Loma Linda University

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Ravi Raghavan, MBBS, MD
Professor, Pathology and Human Anatomy
School of Medicine
Publications    Scholarly Journals--Published
  • Nickerson JP, Tong KA, Raghavan R. Imaging cerebral malaria with a susceptibility-weighted MR sequence. AJNR Am J Neuroradiol. 2009 Jun;30(6):e85-6. Epub 2009 Mar 25 ( 7/2008 - 6/2009 )
  • Schuster FL, Yagi S, Gavali S, Michelson D, Raghavan R, blomquist I, Glastonbury C, Bollen AW, Scharnhorst D, Reed SL, Kuriyama S, Visvesvara GS, Glaser CA: "Under the Radar: Balamuthia Amebic Encephalitis"  Clin Infect Dis. 2009 Apr 1;48(7):879-87. (7/2008-6/2009) ( 7/2008 - 6/2009 )
  • Ghostine S, Raghavan R, Khanlou N, Vinters HV, Tong KA, Johnson WD, Oyoyo U, Kido D.Cerebral amyloid angiopathy: micro-haemorrhages demonstrated by magnetic resonance susceptibility-weighted imaging.Neuropathol Appl Neurobiol. 2009 Feb;35(1):116-9 ( 7/2008 - 6/2009 )
  • Wang J, Chen C, Lau S, Raghavan R, Rowsell EH, Said J, Weiss LM, Huang Q. CD3-positive large B-cell lymphoma. Am J Surg Pathol. 2009 Apr;33(4):505-12. ( 7/2008 - 6/2009 )
  • C Glaser, F Schuster Yagi S, S Gavali, A Bollen, C Glastonbury, R Raghavan, D michelson, I Blomquist, D Scharnhorst, S Kuriyama, S Reed, M Ginsberg, G Visvesvara, P Wilkins, L Anderson, N Khetsuriani, AL Fowlkes: "Balamuthia Amebic Encephalitis - California, 1999-2007.  CDC-MMWR 2008; 57(28); 768-771. ( 1/2008 - 6/2008 )
  • Perry A, Miller CR, Gujrati M, Scheithauer BW, Zambrano SC, Jost SC, Raghavan R, Qian J, Cochran EJ, Huse JT, Holland EC, Burger PC, Rosenblum MK. Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. Brain Pathol. 2009 Jan;19(1):81-90. Epub 2008 Apr 29 ( 4/2008 )
  • R. Agrawal, R. Raghavan: "Malignant Glioneuronal Tumor, an Emerging Neoplasm: Clinical, Radiologic, and Immunohistochemical Characterization"  Archives of Pathology and Laboratory Medicine.  Sept, 2007. Vol. 131, page 1426. ( 9/2007 )
  • Magaki S, Raghavan R, Mueller C, Oberg KC, Vinters HV, Kirsch WM. "Iron, copper, and iron regulatory protein 2 in Alzheimer?s disease and related dementias." Neuroscience Letters 418.1 (2007): 72-76. ( 1/2007 ) Link...
    Accumulating evidence implicates a role for altered iron and copper metabolism in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). However, imbalances in the levels of the various forms of iron at different stages of AD have not been examined. In this pilot study we extracted and measured the levels of loosely bound, non-heme and total iron and copper in the frontal cortex and hippocampus of patients with mild-moderate AD (n=3), severe AD (n=8) and dementia with Lewy bodies (DLB, n=6), using graphite furnace atomic absorption spectrometry (GFAAS). Additionally, the expression of iron regulatory protein 2 (IRP2) was examined in relation to the pathological hallmarks of AD and DLB, amyloid plaques, neurofibrillary tangles (NFT), and Lewy bodies, by immunohistochemistry. We found significantly decreased loosely bound iron in the hippocampal white matter of mild-moderate and severe AD patients and a trend towards increased non-heme iron in the hippocampal gray matter of severe AD patients. Furthermore, decreased levels of total copper were seen in severe AD and DLB frontal cortex compared to controls, suggesting an imbalance in brain metal levels in both AD and DLB. The decrease in loosely bound iron in mild-moderate AD patients may be associated with myelin breakdown seen in the beginning stages of AD and implicates that iron dysregulation is an early event in AD pathogenesis.
  • Raghavan R, de Kruijff L, Sterrenburg MD, Rogers BB, Hladik CL, White CL.. "Alpha-synuclein expression in the developing human brain (selected/invited reprint)." Perspectives in Pediatric Pathology (Society for Pediatric Pathology) 26. (2007): -. ( 1/2007 )
    Alpha-synuclein is a presynaptic protein, abnormal expression of which has been associated with neurodegenerative and neoplastic diseases. It is abundant in the developing vertebrate central nervous system (CNS), but less is known about its developmental expression in the human CNS. Immunohistochemical expression of alpha-synuclein was studied in 39 fetal, perinatal, pediatric, and adolescent brains. Perikaryal expression of alpha-synuclein is observed as early as 11-wk gestation in the cortical plate. Several discrete neuronal groups in the hippocampus, basal ganglia, and brain stem express perikaryal alpha-synuclein by 20-wk gestation, persisting through the first few years of life. In the cerebellum, alpha-synuclein is present by 21-wk gestation and persists into adult life as a coarse granular neuropil reaction product in the internal granular layer, and as a diffuse neuropil "blush" in the molecular layer. The germinal matrix, glia, endothelial cells, external granular layer, Pukinje cells, and dentate neurons are consistently negative for alpha-synuclein. We conclude that alpha-synuclein is expressed very early in human gestation, and that its distribution and temporal sequence of expression varies in discrete neuronal groups. Perikaryal alpha-synuclein starts disappearing from the neuronal cytosol in early childhood, and only the neuropil retains immunoreactivity into adulthood. The reappearance of alpha-synuclein in the adult neuronal cytosol in certain disease processes may represent reemergence of cues from an earlier developmental stage as part of a stress response.
  • N. Zekry, MJ Klooster, R Raghavan, J Wang. "A 7-year-old Child with History of Acute Myeloid Leukemia Presenting with Multiple Gastrointestinal Polyps." Archives of Pathology and Laboraratory Medicine . (2005): -. ( 1/2005 )
  • R Ben-Yousef, P Baron, E Franco, R Raghavan, O Ojogho. "Strongyloides Stercoralis Infection From Pancreas Allograft." Transplantation . (2004): -. ( 10/2004 )
  • R Raghavan, L deKruiiff, MD Sterrenburg, BB Rogers, CL Haladik, CL White. "Alpha-synuclein Expression in the Developing Human Brain." Pediatric & Developmental Pathology 7.5 (2004): 506-516. ( 7/2004 )
  Scholarly Journals--Accepted
  •  Ghostine S, Perry E, Raghavan R, Michelson D, Tong K, Colohan A. Intra-medullary Spinal Cord Teratoma in Adults - Case Report and Literature Review. SPINE 2009 (in press) ( 7/2009 - 6/2010 )
     
