Marino De Leon, PhD Professor, Basic Sciences School of Medicine

Publications 

  Scholarly Journals--Published

• A Padilla, LK Almeyda, Magda Descorbeth, K Payne and M De Leon. Hyperglycemia magnifies palmitic acid-induced lipotoxicity in Schwann cells cultures.Brain Research.In press ( 11/2010 )

• Basu A, Banerjee H, Rojas H, Martinez S, Roy S, Jia Z, De León, M, Lilly MB and Casiano CA. Peroxiredoxin expression in prostate cancer: consistent upregulation of PRDX3 and PRDX4. Prostate. In press  ( 8/2010 )

• Beeson W. Larry, Batech Michael, Schultz Eloy, Salto Lorena, Firek Anthony, De León, M, Balcazar Hector, Cordero-MacIntyre Zaida. Comparison of Body Composition by Bioelectrical Impedance Analysis and Dual-Energy X-Ray Absorptiometry in Hispanic Diabetics,  International Journal of Body Composition Research, 8/ 45-50/ 2010. ( 6/2010 )

• Kalla Singh S, Tan QW, Brito C, De León M, Garberoglio C, De León D. Differential insulin-like growth factor II (IGF-II) expression: A potential role for breast cancer survival disparity. Growth Hormone and IGF Research 20:162-70, 2010. ( 6/2010 )

• Almaguel, FG., Liu, J-W., Pacheco, FJ., De León, D., Casiano, CA., De León, M. Lipotoxicity-mediated cell dysfunction and death involve lysosomal membrane permeabilization and cathepsin L activity. Brain Research 1318C:133-143, 2010. ( 6/2009 - 6/2010 )

• Ojo, E., Beeson, L., Shulz, E., Firek, A., De León, M., Balcazar, H., and Cordero-McIntyre, Z. Effect of the “En Balance”, a cultural and language-sensitive diabetes education program, on dietary changes and plasma lipid profile in Hispanic diabetics. International Journal of Body Composition 8:S69-76, 2010. ( 6/2009 - 6/2010 )

• Kalla Singh S, Tan QW, Brito C, De León M and De León D. Insulin-like growth factors I and II receptors in the breast cancer survival disparity among African-American women Growth Hormone & IGF Research 20:245-254, 2010. ( 6/2009 - 6/2010 )

• Almaguel, FG., Liu, J-W., Pacheco, FJ., Casiano, CA., and De León, M. Activation and reversal of lipotoxicity in PC12 and rat cortical cells following exposure to palmitic acid. Journal of Neuroscience Research. 87:1207-1218, 2009.  ( 6/2009 - 6/2010 )

• Khan, S., Aspe, JR., Asumen, MG., Almaguel, F., Odumosu, O., Acevedo-Martinez, S., De León, M., Langridge, WH., Wall, NR. Extracellular, cell-permeable surviving inhibits apoptosis while promoting proliferative and metastatic potential. Br J Cancer 100(7):1073-86, 2009. ( 6/2009 - 6/2010 )

• Mediavilla-Varela, M., Pacheco, FJ., Almaguel, F., Perez, J., Sahakian, E., Daniels, TR., Wall, NR., Lilly, MB., De León, M., and Casiano. CA. Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75. Molecular Cancer. 8:68,  2009 ( 6/2009 - 6/2010 )

• Peterson1, RM., Beeson1, L., Shulz, E., Firek, A., De León, M, Balcazar, H., Tonstad, S., and Cordero-MacIntyre, ZR. Impacting obesity and glycemic control using a culturally-sensitive diabetes education program in Hispanic patients with type 2 diabetes. International Journal of Body Composition Research 8:87-96, 2010. ( 6/2009 - 6/2010 )

• Beeson W. Larry, Batech Michael, Schultz Eloy, Salto Lorena, Firek Anthony, De Leon Marino, Balcazar Hector, Cordero-MacIntyre Zaida. Comparison of Body Composition by Bioelectrical Impedance Analysis and Dual-Energy X-Ray Absorptiometry in Hispanic Diabetics.  International Journal of Body Composition Research. April Vol. 8 No 2: 45-50. 2010. ( 4/2010 )

• Metghalchi, S., Rivera, M., Beeson, L., Firek, A., De León, M., Balcazar, H., Cordero-Macintyere, ZR. Improved clinical outcomes using a culturally sensitive diabetes education program in a Hispanic population. The Diabetes Educ 34:698-706, 2008. ( 6/2008 - 6/2009 )

• Liu, J-W., Almaguel, FG., Bu, L., De Leon, DD., and De León, M. Expression of E-FABP in PC12 cells increases neurite extension during differentiation: involvement of n-3 and n-6 fatty acids. Journal of Neurochemistry 1006(5):2015-2029, 2008. ( 6/2008 - 6/2009 )

