoptosis. 2003. 51st Annual Congress of Neurological Surgeons, San Diego, California. ( 7/2003 )

• Figuereo SJ, De Leon M, Liu JW, Colohan ART: Secondary Brain Injury: Potential Role for the Glucose-Fatty Acid Cycle of Randle. J Neurosurgery 98(3): 695, 2003. ( 7/2003 )

• Santiago Figuereo, Joel Ulloth, Colahan A and Marino De Leon. Palmitic and Stearic Acid induce Neuronal Fas Receptor-Ligand Mediated Apoptosis. Paper Presented in the American Society for neurosurgeons Meeting, Philadelphia, PA.           ( 7/2003 )

• Jo-Wen Liu and Marino De Leon. Effects of Epidermal fatty acid binding protein (EFABP) in differentiating PC12 cells. Paper presented in the 35th Annual Meeting of  the American Society for Neurochemistry, May 5-9, Newport Beach, CA. 2003. ( 7/2003 )

• Ying Nie, Jo-Wen Liu, Marino De Leon, Daisy D. De León. 2002. Humanepidermal-type fatty acid-binding protein as a breast tumor suppressor. 93rd Annual Meeting of  American Association for Cancer Research, San Francisco, California ( 7/2002 )

• Ulloth J, Figuereo SJ, Colohan ART, De Leon M: Palmitic and Stearic Acids induced Neuronal Fas receptor-ligand mediated Apoptosis. Congress of Neurological Surgeons Annual Meeting, San Diego CA, September 2002. ( 7/2002 )

• G.W. Allen, M.A. Kirby, J-W. Liu, M. De León. A novel fatty acid-binding protein (E-FABP) expressed in rat retinal ganglion cells during development and regeneration. Presented at the Association for Vision and Research in Ophthalmology (ARVO), Fort Lauderdale, FL. 2001 ( 7/2001 )

• Ulloth J and Marino De León. Fatty acids mediated apoptosis in PC-12 cells is mediated through the activation caspase 8. Presented at the 40Th Annual meeting of the  American Society For Cell Biology, San Francisco, California. 2001. ( 7/2001 )

• Allen, GW, J-W Liu, Kirby, MA, De Leon M. E-FABP expression and localization in developing rat retina and dissociated retinal culture. Society For Neuroscience Abstract 26(1): 835. 2000. ( 7/2000 )

• Pakianathan, S M De Leon and LD Longo. Differential Gene Expression in Neonatal rat brain. 46th Annual Meeting Society for Gynecological Investigation, Atlanta, GA. 1999. ( 7/1999 )

• Allen W Gregory, Jo-Wen Liu and Marino De Leon. A novel fatty acid Binding protein is up- regulated in PC12 cells by nerve growth factor. J Neurochemistry 70(1): S33. 1998. ( 7/1998 )

• De Leon Marino. Regulation of the expression of a fatty acid binding protein during the development of the central nervous system. NIHCHD special meeting entitled: Scientist, Tools and Research for the 21st century, 1998. ( 7/1998 )

• Liu J-W, GW Allen and Marino De Leon. A fatty acid binding protein is required for NGF-mediated neurite outgrowth in PC12 cells. Paper presented at the “Acute Neuronal Injury: New Therapeutic opportunities” meeting, Las Vegas, Nevada, 1998. ( 7/1998 )

• Ulloth J E and Marino De Leon. Fatty acids induce apoptosis in PC12 cells. American Society for Cell Biology Annual meeting, San Francisco, California, 1998. ( 7/1998 )

• Ulloth JE and Marino De León. The effects of free fatty acid exposure on PC12 cells. 28th Annual meeting of the Society For Neuroscience, Los Angeles, CA, 1998. ( 7/1998 )

• Allen GW, Liu J-W and Marino De Leon. A fatty acid binding protein is required for NGF-mediated neurite outgrowth in PC12 cells. 28th Annual meeting of the Society For Neuroscience, Los Angeles, CA, 1998. ( 7/1998 )

• S. Pakianathan, LD Longo and Marino De Leon. Novel Hypoxia-Ischemia-associated gene sequences in neonatal rat brain using differential display. 28th Annual meeting of the Society For Neuroscience, Los Angeles, CA, 1998. ( 7/1998 )

• Allen W Gregory, Jo-Wen Liu and Marino De Leon. A novel fatty acid Binding protein is up- regulated in PC12 cells by nerve growth factor. J Neurochemistry 70 (1): S33. 1998 ( 7/1998 )

