Loma Linda University

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Mia Nepomuceno-Perez, MD
Associate Professor, Pathology and Human Anatomy
School of Medicine
Associate Professor, Otolaryngology & Hed/Neck Surg
School of Medicine
Publications    Book Review - Scholarly Journals--Published
  • Salma Khan , Heather Ferguson, Bennit, David Turay, Mia Perez, Saied Mirshahidi, Yuan Yuan and Nathan R Wall. Early diagnostic value of survivin and its alternative splice variants in breast cancer. BMC Cancer 2014 14:176 ( 1/2014 - 6/2014 )
    Abstract Background: breast cancer tissues. Our previous work showed Survivin is released from tumor cells via small membrane-bound vesicles called exosomes. We, therefore, hypothesize that analysis of serum exosomal Survivin and its splice variants may provide a novel biomarker for early diagnosis of breast cancer. The inhibitor of apoptosis (IAP) protein Survivin and its splice variants are differentially expressed in Methods: for 5 years after treatment. In addition, twenty-three paired breast cancer tumor tissues from those same 40 patients were analyzed for splice variants. Serum levels of Survivin were analyzed using ELISA and exosomes were isolated from this serum using the commercially available ExoQuick kit, with subsequent Western blots and immunohistochemistry performed. We collected sera from forty breast cancer patients and ten control patients who were disease free Results: with exosome amounts significantly higher in cancer patient sera compared to controls (p < 0.01). While Survivin and Survivin- Survivin-2B protein existed in the exosomes. Similarly, Survivin and Survivin- detected in all of the breast cancer tissues evaluated in this study, whereas a more variable expression of Survivin-2B level was found at different cancer stages. Survivin levels were significantly higher in all the breast cancer samples compared to controls (p < 0.05)ΔEx3 splice variant expression and localization was identical in serum exosomes, differential expression ofΔEx3 proteins were the predominant forms Conclusion: exosomally packaged in the breast cancer patients report in breast cancer tissues. Differential expression of exosomal-Survivin, particularly Survivin-2B, may serve as a diagnostic and/or prognostic marker, a a more thorough understanding of the role of this prominent antiapoptotic pathway could lead to the development of potential therapeutics for breast cancer patients. In this study we show for the first time that like Survivin, the Survivin splice variants are also’ sera, mimicking the survivin splice variant pattern that we also“liquid biopsy” if you will, in early breast cancer patients. Furthermore, Keywords: Survivin, Splice variants, Exosomes, Breast cancer
  • Rachel Conrad, MD; Mia C.N. Perez, MD.Congenital (Gingival) Granular Cell Epulis Tumor.  Arch Pathol Lab Med. 2014;138:128–131; doi: 10.5858/ arpa.2012-0306-RS)  PMID:24377822 ( 1/2014 )
    Congenital granular cell epulis is a rarely reported lesion of unknown histogenesis with a strong predilection for the maxillary alveolar ridge of newborn girls. Microscopically, it demonstrates nests of polygonal cells with granular cytoplasm, a prominent capillary network, and attenuated overlying squamous epithelium. The lesion lacks immunoreactivity for S-100, laminin, chromogranin, and most other markers except neuron-specific enolase and vimentin. Through careful observation of its unique clinical, histopathologic, and immunohistochemical features, this lesion can be distinguished from the more common adult granular cell tumor as well as other differential diagnoses.
  • Quan WD Jr, Quan FM, Perez M, Johnson E. Outpatient Intravenous Interleukin-2 with Famotidine Has Activity in Metastatic Melanoma. 2012 Jun 25. [Epub ahead of print]   ( 6/2012 ) Link...
  Scholarly Journals--Submitted
  • Yang G, Qin H, Zaheer S, Nepomuceno-Perez. Pleural Malignant Mesothelioma with Micropapillary Pattern: A Case Report and Literature Review. Submitted to Austin Journal of Lung Cancer Research

    ( 1/2015 )
  Scholarly Journals--Published
  • L Lei, C Cobb, MN Perez: "Functioning gangliocytic paraganglioma of the ampulla: clinicopathological correlations and cytologic features" ( 2/2015 ) Link...
    Case report , Journal of Gastrointestinal Oncology 2015, doi: 10.3978/j.issn.2078-6891.2015.028
    View this article at: http://dx.doi.org/10.3978/j.issn.2078-6891.2015.028
  • Pedro W. Baron, Thomas Amankonah, Robert F. Cubas, Arputharaj H. Kore, Arvand Elihu, Michael E. de Vera, Mia C.N. Perez; Case Report: Diffuse Hepatic Epithelioid Hemangioendothelioma Developed in a Patient with Hepatitis C Cirrhosis.  Hindawi Publishing Corporation, Case Reports in Transplantation, Vol. 2014, Article ID 694903, 4 pages ( 9/2014 ) Link...
  • PW Baron, T Amankonah, RF Cubas, AH Kore, A Elihu, ME deVera; M CN Perez: Case Report:  "Diffuse Hepatic Epithelioid hemangioendothelioma Developed in a Patient with Hepatitis C Cirrhosis". ( 9/2014 ) Link...
    Case report in Transplantation, Volume 2014, Article ID 694903, 4 pages, Hindawi Publishing Corporation.
  • Skaugset M, Perez M, Chase DR. A 79 year old female with an inner cheek mass (Canalicular adenoma). California Tumor Tissue Registry’s Case of the Month May, 2012 CTTR COTM Vol.14:8  ( 5/2012 ) Link...
  •  Kerstetter J, McHugh R, Raghavan R, Perez M. Carcinoma ex pleomorphic adenoma of the nasal                 cavity. Arch Pathol Lab Med 2010 134: 1381-1382. ( 1/2010 - 6/2010 )
  • Miller, Todd C. MD; Simental Alfred A. MD; Perez, Mia MD. "Sinonasal Adenoid Cystic Carcinoma Seeding to the Tracheostomy Site." The Laryngoscope 114.4 (2006): 661-662. ( 4/2006 )
  Scholarly Journals--Accepted
    1. Choi AH, Blount S, Perez MCN, de Paz Villanueva CC, Rodríguez SA,  Surrusco M , Garberoglio C, Lum SS , Senthil M, Extranodal Extension on Sentinel Lymph Node Dissection in the ACOSOG Z011 Era: Does Size Matter? Accepted for publication to JAMA Surgery
    ( 7/2015 )
    1. Lei L, Cobb C, Perez MN. Functioning gangliocytic paraganglioma of the ampulla: clinicopathological correlations and cytologic features. Accepted for publication

    E-published ahead of print

    doi: 10.3978/j.issn.2078-6891.2015.028


    ( 6/2014 )
  • Rachel Conrad, MD; Mia C.N. Perez, MD.Congenital (Gingival) Granular Cell Epulis Tumor.  Accepted to Archives of Pathology and Laboratory Medicine ( 7/2012 - 6/2013 )
  •       Bautista-Quach M, Iverson M., Baron P, Perez M. Cirrhotic Cardiomyopathy: An Underrecognized Cause of Mortality in Post Liver Transplant Patients. Arch Pathol Lab Med September 2011  ( 9/2011 )
  Non-Scholarly Journals
  • Singh V, Perez M, Chase DR"Heterologous Metaplastic Carcinoma of the Breast." California Tumor Tissue Registry's Case of the Month Vol 8(6) 01 03 2006: ( 3/2006 )