• Shiva M, Rivera M, Fukuda D, Beeson L, Libanati C, Firek, D, Balcazar H, De León, M, and Cordero-Macintyre, ZR. Impact of Spanish Diabetes Education Program on Plasma Glucosa, Insulin, HemoglobinA1c, Plasma Lipids and Body Composition in Hispanic Population. Diabetes Educator 34(4):698-706, 2008. ( 6/2008 - 6/2009 )

• Singh KS., Moretta D., Almaguel F., De León, M., De Leon DD. Precursor Igf-II (Proigf-II) and Mature Igf-II (MIgf-II) Induce Bcl-2 And Bcl-x(l) Expression Through Different Signalling Pathways In Breast Cancer Cells. Growth Factors 26(2): 92-103, 2008. ( 6/2008 )

• Sing, KS., Moretta, D., Almaguel, F., Wall, NR., De León, M, De Leon, DD. Differential effect of proIGF-II and IGF-II on resveratrol induced cell death by regulating surviving cellular localization and mitochondrial depolarization in breast cancer cells. Growth Factors 25(6): 363-372, 2008. ( 6/2008 )

• Ulloth JE., Almaguel FG., Padilla A., Bu, L., Liu, J-W., De León, M. "Characterization of methyl-beta-cyclodextrin toxicity in NGF-differentiated PC12 cell death." Neurotoxicology 28:613-621, 2007. ( 5/2007 )

• Chang Y, Edeen K, Lu X, De Leon M, Mason RJ. "Keratinocyte growth factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway." Am J Respir Cell Mol Biol 35.2 (2006): 268-274. ( 8/2006 ) Link...

• Allen, GA., Denes, B., Fodor, I., De León, M. "Vacinia virus infection & gene transduction in cultured neurons." Journal of Microbes and Infection 7. (2005): 1087-1096. ( 1/2005 ) Link...

• Ulloth JE., Casiano, CA., and De León, M. "Palmitic and Stearic Fatty Acids Induce Caspase Dependent and Independent Cell Death in Nerve Growth Factor Differentiated PC12 Cells.." Journal of Neurochem 84. (2003): 655-668. ( 1/2003 )

• Allen GW., Liu, J-W., Kirby, MA., and De León, M. . "Induction and axonal localization of E-FABP in retinal Ganglion cells is associated with axonal growth and regeneration.." Journal of Neurosci Research 66. (2001): 396-400. ( 1/2001 )

• Allen GW, Liu, J-W., and De León, M. "Depletion of a fatty acid-binding protein impairs neurite outgrowth in PC12 cells. " Molecular Brain Research 29. (2000): 315-324. ( 1/2000 )

• Liu Y., Longo, LD., and De León, M. "In situ and immunocytochemical localization of E-FABP mRNA and protein during neuronal migration and differentiation in rat brain, ." Brain Research 852.1 (1999): 16-27. ( 1/1999 )

• De León, M.: "Cloning: Dolly?s Mother is her sister?." Update: 14.2 (1998): 4-5. ( 1/1998 )

• Patel, IP., Suter, U., Snipes, GJ., Welcher, AA., De León, M., Lupkski, JR., and EM Shooter. Peripheral Myelin Protein coding sequence and method. USA Patent number 005,599,920A. 1997. ( 2/1997 )

• Liu Y, Molina CA, Welcher AA, Longo LD,  De León, M. "Expression of DA11, a neuronal-Injury induced fatty acid binding protein, coincides with axon growth and neuronal differentiation during central nervous system development.." Journal of Neuroscience Research 48. (1997): 551-562. ( 1/1997 )

• De León, M., Welcher, AA., R.H Nahin, RL., Liu, Y., Ruda, MA, Shooter, EM. and Molina,CA. "Fatty Acid Binding Protein is induced in Neurons of the dorsal root ganglia after peripheral nerve injury.." Journal of Neuroscience Research 44. (1996): 283-292. ( 1/1996 )

• De León, M. "Clinical insight in the cause and diagnosis of inherited human peripheral neuropathies: contribution from basic molecular neurobiology research.." The Bulletin (November): . (1995): 15-18. ( 11/1995 )

• De León, M., Nahin, R.L., Molina, C., De León, D.D. and Ruda, M.A.. "Comparison of c-jun, jun B and jun D on RNA expression and protein in the rat dorsal root ganglia following sciatic nerve transection.." Journal of Neuroscience Research 42. (1995): 391-401. ( 1/1995 )

• Ruda, M.A., Besse, D., Inagaki, S., De León, M. and Ren, K.. "Nitric oxide expression and regulation in the dorsal root ganglion and spinal cord.." Annuals New York Academy of Science 738. (1995): 181-190. ( 1/1995 )

