Michael Lilly, MD Clinical Professor, Medicine School of Medicine

Publications 

  Scholarly Journals--Published

• Fodor I, Timiryasova T, Denes B, Yoshida J, Ruckle H, Lilly M. "Vaccinia virus-mediated p53 gene therapy of bladder cancer in an orthotopic murine model." J Urology 173. (2005): 604-609. ( 1/2005 )

• Kim K-T, Baird K, Ahn J-Y, Meltzer P, Lilly M, Small D. "Pim-1 is upregulated in constitutively activating FLT3 mutants and plays a role in FLT3-mediated cell survival." Blood 105(4). (2005): 1759-1767. ( 1/2005 )

• Aho TLT, Sandholm J, Peltola KJ, Mankonen H, Lilly M, Koskinen PJ. "Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site." FEBS Letters 571. (2004): 43-49. ( 1/2004 )

• Ionov Y, Le X, Tunquist BJ, Sweetenham J, Sachs T, Ryder J, Johnson T, Lilly MB, Kraft AS. "Nuclear localization of the pim-1 protein kinase is necessary for its biologic effects." Anticancer Res 23(1A). (2003): 167-178. ( 1/2003 )

• Yan B, Zemskova M, Holder S, Chin V, Kraft AS, Koskinen PJ, Lilly MB. "The PIM-2 kinase phosphorylates BAD on serine-112 and reverses BAD induced cell death." J Biol Chem 278. (2003): 45358-45367. ( 1/2003 )

• Wu X, Daniels T, Molinaro C, Lilly MB, Casiano C. "Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogatres its prosurvival function: implications for autoimmunity in atopic disorders." Cell Death Differentiation 9. (2002): 915-924. ( 1/2002 )

• Lombano F, Kidder MY, Lilly M, Gollin YG, Block BS. "Recurrence of microangiopathic hemolytic anemia after apparent recovery from the HELLP syndrome: A case report." J Reprod Med 47. (2002): 875-877. ( 1/2002 )

• Lilly M, Zemskova M, Frankel AE, Salo J, Kraft AS. "Distinct domains of the human GM-CSF receptor alpha subunit mediate activation of JAK/STAT signaling and differentiation." Blood 97. (2001): 1662-1670. ( 1/2001 )

• Lilly M, Kiskonen P, Sandholm J, Cooper JJ, Kraft AS. "The Pim-1 kinase prevents apoptosis-associated mitochondrial dysfunction, and supports cytokine-independent survival of myeloid cells in part through regulation of bcl-2 expression." Oncogene 18. (1999): 4022-4031. ( 1/1999 )

• Matsuguchi T, Lilly MB, Kraft AS. "Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor receptor * chain (h*c) responsible for human GM-CSF-induced myeloid cell differentiation." J Biol Chem 273. (1998): 19411-19418. ( 1/1998 )

• Frankel A, Lilly M, Kreitman R, Hogge D, Beran M, Freedman MH, Emanuel PD, McLain C, Hall P, Tagge E, Berger M, Eaves C. " Diptheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia." Blood 92. (1998): 4279-4286. ( 1/1998 )

• Matsuguchi T, Zhao Y, Lilly MB, Kraft AS. "The cytoplasmic domain of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor * subunit is essential for both GM-CSF-mediated growth and differentiation." J Biol Chem 272. (1997): 17450-17459. ( 1/1997 )

• Lilly M, Kraft A. "Enforced expression of the 33kd pim-1 kinase enhances factor-independent growth and inhibits apoptosis in murine myeloid cells." Cancer Res 57. (1997): 5348-5355. ( 1/1997 )

• Lilly M, Vo K, Lee T, Takahashi G. "Bryostatin 1 acts synergistically with interleukin 1 to promote the release of G-CSF and other myeloid cytokines from marrow stromal cells." Exp Hematol 24. (1996): 613-621. ( 1/1996 )

• Sensebe L, Li J, Lilly M, Crittenden C, Herve P, Charbord P, Singer J. "Non-transformed colony-derived stromal cell lines from normal human marrows. I. Growth requirements, characterization ,and myelopoieisis-supportive ability." Exp Hematol 23. (1995): 507-513. ( 1/1995 )