• Yi Liu, CA Molina, LD Longo and De León M. A novel growth and differentiation regulated fatty acid binding protein in developing rat central nervous system. Society for gynecological investigation 4:241. 1997. ( 7/1997 )

• S Packianathan, LD Longo, M De León. Identification of novel hypoxia-ischemia associated gene sequences in neonatal brain using differential display. Society For Neuroscience Abstracts 23 (2): 2180. 1997. ( 7/1997 )

• Allen W Gregory, Jo-wen Liu and Marino De Leon. A novel Fatty acid binding protein is up-regulated in PC12 cells by nerve growth factor. Fifth International Symposium on Neuronal Regeneration, Asilomar, California. 1997. ( 7/1997 )

• Allen W Gregory, Jo-Wen Liu and Marino De Leon. DA11. A novel neuronal fatty acid binding protein is up-regulated by nerve growth factor. National M.D./Ph.D. Conference, Aspen, Colorado, 1997. ( 7/1997 )

• CA Molina, Y Liu, AA Welcher, De León M. Differential regulation of a novel FABP    (DA11) in axotomized neurons following sciatic nerve crush. Society for Neuroscience Abstract 22:575. 1996. ( 7/1996 )

• Y. Liu, CA Molina, M Kirby, LD Longo and De León M. Comparison of the expression of a novel FABP in developing and adult rat central nervous system. Society for Neuroscience Abstract 22:1019. 1996. ( 7/1996 )

• Molina CA, Welcher AA, De Leon M. The Expression and localization of a fatty acid lipid binding protein (FABP) in the rat dorsal root ganglia after sciatic nerve transection. Society for Neuroscience Abstract 21:1073. 1995. ( 7/1995 )

• Y Liu, CA Molina, AA Welcher, De León M. The expression of a novel FABP (DA11) in rat CNS during development. Society for Neuroscience Abstract 21: 1073.1995. ( 7/1995 )

• De León, M., Nahin, R.L., Liu Yi, Welcher, A.A., Shooter, E.M., Ruda, M.A. The cloning and characterization of a cDNA associated with neuronal injury and sciatic nerve regeneration in the rat. Society for Neuroscience Abstract, 1994. ( 7/1994 )

• Haney, C.A., De León, M., Quarles, R.H. and Trapp, B.D. Ultrastructural distribution of PMP-22 in rat peripheral nerve. Paper presented in the American Association for Neurochemistry meeting, 1993. ( 7/1993 )

• Verity, A.N., De León M., Suter, U., Welcher, A.A., Shooter, E.M. Expression of a novel cDNA in the rat sciatic nerve. in: Fifth International Symposium on Neuronal Regeneration, 1993. ( 7/1993 )

• Nahin, R.L., De León, M. and Ruda, M.A. Gap 43 response to nerve injury and peripheral inflammation. Society for Neuroscience Abstract 17(1):1312, 1993. ( 7/1993 )

• Noguchi, K., De León, M., Nahin, R.L., and Ruda, M.A. Differential effect of peripheral nerve axotomy on neuropeptide gene expression in the dorsal root ganglia. VIth World Congress on Pain, 1992. ( 7/1993 )

• De León, M., Nahin, R.H., Molina C Allen, B. and Ruda, M.A. Analysis of c-jun mRNA and protein in dorsal root ganglia after sciatic nerve transection. Society for Neuroscience Abstract 18(1): 427, 1992. ( 7/1992 )

• Divish, M.M., De León, M., Nahin, R.L., and Ruda, M.A. Analysis of the RNA levels of SR13 (GAS-3) in rat spinal cord after sciatic nerve transection and complete Freund''''s Adjuvant (CFA)-induced inflammation. Society for Neuroscience Abstract 17(1):562, 1991. ( 7/1991 )

• De León, M., Welcher, A.A., Suter, U., Ruda. M.A. and Shooter, E.M. Identification of genes transcriptionally regulated after sciatic nerve crush. Society for Neuroscience Abstract 17(1):562, 1991. ( 7/1991 )

• Suter, U., Welcher, A.A., De León, M., Snipes, G.J. and Shooter, E.M. A novel myelin protein is encoded by the homologue of a growth arrest specific gene. Society for Neuroscience Abstract 17(2):552, 1991. ( 7/1991 )

• Welcher, A.A., De León, M., Suter, U. and Shooter, E.M. Isolation of genes whose expression is regulated during rat sciatic nerve regeneration. VA/PVA/NIH/APA Third International Symposium on Neural Regeneration, 1989. Pacific Grove, CA. ( 7/1989 )