• Nahin, R.L., Ren, K., De León, M., and Ruda, M.A.. "A rat model of peripheral mononeuropathy identifies alterations in gene expression in primary sensory neurons in the rat.." Pain 58. (1994): 95-108. ( 1/1994 )

• De León, M., Mendoza, M.E., Nahin, R.L., and Ruda, M.A.. " SR13/PMP-22 expression in rat nervous system, in PC12 cells and C6 gliomas cell lines.." J. Neuroscience Research 38. (1994): 167-181. ( 1/1994 )

• Noguchi, K., Dubner, R., De León, M., Senba, E., and Ruda, M.A.. "Axotomy induces preprotachykinin gene expression in a subpopulation of dorsal root ganglion neurons.." J. Neuroscience Research 37. (1994): 569-603. ( 1/1994 )

• Noguchi, K., De León, M., Nahin, R.L., Senba, E. and Ruda, M.A. . "Quantization of axotomy-induced alteration of neuropeptide mRNAs in dorsal root ganglion neurons with special reference to neuropeptide Y mRNA and the effects of neonatal capsaicin treatment.." Journal Neurosci Research 35. (1993): 54-66. ( 1/1993 )

• Hammer, J.A., O''Shannessy, D.J., De León, M., Gould, B., Zank, D., Daune, G., and Quarles, R.H.. "Immunoreactivity of PMP-22, PO and mammals and fish with HNK1 and other related antibodies. ." Journal Neurosci Research 35. (1993): 546-558. ( 1/1993 )

• Welcher, A.A., De León, M., Suter, U., Snipes, G.J., Meakin, S.O. and Shooter, E.M.. "Isolation of transcriptionally regulated sequences associated with neuronal and non-neuronal cell interactions.." Progress in Brain Research 94. (1992): 163-176. ( 1/1992 )

• De León, M., Van Eldik, L.E. and Shooter, E.M.. "Differential regulation of S100B and mRNAs coding for S100-like proteins (42A and 42C) during development and after lesion of rat sciatic nerve.." Journal of Neuroscience Research 29. (1991): 155-162. ( 1/1991 )

• De León, M., Welcher, A.A., Suter, U. and Shooter, E.M.. "Identification of transcriptionally regulated genes after sciatic nerve injury.." Journal of Neuroscience Research 29. (1991): 437-448. ( 1/1991 )

• Welcher, A.A., Suter, U., De León, M., Snipes, G.J., and Shooter, E.M. . "A myelin protein is encoded by the homologue of a growth arrest-specific gene.." Proceedings National Academic of Sciences USA 88. (1991): 7195-7199. ( 1/1991 )

• Welcher, A.A., Suter, U., De León, M., Bitler, C.M., and Shooter, E.M.. "Molecular approaches to nerve regeneration.." Philosophical Transactions of the Royal Society of London. 331.Series B (1991): 295-301. ( 1/1991 )

• Richard Carlsen, De León, M., Tetzlaff, W., Swedberg, E., Parhad, I. and Bisby, M.A. . "Increase in protein and tubulin mRNA synthesis in frog sensory neurons treated with the adenylate cyclase activator, forskolin.." Restorative Neurology and Neuroscience 1. (1990): 225-232. ( 1/1990 )

• Bisby, M.A., Redshaw, J.D., Tezlaff, W., De León, M. and Carlsen, R.C. . "Expression of Growth-Associated proteins (GAPs) in injured sensory axons acclimatized to 15oC is not sufficient to sustain regeneration.." Restorative Neurology and Neuroscience 1. (1989): 25-29. ( 1/1989 )

• De León, M. and Carlsen, R.C.. "Comparison of the synthesis and axonal transport of fucosylated glycoproteins by intact and regenerating sensory neurons in the frog.." Restorative Neurology and Neuroscience 1. (1989): 65-75. ( 1/1989 )

• Cox, D., Jackson, H., Vargas, V., Baez, A., Colon, J., Gonzales, B. and De León, M.. "Synthesis and biological activity of benzothiazolo and benzoxazolo [3,2a] quinolinium salts.." Journal of Medicinal Chemistry. 25. (1982): 1378-1381. ( 1/1982 )

• De Motta, G.E., Cordova, F., De León, M. and del Castillo, J.. "Inhibitory action of high formamide concentrations on excitation-contraction coupling in skeletal muscle.." Journal of Neuroscience Research 7. (1982): 163-178. ( 1/1982 )

• Cordoba F, del Castillo J, De León, M, Escalona de Motta G, Garcia-Salazar M, Jimenez C.. "Effects of high concentrations of formamide on muscle contraction.." Journal of Physiology (London) 291. (1979): 73-74. ( 1/1979 )