• Asiedu C, Biggs J, Lilly M, Kraft A. "Inhibition of leukemic cell growth by the protein kinase C activator Bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2." Cancer Res 55. (1995): 3716-3720. ( 1/1995 )

• Polostkya A, Zhao C, Lilly M, Kraft A. "Mapping the intracytoplasmic regions of the alpha granulocyte-macrophage colony-stimulating factor receptor necessary for cell growth regulation." J Biol Chem 269. (1994): 14607-14613. ( 1/1994 )

• Takahashi G, Montgomery B, Stahl W, Crittenden C, Thorning D, Lilly M. "Pentoxifylline inhbits tumor necrosis factor-alpha mediated cytotoxicity and activation of phospholipase A2 in L929 murine fibrosarcoma cells." Intl J Immunopharm 16. (1994): 723-736. ( 1/1994 )

• Takahashi G, Andrews D, Tompkins C, Montgomery R, Lilly M, Singer J, Alderson M. " Effect of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 3(IL3) on interleukin 8 (IL8) production in neutrophils and monocytes." Blood 81. (1993): 357-364. ( 1/1993 )

• Polostkya A, Zhao C, Lilly M, Kraft A. "A critical role for the intracellular domain of the alpha chain of the GM-CSF receptor in cell cycle transition." Cell Growth & Diff 4. (1993): 525-531. ( 1/1993 )

• Andrews D, Lilly M, Tompkins C, Singer J. "Sodium vanadate, a tyrosine phoshpatase inhibitor, affects expression of hematopietic gorwth factors and extracelular matrix RNAs in SV40-transformed human marrow stromal cells." Exp Hematol 20. (1992): 391-400. ( 1/1992 )

• Lilly M, Le T, Holland P, Hendrickson S. "Expression of the pim-1 kinase is specifically induced in myeloid cells by growth factors whose receptors are structurally related." Oncogene 7. (1992): 727-732. ( 1/1992 )

• Lilly M, Brown C, Pettit R, Kraft A. "Bryostatin 1: a potential cytotoxic agent for chronic myelomonocytic leukemia cells." Leukemia 5. (1991): 282-287. ( 1/1991 )

• Brezovich I, Lilly M, Meredith R, Weppleman B, Brawner W, Henderson R, Salter M. "Hyperthermia of pet animal tumors with self-regulating ferromagnetic thermoseeds." Intl J Hyperthermia 6. (1990): 117-130. ( 1/1990 ) : . 6:117-130, 1990

• Lilly M, Tompkins C, Brown C, Pettit R, Kraft A. " Differentiation and growth modulation of chronic myelogenous leukemia cells by bryostatin 1." Cancer Res 50. (1990): 5520-5525. ( 1/1990 )

• Bailey A, Lilly M, Bertoli L, Ball E. "An antibody which inhibits in vitro bone marrow proliferation in a patient with system lupus erythematosus and aplastic anemia." Arthritis and Rheumatism 32. (1989): 901-905. ( 1/1989 )

• Kraft A, Williams F, Pettit R, Lilly M. "Variable response of human myeloid leukemia lines and fresh cells to differentiating activity of bryostatin 1." Cancer Res 49. (1989): 1287-1293. ( 1/1989 )

• Everson M, Brown C, Lilly M. "IL6 and GM-CSF are candidate growth factors for chronic myelomonocytic leukemia cells." Blood 74. (1989): 1472-1476. ( 1/1989 )

• Nemunaitis J, Andrews F, Mochizuki D, Lilly M, Singer J. "Human marrow stromal cells: response to IL6 and control of IL6 expression." Blood 74. (1989): 1693-1699. ( 1/1989 )

• Barton J, Parmley R, Butler T, Williamson S, Lilly M, Gualtieri R, Heck L. "Differential staining of neutrophils and monocytes: surface and cytoplasmic iron-binding proteins." Histochem J 210. (1988): 147-155. ( 1/1988 )