• De León, M., Masiakowski, P., and Shooter, E.M. Analysis of the induction of the genes of two putative calcium binding proteins during sciatic nerve regeneration. Society for Neuroscience Abstract 14(2): 805, 1988. ( 7/1988 )

• Carlsen, R.C., De León, M., Tetzlaff, W., Swedberg, E., Parhad, I., and Bisby, M.A. Expression of tubulin mRNA is increased by cAMP in vitro. Federation Proceedings 46(3):964, 1987. ( 7/1987 )

• De León, M., and Carlsen, R.C. Changes in glycoprotein synthesis and axonal transport in regenerating and non-regenerating axotomized peripheral neurons. International Symposium on Neuronal Regeneration. F.J. Seil, Ed., Vet. Adm. p. 35, 1985. ( 7/1985 )

• Carlsen, R.C., Redshaw, J.D., De León, M. and Bisby, M.A. Changes in fast transported proteins in injured peripheral neurons in the absence of a cell body response. International Symposium on Neural Regeneration. F.J. Seil, Ed., Vet. Adm. p. 36, 1985. ( 7/1985 )

• Carlsen, R.C. and De León, M. Time to initiation of axonal transport is decreased following axotomy. Transactions of the American Society for Neurochemistry 15(1):248, 1984. ( 7/1984 )

• De León, M. and Carlsen, R.C. Effect of forskolin on neuronal protein synthesis and transport in frog. Society Neuroscience Abstract 10(1): 354, 1984. ( 7/1984 )

• De León, M. and Carlsen, R.C. The synthesis and axonal transport of glycoproteins in axotomized frogs neurons from animal maintained at 15oC and 25oC. Society Neuroscience Abstract 9(1):49, 1983.     ( 7/1983 )

• De León, M., and de Motta, G.E. Possible mechanism of the irreversible effect of formamide in frog skeletal muscle. Paper presented in the 9th Annual MBRS Symposium, sponsored by NIH, NIGMS San Louis, Missouri, 1979. ( 7/1979 )

  Research Presentations -- Local/Campus

• A Padilla, A.L.K. Almeyda, K. Payne, M. De León, PA induced Lipotoxicity on Schwann cells. LLU-NIH Annual Health Disparities Research Symposium. Loma Linda University, Loma Linda, CA (2009). ( 8/2009 )

• M Serrano-Illian, A. Padilla, M .De León.Myelin proteins and palmitic acid-induced lipotocicity in immortalized schwann cells. LLU-NIH Annual Health Disparities Research Symposium. Loma Linda University, Loma Linda, CA (2009). ( 8/2009 )

• H Haj, A. Padilla, M. De León.The Role of Increased Intracellular calcium concentration in Palmitic Acid-Induced Lipotoxicity in Immortalized Schwann cells. LLU-NIH Annual Health Disparities Research Symposium. Loma Linda University, Loma Linda, CA (2009). ( 8/2009 )

• L Barcelo, A. Padilla, J.W. Liu, M. De León. Effects of palmitic acid lipotoxicity on ER stress genes in an immortalized Schwann cell clone. LLU-NIH Annual Health Disparities Research Symposium. Loma Linda University, Loma Linda, CA (2008). ( 8/2008 )

• A Padilla, M. De León, Palmitic acid-induced lipotoxicity on immortalized Schwann cells. LLU-NIH Annual Health Disparities Research Symposium. Loma Linda University, Loma Linda, CA (2008). ( 8/2008 )

• A.L.K. Almeyda, A. Padilla, M. De León.Effects of Lipotoxicity and Oxidative Stress on PMP22 Expression Levels in Schwann cells. LLU-NIH Annual Health Disparities Research Symposium. Loma Linda University, Loma Linda, CA (2007). ( 8/2007 )

• J. Perez, M. Mediavilla-Varela, A. Padilla, F. Almaguel, M.B. Lilly, M. De León, and C. Casiano. Characterization of the caspase- independent cell death induced by docetaxel in PC3 cells. LLU-NIH Annual Health Disparities Research Symposium. Loma Linda University, Loma Linda, CA (2007). ( 8/2007 )

• A. Padilla, M, De León.The Effects of Levels of Free Fatty Acid on Schwann cell Survival. LLU-NIH Annual Health Disparities Research Symposium. Loma Linda University, Loma Linda, CA (2007). ( 8/2007 )