  •  Olaya JE, Raghavan R, Totaro L, Zouros A,. Pineal Anlage Tumor in a 5-month-old boy - Case Report and Review of the Literature. Journal of Neurosurgery: Pediatrics 2010 (in press) ( 7/2009 - 6/2010 )
     
  •  Sukov WR, Ketterling RP, Raghavan R, Viktor AE, Keeney GL, OLiviera AM, Wei S, Monaghan K, Mazzara P, Van Dyke DL. Nearly identical near-haploid karyotype in a peritoneal mesothelioma and retroperitoneal malignant peripheral nerve sheath tumor Cancer Genet & Cytogen 2010 (in press) ( 7/2009 - 6/2010 )
     
  • Kyle JR, Kyle M, Raghavan R, Ozkan C, Ozkan M. Analysis of light scattering from human breast tissue using a custom dual-optical scanning near-field optical microscope. J. Biophotonics 2010 (in press) ( 7/2009 - 6/2010 )
  • S. Ghostine, R. Raghavan, D Michelson, B Holshouser, K. Tong: "Gliomatosis Cerebri Mimicking Rasmussen Encephalitis.  J. Neurosurgery, 2007  Aug: 107(2): 143-146. ( 8/2007 )
  Non-Scholarly Journals
  • S. Ghostine, K Tong, B Holshouser, R Raghavan: "Granular Cell Astrocytic Tumor: Report of a Rare Glial Neoplasm"  Medimond International 2008 (web-publication with Current Contents citation). ( 1/2008 - 6/2008 )