William Pearce, PhD Professor, Basic Sciences School of Medicine Member, Physiology, SM, Faculty of Graduate Studies

Research & Grantsmanship 

  Funded Research Project (PI)

• Maturation of cerebrovascular contractile mechanisms ( 7/2006 - 6/2007 )

• Maturation of cerebrovascular relaxant mechanisms ( 7/2006 - 6/2007 )

• Mechanisms of Acclimatization: Fetus and Adult ( 7/2006 - 6/2007 )

• Maturation of cerebrovascular relaxant mechanisms ( 7/2005 - 6/2006 )

• Mechanisms of acclimatization: Fetus and Adult ( 7/2005 - 6/2006 )

• Maturation of cerebrovascular contractile mechanisms ( 7/2005 - 6/2006 )

• Maturation of cerebrovascular relaxant mechanisms ( 7/2004 - 6/2005 )

• Mechanisms of acclimatization: Fetus and Adult ( 7/2004 - 6/2005 )

• Maturation of cerebrovascular contractile mechanisms ( 7/2004 - 6/2005 )

  Funded Research Project (CI)

• Maturation and myogenic reactivity of cerebral arteries ( 7/2005 - 6/2006 )

• Maturation and myogenic reactivity of cerebral arteries ( 7/2004 - 6/2005 )

  Abstracts Reporting Research -- Peer Reviewed

• Charles, S.M., Zhang, L., Longo, L.D., Pearce, W.J., Buchholz, J.N. "Maturation alters calcium dependent sensitivity of pressure-dependent cerebrovascular myogenic tone." Faseb Journal 21.(Supplement) (2007): 208.15-. ( 1/2007 )

• Sandoval, R., Pearce, W.J.. "Age-dependent stretch-induced myofilament calcium sensitization in ovine cerebral arteries ." Faseb Journal 21.(Supplement) (2007): 466.6-. ( 1/2007 )

• Williams, J.M., Pearce, W.J. . "Physiological modulation of protein kinase G by chronic hypoxia and maturation in adult and fetal ovine common carotid arteries." Faseb Journal 21.(Supplement) (2007): 753.6-. ( 1/2007 )

• Injeti, E.R., Sandoval, R.J., Williams, J.M., Pearce, W.J. . "Postnatal maturation increases the abundance, but decreases the specific activity of MLCK in ovine carotids." Faseb Journal 21.(Supplement) (2007): 599.7-. ( 1/2007 )

• Goyal, R., Pearce, W.J., Longo, L.D., Wilson, S.M.. "Chronic hypoxia and the influence of maturation on serotonergic contractility in ovine pulmonary arteries.." Faseb Journal 21.(Supplement) (2007): 939.3-. ( 1/2007 )

• Buchholz, J.N., Vanterpool, C.K., Pearce, W.J., Behringer, E.J. "Advancing age alters the contribution of release of calcium from internal stores to stimulation-evoked calcium transients." Faseb Journal 21.(Supplement) (2007): 945.9-. ( 1/2007 )

• Charles, S., Zhang, L., Longo, L.D., Pearce, W.J., Buchholz, J.N.. "Generation of myogenic tone requires release of calcium in rat cerebral arteries.." Faseb Journal 21.(Supplement) (2007): 960.16-. ( 1/2007 )

• Sandoval, R.J., Pearce, W.J.. "Maturational differences in the contributions of thick- and thin-filament reactivity to myofilament Ca2+ sensitivity in ovine cerebral arteries. ." Faseb Journal 21.(Supplement) (2007): 960.26-. ( 1/2007 )

• Williams, J.M., Pearce, W.J. . "Chronic hypoxia and postnatal maturation alter isoform expression and specific activity of protein kinase G in ovine carotid arteries." Faseb Journal 21.(Supplement) (2007): 960.27-. ( 1/2007 )

• Sandoval, R., Injeti, E., Williams, J.M., Pearce, W.J.. " Postnatal maturation enhances calcium influx, and reduces myofilament Ca++ sensitization in myogenic responses to cerebral artery stretch.." Journal of Cerebral Blood Flow and Metabolism 27.(Supplement) (2007): BP31-3W-. ( 1/2007 )

• James M Williams & William J Pearce. "Physiological modulation of protein kinase G by chronic hypoxia and maturation in adult and fetal ovine common carotid arteries." Faseb Journal . (2006): -. ( 1/2006 )

• Renan Sandoval & William J Pearce. "Age-dependent stretch-induced myofilament calcium sensitization in ovine cerebral arteries ." Faseb Journal . (2006): -. ( 1/2006 )