• Csepreghy M, Yielding A, Lilly M, Scott C, Prchal J. "Characterization of a new G6PD variant: G6PD Central City." Am J Hematol 28. (1988): 61-62. ( 1/1988 )

• Lilly M, Kraft A. "Leukemia-differentiating activity expressed by the human melanoma cell line LD1." Leukemia Res 12. (1988): 213-218. ( 1/1988 )

• Prchal J, Hauk M, Csepreghy M, LIlly M, Berkow R, Scott C. "Two apparent G6PD variants in normal XY man: G6PD Alabama." Am J Med 84. (1988): 517-523. ( 1/1988 )

• Tucker K, Lilly M, Heck L, Rado T. "Characterization of a new human diploid myeloid leukemia cell line (PLB985) with granulocytic and monocytic differentiating capacity." Blood 70. (1987): 372-378. ( 1/1987 )

• Devlin J, Devlin P, Myambo K, Lilly M, Rado T, Warren K. "Isolation and expression of a cDNA encoding a human granulcyte colony-stimulating factor." J Leukocyte Biol 41. (1987): 302-306. ( 1/1987 )

• Lilly M, Devlin J, Devlin P, Rado T. "Production of granulocyte colony-stimulating factor by a human melanoma line." Exp Hematol 15. (1987): 966-971. ( 1/1987 )

• M, Carroll A, Prchal J. "Lack of association between glutathione content and development of thermal tolerance in human fibroblasts." Radiation Res 106. (1986): 41-46. ( 1/1986 )

• Lilly M, Brezovich I, Atkinson W. "Hyperthermia with thermally self-regulating ferromagnetic implants." Radiology 154. (1985): 243-244. ( 1/1985 )

• Lilly M, Katholi C, Ng T. "Direct relationship between high-energy phosphate content and blood flow in thermally treated tumors." JNCI 75. (1985): 885-889. ( 1/1985 )

• Lilly M, Omura G. "Clinical pharmacology of oral intermediate dose methotrexate with or without probenecid." Cancer Chemo Pharm 15. (1985): 220-222. ( 1/1985 )

• Lilly M, Ng T, Evanochko W, Kumar N, Elgavish G, Durant J, Hiramoto R, Ghanta V, Glickson J. "in vivo 31P-NMR study of hyperthermia tumor treatment." Cancer Res 44. (1984): 633-638. ( 1/1984 )

• Hiramoto R, Ghanta V, Lilly M. "Reduction in tumor burden in murine osteosarcoma by hyperthermia and cyclophosphamide." Cancer Research 44. (1984): 1405-1408. ( 1/1984 )

• Brezovich I, Atkinson W, Lilly M. "Local hyperthermia with interstitial techniques." Cancer Research 44. (1984): 46752s-4756s. ( 1/1984 )

• Lilly M, Brezovich I, Chakraborty D, Atkinson W, Durant J, Ingram J, McElvein R. "Hyperthermia with implanted electrodes: in vitro and in vivo correlations." Int J Rad Onc Biol Phys 9. (1983): 373-382. ( 1/1983 )

• Evanochko W, Ng T, Lilly M, Kumar N, Durant J, Glickson J. "In vivo 31P-NMR studies of the effect of cancer therapy on a murine mammary carcinoma." Proc Natl Acad Sci USA 80. (1983): 334-338. ( 1/1983 )

• Ng T, Evanochko W, Hiramoto R, Ghanta V, Lilly M, Lawson A Corbett T, Durant J, Glickson J. "31P-topical NMR spectroscopy of in vivo tumors." Mag Res 49. (1982): 271-286. ( 1/1982 )

• Brezovich I, Lilly M, Durant J, Richards D. "A practical system for clinical radiofrequency hyperthermia." Int J Rad Onc Biol Phys 7. (1981): 423-430. ( 1/1981 )

  Books and Chapters

• Singer J, Slack J, Lilly M, Andrews D. Marrow stromal cells: response to cytokines and control of gene expresssion (in) The Hematopoietic Microenvironment. Baltimore: Johns Hopkins Press, 1993. ( 1/1993 )