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Aim: Oral Lichen Planus (OLP) is an oral lesion with an enigmatic etiology. To explore the possibility of psycho-somatisation, we evaluated the psychological personality profiles of OLP patients. Methods: 20 patients with reticular; 20 with erosive form of OLP, and 25 controls were tested with the psychological MMPI-202 test. Eight clinical scales (hypochondriasis, depression, hysteria, psychopathic deviate, paranoia, psychasthenia, schizophrenia, and hypomania) were compared using one-way ANOVA with Student-Newman-Keuls multiple range test for multiple comparisons. Similarly, one-way ANOVA was used to compare cortisol level, CD3, CD4, CD8, and CD16 markers by group, and Student-Newman-Keuls multiple range test was used for multiple comparisons. Psycho-somatisation was evaluated by the use of IR (Internalization Ratio) Index. Results: A characteristic MMPI profile was noted in the OLP groups with high IR index value. Significant differences among the three groups were detected for cortisol, CD4, CD8, and CD16 counts. Mean values for hypochondriasis, depression, and hysteria were all significantly different with significantly higher mean scores for both reticular OLP subjects and erosive OLP subjects compared to control subjects. Conclusions: Prolonged emotive stress in many OLP patients may lead to psychosomatisation and may contribute to the initiation and clinical expression of this oral disorder. Clinical significance: Adjunctive psychological intervention may provide a clinical beneficial in the treatment of OLP..