Objective: To report Clostridium difficile sepsis for the first time in a pediatric patient. Design: Case Study Setting: 20 bed pediatric intensive care unit Patient: 5 year old girl with sickle cell disease Interventions: Management of abdominal sepsis and respiratory failure. Measurements and Main results: Patient died from sepsis and autopsy found to have diffuse pseudomembranous colitis. All blood cultures negative, but stool positive for C. difficile toxin. Conclusion: C. difficile can cause overwhelming sepsis in pediatric patients and should be considered a pathogen.