Mark Reeves, MD, PhD Associate Professor, Surgery School of Medicine Associate Professor, Basic Sciences School of Medicine

Research & Grantsmanship 

  Patents Earned

• Methods and Compositions for Transforming Dendritic Cells and Activating T Cells - Inventors: Patrick Hwu, Mark E. Reeves, Steven A. Rosenberg. US Patent Serial No 09/117,764 ( 1/1999 - Present )

  Funded Research Project (PI)

• NSABP C-11 ( 1/2010 - 10/2011 )

• The Effect of Silencing RASSF1C & IGFBP-IP Gene Expression on Tumor Growth and Proliferation ( 10/2004 - 6/2009 )

• Antibiotic irrigation for prophylaxis of post-operative abdominal wound infection in major clean-contaminated colorectal surgery ( 7/2004 - 6/2009 )

• NSABP C-09 ( 4/2006 - 1/2008 )

• Phase 3, Randomized, Investigator-Blind, Multi-Center Study to Evaluate Efficacy and Safety of Intravenous Iclaprim Versus Intravenous Linezolid in Complicated Skin and Skin Structure Infections ( 10/2005 - 8/2006 )

• Zevalin trial - A prospectively randomized, phase III, multicenter, controlled trial to evaluate the safety and efficacy of the Zevalin therapeutic regimen plus Rituxan compared with Rituxan alone in patients with relapsed or refractory follicular non-Hodgkin?s lymphoma ( 7/2004 - 8/2006 )

• NSABP B36 ( 7/2004 - 3/2006 )

• NSABP CI66 ( 7/2004 - 10/2004 )

• Treatment of Colorectal Liver Metastasis with Fv-p53 Using a Hemispleen Method ( 6/2005 - Present )

• NSABP STAR (P-2) ( 7/2006 - Present )

• ECOG 5202 ( 3/2006 - Present )

• SWOG 0424 ( 2/2006 - Present )

• Biomarkers associated with cellular survival in pancreatic cancer ( 9/2005 - Present )

• NSABP C-08 ( 7/2004 - Present )

• CALGB 90202 ( 7/2004 - Present )

• ACOSOG Z4031 ( 7/2004 - Present )

  Grant Proposals--Submitted

• Principal Investigator – RASSF1C protein displays oncogenic functions in lung cancer cells R21 grant Funding: NCI ( 6/2012 )

• Principal Investigator – The Functions of RASSF1C/PIWIL1 in Lung Cancer Stem Cells R21 grant Funding: NCI ( 10/2011 )

  Abstracts Reporting Research -- Peer Reviewed

• Aragon RJ, Machado GR, Kuo IJ, Coutsoumpos A, Zmaj KB, Reeves ME. Sphincter Preservation and Local Recurrence Using a Multimodal Algorithm for Treatment of Surgically Difficult Rectal Cancer. Ann Surg Oncol 2010;17:S101. ( 3/2010 )

• Amaar YG, Aragon RJ, Baldwin SW, Baldwin ML, Moretz J, Reeves ME. The Role of Ras-Association Domain Family 1C (RASSF1C) Protein on Lung Cancer Cell Proliferation. Ann Surg Oncol 2009;16:S34-5. ( 3/2009 )

• Baldwin SW, Smallwood J, Moretz J, Nwosu S, Reeves ME. Use of Near-Infrared Imaging for Detection of Tumors in vivo. Ann Surg Oncol 2008;15:S36. ( 3/2008 )

• Fischer LK, Aragon RJ, Baldwin SW, Minera MG, Carter JJ, Amaar YG, Weisbart RH, Reeves ME. "Fv-p53 Therapy Decreases Colorectal Liver Metastasis in a Mouse Model." Ann Surg Oncol 14. (2007): S34-S35. ( 1/2007 )