Faculty Directory

Lekic, T., Rolland, W., Hartman, R., Kamper, J., Suzuki, H., & Tang, J. (2011). Characterization of the brain injury, neurobehavioral profiles and histopathology in a rat model of cerebellar hemorrhage. Experimental Neurology 227, 96-103. ( 9/2011 )

Chen, W., Ma, Q., Suzuki, H., Hartman, R., Tang, J., & Zhang, J. (2011). Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke, 42(3), 764-769. ( 9/2011 )

Lekic, T., Manaenko, A., Rolland, W., Virbel, K., Hartman, R., Tang, J., Zhang, J.H. (2011) Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats. Acta Neurochir Suppl, 111, 201-206. ( 9/2011 )

Bertolizio G, Bissonnette B, Mason L, Ashwal S, Hartman R, Marcantonio S, Obenaus A. (2011) Effects of hemodilution after traumatic brain injury in juvenile rats. Paediatr Anaesth

( 9/2011 )

Obenaus, A., Dilmac, N., Tone, B., Tian, H.R., Hartman, R.E., Digicaylioglu, M., Snyder, E.Y., & Ashwal, S. (2011). Long-Term magnetic resonance imaging of stem cells in neonatal ischemic injury. Annals of Neurology

( 8/2011 )

Lekic, T., Hartman, R.E., Rojas, H., Manaenko, A., Chen, W., Ayer, R., Tang, J., & Zhang, J.H. (2010) Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. Journal of Neurotrauma, 27(3), 627-37.

( 1/2010 )

Chen, W., Hartman, R.E., Ayer, R., Marcantonio, S., Kamper, J., Tang, J., Zhang, J. (2009). Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain. Journal of Neurochemistry,

( 12/2009 )

Hartman, R.E., Shah, A., Fagan, A.M., Schwetye, K.E., Parsadanian, M., Schulman, R.N., Finn, M.B., & Holtzman, D.M.. "Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimers disease." Neurobiology of Disease 24. (2006): 506-515. ( 12/2006 ) Link...

Although there are no proven ways to delay onset or slow progression of Alzheimer''s disease (AD), studies suggest that diet can affect risk. Pomegranates contain very high levels of antioxidant polyphenolic substances as compared to other fruits and vegetables. Polyphenols have been shown to be neuroprotective in different model systems. We asked whether dietary supplementation with pomegranate juice (PJ) would influence behavior and AD-like pathology in a transgenic mouse model. Transgenic mice (APP(sw)/Tg2576) received either PJ or sugar water control from 6 to 12.5months of age. PJ-treated mice learned water maze tasks more quickly and swam faster than controls. Mice treated with PJ had significantly less (approximately 50%) accumulation of soluble Abeta(42) and amyloid deposition in the hippocampus as compared to control mice. These results suggest that further studies to validate and determine the mechanism of these effects, as well as whether substances in PJ may be useful in AD, should be considered.

Wahrle, S.E., Jiang, H., Parsadanian, M., Hartman, R.E., Bales, K.R., Paul, S.M., & Holtzman, D.M.(2005). Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer’s disease. Journal of Biological Chemistry, 280(52), 43236-43242. ( 12/2005 )